12,420 results match your criteria icu pneumonia


[Weaning from Mechanical Ventilation in Patients with SARS-CoV-2 Infection after Prolonged Mechanical Ventilation - First Experience].

Pneumologie 2021 Apr 19;75(4):261-267. Epub 2021 Apr 19.

Klinik für Pneumologie, Kardiologie und Beatmungsmedizin mit Sektion Gastroenterologie, Weaningzentrum Frankfurt am Main (DGP), Bürgerhospital und Clementine Kinderhospital gGmbH, Frankfurt am Main.

Aim:  With the emergence of a new virus and the associated pandemic, the ICU started to see a brand new kind of patient with severe ARD. As with any disease, sometimes the discontinuation of mechanical ventilation for any reason can be difficult. As a center specializing in weaning patients after prolonged mechanical ventilation, we wanted to compare our results with weaning patients who had prolonged mechanical ventilation for other reasons than those of patients who had prolonged mechanical ventilation due to SARS-CoV-2 infection. Read More

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Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort.

J Crit Care 2021 Apr 16;64:114-119. Epub 2021 Apr 16.

Medical Intensive Care Unit, APHP, Hôpital Saint-Louis, Famirea Study Group, ECSTRA team, and Clinical Epidemiology, UMR 1153, Center of Epidemiology and Biostatistics, Sorbonne Paris Cité, CRESS, INSERM, Paris Diderot Sorbonne University, Paris, France.

Purpose: The characteristics and impact of bacteremia have not been widely investigated in immunocompromised patients with acute respiratory failure (ARF).

Methods: We performed a secondary analysis of a prospective cohort of immunocompromised patients with ARF (EFRAIM study). After exclusion of blood cultures positive for coagulase negative Staphylococci, we compared patients with (n = 236) and without (n = 1127) bacteremia. Read More

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Predictive Value of the Methicillin-Resistant Nasal Swab for Methicillin-Resistant Ventilator-Associated Pneumonia in the Trauma Patient.

Surg Infect (Larchmt) 2021 Apr 19. Epub 2021 Apr 19.

Department of Section of Acute Care Surgery, Department of Surgery, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.

Many trauma centers have empiric treatment algorithms for ventilator-associated pneumonia (VAP) treatment prior to culture results that include antibiotic agents for methicillin-resistant (MRSA) coverage that can have adverse effects. This is the only study to evaluate risk factors and MRSA nasal swabs to risk-stratify trauma patients for MRSA VAP, thereby potentially limiting the need for empiric vancomycin. This was a single institution retrospective cohort study. Read More

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Pediatric Acute Alcohol Intoxication Admitted to the ICU: A Review of 102 Cases in France.

Crit Care Med 2021 Apr 19. Epub 2021 Apr 19.

Paediatric Intensive Care Unit, Kremlin Bicêtre University Hospital, AP-HP, Paris, France. Intensive Care Department, Grand Hôpital de l'Est Francilien, Jossigny Hospital, Marne la Vallée, France. Pediatric Intensive Care Department, Lyon University Hospital, Lyon, France. Intensive Care Department, Lariboisière University Hospital, AP-HP, Paris, France. Intensive Care Department, Lariboisière University Hospital, APHP, Paris, France. Pediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France. Pediatric Intensive Care Unit, University Hospital, Lille, France. Pediatric Intensive Care Department, Hôpital Jeanne de Flandre, University Hospital, Lille, France. Intensive Care Department, Cochin University Hospital, AP-HP, Paris, France. Intensive Care Department, Cochin University Hospital, APHP, Paris, France. Pediatric Intensive Care Unit, Raymond Poincaré University Hospital, AP-HP, Garches, France.

Objectives: To describe the profile and clinical outcomes of children (<18 yr) admitted to intensive care for acute alcohol intoxication, with special attention to complications and to the subgroup that required intubation.

Design: Retrospective observational study.

Setting: Seven pediatric and three adult ICUs in France. Read More

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A comparison of radiographic features between non-survivors and survivors from ICU.

Eur J Radiol Open 2021 13;8:100338. Epub 2021 Apr 13.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

The clinical and imaging data of 121 ICU patients with SARS-CoV-2 infection (63 survivors and 58 non-survivors) were retrospectively reviewed. The clinical results and radiographic features were compared between survivors and non-survivors. Compared with survivors, non-survivors were more likely to develop ARDS (53 [91 %] vs. Read More

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Pulmonary Fibrosis After COVID-19 Pneumonia.

Cureus 2021 Mar 16;13(3):e13923. Epub 2021 Mar 16.

Pulmonary and Critical Care Medicine, McLaren Health Care, Flint, USA.

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), emerged in Wuhan, China, and rapidly spread across the world. Today, we present an interesting case of a patient with no prior history of pulmonary disease who was diagnosed with COVID-19, recovered after a prolonged hospital course, and was diagnosed with pulmonary fibrosis requiring oxygen therapy thereafter. The patient is currently on pirfenidone and has had a significant improvement in his functional status. Read More

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Severe pneumonia caused by Parvimonas micra: a case report.

BMC Infect Dis 2021 Apr 17;21(1):364. Epub 2021 Apr 17.

Department of Intense Care Unit, Shenzhen Longhua Central Hospital, Guanlan Boulevard, Shenzhen, 187, China.

Background: Parvimonas micra (P. micra) is a gram-positive anaerobic coccus that is detected widely on the skin, in the oral mucosa and in the gastrointestinal tract. In certain circumstances, P. Read More

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Klebsiella pneumoniae pneumonia in patients with rheumatic autoimmune diseases: clinical characteristics, antimicrobial resistance and factors associated with extended-spectrum β-lactamase production.

BMC Infect Dis 2021 Apr 17;21(1):366. Epub 2021 Apr 17.

Department of Emergency Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, China.

Background: Over the past decades, Klebsiella pneumoniae (K. pneumoniae) infections have been increasing and affected immunocompromised patients nosocomially and communally, with extended-spectrum β-lactamase (ESBL) production becoming a major concern. Patients with rheumatic autoimmune diseases, mostly receiving immunosuppressive therapy, are vulnerable to various infections, including K. Read More

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Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation-Adjusted Mortality and Length of Stay Than Viral Pneumonia ICU Patients.

Crit Care Med 2021 Apr 2. Epub 2021 Apr 2.

1 Center for Case Management, Natick, MA. 2 Division of Pulmonary and Critical Care Medicine, Baystate Medical Center, Springfield, MA. 3 Department of Anesthesiology, University of Massachusetts Medical School-Baystate, Springfield, MA. 4 Cerner Corporation, Kansas City, MO.

Objectives: To compare Acute Physiology and Chronic Health Evaluation-IV-adjusted mortality and length of stay outcomes of adult ICU patients who tested positive for coronavirus disease 2019 with patients admitted to ICU with other viral pneumonias including a subgroup with viral pneumonia and concurrent acute respiratory distress syndrome (viral pneumonia-acute respiratory distress syndrome).

Design: Retrospective review of Acute Physiology and Chronic Health Evaluation data collected from routine clinical care.

Setting: Forty-three hospitals contributing coronavirus disease 2019 patient data between March 14, and June 17, 2020, and 132 hospitals in the United States contributing data on viral pneumonia patients to the Acute Physiology and Chronic Health Evaluation database between January 1, 2014, and December 31, 2019. Read More

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A qualitative assessment of the diagnosis and management of ventilator-associated pneumonia among critical care clinicians exploring opportunities for diagnostic stewardship.

Infect Control Hosp Epidemiol 2021 Apr 16:1-7. Epub 2021 Apr 16.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Prompt diagnosis and intervention for ventilator-associated pneumonia (VAP) is critical but can lead to overdiagnosis and overtreatment.

Objectives: We investigated healthcare provider (HCP) perceptions and challenges associated with VAP diagnosis, and we sought to identify opportunities for diagnostic stewardship.

Methods: We conducted a qualitative study of 30 HCPs at a tertiary-care hospital. Read More

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Bronchoalveolar lavage fluid characteristics and outcomes of invasively mechanically ventilated patients with COVID-19 pneumonia in Genoa, Italy.

BMC Infect Dis 2021 Apr 15;21(1):353. Epub 2021 Apr 15.

Infectious Diseases Unit, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.

Background: The primary objective of the study is to describe the cellular characteristics of bronchoalveolar lavage fluid (BALF) of COVID-19 patients requiring invasive mechanical ventilation; the secondary outcome is to describe BALF findings between survivors vs non-survivors.

Materials And Methods: Patients positive for SARS-CoV-2 RT PCR, admitted to ICU between March and April 2020 were enrolled. At ICU admission, BALF were analyzed by flow cytometry. Read More

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Trauma Center Outcomes After Transition From Level 2 to Level 1: A National Trauma Data Bank Analysis.

J Surg Res 2021 Apr 12;264:499-509. Epub 2021 Apr 12.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Previous US-based studies have shown that a trauma center designation of level 1 is associated with improved patient outcomes. However, most studies are cross-sectional, focus on volume-related issues and are direct comparisons between levels. This study investigates the change in patient characteristics when individual trauma centers transition from level 2 to level 1 and whether the patients have similar outcomes during the initial period of the transition. Read More

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Hospital-acquired infections in critically-ill COVID-19 patients.

Chest 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Few small studies have described hospital-acquired infections (HAIs) during COVID-19.

Research Question: What patient characteristics in critically ill patients with COVID-19 are associated with HAIs and how do HAIs associate with outcomes in these patients?

Study Design And Methods: Multicenter retrospective analysis of prospectively collected data including adult patients with severe COVID-19, admitted to 8 Italian hub hospitals from February 20, 2020, to May 20, 2020. Descriptive statistics, univariable and multivariable Weibull regression models were used to assess incidence, microbial etiology, resistance patterns, risk factors (i. Read More

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Prognostic value of serial neutrophil-to-lymphocyte ratio measurements in hospitalized community-acquired pneumonia.

PLoS One 2021 15;16(4):e0250067. Epub 2021 Apr 15.

Department of Internal Medicine, Pulmonology Division, Dong-A University Hospital, College of Medicine, Dong-A University, Busan, Republic of Korea.

Introduction: Several serum inflammatory markers are associated with poor clinical outcomes in community-acquired pneumonia (CAP). However, the prognosis and early treatment response in hospitalized CAP patients based on serial neutrophil-to-lymphocyte ratio (NLR) measurement has never been investigated.

Methods: We performed a retrospective observational study for 175 consecutive patients hospitalized with CAP between February 2016 and February 2018. Read More

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Impact of Providing a Tape Measure on the Provision of Lung-protective Ventilation.

West J Emerg Med 2021 Jan 11;22(2):389-393. Epub 2021 Jan 11.

University of Michigan Medical School, Department of Emergency Medicine, Ann Arbor, Michigan.

Introduction: Emergency department (ED) patients are frequently ventilated with excessively large tidal volumes for predicted body weight based on height, which has been linked to poorer patient outcomes. We hypothesized that supplying tape measures to respiratory therapists (RT) would improve measurement of actual patient height and adherence to a lung-protective ventilation strategy in an ED-intensive care unit (ICU) environment.

Methods: On January 14, 2019, as part of a ventilator-associated pneumonia prevention bundle in our ED-based ICU, we began providing RTs with tape measures and created a best practice advisory reminding them to record patient height. Read More

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January 2021

Heparin dosage, level, and resistance in SARS-CoV2 infected patients in intensive care unit.

Int J Lab Hematol 2021 Apr 14. Epub 2021 Apr 14.

Transfusion Center and Haematology Laboratory, Legnano Hospital, ASST Ovest Milanese, Legnano, Italy.

Introduction: Patients with COVID-19 frequently exhibit a hypercoagulable state with high thrombotic risk, particularly those admitted to intensive care units (ICU). Thromboprophylaxis is mandatory in these patients; nevertheless, thrombosis still occurs in many cases. Thus, the problem of assessing an adequate level of anticoagulation in ICU patients becomes evident during the COVID-19 pandemic. Read More

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Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain.

J Clin Immunol 2021 Apr 13. Epub 2021 Apr 13.

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: In a recent study, autoantibodies neutralizing type I interferons (IFNs) were present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies neutralized most type I IFNs but rarely IFN-beta.

Objectives: We aimed to define the prevalence of autoantibodies neutralizing type I IFN in a cohort of patients with severe COVID-19 pneumonia treated with IFN-beta-1b during hospitalization and to analyze their impact on various clinical variables and outcomes. Read More

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Invasive pulmonary aspergillosis in a COVID-19 recovered patient: unravelling an infective sequalae of the SARS-CoV-2 virus.

Monaldi Arch Chest Dis 2021 Apr 6;91(2). Epub 2021 Apr 6.

Department of Pulmonary Medicine, Pushpanjali Hospital, Agra.

Dear Editor, A 55-year-female, house wife, non-smoker, morbidly obese (BMI>35) with no other co-morbidities or pre-existing lung disease presented to the emergency room with complaints of highgrade fever, cough with minimal sputum, progressive breathlessness, streaky haemoptysis, and anorexia for the past 5 days. She was admitted in intensive care unit (ICU) for severe COVID-19 pneumonia three months back and had successfully recovered after 24 days of hospitalization.. Read More

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A Before-and-After Study of Evidence-Based Recommendations for On-Call Bronchoscopy.

Respiration 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Background: Bronchoscopy is widely used and regarded as standard of care in most intensive care units (ICUs). Data concerning recommendations for on-call bronchoscopy are lacking.

Objectives: Evaluation of recommendations, complications, and outcome of on-call bronchoscopies. Read More

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Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19.

Thorax 2021 Apr 12. Epub 2021 Apr 12.

Department of Molecular Cell Biology & Immunology, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.

Background: Knowledge of the pathophysiology of COVID-19 is almost exclusively derived from studies that examined the immune response in blood. We here aimed to analyse the pulmonary immune response during severe COVID-19 and to compare this with blood responses.

Methods: This was an observational study in patients with COVID-19 admitted to the intensive care unit (ICU). Read More

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COVID-19 pneumonia successfully managed with high-flow nasal cannula in a 15-year-old boy.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Maastricht University, Maastricht, The Netherlands.

We report an otherwise healthy, fully immunised 15-year-old boy who was transferred to our Pediatric intensive care unit with 4 days of fever, dry cough, increased work of breathing and impending respiratory failure. Two days prior, amoxicillin/clavulanic acid was prescribed for lower airway symptoms resembling pneumonia. PCR of the nasopharyngeal swab revealed an active COVID-19 infection (Ct 19). Read More

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Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome.

Crit Care 2021 04 12;25(1):140. Epub 2021 Apr 12.

Immunology Laboratory, Hôpital E. Herriot - Hospices Civils de Lyon, 5 place d'Arsonval, 69437, Lyon Cedex 03, France.

Background: Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune parameters may drive or associate with delayed unfavorable outcome in these critically ill patients remains unsolved.

Methods: We present a dynamic description of immuno-inflammatory derangements in 64 critically ill COVID-19 patients including plasma IFNα2 levels and IFN-stimulated genes (ISG) score measurements. Read More

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Vitamin D status in children with community acquired pneumonia and its association with severity: a hospital-based study.

Minerva Pediatr (Torino) 2021 Apr 12. Epub 2021 Apr 12.

Department of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.

Background: International and observational epidemiological studies provide evidence that vitamin D deficiency may confer increased risk of influenza and respiratory tract infection. This study was undertaken in an effort to evaluate the prevalence of vitamin D deficiency in pneumonia in children and assess its relationship with the severity.

Methods: Study group included children aged between 2 months to 5 years of age admitted as inpatients who presented with clinical features of pneumonia as per WHO classification. Read More

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Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center.

Rev Med Chil 2020 Nov;148(11):1577-1588

Facultad de Medicina, Campus Isla Teja, Universidad Austral de Chile, Valdivia, Chile.

Background: During the first pandemic wave, Covid-19 reached Latin America cities.

Aim: To report clinical features and outcomes of a group of patients with Covid-19 admitted to a Chilean regional reference Center.

Material And Methods: Cases were identified by a compatible clinical picture and a positive PCR or serological test. Read More

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November 2020

[Features of 50 patients with SARS-CoV2 admitted to an intensive care unit and requiring mechanical ventilation].

Rev Med Chil 2020 Dec;148(12):1725-1733

Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.

Background: Since March, Chile experienced an exponential increase in SARS-CoV2 cases, which led to an almost full occupancy of the intensive care units (ICU).

Aim: To characterize patients with SARS-CoV2 disease who required hospitalization in the ICU and invasive mechanical ventilation (IMV) in our hospital.

Material And Methods: A prospective observational study was performed, which included the first 50 patients, aged 54 ± 13 years (58% men), with SARS-CoV2 disease, with ICU and IMV requirements between March 23 and June 2, 2020. Read More

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December 2020

[Clinical features and predictors of severity in 1022 adults with COVID-19].

Rev Med Chil 2020 Oct;148(10):1387-1397

Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world.

Aim: To describe the clinical features, risk factors, and predictors of hospitalization in adult patients treated for acute respiratory infections associated with coronavirus SARS-CoV-2.

Material And Methods: Descriptive prospective study of ambulatory and hospitalized adult patients with confirmed COVID-19 attended between April 1 and May 31, 2020. Read More

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October 2020

Incidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement.

Front Cardiovasc Med 2021 26;8:645724. Epub 2021 Mar 26.

General and Interventional Cardiology, Heart and Diabetes Centre Nordrhein-Westfalen, Bad Oeynhausen, Germany.

The aim of the present study was to analyze incidence, risk factors, and association with long-term outcome of postoperative delirium (POD) after transcatheter aortic valve replacement (TAVR). Six hundred and sixty one consecutive patients undergoing TAVR were prospectively enrolled from January 2016 to December 2017. POD was assessed regularly during ICU-stay using the CAM-ICU test. Read More

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Predictors of Successful Extubation in Neurocritical Care Patients.

Acta Neurochir Suppl 2021 ;131:91-93

Adult ICU Hospital Municipal Eva Perón de Merlo, Buenos Aires, Argentina.

Introduction: Delayed extubation in neurocritical care patients is associated with an increased length of stay in the intensive care unit (ICU), a greater incidence of ventilator-associated pneumonia (VAP), and a poor outcome. There is no evidence available to support use of certain variables over others as predictors of successful extubation in these patients.

Objective: This study aimed to identify predictors of successful extubation. Read More

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January 2021

Does Macrophage Migration Inhibitory Factor predict the prognosis of COVID-19 disease?

J Infect Dev Ctries 2021 Mar 31;15(3):398-403. Epub 2021 Mar 31.

Department of Infectious Diseases and Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Introduction: The aim of this study is to investigate whether macrophage migration inhibitory factor (MIF) predicts the prognosis of COVID-19 disease.

Methodology: This descriptive and cross-sectional study was conducted on 87 confirmed COVID-19 patients. The patients were separated into two groups according to the admission in the ICU or in the ward. Read More

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Integrative respiratory follow-up of severe COVID-19 reveals common functional and lung imaging sequelae.

Respir Med 2021 Apr 4;181:106383. Epub 2021 Apr 4.

Radiology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Bruxelles, Belgium; Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Belgium.

Background: COVID-19 pandemic resulted in an unprecedented number of hospitalizations in general wards and intensive care units (ICU). Severe and critical COVID-19 patients suffer from extensive pneumonia; therefore, long-term respiratory sequelae may be expected.

Research Question: We conducted a cohort study to determine respiratory sequelae in patients with severe and critical COVID-19. Read More

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