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Light-Addressable Square Wave Voltammetry (LASWV) Based on a Field-Effect Structure for Electrochemical Sensing and Imaging.

ACS Sens 2021 Apr 8. Epub 2021 Apr 8.

Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.

Here, we describe a new photoelectrochemical imaging method termed light-addressable square wave voltammetry (LASWV). It measures local SWV currents at an unstructured electrolyte/insulator/semiconductor (EIS) field-effect substrate by illuminating and addressing the substrate with an intensity-constant laser. Due to the continuous generation of charge carriers in the light-irradiated semiconductor, the drift and diffusion of photoinjected carriers within the semiconductor bulk would slow down the equilibrium processes of charge and discharge in one potential pulse cycle. Read More

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Irreversible electroporation (IRE) in renal cell carcinoma (RCC): a mid-term clinical experience.

Eur Radiol 2021 Mar 30. Epub 2021 Mar 30.

Division of Urology, Institute of Oncology, St. James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

Objectives: To evaluate the safety and efficacy of CT-guided IRE of clinical T1a (cT1a) renal tumours close to vital structures and to assess factors that may influence the technical success and early oncological durability.

Methods: CT-guided IRE (2015-2020) was prospectively evaluated. Patients' demographics, technical details/success, Clavien-Dindo (CD) classification of complications (I-V) and oncological outcome were collated. Read More

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Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1.

Transplant Cell Ther 2021 Mar 6. Epub 2021 Mar 6.

Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan.

Consolidation using high-dose chemotherapy with autologous stem cell transplantation (ASCT) is an important component of frontline therapy for children with high-risk neuroblastoma. The optimal preparative regimen is uncertain, although recent data support a role for busulfan/melphalan (BuMel). The Children's Oncology Group (COG) conducted a trial (ANBL12P1) to assess the tolerability and feasibility of BuMel ASCT following a COG induction. Read More

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Vascular and Parenchymal Enhancement Assessment by Dual-Phase Dual-Energy CT in the Diagnostic Investigation of Pulmonary Hypertension.

Radiol Cardiothorac Imaging 2020 Dec 17;2(6):e200009. Epub 2020 Dec 17.

Departments of Cardiothoracic Medicine (J.L.B., B.P.M.) and Thoracic Imaging (I.V.), St George's University Hospitals NHS Foundation Trust and St George's University of London, Blackshaw Road, London SW17 0QT, England; School of Sport, Health and Applied Science, St Mary's University, London, England (C.G.); and Department of Radiology, St George's University Hospitals NHS Foundation Trust, London, England (C.S., S.S.).

Purpose: To evaluate pulmonary hypertension (PH) determination by dual-phase dual-energy CT pulmonary angiography vascular enhancement and perfused blood volume (PBV) quantification.

Materials And Methods: In this prospective study, consecutive participants who underwent both right heart catheterization and dual-phase dual-energy CT pulmonary angiography were included between 2012 and 2014. CT evaluation comprised a standard pulmonary arterial phase dual-energy CT pulmonary angiography acquisition (termed series 1) followed 7 seconds after series 1 completion by a second dual-energy CT pulmonary angiography acquisition limited to the central 10 cm of the pulmonary vasculature (termed series 2). Read More

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December 2020

Development of a prediction model of treatment response in patients with cutaneous arteritis: Insights from a cohort of 33 patients.

J Dermatol 2021 Mar 25. Epub 2021 Mar 25.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Cutaneous arteritis (CA) is necrotizing vasculitis invading the small- to medium-sized arteries of the skin. The majority of patients can be favorably managed by low- to medium-dose systemic corticosteroids (prednisolone, <0.5 mg/kg/day) or other oral medications such as non-steroidal anti-inflammatory drugs, dapsone, and azathioprine. Read More

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A nanoscale CuSe ultrathin film deposited via atomic layer deposition and its memristive effects.

Nanotechnology 2021 Mar 25;32(24):245202. Epub 2021 Mar 25.

School of Chemistry, Seoul National University, Gwanak-Ro 1, Gwanak-Gu, Seoul, 08826, Republic of Korea.

An ultrathin film of copper selenide 50 nm thick was deposited using a home-made atomic layer deposition apparatus. Synthesized copper pivalate and bis(triethylsilyl) selenide precursors were used. The deposition rate at 160 °C was 0. Read More

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CT-derived Chest Muscle Metrics for Outcome Prediction in Patients with COVID-19.

Radiology 2021 Mar 16:204141. Epub 2021 Mar 16.

From Unit of Radiology, IRCCS Policlinico San Donato, Via Rodolfo Morandi 30, 20097 San Donato Milanese, Italy (S.S., L.A.C., F.S.); Department of Biomedicine, Neurosciences and Advanced Diagnostics, Section of Radiological Sciences, Università degli Studi di Palermo, Via del Vespro 127, 90127 Palermo, Italy (D.A.); Unit of Radiology, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano, Italy (D.A., C.M., L.M.S.); Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Luigi Mangiagalli 31, 20133 Milano, Italy (A.C., C.M., S.G., F.S., F.S., L.M.S.); Radiodiagnostics, Department of Diagnosis and Treatment Services, Azienda Ospedaliero Universitaria Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy (R.A., A.C., P.S.C.D., Z.F., A.P., D.Z.); Department of Radiology, Fondazione Poliambulanza Istituto Ospedaliero, Via Leonida Bissolati 57, 25124 Brescia, Italy (C.B., L.M.); Radiology Department, Ospedale SS. Annunziata, Via Giovanni Vicini 2, 44042 Cento, Italy (A.B., R.R.); DIMET, Università degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy (A.C.); Postgraduate School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milano, Italy (S.C., E.D., C.D.B., G.D.P., I.V.); High Speciality Center for Dietetics, Nutritional Education and Cardiometabolic Prevention, IRCCS Policlinico San Donato, Via Rodolfo Morandi 30, 20097 San Donato Milanese, Italy (A.E.M.); Division of Interventional Radiology, IRCCS Istituto Europeo di Oncologia - IEO, Via Ripamonti 435, 20141 Milano, Italy (G.M.); Department of Oncology and Hematology-Oncology, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milano, Italy (G.M., A.V.); ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore 3, 20162 Milano, Italy (A.V., V.T.).

Background Lower muscle mass is a known predictor of unfavorable outcome, but its prognostic impact on COVID-19 patients is unknown. Purpose To investigate the contribution of CT-derived muscle status in predicting clinical outcomes in COVID-19 patients. Materials and Methods Clinical/laboratory data and outcomes (intensive care unit [ICU] admission and death) were retrospectively retrieved for patients with reverse transcriptase polymerase chain reaction-confirmed COVID-19, who underwent chest CT on admission in four hospitals in Northern Italy from February 21 to April 30, 2020. Read More

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Scanning ion conductance microscopy of isolated metaphase chromosomes in a liquid environment.

Chromosome Res 2021 Mar 11;29(1):95-106. Epub 2021 Mar 11.

Department of Mechanical Engineering, Faculty of Engineering, Shizuoka University, Hamamatsu, 432-8561, Japan.

Scanning probe microscopy (SPM) uses a probing tip which scans over a sample surface for obtaining information on the sample surface characteristics. Among various types of SPM, atomic force microscopy (AFM) has been widely applied to imaging of biological samples including chromosomes. Scanning ion conductance microscopy (SICM) has been also introduced for visualizing the surface structure of biological samples because it can obtain "contact-free" topographic images in liquid conditions by detecting ion current flow through a pipette opening. Read More

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Hysteresis in centrosymmetric CuPbI perovskite halide: apolar dielectric or orientable dielectric?

J Phys Condens Matter 2021 Mar 8;33(15):155703. Epub 2021 Mar 8.

Department of Physics, Indian Institute of Technology (Banaras Hindu University) Varanasi, Varanasi-221005 India.

We demonstrated the change in polarization behaviour at the surface/interface before and after light through Havriliak-Negami equation of lesser known CuPbI. We have synthesized CuPbI through cold sintering technique and the polarization mechanisms are altered by increasing (cold) sintering temperature. The structure of CuPbI was not known and we predicted it to be hexagonal (R[Formula: see text]m) with 21R prototype representation. Read More

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A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism.

Front Endocrinol (Lausanne) 2020 19;11:614993. Epub 2021 Feb 19.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Background: The diagnosis of congenital hyperinsulinism (CHI) may be hampered by a plasma (p-) insulin detection limit of 12-18 pmol/L (2-3 mU/L).

Objective: To evaluate the diagnostic performance of a sensitive insulin immunoassay and to find the optimal p-insulin cut-off for the diagnosis of CHI.

Methods: Diagnostic fasting tests, performed without medication or i. Read More

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February 2021

The nm-thickness CuSe ultrathin film via atomic layer deposition and its memristive effect.

Nanotechnology 2021 Feb 26. Epub 2021 Feb 26.

Department of Chemistry, Seoul National University, Seoul, Seoul, Korea (the Republic of).

The ultrathin film of copper selenide with 50 nm in thickness by the home-made atomic layer deposition apparatus was deposited. Synthesized copper pivalate and bis(triethylsilyl) selenide precursors were used. The deposition rate at 160C was 0. Read More

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February 2021

Influence of the Substrate, Process Conditions, and Postannealing Temperature on the Properties of ZnO Thin Films Grown by the Successive Ionic Layer Adsorption and Reaction Method.

ACS Omega 2021 Feb 21;6(4):2665-2674. Epub 2021 Jan 21.

Department of Electrical and Electronic Engineering, Saga University, Honjo, Saga 840-8502, Japan.

Here, we report the effect of the substrate, sonication process, and postannealing on the structural, morphological, and optical properties of ZnO thin films grown in the presence of isopropyl alcohol (IPA) at temperature 30-65 °C by the successive ionic layer adsorption and reaction (SILAR) method on both soda lime glass (SLG) and Cu foil. The X-ray diffraction (XRD) patterns confirmed the preferential growth thin films along (002) and (101) planes of the wurtzite ZnO structure when deposited on SLG and Cu foil substrates, respectively. Both XRD and Raman spectra confirmed the ZnO and Cu-oxide phases of the deposited films. Read More

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February 2021

Deep Learning for the Preoperative Diagnosis of Metastatic Cervical Lymph Nodes on Contrast-Enhanced Computed ToMography in Patients with Oral Squamous Cell Carcinoma.

Cancers (Basel) 2021 Feb 3;13(4). Epub 2021 Feb 3.

Department of Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan.

We investigated the value of deep learning (DL) in differentiating between benign and metastatic cervical lymph nodes (LNs) using pretreatment contrast-enhanced computed tomography (CT). This retrospective study analyzed 86 metastatic and 234 benign (non-metastatic) cervical LNs at levels I-V in 39 patients with oral squamous cell carcinoma (OSCC) who underwent preoperative CT and neck dissection. LNs were randomly divided into training (70%), validation (10%), and test (20%) sets. Read More

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February 2021

Influence of Gas Annealing on Sensitivity of AlN/4H-Sic-Based Temperature Sensors.

Materials (Basel) 2021 Feb 2;14(3). Epub 2021 Feb 2.

Department Electronic Materials Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Korea.

In this study, the physical and electrical characteristics of an AlN/4H-SiC Schottky barrier diode-based temperature sensor annealed in various gas atmospheres were investigated. An aluminum nitride (AlN) thin film was deposited on a 4H-SiC substrate via radio-frequency sputtering followed by annealing in N or O gas. The chemical composition of the film was determined by X-ray photoelectron spectroscopy (XPS) before and after annealing, and its electrical properties were evaluated by plotting a current-voltage (I-V) curve. Read More

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February 2021

Photoelectrical Properties Investigated on Individual Si Nanowires and Their Size Dependence.

Nanoscale Res Lett 2021 Jan 28;16(1):18. Epub 2021 Jan 28.

State Key Laboratory of Surface Physics, Fudan University, Shanghai, 200433, China.

Periodically ordered arrays of vertically aligned Si nanowires (Si NWs) are successfully fabricated with controllable diameters and lengths. Their photoconductive properties are investigated by photoconductive atomic force microscopy (PCAFM) on individual nanowires. The results show that the photocurrent of Si NWs increases significantly with the laser intensity, indicating that Si NWs have good photoconductance and photoresponse capability. Read More

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January 2021

Comparative pharmacokinetics of metronidazole in healthy and infected pigeons (, var. ).

Br Poult Sci 2021 Apr 16:1-7. Epub 2021 Apr 16.

Department of Veterinary Sciences, University of Pisa, Pisa, Italy.

1. This study investigated the pharmacokinetics of metronidazole after intravenous (i.v. Read More

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The Role of New Posaconazole Formulations in the Treatment of Candida albicans Infections: Data from an Pharmacokinetic-Pharmacodynamic Model.

Antimicrob Agents Chemother 2021 03 18;65(4). Epub 2021 Mar 18.

Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Posaconazole is more active than fluconazole against and is approved for the treatment of oropharyngeal candidiasis but not for that of invasive candidiasis (IC). Here, we explored the efficacy of posaconazole against in an pharmacokinetic/pharmacodynamic (PK/PD) model of IC and determined the probability of pharmacodynamic target attainment for the oral solution and intravenous (i.v. Read More

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Predicting human pharmacokinetics from preclinical data: volume of distribution.

Transl Clin Pharmacol 2020 Dec 15;28(4):169-174. Epub 2020 Dec 15.

Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

This tutorial introduces background and methods to predict the human volume of distribution (V) of drugs using and animal pharmacokinetic (PK) parameters. The physiologically based PK (PBPK) method is based on the familiar equation: = + ∑ ( × ). In this equation, V (plasma volume) and V (tissue volume) are known physiological values, and k (tissue plasma partition coefficient) is experimentally measured. Read More

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December 2020

Universal Features of Non-equilibrium Ionic Currents through Perm-Selective Membranes: Gating by Charged Nanoparticles/Macromolecules for Robust Biosensing Applications.

J Phys Chem B 2021 02 7;125(7):1906-1915. Epub 2021 Jan 7.

Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.

The presence of a small number (∼1000) of charged nanoparticles or macromolecules on the surface of an oppositely charged perm-selective membrane is shown to sensitively gate the ionic current through the membrane at a particular voltage, thus producing a voltage signal much larger than thermal noise. We show that, at sufficiently high voltages, surface vortices appear on the membrane surface and sustain an ion-depleted boundary layer that controls the diffusion length and ion current. An asymmetric vortex bifurcation occurs beyond a critical voltage to reduce the diffusion length and the differential resistance by half. Read More

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February 2021

Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis.

J Ethnopharmacol 2021 Apr 28;269:113764. Epub 2020 Dec 28.

Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan; Graduate Institute of Acupuncture Science, China Medical University, Taichung, 40402, Taiwan; School of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. Electronic address:

Ethnopharmacological Relevance: Ambroxol elevates glucocerebrosidase (GCase) activity and reduces nigrostriatal alpha-synuclein burden to better ameliorate motor function in Parkinson's disease (PD). Polygala tenuifolia is a potential alternative botanical medicine for the treatment of many nonmotor symptoms of PD commonly used in Taiwanese patients. Co-administration of these two medicines pose potential herb-drug interaction. Read More

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Allometric Optimization of Enrofloxacin Dosage in Growing Male Turkeys: Empirical Evidence for Improved Internal Exposure.

Antibiotics (Basel) 2020 Dec 18;9(12). Epub 2020 Dec 18.

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, ul. Norwida 31, 50-375 Wrocław, Poland.

Rapid weight gain in turkeys causes a major change in the pharmacokinetics of drugs, leading to age-dependent variability in the internal exposure and, possibly, treatment failure and/or selection for antimicrobial resistance in young individuals. The aim of the study was to investigate whether a non-linear dosing protocol that accounts for the previously established allometric relation between enrofloxacin clearance and body weight (BW) may optimize the internal exposure to enrofloxacin in growing male turkeys. Enrofloxacin was administered four times, between the age of 5 and 16. Read More

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December 2020

Design and fabrication of CuInS/ZnS-based QLED for automotive lighting systems.

Nanotechnology 2020 Dec 17;32(10):105204. Epub 2020 Dec 17.

Departamento de Electrónica y Tecnología de los Computadores, Facultad de Ciencias, Universidad de Granada, E-18071, Granada, Spain. VALEO Lighting Systems, Department of Electronics, Martos, Spain.

This work reports the design, manufacturing and numerical simulation approach of a 6-pixel (4.5 mm/pixel) electroluminescent quantum dot light emitting device (QLED) based on CuInS/ZnS quantum dots as an active layer. The QLED device was fabricated using a conventional multi-layer thin film deposition. Read More

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December 2020

Population Pharmacokinetics of Intravenous Ganciclovir and Oral Valganciclovir in a Pediatric Population To Optimize Dosing Regimens.

Antimicrob Agents Chemother 2021 02 17;65(3). Epub 2021 Feb 17.

EA7323, Evaluation des Thérapeutiques et Pharmacologie Périnatale et Pédiatrique, Université de Paris, Paris, France

Ganciclovir is indicated for curative or preventive treatment of cytomegalovirus (CMV) infections. This study aimed to characterize ganciclovir pharmacokinetics, following intravenous ganciclovir and oral valganciclovir administration, to optimize dosing schemes. All children aged <18 years receiving ganciclovir or valganciclovir were included in this study. Read More

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February 2021

The Pharmacodynamic-Toxicodynamic Relationship of AUC and in Vancomycin-Induced Kidney Injury in an Animal Model.

Antimicrob Agents Chemother 2021 02 17;65(3). Epub 2021 Feb 17.

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

Vancomycin induces exposure-related acute kidney injury. However, the pharmacokinetic-toxicodynamic (PK-TD) relationship remains unclear. Sprague-Dawley rats received intravenous (i. Read More

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February 2021

Randomized controlled trial comparison of analgesic drugs for control of pain associated with induced lameness in lactating dairy cattle.

J Dairy Sci 2021 Feb 11;104(2):2040-2055. Epub 2020 Dec 11.

Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames 50011. Electronic address:

Both the economic loss and welfare implications of lameness affect the dairy industry. Currently no analgesic drugs are approved to alleviate lameness-associated pain in lactating dairy cattle in the United States. In this randomized controlled trial, 48 lactating Holsteins were enrolled to evaluate the effect of oral meloxicam and i. Read More

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February 2021

Evaluation of Linezolid Pharmacokinetics in Critically Ill Obese Patients with Severe Skin and Soft Tissue Infections.

Antimicrob Agents Chemother 2021 01 20;65(2). Epub 2021 Jan 20.

Department of Pharmacy Practice and Sciences, University of Maryland, Baltimore, Maryland, USA

Linezolid standard dosing is fixed at 600 mg every 12 h (q12h) for adults. Literature suggests critically ill, obese patients require higher doses. The study aim is 2-fold: (i) to describe linezolid pharmacokinetics (PK), and (ii) to evaluate if PK/pharmacodynamic (PD) target attainment is achieved with standard dosing in critically ill, obese patients with severe skin and soft tissue infections (SSTIs). Read More

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January 2021

Real-time monitoring of geosmin based on an aptamer-conjugated graphene field-effect transistor.

Biosens Bioelectron 2021 Feb 11;174:112804. Epub 2020 Nov 11.

Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea; Nanobiotechnology and Bioinformatics (Major), University of Science & Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea. Electronic address:

In this paper, we propose a novel field-effect transistor (FET) using graphene, which is a two-dimensional (2D) nanomaterial, capable of evaluating water quality, and immobilizing the surface of a graphene micropatterned transistor with a highly responsive bioprobe for a water contamination indicator, geosmin, with high selectivity. A high-quality bioprobe-immobilized graphene FET (GFET) was fabricated for the real-time monitoring of geosmin using a liquid-gate measurement configuration. Immobilization was confirmed by measuring the change in the electrical characteristics of the platform (slope of the current-voltage (I-V) curve) and fluorescence images. Read More

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February 2021

Gas Sensing with Solar Cells: The Case of NH Detection through Nanocarbon/Silicon Hybrid Heterojunctions.

Nanomaterials (Basel) 2020 Nov 21;10(11). Epub 2020 Nov 21.

I-Lamp and Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, via dei Musei 41, 25121 Brescia, Italy.

Photovoltaic (PV) cells based on single-walled carbon nanotube (SWCNT)/silicon (Si) and multiwalled carbon nanotube (MWCNT)/Si junctions were tested under exposure to NH in the 0-21 ppm concentration range. The PV cell parameters remarkably changed upon NH exposure, suggesting that these junctions, while being operated as PV cells, can react to changes in the environment, thereby acting as NH gas sensors. Indeed, by choosing the open-circuit voltage, V, parameter as read-out, it was found that these cells behaved as gas sensors, operating at room temperature with a response higher than chemiresistors developed on the same layers. Read More

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November 2020

CuInS/ZnS-based QLED design and modelling for automotive lighting systems.

Nanotechnology 2020 Nov 23. Epub 2020 Nov 23.

Departamento de Electronica y Tecnologia de Computadores, Universidad de Granada, GRANADA, GRANADA, SPAIN.

This work reports the design, manufacturing and numerical simulation approach of a 6-pixel (4.5mm/pixel) electroluminescent quantum dot light emitting device (QLED) based on CuInS/ZnS quantum dots as an active layer. Following a conventional thin-film deposition multilayer approach, the QLED device was fabricated. Read More

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November 2020

Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN).

Antimicrob Agents Chemother 2021 02 17;65(3). Epub 2021 Feb 17.

Northwestern University, Chicago, Illinois, USA.

Intravenous (i.v.) minocycline is increasingly used to treat infections caused by multidrug-resistant (MDR) Despite its being approved nearly 50 years ago, published information on its pharmacokinetic (PK) profile is limited. Read More

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February 2021