147,676 results match your criteria icu


The impact of the COVID-19 pandemic in an intensive care unit (ICU): Psychiatric symptoms in healthcare professionals - A systematic review.

J Psychiatr Res 2021 Mar 25;140:474-487. Epub 2021 Mar 25.

Faculty of Medicine of Juazeiro do Norte - FMJ / Estacio, Juazeiro do Norte, Ceará, Brazil. Electronic address:

Introduction: During the COVID-19 pandemic period, the structure of the Intensive Care Unit (ICU) activities changed fast. It was observed that the mental and physical health of the frontline workers reached levels of extreme clinical and psychological concern.

Objective: Understand the impact that COVID-19 is having on the front-line clinical team in the ICU environment, as well as reveal what proposals are being made to mitigate the clinical and psychological impacts that this group experiences. Read More

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Early neuro-prognostication with the Patient State Index and suppression ratio in post-cardiac arrest patients.

J Crit Care 2021 Jun 7;65:149-155. Epub 2021 Jun 7.

Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

Purpose: Cardiopulmonary resuscitation guidelines recommend multimodal neuro-prognostication after cardiac arrest using neurological examination, electroencephalography, biomarkers, and brain imaging. The Patient State Index (PSI) and suppression ratio (SR) represent the depth and degree of sedation, respectively. We evaluated the predictive ability of PSI and SR for neuro-prognostication of post-cardiac arrest patients who underwent targeted temperature management. Read More

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Clinical characteristics and predictors of mortality among COVID-19 patients in Saudi Arabia.

J Infect Public Health 2021 Jun 11;14(8):994-1000. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia. Electronic address:

Background: The new coronavirus disease (COVID-19) has caused more than 1.8 million deaths, with a fatality rate of 2.5% in more than 200 countries as of January 4, 2021. Read More

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Intravenous methylprednisolone with or without tocilizumab in patients with severe COVID-19 pneumonia requiring oxygen support: A prospective comparison.

J Infect Public Health 2021 Jun 10;14(8):985-989. Epub 2021 Jun 10.

Health Regulation Sector, Dubai Health Authority, United Arab Emirates. Electronic address:

Background: Cytokine storm is a marker of severity and severe mortality in patients with coronavirus disease 2019 (COVID-19) pneumonia. Immunomodulatory treatments may reduce morbidity and mortality.

Objectives: To determine whether a 7-day course of methylprednisolone (MP) administered with and without tocilizumab improves outcomes in patients with severe COVID-19 (SARS-CoV-2) pneumonia requiring oxygen therapy, relative to historical controls. Read More

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Covid-19 severe hypoxemic pneumonia: A clinical experience using high-flow nasal oxygen therapy as first-line management.

Respir Med Res 2021 Jun 4;80:100834. Epub 2021 Jun 4.

UNIROUEN, Inserm U1096, medical intensive care unit, Rouen university hospital, Normandie university, 76000 Rouen, France.

Purpose: To report a French experience in patients admitted to Intensive Care Unit (ICU) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requiring high fractional concentration of inspired oxygen supported by high flow nasal cannula (HFNC) as first-line therapy.

Methods: Retrospective cohort study conducted in two ICUs of a French university hospital. All consecutive patients admitted during 28-days after the first admission for SARS-CoV-2 pneumonia were screened. Read More

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Repeated maternal ICU admission: results from a nationwide analysis.

Anaesth Crit Care Pain Med 2021 Jun 18:100905. Epub 2021 Jun 18.

Université de Paris, Center of Research in Epidemiology and Statistics/CRESS/Obstetrical Pediatric and Perinatal Epidemiology Research Team (EPOPé), INSERM, INRA, 53 avenue de l'observatoire, 75014 Paris, France.

Objective: To determine the rate and profile of repeated maternal ICU admissions during or after pregnancy and to compare the characteristics of these women's first and second ICU admissions.

Methods: A descriptive analysis from the French national hospital discharge database that included all women admitted to an ICU during pregnancy or within 42 days after delivery, between 2010 and 2014.

Results: During the 5-year study period, there were 371 women with more than one maternal ICU admission, representing 2. Read More

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Palliative Rehabilitation Improves Health Care Utilization and Function in Frail Older Adults With Chronic Lung Diseases.

J Am Med Dir Assoc 2021 Jun 18. Epub 2021 Jun 18.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.

Objectives: The Integrated Care for Advanced REspiratory Disorders (ICARE) service is a stay-in, post-acute care program for hospitalized patients with chronic, nonmalignant lung diseases. It provides palliative rehabilitation-a novel model integrating functional rehabilitation with early palliative care. We compare reduction of health care utilization among ICARE participants vs matched controls receiving usual care. Read More

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Improving access to ward-based respiratory failure management: a case study in the development of a respiratory care unit at an Australian metropolitan health service.

Aust Health Rev 2021 Jun 22. Epub 2021 Jun 22.

This case study describes the implementation of a ward-based respiratory care unit to improve access to specialised respiratory failure management at an Australian metropolitan health service. Using a case study approach, we describe the conception, development and implementation of a respiratory care unit within a previously inexperienced ward. Key barriers and facilitators are explored and the importance of a safety culture and an aspiration for continuous quality improvement are detailed. Read More

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The Lung-brain Axis in Ventilator-induced Brain Injury- Enter Interleukin-6.

Am J Respir Cell Mol Biol 2021 Jun 21. Epub 2021 Jun 21.

Institute of Physiology. Charité Universitätsmedizin, Berlin, Germany;

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Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.

Epilepsia 2021 Jun 21. Epub 2021 Jun 21.

Department of Pediatrics, Saint-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.

Objective: Although most seizures in neonates are due to acute brain injury, some represent the first sign of neonatal onset genetic epilepsies. Delay in recognition and lack of expert assessment of neonates with epilepsy may result in worse developmental outcomes. As in older children and adults, seizure semiology in neonates is an essential determinant in diagnosis. Read More

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Melioidosis-a disease of socioeconomic disadvantage.

PLoS Negl Trop Dis 2021 Jun 21;15(6):e0009544. Epub 2021 Jun 21.

Torres and Cape Hospital and Health Service, Cairns, Queensland, Australia.

Background: There is growing recognition of the contribution of the social determinants of health to the burden of many infectious diseases. However, the relationship between socioeconomic status and the incidence and outcome of melioidosis is incompletely defined.

Methods: All residents of Far North Queensland, tropical Australia with culture-proven melioidosis between January 1998 and December 2020 were eligible for the study. Read More

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Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy: A Population-Based Observational Study.

Anesth Analg 2021 Jun 21. Epub 2021 Jun 21.

Departments of Orthopaedic Surgery, Population Health Science & Policy, and Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. Read More

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Emergency Airway Management Outside the Operating Room: Current Evidence and Management Strategies.

Anesth Analg 2021 Jun 21. Epub 2021 Jun 21.

Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Emergency airway management outside the operating room (OR) is often associated with an increased risk of airway related, as well as cardiopulmonary, complications which can impact morbidity and mortality. These emergent airways may take place in the intensive care unit (ICU), where patients are critically ill with minimal physiological reserve, or other areas of the hospital where advanced equipment and personnel are often unavailable. As such, emergency airway management outside the OR requires expertise at manipulation of not only the anatomically difficult airway but also the physiologically and situationally difficult airway. Read More

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Blood purification with CytoSorb in critically ill COVID-19 patients: A case series of 26 patients.

Artif Organs 2021 Jun 21. Epub 2021 Jun 21.

Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Severe forms of the coronavirus disease 2019 (COVID-19) can progress to sepsis-like complications accompanied by "cytokine storm" for which the most effective treatment has not yet been established. Our study describes the results of CytoSorb hemoadsorption in COVID-19 patients treated on the intensive care unit (ICU).

Patients And Methods: In this retrospective study, 26 patients with COVID-19 and acute respiratory dysfunction syndrome (ARDS) were treated with hemoadsorption therapy. Read More

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Administration of Fibrinogen Concentrate Combined with Prothrombin Complex Maintains Hemostasis in Children Undergoing Congenital Heart Repair (A Long-Term Propensity Score-Matched Study).

Acta Anaesthesiol Scand 2021 Jun 21. Epub 2021 Jun 21.

Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria.

Background: Bleeding is a common problem in children with congenital heart disease undergoing major cardiac surgery requiring cardiopulmonary bypass (CPB). Little is known about optimal management with blood products.

Objective: To investigate clinical outcome and hemostatic effects of fibrinogen concentrate (FC) in combination with prothrombin complex concentrate (PCC) versus standard treatment with fresh frozen plasma (FFP) in children undergoing cardiac surgery. Read More

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Long-Term Patient-Centred Follow-up in a Prospective Cohort of Patients with COVID-19.

Infect Dis Ther 2021 Jun 21. Epub 2021 Jun 21.

Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.

Introduction: To better define COVID-19 long-term impact we prospectively analysed patient-centred outcomes, including general health and symptom duration.

Methods: Barthel index (BI), St. George's Respiratory Questionnaire adapted to patients with COVID-19 (aSGRQ) and WHO Clinical Progression Scale (CPS) were measured at enrolment and at 6 weeks from the onset of symptoms. Read More

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[Sepsis in German intensive care units-Last position worldwide?… Not so fast].

Anaesthesist 2021 Jun 21. Epub 2021 Jun 21.

Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie, Vivantes Klinikum Neukölln, Rudower Straße 48, 12351, Berlin, Deutschland.

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Lived Experiences of Family Members of Patients With Severe COVID-19 Who Died in Intensive Care Units in France.

JAMA Netw Open 2021 Jun 1;4(6):e2113355. Epub 2021 Jun 1.

Famiréa Research Group, Medical Intensive Care Unit, Assistance Publique-Hȏpitaux de Paris, Saint Louis University Hospital, Paris, France.

Importance: During the initial surge of the COVID-19 pandemic, family members were often separated from their loved ones admitted to intensive care units (ICUs), with a potential for negative experiences and psychological burden.

Objective: To better understand the experiences of bereaved family members of patients who died in an ICU during the COVID-19 pandemic, from the time of hospital admission until after the patient's death.

Design, Setting, And Participants: This qualitative study used semistructured, in-depth interviews to collect experiences from bereaved family members of patients who died from severe COVID-19 in 12 ICUs during the first wave of the pandemic in France. Read More

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MicroRNA miR-497 is closely associated with poor prognosis in patients with cerebral ischemic stroke.

Bioengineered 2021 Dec;12(1):2851-2862

Department of ICU, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Cerebral ischemic stroke (CIS) is the most common type of stroke, which is highly hazardous. This investigation aims to analyze the correlation of miR-497 with CIS, so as to provide reliable evidence for clinical response to CIS and lay a solid foundation for follow-up research. Eighty-nine CIS patients and 39 concurrent physical examinees selected between June 2017 and October 2018 were enrolled as the research participants. Read More

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December 2021

Risk and outcomes of covid-19 in patients with multiple sclerosis.

Eur J Neurol 2021 Jun 21. Epub 2021 Jun 21.

Unidad de Enfermedades Desmielinizantes, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Limited information is available on incidence and outcomes of COVID-19 in patients with multiple sclerosis (MS). This study investigated the risks of SARS-CoV-2 infection and COVID-19-related outcomes in patients with MS, and compared these with the general population.

Methods: A regional registry was created to collect data on incidence, hospitalization rates, intensive care unit (ICU) admission and death in patients with MS and COVID-19. Read More

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Retroperitoneal versus transperitoneal approach for elective open abdominal aortic aneurysm repair.

Cochrane Database Syst Rev 2021 Jun 21;6:CD010373. Epub 2021 Jun 21.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, China.

Background: There has been extensive debate in the surgical literature regarding the optimum surgical access approach to the infrarenal abdominal aorta during an operation to repair an abdominal aortic aneurysm. The published trials comparing retroperitoneal (RP) and transperitoneal (TP) aortic surgery show conflicting results. This is an update of the review first published in 2016. Read More

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Wireless point-of-care ultrasound: First experiences with a new generation handheld device.

Clin Hemorheol Microcirc 2021 Jun 11. Epub 2021 Jun 11.

Institute of Diagnostic Radiology and Interdisciplinary Ultrasound Department, University Hospital, Regensburg, Germany.

Aim: To evaluate the diagnostic reliability of a new generation wireless point-of care ultrasound device for abdominal and thoracic findings.

Material And Methods: 40 patients (16 females, 24 males 19 -80 years, on average 56.1 years) were scanned by an experienced examiner using the new wireless Vscan Air device for abdominal and thoracic findings. Read More

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COVID-19 outcomes in patients with inflammatory bowel diseases in Latin America: results from SECURE-IBD registry.

J Gastroenterol Hepatol 2021 Jun 20. Epub 2021 Jun 20.

Health Sciences Postgraduate Program, School of Medicine, Pontifical Catholic University of Paraná (PUCPR), Curitiba, Brazil.

Background: One of the most impacted regions by the pandemic globally, Latin America is facing socio-economic and healthcare challenges that can potentially affect disease outcomes. Recent data suggest that IBD patients do not have an increased risk of the development of COVID-19 complications. However, the impact of COVID-19 on IBD patients living in least developed areas remains to be fully elucidated. Read More

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The Effect of Changing Arterial Transducer Position on Stroke Volume Measurements Using FloTrac System Version 4.0: A Pilot Experimental Study.

Crit Care Explor 2021 Jun 15;3(6):e0465. Epub 2021 Jun 15.

Department of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Kobe, Japan.

Objectives: We conducted a pilot study using an experimental study protocol to evaluate the measurement error of arterial pulse contour analysis-derived stroke volume due to improper transducer leveling during the passive leg raising test and the impact of such error on the determination of fluid responsiveness.

Design: Prospective observational study.

Setting: A medical-surgical ICU at a tertiary referral center in Kobe, Japan. Read More

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A Framework to Assess Alarm Fatigue Indicators in Critical Care Staff.

Crit Care Explor 2021 Jun 14;3(6):e0464. Epub 2021 Jun 14.

Raytheon Technologies, Waltham, MA.

This article examines work-related and Personality personality factors that could influence health providers in experiencing alarm fatigue. The purpose of this study is to provide a basis to determine factors that may predict the potential of alarm fatigue in critical care staff.

Design: A questionnaire-based survey and an observational study were conducted to assess factors that could contribute to indicators of alarm fatigue. Read More

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Humanizing the ICU Patient: A Qualitative Exploration of Behaviors Experienced by Patients, Caregivers, and ICU Staff.

Crit Care Explor 2021 Jun 15;3(6):e0463. Epub 2021 Jun 15.

Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY.

Objectives: To understand how patients and family members experience dehumanizing or humanizing treatment when in the ICU.

Design: Qualitative study included web-based focus groups and open-ended surveys posted to ICU patient/family social media boards. Focus groups were audio recorded and transcribed. Read More

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Prediction of Impending Septic Shock in Children With Sepsis.

Crit Care Explor 2021 Jun 15;3(6):e0442. Epub 2021 Jun 15.

Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD.

Objectives: Sepsis and septic shock are leading causes of in-hospital mortality. Timely treatment is crucial in improving patient outcome, yet treatment delays remain common. Early prediction of those patients with sepsis who will progress to its most severe form, septic shock, can increase the actionable window for interventions. Read More

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Time to Lung Volume Stability After Pressure Change During High-Frequency Oscillatory Ventilation.

Crit Care Explor 2021 Jun 14;3(6):e0432. Epub 2021 Jun 14.

Neonatal Research, Murdoch Children's Research Institute, Parkville, VIC, Australia.

Clinicians have little guidance on the time needed before assessing the effect of a mean airway pressure change during high-frequency oscillatory ventilation. We aimed to determine: 1) time to stable lung volume after a mean airway pressure change during high-frequency oscillatory ventilation and 2) the relationship between time to volume stability and the volume state of the lung.

Design: Prospective observational study. Read More

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