24,020 results match your criteria identified regulators

Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis.

J Cell Biol 2021 Jul 12;220(7). Epub 2021 May 12.

National Laboratory of Biomacromolecules, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Polarity is essential for diverse functions in many cell types. Establishing polarity requires targeting a network of specific signaling and cytoskeleton molecules to different subregions of the cell, yet the full complement of polarity regulators and how their activities are integrated over space and time to form morphologically and functionally distinct domains remain to be uncovered. Here, by using the model system Dictyostelium and exploiting the characteristic chemoattractant-stimulated translocation of polarly distributed molecules, we developed a proteomic screening approach, through which we identified a leucine-rich repeat domain-containing protein we named Leep1 as a novel polarity regulator. Read More

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A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.

J Dent Res 2021 May 12:220345211012000. Epub 2021 May 12.

Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

The parotid, submandibular, and sublingual glands represent a trio of oral secretory glands whose primary function is to produce saliva, facilitate digestion of food, provide protection against microbes, and maintain oral health. While recent studies have begun to shed light on the global gene expression patterns and profiles of salivary glands, particularly those of mice, relatively little is known about the location and identity of transcriptional control elements. Here we have established the epigenomic landscape of the mouse submandibular salivary gland (SMG) by performing chromatin immunoprecipitation sequencing experiments for 4 key histone marks. Read More

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Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure.

FASEB J 2021 Jun;35(6):e21608

Garvan Institute of Medical Research, Sydney, NSW, Australia.

The mechanisms underpinning beta-cell compensation for obesity-associated insulin resistance and beta-cell failure in type 2 diabetes remain poorly understood. We used a large-scale strategy to determine the time-dependent transcriptomic changes in islets of diabetes-prone db/db and diabetes-resistant ob/ob mice at 6 and 16 weeks of age. Differentially expressed genes were subjected to cluster, gene ontology, pathway and gene set enrichment analyses. Read More

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ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.

Nat Commun 2021 May 11;12(1):2666. Epub 2021 May 11.

National Cancer Institute; National Institutes of Health, Laboratory of Immune Cell Biology, Bethesda, MD, USA.

Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis plays a major role in tumor necrosis. Although several key necroptosis regulators including receptor interacting protein kinase 1 (RIPK1) have been identified, the regulation of tumor necroptosis during tumor development remains elusive. Read More

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The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in .

Proc Natl Acad Sci U S A 2021 May;118(20)

Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, 710061 Xi'an, China;

Fibroblast growth factor (FGF)/extracellular signal-regulated kinase (ERK) signaling plays a crucial role in anterior-posterior (A-P) axial patterning of vertebrate embryos by promoting posterior development. In our screens for novel developmental regulators in embryos, we identified Fam3b as a secreted factor regulated in ectodermal explants. Family with sequence similarity 3 member B (FAM3B)/PANDER (pancreatic-derived factor) is a cytokine involved in glucose metabolism, type 2 diabetes, and cancer in mammals. Read More

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Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum.

Mol Biochem Parasitol 2021 May 8:111374. Epub 2021 May 8.

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, UK. Electronic address:

Recent studies highlight the emerging role of lipids as important messengers in malaria parasite biology. In an attempt to identify interacting proteins and regulators of these dynamic and versatile molecules, we hypothesised the involvement of phospholipid translocases and their substrates in the infection of the host erythrocyte by the malaria parasite Plasmodium spp. Here, using a data base searching approach of the Plasmodium Genomics Resources (www. Read More

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Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.

Genes Genomics 2021 May 11. Epub 2021 May 11.

Department of General Surgery, Qilu Hospital of Shandong University, #107 Wenhua Road, Jinan, 250012, Shandong, China.

Background: Disheveled-associated activator of morphogenesis (DAAM) family, including DAAM1 and DAAM2, is key regulators in Wnt signaling pathway. Although the oncogenic role of Wnt signaling pathway in colorectal cancer (CRC) was investigated in several lines, the expression and function of DAAM in CRC are still obscure.

Objective: To investigate the expression and function of DAAM in CRC. Read More

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Transcription factor control of virulence in phytopathogenic fungi.

Mol Plant Pathol 2021 May 11. Epub 2021 May 11.

Centre for Crop and Disease Management, Curtin University, Bentley, Western Australia, Australia.

Plant-pathogenic fungi are a significant threat to economic and food security worldwide. Novel protection strategies are required and therefore it is critical we understand the mechanisms by which these pathogens cause disease. Virulence factors and pathogenicity genes have been identified, but in many cases their roles remain elusive. Read More

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Differentially expressed microRNAs that target functional genes in mature soybean nodules.

Plant Genome 2021 May 10:e20103. Epub 2021 May 10.

School of Life Sciences and Center for Soybean Research of the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, HKSAR, Hong Kong.

MicroRNAs (miRNAs) are important regulators of biological functions in plants. To find out what roles miRNAs play in regulating symbiotic nitrogen fixation (SNF) in soybean [Glycine max (L.) Merr. Read More

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Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2.

Sci Rep 2021 May 10;11(1):9892. Epub 2021 May 10.

Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Meibergdreef 69-71, Amsterdam, The Netherlands.

Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress, causes rapid stem cell differentiation in normal intestinal and colon cancer cells. We previously found that stem cell differentiation was mediated by a Protein kinase R-like ER kinase (PERK) dependent arrest of mRNA translation, resulting in rapid protein depletion of WNT-dependent transcription factor c-MYC. Read More

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Application of the targeted sequencing approach reveals the single nucleotide polymorphism (SNP) repertoire in microRNA genes in the pig genome.

Sci Rep 2021 May 10;11(1):9848. Epub 2021 May 10.

Department of Animal Reproduction, Anatomy and Genomics, The University of Agriculture in Kraków, al. Mickiewicza 24/28, 30-059, Kraków, Poland.

MicroRNAs (miRNAs) are recognized as gene expression regulators, indirectly orchestrating a plethora of biological processes. Single nucleotide polymorphism (SNP), one of the most common genetic variations in the genome, is established to affect miRNA functioning and influence complex traits and diseases. SNPs in miRNAs have also been associated with important production traits in livestock. Read More

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Exosomal circ_0030167 derived from BM-MSCs inhibits the invasion, migration, proliferation and stemness of pancreatic cancer cells by sponging miR-338-5p and targeting the Wif1/Wnt8/β-catenin axis.

Cancer Lett 2021 May 7. Epub 2021 May 7.

Research Center of Clinical Medical and Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu province, 226001, PR China. Electronic address:

Pancreatic cancer (PC) is one of the most lethal malignant tumors and has the lowest survival rate due to early metastasis and drug resistance. Exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs) have emerged as crucial regulators of the progression of various tumors. These vesicles contain abundant circRNAs that have important biological functions. Read More

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Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression.

Toxicol Appl Pharmacol 2021 May 7:115569. Epub 2021 May 7.

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Activated macrophages have been implicated in lung injury and fibrosis induced by the cytotoxic alkylating agent, nitrogen mustard (NM). Herein, we determined if macrophage activation is associated with histone modifications and altered miRNA expression. Treatment of rats with NM (0. Read More

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Recent developments of HDAC inhibitors: Emerging indications and novel molecules.

Br J Clin Pharmacol 2021 May 10. Epub 2021 May 10.

Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.

The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically well-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a high number of clinical trials involving HDAC inhibitors, prompting us to further evaluate the current status of this class of therapeutic agents. In total, we have identified 32 agents with HDAC-inhibiting properties, of which 29 were found to interact with the HDAC enzymes as their primary therapeutic target. Read More

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Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML.

Blood 2021 05 10. Epub 2021 May 10.

Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, Massachusetts, United States.

The mechanism underlying cell type-specific gene induction conferred by ubiquitous transcription factors as well as disruptions caused by their chimeric derivatives in leukemia is not well understood. Here we investigate whether RNAs coordinate with transcription factors to drive myeloid gene transcription. In an integrated genome-wide approach surveying for gene loci exhibiting concurrent RNA- and DNA-interactions with the broadly expressed transcription factor RUNX1, we identified the long noncoding RNA LOUP. Read More

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Strigolactones regulate sepal senescence in Arabidopsis.

J Exp Bot 2021 May 10. Epub 2021 May 10.

The New Zealand Institute for Plant and Food Research Limited, Private Bag, Palmerston North, New Zealand.

Flower sepals are critical for flower development and vary greatly in lifespan depending on their function post-pollination. Very little is known about what controls sepal longevity. Using a sepal senescence mutant screen, we identified two Arabidopsis mutants with delayed senescence directly connecting strigolactones (SL) with senescence regulation in a novel floral context that hitherto has not been explored. Read More

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A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma.

Front Cell Dev Biol 2021 21;9:612518. Epub 2021 Apr 21.

Systems Biology Ireland and Precision Oncology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.

Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving this cancer. While an increasing number of reports suggest an association of MYCN with epigenetic machinery, the mechanisms of these interactions are poorly understood in the neuroblastoma setting. Read More

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Long Noncoding RNA MLK7-AS1 Promotes Non-Small-Cell Lung Cancer Migration and Invasion the miR-375-3p/YWHAZ Axis.

Front Oncol 2021 22;11:626036. Epub 2021 Apr 22.

Department of Oncology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huaian, China.

Long noncoding RNAs act essential regulators in lung cancer tumorigenesis. Our research aimed to investigate the potential function and molecular mechanisms of MLK7-AS1 in NSCLC (non-small-cell lung cancer). QRT-PCR results indicated that the MLK7-AS1 expression level was upregulated in NSCLC cells and tissues. Read More

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MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells.

Oncol Lett 2021 Jun 21;21(6):482. Epub 2021 Apr 21.

Department of Microbiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

Tumor development and progression are closely associated with various microRNAs (miRNAs/miRs). We have previously shown that Newcastle disease virus (NDV) strain 7793 induces oncolysis in lung cancer. However, how NDV exerts its oncolytic effect on lung cancer remains to be investigated. Read More

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Differential proteomic analysis of tibial subchondral bone from male and female guinea pigs with spontaneous osteoarthritis.

Exp Ther Med 2021 Jun 15;21(6):633. Epub 2021 Apr 15.

Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.

A proteomic study on the tibial subchondral bone in guinea pigs with spontaneous osteoarthritis was performed to investigate the molecular alterations that occur in early osteoarthritis. A total of 132 healthy Hartley guinea pigs (aged 1 month; 66 female and 66 male) were randomly divided into 11 groups of six. Changes in articular cartilage and tibial subchondral bone were assessed using macroscopic examinations and micro-computed tomography. Read More

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The evolution, devolution and distribution of UK Biometric Imaginaries.

Biosocieties 2021 May 5:1-21. Epub 2021 May 5.

Department of Sociology, Durham University, 32 Old Elvet, Durham, DH1 3HN UK.

This article critically examines UK biometric policymaking by charting the bodies identified by the 2018 Home Office Biometric Strategy as playing key roles in the oversight of biometric data used in law enforcement and other related functions. The article argues that oversight actors are embedded in biometric imaginaries promoted by the UK Home Office and the devolved Scottish administration. By mapping oversight of UK biometrics policy together with developments in Scotland, the article challenges sociotechnical imaginaries studies which assume the power of national governments to project dominant, cohesive and instrumental visions. Read More

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Over-the-counter sale of antibiotics - Using Net-Map to identify and segment stakeholders as the first step towards the development of smart regulation.

Indian J Med Microbiol 2021 Apr 16;39(2):184-187. Epub 2020 Dec 16.

Amity Institute of Public Health, Amity Institute, NOIDA, Uttar Pradesh, India; Center for Disease Dynamics & Economic Policy, New Delhi, India.

Introduction: Antimicrobial resistance (AMR) is a complex public health problem requiring coordinated efforts by a multitude of public and private sector stakeholders. Over-the-counter (OTC) antibiotics sale is contributing to rising AMR. We applied NetMap, a research tool to identify, prioritize and assess relationships among stakeholders, also to identify the stakeholders that must be engaged for regulating antibiotic OTC sale for humans in India. Read More

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Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice.

G3 (Bethesda) 2021 May 7. Epub 2021 May 7.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.

Metastasis is the spread of cancer cells to a secondary site within the body, and is the leading cause of death for cancer patients. The lung is a common site of metastasis for many cancer types, including melanoma. Identifying the genes involved in aiding metastasis of melanoma cells to the lungs is critical for the development of better treatments. Read More

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LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer.

Cell Death Dis 2021 May 7;12(5):454. Epub 2021 May 7.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008, Changsha, P. R. China.

Radioresistance continues to be the leading cause of recurrence and metastasis in nasopharyngeal cancer. Long noncoding RNAs are emerging as regulators of DNA damage and radioresistance. LINC-PINT was originally identified as a tumor suppressor in various cancers. Read More

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Hierarchies, markets, and collaborative networks in energy governance: Multilevel drivers of renewable energy deployment.

J Environ Manage 2021 May 4;290:112614. Epub 2021 May 4.

Florida State University Askew School of Public Administration, USA. Electronic address:

State renewable portfolio standard (RPS) mandates, competitive wholesale electricity markets, and cooperative regional transmission planning have all been identified as potential drivers of RE production. However, these factors are typically studied in isolation, and studies come to mixed conclusions about their actual effects on RE deployment. In this article, we a) use a novel "networks of action situations" (NAS) approach to examine the way that state RPS mandates, competitive markets, and regional transmission planning interact to jointly affect RE production; and b) ask whether these patterns differ across traditionally regulated and "deregulated" jurisdictions. Read More

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Structure-based design approach of potential BCL-2 inhibitors for cancer chemotherapy.

Comput Biol Med 2021 Apr 30;134:104455. Epub 2021 Apr 30.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, 560054, Karnataka, India. Electronic address:

B-cell lymphoma 2 (BCL-2) family is one of the chief regulators of cellular apoptosis. The intricate interactions between pro-apoptotic and anti-apoptotic genes of the BCL-2 family dictate the apoptotic balance of the cell. An overexpression of the anti-apoptotic members of BCL-2 is indicative of cell death evasion and cancer metastasis. Read More

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Variance in expression and localization of sex-related genes CgDsx, CgBHMG1 and CgFoxl2 during diploid and triploid Pacific oyster Crassostrea gigas gonad differentiation.

Gene 2021 May 4:145692. Epub 2021 May 4.

Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, China.

Several evolutionarily conserved classes of transcriptional regulators were involved in diverse sex determination and differentiation pathways across taxa, whereas their roles in most mollusks is still limited. The Pacific oyster Crassostrea gigas, a dioecious bivalve with sex reversal, could be an ideal model for this issue because of its complex sexuality and potential disruption of sex differentiation in triploid individuals. Here, two mRNA splicing isoforms of a DM domain gene CgDsx and two isoforms of a novel sex-related CgBHMG1 (ortholog of BHMG1 in mammals) were identified in C. Read More

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The comprehensive landscape of miR-34a in cancer research.

Cancer Metastasis Rev 2021 May 6. Epub 2021 May 6.

New Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.

MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers. Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal controls, implying its potential tumor-suppressive effect. Clinically, miR-34 has been identified as promising prognostic indicators for various cancers. Read More

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Identification, Expression, and Interaction Analysis of Ovate Family Proteins in Reveals a Role of PtOFP1 Regulating Drought Stress Response.

Front Plant Sci 2021 20;12:650109. Epub 2021 Apr 20.

Northeast Agricultural University, Harbin, China.

Ovate family proteins (OFPs) are a family of plant growth regulators that play diverse roles in many aspects of physiological processes. OFPs have been characterized in various plant species including tomato, , and rice. However, little is known about OFPs in woody species. Read More

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Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.

J Am Soc Nephrol 2021 May 6. Epub 2021 May 6.

Pediatric Nephrology Unit and Research Lab, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel

Background: Low nephron number at birth is associated with a high risk of CKD in adulthood because nephrogenesis is completed . Poor intrauterine environment impairs nephron endowment an undefined molecular mechanism. A calorie-restricted diet (CRD) mouse model examined the effect of malnutrition during pregnancy on nephron progenitor cells (NPCs). Read More

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