9,496 results match your criteria identified necropsy

Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

Ann Diagn Pathol 2021 Apr 19;53:151744. Epub 2021 Apr 19.

Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, United States of America. Electronic address:

Objectives: Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.

Methods: Lungs of 12 consecutive COVID-19 decedents consented for autopsy were evaluated for gross and histopathologic abnormalities. A complete Ghon "en block" dissection was performed on all cases; lung weights and gross characteristics recorded. Read More

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First case of lethal encephalitis in Western Europe due to European bat lyssavirus type 1.

Clin Infect Dis 2021 May 15. Epub 2021 May 15.

Sorbonne Université, Brain Institute (ICM; INSERM, UMRS 1127; CNRS, UMR 7225), Paris, France.

Background: Inaccurate diagnosis of encephalitis is a major issue as immunosuppressive treatments can be deleterious in case of viral infection. The European bat lyssavirus type 1, a virus related to rabies virus, is endemic in European bats. No human case has yet been reported in Western Europe. Read More

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Comparison of the clinical, ultrasound, and CT findings in 13 dogs with gastric neoplasia.

Vet Radiol Ultrasound 2021 May 14. Epub 2021 May 14.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Diagnosis of gastric tumors in dogs is difficult and is often obtained by biopsy following identification of a mass through ultrasound (US) or endoscopy. In human medicine, modalities such as CT and endoscopy are standard of care in the diagnosis and staging of gastric tumors. Although one veterinary study has described CT findings of gastric tumors in dogs using iatrogenic gas dilation, there are no veterinary studies that have directly compared the usefulness of US versus CT in the diagnosis and staging of these tumors. Read More

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Role of autopsy imaging-computed tomography in the post-mortem study of farm animals.

Vet Rec Open 2021 Dec 7;8(1):e1. Epub 2021 Apr 7.

Faculty of Agriculture University of Miyazaki Miyazaki Japan.

Background: Autopsy imaging (Ai) is used to determine the cause of death, providing pre-dissection information. Ai is often used in the field of human forensic medicine but has never been applied on farm animals.

Methods: Ai-computed tomography (CT) was performed before necropsy for farm animals (one goat, one ox, one cow and three calves) that died or were euthanised. Read More

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December 2021

COVID-19 autopsy reports from the Ga-East Municipal and the 37 Military Hospitals in Accra, Ghana.

Ghana Med J 2020 Dec;54(4 Suppl):52-61

Department of Pathology, School of Medical Sciences, University of Cape Coast and Cape Coast Teaching Hospital, Cape Coast, Ghana.

Introduction: Since the declaration of COVID-19 by the World Health Organisation (WHO) as a global pandemic on 11th March 2020, the number of deaths continue to increase worldwide. Reports on its pathologic manifestations have been published with very few from the Sub-Saharan African region. This article reports autopsies on COVID-19 patients from the Ga-East and the 37 Military Hospitals to provide pathological evidence for better understanding of COVID-19 in Ghana. Read More

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December 2020

Endoscopically unobservable appendiceal adenoma treated using laparoscopically assisted surgery.

Int J Surg Case Rep 2021 Apr 30;83:105949. Epub 2021 Apr 30.

Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Japan.

Introduction: Primary benign adenomas of the appendix occur rarely. According to appendectomy and autopsy reports, benign adenomas of the appendix are sporadically reported, accounting for ~0.02-0. Read More

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Molecular detection of Anaplasma phagocytophilum in hair and spleen of cats revealed a possible underestimation of feline vector-borne pathogens.

Res Vet Sci 2021 May 5;137:144-149. Epub 2021 May 5.

Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia (BO), Italy. Electronic address:

Feline Vector-Borne Diseases show increased global prevalence and some Anaplasma and Ehrlichia species may pose a risk to human health. The diagnosis of Anaplasma and Ehrlichia species infection in cats is achieved by the combined use of different methods as cytologic examination evidencing intracytoplasmic morulae, serologic tests and molecular assays. The peripheral whole blood is considered the sample of choice for Anaplasma and Ehrlichia species DNA detection in cats, but false negative results are reported leading to underestimation of infection prevalence. Read More

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Development and Application of an Interactive Neuropathology iBook as a Complementary Learning Tool for Veterinary Medicine Students.

J Vet Med Educ 2021 May 10:e20200105. Epub 2021 May 10.

Neuropathology is a challenging subject for most medical students. Delivering a gamified learning tool on this topic may motivate students and increase knowledge in the discipline. We report the development of such a tool in iBook format for the systemic pathology course delivered at Ross University School of Veterinary Medicine. Read More

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COVID-19 - neuropathological point of view, pathobiology, and dilemmas after the first year of the pandemic struggle.

Folia Neuropathol 2021 ;59(1):1-16

Department of Pathology and Neuropathology, Medical University of Gdansk, Poland.

This article constitutes a summary of the knowledge on the involvement of the nervous system in COVID-19, concerning its general pathobiology, clinical presentation and neuropathological features as well as the future directions of investigation. Variable definitions, selection bias, mainly retrospective analyses of hospitalized patients and different methodologies are implemented in the research of this new disease. Central nervous system (CNS) pathology presents most frequently features of non-specific neuroinflammation with microglial activation and lymphoid infiltrations, ischemic/hypoxic encephalopathy, acute cerebrovascular disease, and microthrombi. Read More

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January 2021

ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature.

Autops Case Rep 2021 Jan 28;11:e2020231. Epub 2021 Jan 28.

Postgraduate Institute of Medical Education and Research, Department of Gastroenterology, Chandigarh, India.

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Read More

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January 2021

Post-mortem cardiac magnetic resonance parameters in normal and diseased conditions.

Cardiovasc Diagn Ther 2021 Apr;11(2):373-382

Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.

Background: Post-mortem cardiac magnetic resonance (CMR) is a non-invasive alternative to conventional autopsy. At present, diagnostic guidelines for cardiovascular conditions such as hypertrophic cardiomyopathy have not been established. We correlated post-mortem CMR images to definite conventional autopsy findings and hypothesed that elevated T2-weighted signal intensity and RV to LV area ratios can identify myocardial infarction and pulmonary emboli respectively. Read More

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Ocular tuberculosis in a calf.

BMC Vet Res 2021 May 8;17(1):187. Epub 2021 May 8.

Laboratorio de Investigación en Tuberculosis Bovina, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico city, Mexico.

Background: Bovine tuberculosis is a chronic inflammatory disease that causes granuloma formation mainly in retropharyngeal, tracheobronchial, mediastinal lymph nodes and lungs of bovines. The presence of these lesions in other tissues such as the eyeball is very rare and difficult to diagnose. This study describes macroscopic and microscopic pathological findings in a calf with ocular and meningeal tuberculosis. Read More

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Fetomaternal Hemorrhage: Evaluation of Recurrence Within a Large Integrated Health Care System.

Am J Obstet Gynecol 2021 May 4. Epub 2021 May 4.

Kaiser Permanente Oakland Department of Pathology, 275 W MacArthur Boulevard Oakland, CA 94610.

Background: Fetomaternal hemorrhage is associated with severe fetal morbidity and mortality. The recurrence risk of fetomaternal hemorrhage is unknown.

Objective: We sought to establish the recurrence rate of fetomaternal hemorrhage in a large integrated healthcare system over a 10-year period. Read More

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Sudden death due to cardiac contusion: Forensic implications in a rare pediatric case.

J Forensic Sci 2021 May 7. Epub 2021 May 7.

Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni, Università degli Studi di Milano, Milano, Italy.

Blunt chest trauma (BCT) often results in blunt cardiac injuries of little clinical concern, but cases of severe heart damage with high mortality rates have also been described. In particular, BCT should never be underestimated, especially when it is located in the anterior thoracic region. Among traffic accidents, motorcyclists are the most vulnerable and at the greatest risk. Read More

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The utility of lung weight to heart weight ratio as a means to identify suspected drug intoxication deaths in a medico-legal autopsy population.

J Forensic Sci 2021 May 6. Epub 2021 May 6.

The National Board of Forensic Medicine, Stockholm, Sweden.

Fatal intoxications are common in a medico-legal autopsy setting and are associated with sparse findings during autopsy. It has been suggested that an increased lung weight may be associated with such fatalities. Previous literature is generally limited to a descriptive approach, including only opioid deaths, and lacking a definition of "heavy" lungs. Read More

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COVID-19 Cardiac Injury: An Important Cause of COVID-19 Related Morbidityand Mortality.

Ann Clin Lab Sci 2021 Mar;51(2):156-162

Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA

Objective: Although coronavirus disease 2019 (COVID-19) typically presents as a respiratory illness, co-existent cardiovascular symptomatology associated with an elevated serum troponin level has been identified as a risk factor for adverse outcomes. Our study addressed the need to correlate serum cardiovascular biomarkers with tissue pathology based on autopsy.

Materials And Methods: In 13 patients, we reviewed the clinical history and measurements of serum troponin and other biomarkers and correlated them with autopsy findings. Read More

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Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies.

Exp Ther Med 2021 Jun 14;21(6):607. Epub 2021 Apr 14.

Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Thyroid cancer accounts for 1% of all malignancies, and is becoming increasingly common worldwide. The literature reports a prevalence of ~50% of thyroid nodules detected during autopsies in subjects with unknown thyroid pathology. An extended retrospective study of 526 autopsy cases was performed to identify the prevalence of thyroid carcinoma, among various types of thyroid nodules identified incidentally. Read More

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Heterobilharzia americana infection in dogs: A retrospective study of 60 cases (2010-2019).

J Vet Intern Med 2021 May 2. Epub 2021 May 2.

Department of Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA.

Background: The trematode Heterobilharzia americana (HA) causes granulomatous gastrointestinal and hepatic disease in dogs. Before 2008, diagnosis relied on saline fecal sedimentation or histopathology, and earlier reports primarily described dogs with advanced disease or cases diagnosed incidentally at necropsy. The advent of a fecal PCR test has facilitated the diagnosis of HA and provided insights into manifestations and response to treatment. Read More

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Key Disease Mechanisms Linked to Alzheimer's Disease in the Entorhinal Cortex.

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Center for Neurodegenerative Diseases and Therapeutics, Discipline of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.

Alzheimer's disease (AD) is a chronic, neurodegenerative brain disorder affecting millions of Americans that is expected to increase in incidence with the expanding aging population. Symptomatic AD patients show cognitive decline and often develop neuropsychiatric symptoms due to the accumulation of insoluble proteins that produce plaques and tangles seen in the brain at autopsy. Unexpectedly, some clinically normal individuals also show AD pathology in the brain at autopsy (asymptomatic AD, AsymAD). Read More

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Role of Infection and Immunity in Bovine Perinatal Mortality: Part 1. Causes and Current Diagnostic Approaches.

Animals (Basel) 2021 Apr 6;11(4). Epub 2021 Apr 6.

Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.

While non-infectious causes are more commonly diagnosed in cases of bovine perinatal mortality (PM), the proportion caused by infections is highly variable between studies (~5-35%); the reasons for this variation, and possible underestimation, are discussed. The most important pathogen-specific infectious causes of PM are bacteria (in particular, and spp.), viruses (in particular BVDv) and a parasite (). Read More

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A molecular single-cell lung atlas of lethal COVID-19.

Nature 2021 Apr 29. Epub 2021 Apr 29.

Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY, USA.

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2 infection, yet the host response at the lung tissue-level is poorly understood. Here, we performed single-nucleus RNA-sequencing of ~116,000 nuclei of lungs from 19 COVID-19 decedents who underwent rapid autopsy and 7 control lungs. Integrated analyses revealed significant alterations in cellular composition, transcriptional cell states, and cell-to-cell interactions, providing insights into the biology of lethal COVID-19. Read More

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Visualizing infection using a small molecule imaging probe.

J Clin Microbiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine, Duke University, Durham, NC, USA.

diagnostic imaging of bacterial infections is currently reliant on targeting their metabolic pathways, an ineffective method to identify microbial species with low metabolic activity. Here we establish HS-198 as a small molecule-fluorescent conjugate that selectively targets the highly conserved bacterial protein, HtpG (High temperature protein G), within , the bacterium responsible for Lyme Disease. We describe the use of HS-198 to target morphologic forms of in both the logarithmic growth phase and the metabolically dormant stationary phase as well as in inactivated spirochetes. Read More

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Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients.

Neurology 2021 Apr 28. Epub 2021 Apr 28.

Comprehensive Epilepsy Center, NYU School of Medicine, New York, NY, USA.

Objective: To identify the molecular signaling pathways underlying sudden unexpected death in epilepsy (SUDEP) and high-risk SUDEP compared to epilepsy control patients.

Methods: For proteomics analyses, we evaluated the hippocampus and frontal cortex from microdissected post-mortem brain tissue of 12 SUDEP and 14 non-SUDEP epilepsy patients. For transcriptomics analyses, we evaluated hippocampus and temporal cortex surgical brain tissue from mesial temporal lobe epilepsy (MTLE) patients: 6 low-risk and 8 high-risk SUDEP as determined by a short (< 50 seconds) or prolonged (≥ 50 seconds) postictal generalized EEG suppression (PGES) that may indicate severely depressed brain activity impairing respiration, arousal, and protective reflexes. Read More

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Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes.

Neurocase 2021 Apr 27:1-11. Epub 2021 Apr 27.

Departments of Neurology, Mayo Clinic Rochester, Minnesota, USA.

We report two cases from the frontotemporal lobar degeneration (FTLD) spectrum with remarkably slow progression. The first case demonstrated insidious-onset behavioral symptoms and personality changes resembling behavioral variant of frontotemporal dementia, followed a benign course over 26 years, his brain autopsy revealed the diffuse form of argyrophilic grain disease. The second case presented with slowly progressive cognitive and motor deficits, reminiscent of the corticobasal syndrome, deteriorated slowly over 22 years, his brain autopsy revealed FTLD-TDP with C9ORF72 pathology. Read More

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First report of Mycobacterium bovis in wild chacma baboons (Papio ursinus) at the human-wildlife interface area in Zambia.

Transbound Emerg Dis 2021 Apr 26. Epub 2021 Apr 26.

The University of Zambia, School of Veterinary Medicine, Lusaka, Zambia.

Mycobacterium bovis (M. bovis) causes tuberculosis in mammals and is a major public health threat worldwide. While M. Read More

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Hypoglycemia and seizures associated with canine primary hepatic neuroendocrine carcinoma.

J Vet Diagn Invest 2021 Apr 26:10406387211012378. Epub 2021 Apr 26.

BluePearl Specialty and Emergency Hospital, Phoenix, AZ, USA.

A 10-y-old intact male Labrador Retriever dog had a history of ataxia, inability to stand, and grand mal seizures. Complete blood count and serum biochemistry profiles revealed profound hypoglycemia, mildly increased alanine aminotransferase (ALT) activity, mild hypernatremia, and lymphopenia. The seizures could not be controlled with intravenous dextrose, diazepam, or propofol. Read More

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Severe pneumonia in a street rat () caused by strain RMC2.

Open Vet J 2021 Jan-Mar;11(1):165-173. Epub 2021 Mar 10.

IRD, AP-HM, MEPHI, Aix Marseille University, Marseille, France.

Background: Rodents are one of the most dangerous reservoirs and carriers of infectious diseases. Gradually, rats have become predominant in cities, sometimes staying in close vicinity to humans, pets, and other animals. Consequently, they tend to increase the transmission risk of pathogens. Read More

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