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Endemic HBV among hospital in-patients in Bangladesh, including evidence of occult infection.

J Gen Virol 2021 Jul;102(7)

Department of Microbiology and Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX1 3SY, UK.

Bangladesh is one of the top-ten most heavily burdened countries for viral hepatitis, with hepatitis B (HBV) infections responsible for the majority of cases. Recombinant and occult HBV infections (OBI) have been reported previously in the region. We investigated an adult fever cohort (=201) recruited in Dhaka, to determine the prevalence of HBV and OBI. Read More

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Analyzing Patient Secure Messages Using a Fast Health Care Interoperability Resources (FIHR)-Based Data Model: Development and Topic Modeling Study.

J Med Internet Res 2021 Jul 30;23(7):e26770. Epub 2021 Jul 30.

Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, United States.

Background: Patient portals tethered to electronic health records systems have become attractive web platforms since the enacting of the Medicare Access and Children's Health Insurance Program Reauthorization Act and the introduction of the Meaningful Use program in the United States. Patients can conveniently access their health records and seek consultation from providers through secure web portals. With increasing adoption and patient engagement, the volume of patient secure messages has risen substantially, which opens up new research and development opportunities for patient-centered care. Read More

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From water-rich to oil-rich gelled non-toxic microemulsions.

Phys Chem Chem Phys 2021 Jul 30. Epub 2021 Jul 30.

Institute of Physical Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.

Gelled non-toxic microemulsions have great potential in transdermal drug delivery: the microemulsion provides an optimum solubilizing capacity for drugs and promotes drug permeation through the skin barrier, while the gel network provides mechanical stability. We have formulated such a gelled non-toxic microemulsion consisting of H2O - isopropyl myristate (IPM) - Plantacare 1200 UP (technical-grade alkyl polyglucoside with an average composition of C12G1.4) - 1,2-octanediol in the presence of the low molecular weight gelator (LMWG) 1,3:2,4-dibenzylidene-d-sorbitol (DBS) at an oil-to-water ratio of φ = 0. Read More

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Variation of the mangrove sediment microbiomes and their phenanthrene biodegradation rates during the dry and wet seasons.

Environ Pollut 2021 Jul 26;289:117849. Epub 2021 Jul 26.

Department of Biology, Faculty of Science, Mahidol University, 272 Rama VI Road, Rachadhavi, Bangkok, 10400, Thailand. Electronic address:

Mangrove sediment is a major sink for phenanthrene in natural environments. Consequently, this study investigated the effects of seasonal variation on the biodegradation rates of low (150 mg kg), moderate (600 mg kg), and high (1200 mg kg) phenanthrene-contaminated mangrove sediments using a microcosm study and identified potential key phenanthrene-degrading bacteria using high throughput sequencing of 16 S rRNA gene and quantitative-PCR of the PAH-ring hydroxylating dioxygenase (PAH-RHD) genes. The biodegradation rates of phenanthrene in all treatments were higher in the wet-season sediments (11. Read More

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Heterotaxy: fluctuat nec mergitur.

Cardiol Young 2021 Jul;31(7):1200-1201

The International Pediatric and Congenital Cardiac Code (IPCCC) states that visceral heterotaxy is defined as "a congenital malformation in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body. By convention, in congenital cardiology, heterotaxy syndrome does not include patients with complete mirror-imaged arrangement of the internal organs along the left-right axis also known as "total mirror imagery" or "situs inversus totalis"." [www. Read More

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Acceptance- and mindfulness-based techniques for physical activity promotion in breast cancer survivors: a qualitative study.

Support Care Cancer 2021 Jul 27. Epub 2021 Jul 27.

Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

Purpose: The purpose of this study was to develop and characterize the relevance and potential utility of an electronically delivered acceptance- and mindfulness-based approaches to physical activity promotion for insufficiently active breast cancer survivors.

Methods: The acceptance- and mindfulness-based physical activity intervention was delivered to participants electronically over the course of 4-8 weeks. It consisted of didactic videos, experiential exercises, and workbook-type activities that targeted principles from acceptance and commitment therapy (ACT). Read More

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Rhythmic and non-rhythmic auditory precues: Multiple mechanisms mediating movement performance.

Hum Mov Sci 2021 Jul 22;79:102846. Epub 2021 Jul 22.

Perceptual Motor Integration Lab, Faculty of Kinesiology and Recreation Management, University of Manitoba, 102 Frank Kennedy Centre, Winnipeg, Manitoba R3T 2N2, Canada.

Rhythmic auditory stimuli presented before a goal-directed movement have been found to improve temporal and spatial movement outcomes. However, little is known about the mechanisms mediating these benefits. The present experiment used three types of auditory stimuli to probe how improved scaling of movement parameters, temporal preparation and an external focus of attention may contribute to changes in movement performance. Read More

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Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis.

BMC Biotechnol 2021 Jul 23;21(1):43. Epub 2021 Jul 23.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

Background: The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cell impurities for downstream processing and reduce the cost of goods. In this study we implemented label-free LC-MS/MS proteomic profiling of IgG4 producing CHO cell lines throughout the duration of the cell culture to identify differentially expressed (DE) proteins and intracellular pathways associated with the high peak viable cell density (VCD) and extended culture VCD phenotypes.

Results: We identified key pathways in DNA replication, mitotic cell cycle and evasion of p53 mediated apoptosis in high peak VCD clonally derived cell lines (CDCLs). Read More

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Clustering of obesity-related characteristics: A latent class analysis from the Canadian Longitudinal Study on Aging.

Prev Med 2021 Jul 21;153:106739. Epub 2021 Jul 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4L8, Canada; Centre for Health Economics and Policy Analysis, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4K1, Canada. Electronic address:

Measures of obesity, including body mass index (BMI) and waist circumference (WC), do not fully capture the complexity of obesity-related health risks. This study identified distinct classes of obesity-related characteristics and evaluated their associations with BMI, WC, and percent body fat (%BF) using cross-sectional data from 30,096 participants aged 45-85 in the Canadian Longitudinal Study on Aging (2011-2015). Sixteen obesity-related variables, including behavioural, metabolic, physical health, and mental health/social factors, were included in a latent class analysis to identify distinct classes of participants. Read More

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Investigating Endocrine Disrupting Properties of Chemicals in Fish and Amphibians: Opportunities to Apply the 3Rs.

Integr Environ Assess Manag 2021 Jul 22. Epub 2021 Jul 22.

Shell Health, Shell International B.V., Carel van Bylandtlaan 16, 2596 HR, The Hague, The Netherlands.

Many regulations are beginning to explicitly require investigation of a chemical's endocrine disrupting properties as a part of the safety assessment process, for substances already on or about to be placed on the market. Different jurisdictions are applying distinct approaches. However, all share a common theme requiring testing for endocrine activity and adverse effects, typically involving in vitro and in vivo assays on selected endocrine pathways. Read More

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Using Micro-Raman Spectroscopy to Investigate Chemical Composition, Mixing States, and Heterogeneous Reactions of Individual Atmospheric Particles.

Environ Sci Technol 2021 Jul 21. Epub 2021 Jul 21.

BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.

Measuring the chemical composition of individual atmospheric aerosol particles can provide direct evidence of their heterogeneous reactions and mixing states in the atmosphere. In this study, micro-Raman spectroscopy was used to measure the chemical composition of 1200 individual atmospheric particles in 11 samples collected in Beijing air. (NH)SO, NHNO, various minerals, carbonaceous species (soot and organics), and NaNO were identified in the measured particles according to their characteristic Raman peaks. Read More

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Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western Part of Romania: Current Practices, International Recommendations, and Future Perspectives Regarding the Overuse and Misuse of Medicines.

Int J Environ Res Public Health 2021 07 1;18(13). Epub 2021 Jul 1.

Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.

The European Commission's 2019 report regarding the state of health profiles highlighted the fact that Romania is among the countries with the lowest life expectancy in the European Union. Therefore, the objectives of the present study were to assess the current prescription habits of general physicians in Romania related to medicines taken by the elderly population for chronic conditions in both urban and rural setting and to discuss/compare these practices with the current international recommendations for the elderly (American-Beers 2019 criteria and European-STOPP/START v.2, 2015 criteria). Read More

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National Study of Nursing Faculty and Administrators' Perceptions of Professional Identity in Nursing.

Nurse Educ 2021 Jul 14. Epub 2021 Jul 14.

Author Affiliations: Assistant Professor (Dr Landis) and Associate Professor and Vice Chancellor for Research (Dr Barbosa-Leiker), College of Nursing, Washington State University, Spokane; Associate Dean, Innovative Partnerships and Practice Professor (Dr Godfrey), University of Kansas; Professor Emeritus and Founder of Civility Matters (Dr Clark), Boise State University, Idaho; Position Chief Program Officer (Dr Brewington), National League for Nursing, Washington, DC; Clinical Professor and Director Health Systems/Administration (Dr Joseph), University of Iowa College of Nursing; Professor (Dr Luparell), Montana State University College of Nursing, Bozeman; Associate Professor, Director (Dr Phillips), Institute for Educational Excellence, Duke University School of Nursing, Durham, North Carolina; Adjunct Faculty (Dr Priddy), Texas Christian University, Fort Worth; and Campus Assistant Director (Ms Weybrew), ADN Program, American Career College, Los Angeles, California.

Background: Establishing a professional identity in nursing is integral to professional development, yet this area of inquiry remains understudied.

Purpose: This segment of a multiphased national study measured nursing faculty's perceived level of importance regarding key components of professional identity in nursing using the newly developed Professional Identity in Nursing Survey (PINS).

Methods: Fifty subject matter experts from nursing education, practice, and regulation utilized the DeVellis scale development process to develop the PINS over the course of 2 years. Read More

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Thecal sac ligation for the treatment of post-infectious intrathecal-prevertebral CSF fistula in a paraplegic patient.

Clin Neurol Neurosurg 2021 Jul 9;207:106803. Epub 2021 Jul 9.

Department of Neurosurgery, University of Louisville, Louisville, KY, USA.

The occurrence of a symptomatic post-infectious intrathecal to prevertebral fistula is rare. We report the presentation and management of a 38-year-old chronically paraplegic male with longstanding thoracic osteomyelitis and epidural infection who developed a cerebrospinal fluid (CSF) fistula causing symptomatic intracranial hypotension (IH). During an interventional radiology (IR)-guided aspiration of what was thought to be residual abscess, pulsatile, clear fluid was observed. Read More

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Evaluating Medicaid Expansion Benefits for Patients with Cancer: National Cancer Database Analysis and Systematic Review.

J Cancer Policy 2021 Sep 5;29. Epub 2021 Jun 5.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA, 90033, USA.

Background: Insurance status modifies healthcare access and inequities. The Affordable Care Act expanded Medicaid coverage for people with low incomes in the United States. This study assessed the consequences of this policy change for cancer care after expansion in 2014. Read More

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September 2021

Carotid Stenting without Embolic Protection Increases Major Adverse Events: Analysis of the National Surgical Quality Improvement Program.

AJNR Am J Neuroradiol 2021 07 1;42(7):1264-1269. Epub 2021 Apr 1.

From the Departments of Neurological Surgery and Radiology Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Background And Purpose: Published data regarding embolic protection device efficacy is mixed, and its use during carotid artery stent placement remains variable. We, therefore, examined the frequency of embolic protection device use and its association with outcomes after carotid artery stent placement using a national quality improvement data base.

Materials And Methods: Patients undergoing carotid artery stent placement with or without embolic protection devices were identified in the American College of Surgeons National Surgical Quality Improvement Program data base. Read More

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Nurses' pandemic lives: A mixed-methods study of experiences during COVID-19.

Appl Nurs Res 2021 08 27;60:151437. Epub 2021 Apr 27.

Jefferson College of Population Health, 901 Walnut Street, 10(th) floor, Philadelphia, PA 19107, USA. Electronic address:

Background: The US healthcare settings and staff have been stretched to capacity by the COVID-19 pandemic. While COVID-19 continues to threaten global healthcare delivery systems and populations, its impact on nursing has been profound.

Objectives: This study aimed to document nurses' immediate reactions, major stressors, effective measures to reduce stress, coping strategies, and motivators as they provided care during COVID-19. Read More

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Genetic diversity of canine parvovirus variants circulating in Nigeria.

Infect Genet Evol 2021 Jul 8;94:104996. Epub 2021 Jul 8.

Faculty of Veterinary Medicine, Sumy National Agrarian University, 160 Herasima Kondratieva Street, Sumy 40021, Ukraine.

Canine parvovirus (CPV) is a fast-evolving single-stranded DNA virus that causes severe and fatal gastrointestinal disease in dogs. Lately, several mutations affecting viral protein (VP) capsid resulting in highly pathogenic variants with distinctive immunological and clinicopathological characteristics abound. This study involved screening stools of 44 randomly selected clinical cases of canine gastroenteritis from 4 cities (Ibadan, Jos, Makurdi, and Zaria) in Nigeria for CPV antigen using an on-the-spot immunoassay test kit, as well as, molecular detection of viral nucleic acid by polymerase chain reaction. Read More

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Subduction history of the Caribbean from upper-mantle seismic imaging and plate reconstruction.

Nat Commun 2021 Jul 9;12(1):4211. Epub 2021 Jul 9.

School of Earth and Environment, University of Leeds, Leeds, UK.

The margins of the Caribbean and associated hazards and resources have been shaped by a poorly understood history of subduction. Using new data, we improve teleseismic P-wave imaging of the eastern Caribbean upper mantle and compare identified subducted-plate fragments with trench locations predicted from plate reconstruction. This shows that material at 700-1200 km depth below South America derives from 90-115 Myr old westward subduction, initiated prior to Caribbean Large-Igneous-Province volcanism. Read More

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Aldosterone signaling defect in young infants: single-center report and review.

BMC Endocr Disord 2021 Jul 9;21(1):149. Epub 2021 Jul 9.

Department of Pediatrics, The First affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan II Rd, Guangzhou, 510080, P. R. China.

Background: Aldosterone (Ald) is a crucial factor in maintaining electrolyte and water homeostasis. Defect in either its synthesis or function causes salt wasting (SW) manifestation. This disease group is rare, while most reported cases are sporadic. Read More

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Mobile low-threshold buprenorphine integrated with infectious disease services.

J Subst Abuse Treat 2021 Jun 24:108553. Epub 2021 Jun 24.

Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD, USA.

Introduction: In 2018, the Baltimore City Health Department launched a mobile clinic called Healthcare on The Spot, which offers low-threshold buprenorphine services integrated with health care services to meet the needs of people who use drugs. In addition to buprenorphine management, The Spot offers testing and treatment for hepatitis C, sexually transmitted infections, and HIV, as well as pre-exposure prophylaxis for HIV, wound care, vaccinations, naloxone distribution, and case management.

Methods And Materials: This cohort analysis includes clinical service data from the first 15 months of The Spot mobile clinic, from September 4, 2018, to November 23, 2019. Read More

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[Determination of atmospheric organochlorine pesticides using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry].

Se Pu 2021 May;39(5):541-551

China National Environmental Monitoring Centre, Beijing 100012, China.

A method for the determination of 25 organochlorine pesticides (OCPs) in the atmosphere using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry (ID-HRGC/HRMS) was developed. Sample extraction was performed using an accelerated solvent extractor (ASE). The extraction parameters were as follows: the extraction solvent was 50% (v/v) hexane in dichloromethane, the extraction temperature was 100 ℃, the static time was 8 min, the cell was rinsed with 60% cell volume using the aforementioned extraction solvent, the purging time was 180 s with N gas, and the extraction proceeded through three cycles. Read More

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Attitude and knowledge of medical students about organ donation - training needs identified from a Canadian survey.

BMC Med Educ 2021 Jul 5;21(1):368. Epub 2021 Jul 5.

Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada.

Background: Appropriate training of health professionals has been recommended to increase organ donation rates. Some studies have shown insufficient knowledge among medical students. This survey aims to describe their knowledge and attitude toward organ donation (OD). Read More

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Transcriptome Dynamics of Epidermal Reprogramming during Direct Shoot Regeneration in Torenia fournieri.

Plant Cell Physiol 2021 Jul 5. Epub 2021 Jul 5.

Botanical Gardens, Graduate School of Science, The University of Tokyo, 3-7-1 Hakusan, Bunkyo-ku, Tokyo 112-0001, Japan.

Shoot regeneration involves reprogramming of somatic cells and de novo organization of shoot apical meristems (SAMs). In the best-studied model system of shoot regeneration using Arabidopsis, regeneration occurs mediated by auxin-responsive pluripotent callus formation from pericycle or pericycle-like tissues according to the lateral root development pathway. In contrast, shoot regeneration can be induced directly from fully differentiated epidermal cells of stem explants of Torenia fournieri (Torenia) without intervening callus mass formation in culture with cytokinin, yet its molecular mechanisms remain unaddressed. Read More

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Liminality, disruption, and change: A prismatic look at pandemic education.

Prospects (Paris) 2021 Jun 29:1-18. Epub 2021 Jun 29.

Union Ironworker, Local 433, Fullerton, CA USA.

Using prismatic inquiry, a team of researchers documented a variety of personal experiences that spanned elementary through higher education, with the goal of determining what helped and what was needed to improve the adaptability of our educational system during the Covid-19 emergency. Three analytical teams identified that students remained at the heart of the conversation, supported by leadership, teachers, parents, and the students themselves. Furthermore, all four groups needed, in differing ways: (a) connection, (b) voice, (c) social-emotional skills, and (d) academic knowledge. Read More

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Development of crash modification factors for roadway illuminance: A matched case-control study.

Accid Anal Prev 2021 Jul 2;159:106279. Epub 2021 Jul 2.

Department of Civil and Environmental Engineering, University of South Florida, 4202 E Fowler Avenue, ENB118, Tampa, FL 33620, United States.

Roadway lighting is used to ensure nighttime safety and security for multimodal road users. However, the absence of reliable quantitative analyses of the safety effects of roadway lighting photometric characteristics prevents accurate assessment of street lighting maintenance and retrofitting projects. This study aimed to investigate the relationship between nighttime crash risk and two critical photometric criteria, i. Read More

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First Report of Black Spot Caused by Penicillium citreosulfuratum on Saffron in Chongming Island, China.

Plant Dis 2021 Jul 2. Epub 2021 Jul 2.

shanghai, China;

Saffron (Crocus sativus L.) is a world-famous source of dye and spices and an important medicinal plant, which is cultivated on a large scale on Chongming Island (31.62° N, 121. Read More

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Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population.

J Nutr Metab 2021 7;2021:5550222. Epub 2021 Jun 7.

Cardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.

Background: Vitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems has been identified. Read More

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Cilostazol for intermittent claudication.

Cochrane Database Syst Rev 2021 06 30;6:CD003748. Epub 2021 Jun 30.

Cochrane Vascular, University of Edinburgh, Edinburgh, UK.

Background: Peripheral arterial disease (PAD) affects between 4% and 12% of people aged 55 to 70 years, and 20% of people over 70 years. A common complaint is intermittent claudication (exercise-induced lower limb pain relieved by rest). These patients have a three- to six-fold increase in cardiovascular mortality. Read More

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