Mol Cell Neurosci 2013 Sep 14;56:436-46. Epub 2012 Dec 14.
Dept of Biological Chemistry, The Life Sciences Institute and The Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, 91904, Israel.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a family of conserved nuclear proteins that associate with nascent RNA polymerase II transcripts to yield hnRNP particles, playing key roles in mRNA metabolism, DNA-related functions and microRNA biogenesis. HnRNPs accompany transcripts from stages of transcriptional regulation through splicing and post-transcriptional regulation, and are believed to affect the majority of expressed genes in mammals. Most hnRNP mRNA transcripts undergo alternative splicing and post-translational modifications, to yield a remarkable diversity of proteins with numerous functional elements that work in concert in their multiple functions. Read More