3 results match your criteria ibv plpro

  • Page 1 of 1

Interplay of the ubiquitin proteasome system and the innate immune response is essential for the replication of infectious bronchitis virus.

Arch Virol 2021 Aug 26;166(8):2173-2185. Epub 2021 May 26.

Key Laboratory of Animal Virology of Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, People's Republic of China.

Infectious bronchitis virus (IBV) is the only coronavirus known to infect poultry. The replication and pathogenesis of IBV are poorly understood, mainly because of the unavailability of a robust cell culture system. Here, we report that an active ubiquitin proteasome system (UPS) is necessary for efficient replication of IBV in Vero cells. Read More

View Article and Full-Text PDF

Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus.

J Biol Chem 2015 Mar 21;290(11):7160-8. Epub 2015 Jan 21.

From the Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China, College of Life Sciences, Nankai University, Tianjin 300071, China, and National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China

Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. Avian infectious bronchitis virus (IBV), the causative agent of bronchitis in chicken that results in huge economic losses every year in the poultry industry globally, encodes a PLpro. The substrate specificities of this PLpro are not clearly understood. Read More

View Article and Full-Text PDF

The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond.

J Biol Chem 2001 Aug 28;276(35):33220-32. Epub 2001 Jun 28.

Institute of Virology and Immunology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg, Germany.

The largest replicative protein of coronaviruses is known as p195 in the avian infectious bronchitis virus (IBV) and p210 (p240) in the mouse hepatitis virus. It is autocatalytically released from the precursors pp1a and pp1ab by one zinc finger-containing papain-like protease (PLpro) in IBV and by two paralogous PLpros, PL1pro and PL2pro, in mouse hepatitis virus. The PLpro-containing proteins have been recently implicated in the control of coronavirus subgenomic mRNA synthesis (transcription). Read More

View Article and Full-Text PDF
  • Page 1 of 1