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Transcriptome analysis of the bursa of Fabricius and thymus of laying ducks reveals immune gene expression changes underlying the impacts of stocking densities.

Br Poult Sci 2021 Jun 21. Epub 2021 Jun 21.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, P.R. China.

The thymus and bursa of Fabricius are important immune organs in poultry as they play essential roles in sustaining the normal immune function to maintain health. The following trial investigated whether the stocking density affected gene expressions in immune organs.Jinding ducklings were raised in either low or high density (4 or 8 birds/m) conditions from four to 14 weeks of age, and were then slaughtered and tissues removed. Read More

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miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia.

Leuk Res 2021 Jun 12;109:106643. Epub 2021 Jun 12.

Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. Electronic address:

Acute lymphoblastic leukemia (ALL) is one of the most frequent hematological malignancies in children, representing approximately 25 % of all pediatric cancers. Despite striking advances in ALL treatments, a small population of patients does not still respond to chemotherapy, raising the number of deaths in children. ABC transporters are one of the major causes of multidrug resistance (MDR) in cancers and overexpression of ABCA3 is directly associated with increased chemo-resistance in pediatric ALL. Read More

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Untargeted Lipidomics for Determining Cellular and Subcellular Responses in Zebrafish () Liver Cells Following Exposure to Complex Mixtures in U.S. Streams.

Environ Sci Technol 2021 Jun 7;55(12):8180-8190. Epub 2021 Jun 7.

U.S. Environmental Protection Agency, Center for Environmental Measurement and Modeling, Athens, Georgia 30605, United States.

Surface waters often contain a variety of chemical contaminants potentially capable of producing adverse outcomes in both humans and wildlife due to impacts from industrial, urban, and agricultural activity. Here, we report the results of a zebrafish liver (ZFL) cell-based lipidomics approach to assess the potential ecotoxicological effects of complex contaminant mixtures using water collected from eight impacted streams across the United States mainland and Puerto Rico. We initially characterized the ZFL lipidome using high resolution mass spectrometry, resulting in the annotation of 508 lipid species covering 27 classes. Read More

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Immune-Related Gene SERPINE1 Is a Novel Biomarker for Diffuse Lower-Grade Gliomas Large-Scale Analysis.

Front Oncol 2021 20;11:646060. Epub 2021 May 20.

Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Glioma is one of the highly fatal primary tumors in the central nervous system. As a major component of tumor microenvironment (TME), immune cell has been proved to play a critical role in the progression and prognosis of the diffuse lower-grade gliomas (LGGs). This study aims to screen the key immune-related factors of LGGs by investigating the TCGA database. Read More

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The Impacts of and Genetic Variants on Rheumatoid Arthritis Risk in the Chinese Han Population: A Case-Control Study.

Int J Gen Med 2021 28;14:2147-2159. Epub 2021 May 28.

Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, People's Republic of China.

Background: Rheumatoid arthritis (RA), an autoimmune systemic inflammatory disease, largely resulted from genetic factor. Our purpose was to explore the association for and genetic variants with RA susceptibility in the Chinese Han population.

Patients And Methods: A total of 508 RA patients and 494 controls were involved in this case-control study; single-nucleotide polymorphisms (SNPs) genotyping was identified by the Agena MassARRAY platform. Read More

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Double-blinded randomized controlled trial to reveal the effects of Brazilian propolis intake on rheumatoid arthritis disease activity index; BeeDAI.

PLoS One 2021 27;16(5):e0252357. Epub 2021 May 27.

Search Institute for Bone and Arthritis Disease (SINBAD), Shirahama Foundation for Health and Welfare, Wakayama, Japan.

Background And Aims: Brazilian propolis reportedly contributed to suppressing disease activity in a mouse model of rheumatoid arthritis (RA), suggesting new treatment options using Brazilian propolis. However, only results from animal experiments have been available, and the suppressive effects of Brazilian propolis on disease activity in humans with RA remain unknown. The purpose of this study was to clinically validate how Brazilian propolis intake changes disease activity in RA patients. Read More

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[National surveillance of in China, 2015-2019].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Apr;33(2):127-132

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China.

Objective: To analyze the monitoring data of s in the national schistosomiasis surveillance sites of China from 2015 to 2019, so as to understand the changes of snail status in the schistosomiasis-endemic areas of China and to provide the scientific evidence for snail control.

Methods: According to the requirements of (), national schistosomiasis surveillance sites were assigned in all schistosomiasis-endemic counties (cities, districts) and the potential endemic counties (cities, districts) in the Three Gorges Reservoir areas, and snail status was monitored according to different epidemic types. In endemic areas, snail survey was performed by means of systematic sampling and environmental sampling, and the occurrence of frames with snails and the prevalence of infections in snails were calculated, while in potential endemic areas, the risk of imported snails and snails in floating debris were monitored. Read More

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Genome-Wide Detection of Runs of Homozygosity in Laiwu Pigs Revealed by Sequencing Data.

Front Genet 2021 29;12:629966. Epub 2021 Apr 29.

Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China.

Laiwu pigs, distinguished by their high intramuscular fat of 7-9%, is an indigenous pig breed of China, and recent studies also found that Laiwu pigs showed high resistance to Porcine circovirus type 2. However, with the introduction of commercial varieties, the population of Laiwu pigs has declined, and some lineages have disappeared, which could result in inbreeding. Runs of homozygosity (ROH) can be used as a good measure of individual inbreeding status and is also normally used to detect selection signatures so as to map the candidate genes associated with economically important traits. Read More

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Birth year dependent increase in axial length of Japanese adult.

Am J Ophthalmol 2021 May 12. Epub 2021 May 12.

Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602 Japan. Electronic address:

Purpose: To determine whether the correlations between the axial length and the aging-dependent and birth year-dependent age are significant.

Design: Retrospective cross-sectional study.

Methods: This study included Japanese patients ≥50 years who had undergone cataract surgery at multiple clinics from 2002 to 2020. Read More

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Mosquito surveillance of West Nile and Usutu viruses in four territorial units of Slovakia and description of a confirmed autochthonous human case of West Nile fever, 2018 to 2019.

Euro Surveill 2021 May;26(19)

The Czech Academy of Sciences, Institute of Vertebrate Biology, Brno, Czech Republic.

BackgroundDespite the known circulation of West Nile virus (WNV) and Usutu virus (USUV) in Slovakia, no formal entomological surveillance programme has been established there thus far.AimTo conduct contemporaneous surveillance of WNV and USUV in different areas of Slovakia and to assess the geographical spread of these viruses through mosquito vectors. The first autochthonous human WNV infection in the country is also described. Read More

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Surgical management and outcome of dogs with primary spontaneous pneumothorax: 110 cases (2009-2019).

J Am Vet Med Assoc 2021 Jun;258(11):1229-1235

Objective: To describe surgical management and associated outcomes for dogs with primary spontaneous pneumothorax.

Animals: 110 client-owned dogs with primary spontaneous pneumothorax that underwent surgical management.

Procedures: Medical records at 7 veterinary teaching hospitals were reviewed. Read More

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Predictors and trajectories of treatment response to SSRIs in patients suffering from PTSD.

Psychiatry Res 2021 Jul 26;301:113964. Epub 2021 Apr 26.

H. Lundbeck A/S, Valby, Copenhagen, Denmark.

Paroxetine and sertraline are the only FDA approved drugs for treatment of posttraumatic stress disorder (PTSD). Although both drugs show better outcomes than placebo, not all patients benefit from treatment. We examined predictors and latent classes of SSRI treatment response in patients with PTSD. Read More

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Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis.

Sci Rep 2021 May 10;11(1):9884. Epub 2021 May 10.

Department of Rheumatology, Kanazawa University Hospital, 13-1, Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

This study aimed to clarify the factors underlying the discrepancy that has been noted between estimated glomerular filtration ratio (eGFR) measured using serum creatinine (Cr) and eGFR using serum cystatin C (CysC) in patients with rheumatoid arthritis (RA) and to identify those patients whose renal function should be evaluated using CysC. We retrospectively evaluated clinical features, disease activity, Steinbrocker radiological staging, and co-morbidities (diabetes mellitus, hypertension, dyslipidemia) in 238 RA patients. eGFR using serum creatinine (eGFR-Cr) and eGFR using serum cystatin C (eGFR-CysC) were calculated using the new Japanese coefficient-modified Modification of Diet in Renal Disease study equation. Read More

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Metabolome and transcriptome profiling reveals anthocyanin contents and anthocyanin-related genes of chimeric leaves in Ananas comosus var. bracteatus.

BMC Genomics 2021 May 7;22(1):331. Epub 2021 May 7.

College of Landscape Architecture, Sichuan Agricultural University, Chengdu, China.

Background: Ananas comosus var. bracteatus is a colorful plant used as a cut flower or landscape ornamental. The unique foliage color of this plant includes both green and red leaves and, as a trait of interest, deserves investigation. Read More

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Validity of claims-based algorithms for selected cancers in Japan: Results from the VALIDATE-J study.

Pharmacoepidemiol Drug Saf 2021 May 7. Epub 2021 May 7.

Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.

Purpose: Real-world data from large administrative claims databases in Japan have recently become available, but limited evidence exists to support their validity. VALIDATE-J validated claims-based algorithms for selected cancers in Japan.

Methods: VALIDATE-J was a multicenter, cross-sectional, retrospective study. Read More

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Canadian national electrophysiology ablation registry report 2011-2016.

BMC Health Serv Res 2021 May 6;21(1):435. Epub 2021 May 6.

Sunnybrook Health Sciences Centre, University of Toronto, 890 Sheppard Avenue West, Ontario, M4N 3M5, Toronto, Canada.

Background/purpose: Interventional cardiac electrophysiology (EP) is a rapidly evolving field in Canada; a nationwide registry was established in 2011 to conduct a periodic review of resource allocation.

Methods: The registry collects annual data on EP lab infrastructure, imaging, tools, human resources, procedural volumes, success rates, and wait times. Leading physicians from each EP lab were contacted electronically; participation was voluntary. Read More

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Plant-based diets and risk of disease mortality: a systematic review and meta-analysis of cohort studies.

Crit Rev Food Sci Nutr 2021 May 6:1-13. Epub 2021 May 6.

Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

We aimed to examine the association between adherence to plant-based diets (PBDs) and the risk of mortality among the general population. Relevant investigations were identified through PubMed, Scopus, Embase, and ISI Web of Knowledge. Data were pooled using a random-effects or a fixed-effects model. Read More

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Bioinformatic analysis and validation of microRNA-508-3p as a protective predictor by targeting NR4A3/MEK axis in pulmonary arterial hypertension.

J Cell Mol Med 2021 Jun 4;25(11):5202-5219. Epub 2021 May 4.

Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, China.

Pulmonary arterial hypertension (PAH) featured a debilitating progressive disorder. Here, we intend to determine diagnosis-valuable biomarkers for PAH and decode the fundamental mechanisms of the biological function of these markers. Two mRNA microarray profiles (GSE70456 and GSE117261) and two microRNA microarray profiles (GSE55427 and GSE67597) were mined from the Gene Expression Omnibus platform. Read More

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Predictors of stillbirth among women who had given birth in Southern Ethiopia, 2020: A case-control study.

PLoS One 2021 3;16(5):e0249865. Epub 2021 May 3.

Department of Midwifery, College of Health Sciences and Medicine, Wolkite University, Wolkite, Ethiopia.

Background: Although the rate of stillbirth has decreased globally, it remains unacceptably high in low- and middle-income countries. Only ten countries including Ethiopia attribute more than 65% of global burden of still birth. Ethiopia has the 7th highest still birth rate in the world. Read More

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Genome wide identification, phylogeny, and synteny analysis of family in common carp ().

Biotechnol Rep (Amst) 2021 Jun 16;30:e00607. Epub 2021 Mar 16.

Division of Fish Genetics and Biotechnology, Fauclty of Fisheries Rangil, Ganderbal, SKUAST-Kashmir, India.

Common carp () is a commercial fish species valuable for nutritious components and plays a vital role in human healthy nutrition. The SOX (SRY-related genes systematically characterized by a high-mobility group HMG-box) encoded important gene regulatory proteins, a family of transcription factors found in a broad range of animal taxa and extensively known for its contribution in multiple developmental processes including contribution in sex determination across phyla. In our current study, we initially accomplished a genome-wide analysis to report the SOX gene family in common carp fish based on available genomic sequences of zebrafish retrieved from gene repository databases, we focused on the global identification of the Sox gene family in Common carp among wide range of vertebrates and teleosts based on bioinformatics tools and techniques and explore the evolutionary relationships. Read More

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Chronic ocular complications in lamotrigine vs. trimethoprim-sulfamethoxazole induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Ocul Surf 2021 Apr 28;21:16-18. Epub 2021 Apr 28.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States. Electronic address:

Purpose: The purpose of this study is to compare the severity of chronic ocular complications of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) induced by lamotrigine (LT) vs. trimethoprim-sulfamethoxazole (TS).

Methods: This retrospective cross-sectional study evaluated all SJS/TEN patients treated within our hospital network from 2008 to 2018. Read More

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Impact of diastolic dysfunction on outcome in heart failure patients with mid-range or reduced ejection fraction.

ESC Heart Fail 2021 May 1. Epub 2021 May 1.

Department of Internal Medicine I, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, 97080, Germany.

Aims: The role of diastolic dysfunction (DD) in prognostic evaluation in heart failure (HF) patients with impaired systolic function remains unclear. We investigated the impact of echocardiography-defined DD on survival in HF patients with mid-range (HFmrEF, EF 41-49%) and reduced ejection fraction (HFrEF, EF < 40%).

Methods And Results: A total of 2018 consecutive hospitalized HF patients were retrospectively included and divided in two groups based on baseline EF: HFmrEF group (n = 951, aged 69 ± 13 years, 74. Read More

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High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia.

Authors:
Jun Li Zheng Ge

BMC Cancer 2021 Apr 29;21(1):475. Epub 2021 Apr 29.

Department of Hematology, Zhongda Hospita, Medical School of Southeast University, Institute of Hematology Southeast University, Nanjing, 210009, China.

Background: Acute myeloid leukemia (AML) remains one of the most common hematological malignancies, posing a serious challenge to human health. HSPA8 is a chaperone protein that facilitates proper protein folding. It contributes to various activities of cell function and also is associated with various types of cancers. Read More

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Molecular and Serological Detection of Piroplasms in Horses from Nigeria.

Pathogens 2021 Apr 23;10(5). Epub 2021 Apr 23.

Animal Disease Research Unit, USDA-ARS, Pullman, WA 99164-6630, USA.

Equine piroplasmosis, an economically important disease of equids caused by the hemoprotozoan parasites , , and , has a worldwide distribution. These parasites are transmitted by ixodid ticks. To improve the detection of horses in Nigeria exposed to piroplasm parasites, 72 horses with variable clinical signs of piroplasmosis were sampled from Northwest and Northcentral Nigeria and tested by nPCR and cELISA. Read More

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The effects of oral anticancer parity laws on out-of-pocket spending and adherence among commercially insured patients with chronic myeloid leukemia.

J Manag Care Spec Pharm 2021 May;27(5):554-564

Department of Pharmaceutical Outcomes & Policy and Center for Drug Evaluation & Safety, University of Florida College of Pharmacy, Gainesville, FL.

Over the past 12 years, 43 states and Washington DC have implemented oral anticancer medication parity laws in response to the burden of pharmacy cost sharing. Parity laws are designed to provide equal coverage and cost sharing between orally and parenterally administered anticancer medications for patients in commercial, fully insured health plans (FIHPs). However, there is considerable state-level variation in the requirements to achieve compliance with parity laws, and the clinical and economic effectiveness of parity is not fully known. Read More

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Penicillium oxalicum secretomic analysis identify plant cell wall degrading enzymes important for fruit juice extraction.

J Food Sci Technol 2021 May 6;58(5):1764-1775. Epub 2020 Aug 6.

Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS Brazil.

Pectinases and other carbohydrate-active enzymes are important for the food industry, mainly for juice processing. In addition, the use of peels to produce enzymes can aggregate value to these agro-industrial residues and at the end of the process enhance qualitatively and quantitatively the juice production. In this work, three different extracts produced by LS09 using agro-industrial residues were optimized and analyzed by mass spectrometry. Read More

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Proteinuria changes in kidney disease patients with clinical remission during the COVID-19 pandemic.

PLoS One 2021 23;16(4):e0250581. Epub 2021 Apr 23.

Division of Nephrology and Hypertension, The Jikei University School of Medicine, Tokyo, Japan.

Backgrounds: Data on how lifestyle changes due to the coronavirus disease 2019 (COVID-19) pandemic have influenced the clinical features of kidney disease patients remain scarce.

Methods: This study retrospectively analyzed clinical variables in patients with stage G1-G4 chronic kidney disease (CKD) with complete or incomplete remission of proteinuria, who were managed in a nephrology outpatient clinic of a university hospital in Tokyo. The clinical variables during the COVID-19 pandemic (term 1, June-July 2020) were compared to those one year before the pandemic (term 0, June-July 2019). Read More

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The Value of Cement Augmentation in Patients With Diminished Bone Quality Undergoing Thoracolumbar Fusion Surgery: A Review.

Global Spine J 2021 Apr;11(1_suppl):37S-44S

4352Mayo Clinic, First Street SW, Rochester, MN, USA.

Study Design: Systematic review.

Objectives: Osteoporosis predisposes patients undergoing thoracolumbar (TL) fusion to complications and revision surgery. Cement augmentation (CA) improves fixation of pedicle screws to reduce these complications. Read More

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Improvement in BMI z-score following adenotonsillectomy in adolescents aged 12-18 years: a retrospective cohort study.

BMC Pediatr 2021 04 20;21(1):184. Epub 2021 Apr 20.

Department of Pediatrics, Carmel Hospital and Technion Faculty of Medicine, Haifa, Israel.

Background: Characteristics of obstructive sleep apnea (OSA) changes with age. Infants, toddlers and prepubertal children with OSA are usually underweight and may suffer from failure to thrive (FTT). Adenotonsillectomy (T&A) is the first line of treatment for OSA in childhood. Read More

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Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer.

BMC Cancer 2021 Apr 20;21(1):435. Epub 2021 Apr 20.

Department of Gastroenterological Surgery; Graduated School of Medicine, Osaka University, 2-2 E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Local recurrence is common after curative resections for rectal cancer. Surgical intervention is among the best treatment choices. However, achieving a negative resection margin often requires extensive pelvic organ resections; thus, the postoperative complication rate is quite high. Read More

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