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Reference Ranges for Vermis Biometry on Prenatal Ultrasound: Systematic Review and Meta-Analysis.

Ultraschall Med 2021 Apr 9. Epub 2021 Apr 9.

Obstetrics and Gynecology Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem Jerusalem, Israel.

Purpose:  To conduct a systematic review and meta-analysis of published nomograms for fetal vermis biometry.

Materials And Methods:  A structured literature search was conducted to identify studies that reported normal measurements of the fetal vermis. A customized quality assessment tool was used to review the selected articles. Read More

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Toward a Healthy and Environmentally Sustainable Campus Food Environment: A Scoping Review of Postsecondary Food Interventions.

Adv Nutr 2021 Apr 9. Epub 2021 Apr 9.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Interventions are urgently needed to transform the food system and shift population eating patterns toward those consistent with human health and environmental sustainability. Postsecondary campuses offer a naturalistic setting to trial interventions to improve the health of students and provide insight into interventions that could be scaled up in other settings. However, the current state of the evidence on interventions to support healthy and environmentally sustainable eating within postsecondary settings is not well understood. Read More

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Generalizing neural signal-to-text brain-computer interfaces.

Biomed Phys Eng Express 2021 Apr 9. Epub 2021 Apr 9.

Biomedical Engineering Department, University of California - Los Angeles, 7523 Boelter Hall, USA, Los Angeles, California, 90095, UNITED STATES.

Objective: Brain-Computer Interfaces (BCI) may help patients with faltering communication abilities due to neurodegenerative diseases produce text or speech by direct neural processing. However, their practical realization has proven difficult due to limitations in speed, accuracy, and generalizability of existing interfaces. The goal of this study is to evaluate the BCI performance of a robust speech decoding system that translates neural signals evoked by speech to a textual output. Read More

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Outcomes for various dural graft materials after posterior fossa decompression with duraplasty for Chiari malformation type I: a systematic review and meta-analysis.

J Neurosurg 2021 Apr 9:1-14. Epub 2021 Apr 9.

Departments of1Neurological Surgery and.

Objective: Posterior fossa decompression with duraplasty (PFDD) is often used for Chiari malformation type I (CM-I), but outcomes associated with different dural graft materials are not well characterized. In this meta-analysis, the authors examined complication rates and outcomes after PFDD for CM-I for autografts and four types of nonautologous grafts.

Methods: A literature search of numerous electronic databases (Ovid Medline, Embase, Scopus, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, Health Technology Assessment Database, NHS Economic Evaluation Database, and ClinicalTrials. Read More

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Individualized blood pressure targets in the postoperative care of patients with intracerebral hemorrhage.

J Neurosurg 2021 Apr 9:1-10. Epub 2021 Apr 9.

1Neurological Intensive Care Unit, Department of Neurology, and.

Objective: Recent guidelines recommend targeting a systolic blood pressure (SBP) < 140 mm Hg in the early management of patients with spontaneous intracerebral hemorrhage (ICH). The optimal SBP targets for ICH patients after hematoma evacuation (HE) remain unclear. Here, the authors aimed to define the optimal SBP range based on multimodal neuromonitoring data. Read More

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24 h urinary creatinine excretion during pregnancy and its application in appropriate estimation of 24 h urinary iodine excretion.

J Trace Elem Med Biol 2021 Mar 26;66:126751. Epub 2021 Mar 26.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, National Health and Family Planning Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology (23618504), Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin, 150086 Heilongjiang, China. Electronic address:

Background: Urinary creatinine can be used to adjust urinary iodine to evaluate iodine nutritional status during pregnancy. However, the reference intervals and impact factors of urinary creatinine are unknown.

Methods: 24 h urine creatinine concentration (24 hUCr) and spot UCr at four different time periods of the day of pregnant women from Part 1 (n = 743) were measured. Read More

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Noninvasive scalp recording of the middle latency responses and cortical auditory evoked potentials in the alert common marmoset.

Hear Res 2021 Mar 27;405:108229. Epub 2021 Mar 27.

Cognitive Neuroscience Section, Primate Research Institute, Kyoto University, 41-2, Kanrin, Inuyama, Aichi, 484-8506, Japan.

The common marmoset (Callithrix jacchus), a New World monkey, serves as a useful animal model in clinical and basic neuroscience. The present study recorded scalp auditory evoked potentials (AEP) in non-sedated common marmoset monkeys (n = 4) using a noninvasive method similar to that used in humans, and aimed to identify nonhuman primate correlates of the human AEP components. A pure tone stimulus was presented while electroencephalograms were recorded using up to 16 disk electrodes placed on the scalp and earlobes. Read More

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Predictors of sinonasal disease onset, progression, and severity in pediatric cystic fibrosis patients.

Am J Otolaryngol 2021 Mar 31;42(5):103016. Epub 2021 Mar 31.

Department of Otolaryngology, Division of Pediatric Otolaryngology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, United States of America.

Purpose: Pediatric cystic fibrosis (CF) patients have a variable onset, severity, and progression of sinonasal disease. The objective of this study was to identify genotypic and phenotypic factors associated with CF that are predictive of sinonasal disease, recurrent nasal polyposis, and failure to respond to standard treatment.

Methods: A retrospective case series was conducted of 30 pediatric patients with CF chronic rhinosinusitis with and without polyps. Read More

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Discriminating cognitive motor dissociation from disorders of consciousness using structural MRI.

Neuroimage Clin 2021 Mar 29;30:102651. Epub 2021 Mar 29.

Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:

An accurate evaluation and detection of awareness after a severe brain injury is crucial to a patient's diagnosis, therapy, and end-of-life decisions. Misdiagnosis is frequent as behavior-based assessments often overlook subtle signs of consciousness. This study aimed to identify brain MRI characteristics of patients with residual consciousness after a severe brain injury and to develop a simple MRI-based scoring system according to the findings. Read More

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Selection and application of natural antimicrobials to control Clostridium perfringens in sous-vide chicken breasts inhibition of C. perfringens in sous-vide chicken.

Int J Food Microbiol 2021 Mar 31;347:109193. Epub 2021 Mar 31.

Center for Food Safety, University of Georgia, 1109 Experiment Street, Griffin, GA 30223, USA.

Current consumer preferences for both clean label food ingredients and convenience-based foods has provided a unique opportunity to explore the application of novel natural food preservatives in sous vide products. The anaerobic environment and relatively low thermal processing of the sous vide process creates a favorable environment for the survival, germination, and outgrowth of spore-forming bacterium Clostridium perfringens. The aim of this study was to identify effective novel natural ingredient formulations against C. Read More

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Nondestructive multiplex detection of foodborne pathogens with background microflora and symbiosis using a paper chromogenic array and advanced neural network.

Biosens Bioelectron 2021 Apr 1;183:113209. Epub 2021 Apr 1.

Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, 01854, MA, USA. Electronic address:

We have developed an inexpensive, standardized paper chromogenic array (PCA) integrated with a machine learning approach to accurately identify single pathogens (Listeria monocytogenes, Salmonella Enteritidis, or Escherichia coli O157:H7) or multiple pathogens (either in multiple monocultures, or in a single cocktail culture), in the presence of background microflora on food. Cantaloupe, a commodity with significant volatile organic compound (VOC) emission and large diverse populations of background microflora, was used as the model food. The PCA was fabricated from a paper microarray via photolithography and paper microfluidics, into which 22 chromogenic dye spots were infused and to which three red/green/blue color-standard dots were taped. Read More

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Inhomogeneous and anisotropic mechanical properties of the triceps surae muscles and aponeuroses in vivo during submaximal muscle contraction.

J Biomech 2021 Mar 24;121:110396. Epub 2021 Mar 24.

Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan. Electronic address:

This study aimed to identify characteristics of the triceps surae muscles and aponeuroses stiffness in vivo, during graded isometric submaximal plantarflexion efforts. A total of twelve healthy male subjects (age: 27 ± 4 years) participated and were required to stay at rest (0% MVC) and perform isometric submaximal plantar flexion contractions (20%, 40%, 60% of MVC) on a dynamometer. Young's modulus of triceps surae muscles and the adjoining aponeuroses between gastrocnemii and soleus at the proximal and distal sites were obtained in the longitudinal direction (along muscle's line of action) during at rest and submaximal plantar flexions. Read More

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Association between extreme ambient temperatures and general indistinct and work-related road crashes. A nationwide study in Italy.

Accid Anal Prev 2021 Apr 6;155:106110. Epub 2021 Apr 6.

Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, RM, Italy.

Despite the relevance of road crashes and their impact on social and health care costs, the effects of extreme temperatures on road crashes risk have been scarcely investigated, particularly for those occurring in occupational activities. A nationwide epidemiological study was carried out to estimate the risk of general indistinct and work-related road crashes related with extreme temperatures and to identify crash and occupation parameters mostly involved. Data about road crashes, resulting in death or injury, occurring during years 2013-2015 in Italy, were collected from the National Institute of Statistics, for general indistinct road crashes, and from the compensation claim applications registered by the national workers' compensation authority, for work-related ones. Read More

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Impacts and challenges of the COVID-19 pandemic on emergency medicine physicians in the United States.

Am J Emerg Med 2021 Apr 2;48:38-47. Epub 2021 Apr 2.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA. Electronic address:

Background: Emergency medicine (EM) physicians have been on the front line of the COVID-19 pandemic. This study aims to determine the impact of COVID-19 pandemic and other related factors such as resource availability and institutional support on well-being, burnout and job-satisfaction of EM physicians in the United States.

Methods: A cross-sectional survey study of EM physicians was conducted through the Emergency Medicine Practice Research Network of the ACEP. Read More

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Pholedrine is a marker of direct disposal of methamphetamine.

Sci Total Environ 2021 Mar 30;782:146839. Epub 2021 Mar 30.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide 5001, South Australia, Australia. Electronic address:

Consumption of methamphetamine has primarily been estimated in wastewater-based epidemiology by measuring the parent compound. However, this could lead to overestimation when methamphetamine is directly disposed into the sewer system. In this respect, it would be advantageous to measure a specific metabolite of methamphetamine instead. Read More

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An interpretable 1D convolutional neural network for detecting patient-ventilator asynchrony in mechanical ventilation.

Comput Methods Programs Biomed 2021 Mar 19;204:106057. Epub 2021 Mar 19.

College of Information Engineering, Zhejiang University of Technology, Liuhe Rd. 288, Hangzhou 310023, China. Electronic address:

Background And Objective: Patient-ventilator asynchrony (PVA) is the result of a mismatch between the need of patients and the assistance provided by the ventilator during mechanical ventilation. Because the poor interaction between the patient and the ventilator is associated with inferior clinical outcomes, effort should be made to identify and correct their occurrence. Deep learning has shown promising ability in PVA detection; however, lack of network interpretability hampers its application in clinic. Read More

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Identifying advanced stage NSCLC patients who benefit from afatinib therapy using F-afatinib PET/CT imaging.

Lung Cancer 2021 Mar 26;155:156-162. Epub 2021 Mar 26.

Department of Pulmonology, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.

Objectives: Non-small cell lung cancer (NSCLC) tumors harboring common (exon19del, L858R) and uncommon (e.g. G719X, L861Q) activating epidermal growth factor receptor (EGFR) mutations are best treated with EGFR tyrosine kinase inhibitors (TKI) such as the first-generation EGFR TKI erlotinib, second-generation afatinib or third-generation osimertinib. Read More

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Method validation of 12 kinds of food dye in chewing gums and soft drinks, and evaluation of measurement uncertainty for soft drinks.

Food Chem 2021 Mar 27;356:129705. Epub 2021 Mar 27.

Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

We developed and validated a method for the simultaneous quantitative analysis of food dyes in two food matrices, i.e., chewing gum and soft drinks. Read More

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Application of UHPLC-Q-TOF-MS/MS metabolomics approach to investigate the taste and nutrition changes in tilapia fillets treated with different thermal processing methods.

Food Chem 2021 Mar 31;356:129737. Epub 2021 Mar 31.

Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.

Thermal processing is a common processing method for tilapia which has an important impact on the quality and characteristics of fish meat. This study aimed to investigate changes in the metabolites of tilapia fillets after thermal processing. In this work, we used a UHPLC-Q-TOF-MS/MS metabolomics method to identify and screen differential metabolites. Read More

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Arc concave sign on thin-section computed tomography:A novel predictor for invasive pulmonary adenocarcinoma in pure ground-glass nodules.

Eur J Radiol 2021 Mar 27;139:109683. Epub 2021 Mar 27.

Depatment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, NO.2 Fuxue Rd, Wenzhou, 325000, China. Electronic address:

Objective: We aimed to investigate the risk factors of invasive pulmonary adenocarcinoma, especially to report and validate the use of our newly identified arc concave sign in predicting invasiveness of pure ground-glass nodules (pGGNs).

Methods: From January 2015 to August 2018, we retrospectively enrolled 302 patients with 306 pGGNs ≤ 20 mm pathologically confirmed (141 preinvasive lesions and 165 invasive lesions). Arc concave sign was defined as smooth and sunken part of the edge of the lesion on thin-section computed tomography (TSCT). Read More

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Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review.

Arch Gerontol Geriatr 2021 Mar 31;95:104411. Epub 2021 Mar 31.

Department of Nursing, Faculty of Allied Health Sciences, University of Peradeniya, Sri Lanka.

Background: Malnutrition among older people is one of the serious public health problem worldwide. Nutritional status and levels of nutrients of older patients with COVID-19 effect on COVID-19 outcomes. The purpose of this systematic review was to identify the prevalence of malnutrition and levels of nutrients associated with outcomes of the older patients with COVID-19. Read More

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Influences on emergency department attendance among frail older people with deteriorating health: a multicentre prospective cohort study.

Public Health 2021 Apr 6;194:4-10. Epub 2021 Apr 6.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College, London, United Kingdom. Electronic address: https://twitter.com/ij_higginson.

Objectives: To examine the patterns and influences on repeated emergency department attendance among frail older people with deteriorating health.

Study Design: Multicentre prospective cohort study (International Access Rights and Empowerment II study) with convergent mixed methods design.

Methods: Eligible patients were aged ≥65 years, with Clinical Frailty Score ≥5, and ≥1 hospital admission or ≥2 acute attendances in the previous 6 months. Read More

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Beyond language impairment: Profiles of apathy in primary progressive aphasia.

Cortex 2021 Mar 16;139:73-85. Epub 2021 Mar 16.

The University of Sydney, Brain & Mind Centre, Sydney, NSW, Australia; The University of Sydney, School of Psychology, Sydney, NSW, Australia. Electronic address:

Primary progressive aphasia (PPA) is characterised by predominant language and communication impairment. However, behavioural changes, such as apathy, are increasingly recognised. Apathy is defined as a reduction in motivation and goal-directed behaviour. Read More

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Exploration of E. coli contamination drivers in private drinking water wells: An application of machine learning to a large, multivariable, geo-spatio-temporal dataset.

Water Res 2021 Mar 27;197:117089. Epub 2021 Mar 27.

Department of Civil Engineering, McMaster University, 1280 Main St. W, Hamilton, Ontario, L8S 4L8, Canada; Department of Geography and Planning and Global Institute for Water Security, University of Saskatchewan, 117 Science Place, Saskatoon, Saskatchewan, S7N 5C8, Canada.

Groundwater resources are under increasing threats from contamination and overuse, posing direct threats to human and environmental health. The purpose of this study is to better understand drivers of, and relationships between, well and aquifer characteristics, sampling frequencies, and microbiological contamination indicators (specifically E. coli) as a precursor for improving knowledge and tools to assess aquifer vulnerability and well contamination within Ontario, Canada. Read More

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Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System.

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Mayo Clinic, Jacksonville, FL.

Objective: To assess the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients with coronavirus disease 2019 (COVID-19) in comparison with a matched cohort with similar cardiovascular risk factors, as well as the impact of DVT/PE on hospital course.

Methods: A retrospective review of prospectively collected data on COVID-19 patients hospitalized from 03/11/2020 to 09/04/2020 was performed. Patients were randomly matched in a 1:1 ratio by age, sex, hospital of admission, smoking history, diabetes mellitus and coronary artery disease with a cohort of non-COVID-19 patients. Read More

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Internal-external cross-validation helped to evaluate the generalizability of prediction models in large clustered datasets.

J Clin Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands; Health Data Research UK and Institute of Health Informatics, University College London, Gibbs Building, 215 Euston Road, London, NW1 2BE, United Kingdom. Electronic address:

Objective: To illustrate how to evaluate the need of complex strategies for developing generalizable prediction models in large clustered datasets.

Study Design And Setting: We developed eight Cox regression models to estimate the risk of heart failure using a large population-level dataset. These models differed in the number of predictors, the functional form of the predictor effects (non-linear effects and interaction) and the estimation method (maximum likelihood and penalization). Read More

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Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis.

Semin Cancer Biol 2021 Apr 6. Epub 2021 Apr 6.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

Arsenic exposure in contaminated drinking water is a global health issue, as more than 200 million people are affected globally. Arsenic has been known to cause skin, liver, lung, bladder and prostate cancers. Accordingly, it has been categorized as a group I human carcinogen by the International Agency for Research on Cancer (IARC). Read More

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Citation of Prior Systematic Reviews in Reports of Randomized Controlled Trials Published in Dental Speciality Journals.

J Dent 2021 Apr 6:103658. Epub 2021 Apr 6.

Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.

Objectives: To assess the extent to which reports of dental Randomised Clinical Trials (RCTs) cite prior systematic reviews (SR) to explain the rationale or justification of the trial. Study characteristics that predicated the citation of SR in the RCT report were explored.

Methods: An electronic database search was undertaken to identify dental RCTs published between 1 January 2014 and 31 December 2019. Read More

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Unique Complications and Failure Modes of Iliac Branch Devices.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular & Endovascular Surgery, Stanford University School of Medicine, Stanford, CA.

Objectives: Iliac branch devices (IBDs) are modular, bifurcated endografts designed to preserve hypogastric flow during endovascular aortoiliac aneurysm repair. We report our single center outcomes, and describe the unique complications of these devices: inability to cannulate the hypogastric artery (technical failure), occlusion of the internal branch, and type III endoleak from separation of components between the main body and IBD.

Methods: A prospectively maintained institutional database of patients undergoing IBD implantation between 2014 and 2019 was reviewed. Read More

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The effects of maternal SSRI exposure on the serotonin system, prefrontal protein expression and behavioral development in male and female offspring rats.

Neurochem Int 2021 Apr 6:105041. Epub 2021 Apr 6.

School of Rehabilitation, Kunming Medical University, Kunming, China. Electronic address:

Fluoxetine (FLX), a commonly used selective serotonin reuptake inhibitor, is often used to treat depression during pregnancy. However, prenatal exposure to FLX has been associated with a series of neuropsychiatric illnesses. The use of a rodent model can provide a clear indication as to whether prenatal exposure to SSRIs, independent of maternal psychiatric disorders or genetic syndromes, can cause long-term behavioral abnormalities in offspring. Read More

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