47,616 results match your criteria hypothyroidism

Triiodothyronine alongside levothyroxine in the management of hypothyroidism?

Curr Med Res Opin 2021 Sep 23. Epub 2021 Sep 23.

Johannes Gutenberg-University Medical Centre, Department of Medicine I, Mainz, Germany.

The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial minority still report symptoms of hypothyroidism unexplained by a comorbid medical condition. LT4 is essentially a prodrug for triiodothyronine (T3), the thyroid hormone that acts on target tissues in the brain and the periphery. Read More

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September 2021

A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211043386

The University of Texas Southwestern Medical Center, Dallas, USA.

The emergence of a novel coronavirus and global pandemic raised the need for the rapid development of new vaccines to reduce the morbidity and mortality associated with Covid-19. Common side effects of these vaccines such as myalgia, arthralgia, nausea, fatigue, and injection site reaction are usually self-resolving. Recognition of other potential adverse effects of these novel vaccines is important due to their rapid and widespread distribution. Read More

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September 2021

[Internal carotid artery dissection in patients with Turner's syndrome].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(8. Vyp. 2):58-65

Research Center of Neurology, Moscow, Russia.

Cervical artery dissection (CeAD) due to arterial wall weakness (dysplasia) is one of the most common causes of ischemic stroke (IS) at a young age. A rare and little known cause of CeAD is Turner's syndrome (TS)-is an inherited disease caused by completely or partially missing X chromosome. In this paper, we describe 2 female patients, aged 27 and 33 years, with genetically confirmed TS (karyotype 45X0) and internal carotid artery dissection(ICAD). Read More

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January 2021

[Thyroid dysfunction in old age].

Alexander Iwen

Dtsch Med Wochenschr 2021 Oct 22;146(19):1298-1308. Epub 2021 Sep 22.

Thyroid dysfunctions are common endocrine disorders. With an increasing number of older persons in European societies, the number of older patients affected will also rise. The physiology of thyroid hormones and their regulation change with increasing age. Read More

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October 2021

Venous Gas Embolism During Radical Robotic Prostatectomy: A Case Report and Evidence-Based Management Algorithm.

Cureus 2021 Aug 19;13(8):e17296. Epub 2021 Aug 19.

Anesthesiology, University of Rochester, Rochester, USA.

Robotic-assisted radical prostatectomy (RARP) has gained rapid popularity in the last two decades after early reports of excellent survival rates, quick learning curves, and minimal invasion or tissue damage. Given the anatomical location of surgical prostatectomies and the utilization of intra-abdominal gas during laparoscopy, there is a risk of developing venous air embolism (VAE). We present a case of a 62-year-old male with hypothyroidism and benign prostatic hyperplasia who underwent robotic suprapubic prostatectomy under general anesthesia. Read More

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Emergence of cutaneous Rosai-Dorfman disease during immunosuppressive treatment of follicular B-cell lymphoma: A case report.

SAGE Open Med Case Rep 2021 16;9:2050313X211046455. Epub 2021 Sep 16.

Department of Dermatology and Skin Science, The University of British Columbia, Vancouver, BC, Canada.

Background: Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a rare proliferation of non-Langerhans histiocytes. Cutaneous Rosai-Dorfman disease is a rare subtype of Rosai-Dorfman disease limited to the skin with variable clinical presentation.

Case Summary: A 59-year-old female with a history of osteoarthritis, hypothyroidism, and follicular B-cell lymphoma presented with pruritic, erythematous, dome-shaped papules that developed while on chemotherapy treatment. Read More

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September 2021

Timing of coronary artery bypass grafting after acute myocardial infarction: does it influence outcomes?

Kardiochir Torakochirurgia Pol 2021 Mar 15;18(1):27-32. Epub 2021 May 15.

Department of Cardiac Surgery, NH Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India.

Introduction: The optimal timing of coronary artery bypass grafting (CABG) operations in patients with recent acute myocardial infarction (AMI) remains unclear.

Aim: To assess the influence of timing on post-operative outcomes in patients undergoing CABG following AMI.

Material And Methods: In this retrospective analysis 12,224 consecutive patients undergoing CABG were included. Read More

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[The role of serum thyroid stimulating hormone reference interval in the diagnosis of subclinical hypothyroidism and its influencing factors].

X C Wang Z Y Shan

Zhonghua Nei Ke Za Zhi 2021 Oct;60(10):925-928

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission of the People's Republic of China Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.

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October 2021

Eye symptoms in patients with benign thyroid diseases.

Sci Rep 2021 Sep 21;11(1):18706. Epub 2021 Sep 21.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland.

Thyroid diseases may cause a variety of functional and structural body changes, including eye and vision abnormalities, which can have a negative impact on a patient's well-being. However, only a few studies on the impact of other benign thyroid diseases on the visual process are available in the literature. In this study, using the Polish version of the thyroid-specific quality of life (ThyPROpl) questionnaire, we aimed to determine the self-reported influence of benign thyroid diseases (e. Read More

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September 2021

High-dose radiation exposure and hypothyroidism: Etiology, prevention and replacement therapy.

J Radiol Prot 2021 Sep 21. Epub 2021 Sep 21.

University Hospital Wuerzburg, Nuclear Medicine, Wuerzburg, GERMANY.

Without any doubt, high dose radiation exposure can induce hypothyroidism. However, there are open questions related to the mechanisms of its induction, corresponding dose tresholds and possible countermeasures. Therefore, this review addresses the etiology, prevention and therapy of radiation induced hypothyroidism. Read More

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September 2021

Myxedema crisis and ovarian hyperstimulation in a child with Down syndrome.

J Pediatr Endocrinol Metab 2021 Sep 22. Epub 2021 Sep 22.

Department of Paediatrics, Dr. Kamakshi Memorial Hospital, Chennai, Tamil Nadu, 600100, India.

Objectives: Myxedema crisis, a fatal complication of severe hypothyroidism, is extremely rare in children and treatment guidelines are lacking. Since availability of intravenous levothyroxine is limited in resource poor settings, myxedema crisis can be treated with oral levothyroxine and/or oral liothyronine (if necessary), in the absence of cardiac risk factors, thus hastening the recovery and significantly decreasing the associated morbidity and mortality. In the background of untreated hypothyroidism, a possible association of ovarian hyperstimulation syndrome (OHSS) and reactive pituitary hyperplasia should be kept in mind, thus preventing unnecessary interventions. Read More

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September 2021

Screening for Congenital Hypothyroidism-Time to Raise the Bar?

Anurag Bajpai

Indian J Pediatr 2021 Sep 21. Epub 2021 Sep 21.

Department of Pediatric Endocrinology, Regency Center for Diabetes, Endocrinology & Research, Kanpur, Uttar Pradesh, 208001, India.

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September 2021

Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.

Am J Med Genet A 2021 Sep 21. Epub 2021 Sep 21.

The Affiliated Hospital of Qingdao University, Department of Endocrinology, Qingdao, China.

Thyroid dysgenesis (TD) accounts for 80% cases of congenital hypothyroidism, which is the most common neonatal disorder. Until now, the gene mutations have been reported associated with TD can only account for 5% cases, suggesting the genetic heterogeneity of the pathology. Nicotinamide nucleotide transhydrogenase (NNT) plays a crucial role in regulating redox homeostasis, patients carrying NNT mutations have been described with a clinical phenotype of hypothyroidism. Read More

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September 2021

Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein.

Commun Biol 2021 Sep 20;4(1):1101. Epub 2021 Sep 20.

School of Pharmacy, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea.

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, potentially with a biological basis; however, its exact cause remains unknown. Thyroid hormone (TH) abnormalities are more prevalent in patients with ADHD than in the general population, indicating a shared pathogenetic mechanism for these conditions. Previously, we identified that overexpression of thyroid hormone-responsive protein (THRSP), a gene highly responsive to TH status, induced inattention in male mice. Read More

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September 2021

Mutation Screening and Functional Study of in Chinese Patients with Congenital Hypothyroidism.

J Clin Res Pediatr Endocrinol 2021 Sep 21. Epub 2021 Sep 21.

The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.

Objective: Defects in the human solute carrier family 26 member 4 () gene are reported to be one of the causes of congenital hypothyroidism (CH). We aimed to identify mutations in Chinese patients with CH and analyze the function of the mutations.

Methods: 273 patients with primary CH were screened for 21 CH candidate genes mutations by targeted next-generation sequencing. Read More

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September 2021

A case of Graves' disease presenting with internal ophthalmoplegia during methylmercaptoimidazole treatment.

Endocr J 2021 Sep 18. Epub 2021 Sep 18.

Dept. of Medicine and Clinical Science, Graduate School of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

A 28-year-old Japanese woman positive for TSH receptor antibody and anti-nuclear antibody complained of difficulty seeing nearby objects, severe throbbing retro-orbital pain, diplopia, blepharoptosis and upward gaze palsy when she became hypothyroid during treatment with 30 mg methylmercaptoimidazole for Graves' hyperthyroidism. Brain magnetic resonance imaging revealed slightly swollen bilateral inferior rectus muscles, suggesting the external ophthalmoplegia due to the muscle pathology commonly encountered in Graves' disease. The retro-orbital pain was associated with marked accommodation failure and the pupillary abnormalities. Read More

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September 2021

Undetected Long-Term Hypothyroidism Caused by Hashimoto's Thyroiditis with Severe Cardiac Complications - An Unusual Case of Child Neglect.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Pediatric Radiology, University of Munich, Munich, Germany.

Neglect in childhood may often be undetected for a long time. Parents of patients of handicapped children are often unable to cope with multiple medical and psychological problems that exist with such patients despite support by the health services [Jacobi G, Dettmeyer R, Banaschak S, Brosig B et al. Child abuse and neglect: diagnosis and management. Read More

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September 2021

Optimal Thyroid Hormone Replacement.

Endocr Rev 2021 Sep 20. Epub 2021 Sep 20.

Georgetown University, Division of Endocrinology, Washington, DC, USA.

Hypothyroidism is a common endocrinopathy and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adjusting levothyroxine being agreed upon, there are many nuances and complexities to consistently maintaining euthyroidism. Understanding the impact of patient weight and residual thyroid function on initial levothyroxine dosage and consideration of age, co-morbidities, TSH goal, life stage, and quality of life as levothyroxine is adjusted can be challenging and continually evolving. Read More

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September 2021

A cross-sectional assessment of long-term effects in adolescent and young adult head and neck cancer survivors treated with radiotherapy.

J Cancer Surviv 2021 Sep 20. Epub 2021 Sep 20.

BC Cancer - Vancouver Centre, Vancouver, BC, Canada.

Purpose: Adolescent and young adult (AYA) head and neck (H&N) cancer survivors are at risk of long-term complications. A cross-sectional study of survivors recalled for clinical evaluation was performed to evaluate late effects in this population.

Methods: Surviving patients who had been diagnosed with H&N cancer between the ages of 15 and 39 years and treated with radiation therapy (RT) in British Columbia between 1970 and 2010 were invited to participate in this study. Read More

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September 2021

Effect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rat.

Eur Thyroid J 2021 Jul 27;10(5):425-433. Epub 2021 May 27.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina.

Introduction: The potential of the thyroid hormone receptor β (TRβ1) selective analog GC-1 has been widely proven in animal models and humans. However, its effect on the reproductive stage of the female rat has not been evaluated.

Methods: The effect of the administration of GC-1 or equimolar doses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroid female rat and the indirect effect on pup thyroid status, weight, and survival. Read More

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Incidence of Thyroid Dysfunction Facing Metabolic Syndrome: A Prospective Comparative Study with 9 Years of Follow-Up.

Eur Thyroid J 2021 Jul 27;10(5):390-398. Epub 2021 Jan 27.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Studies assessing thyroid hormones in metabolic syndrome (MetS) patients are contradictory. Also, the effect of MetS on thyroid function over time is not yet evaluated. This study investigated the prevalence and incidence of thyroid dysfunction (TD) as well as time trends of thyroid hormones in subjects with and without MetS, during a 10-year follow-up in Tehranian adult population. Read More

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The Efficacy and Short- and Long-Term Side Effects of Radioactive Iodine Treatment in Pediatric Graves' Disease: A Systematic Review.

Eur Thyroid J 2021 Jul 12;10(5):353-363. Epub 2021 Jul 12.

Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Graves's disease (GD) is the most common cause of hyperthyroidism. Maximal 30% of pediatric GD patients achieve remission with antithyroid drugs. The majority of patients therefore require definitive treatment. Read More

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A safety and clinical efficacy analysis of PCSK9 monoclonal antibodies in patients with markedly elevated creatine phosphokinase levels.

Am J Blood Res 2021 15;11(4):399-404. Epub 2021 Aug 15.

Faculty of Medicine, Technion, Israel Institute of Medicine Haifa, Israel.

Introduction: PCSK9 inhibitors (PCSK9i) are often used in statin-intolerant patients, aiming to reduce low-density lipoprotein cholesterol (LDL-C). Along with the growing experience with their use, there is a lack of evidence regarding the safety, tolerability, and clinical utility of PCSK9i in patients with markedly elevated creatine phosphokinase (CPK) levels.

Methods: We screened a comprehensive HMO database for patients treated with PCSK9i (Jan 2016-Dec 2019), in whom elevated CPK levels (>1,000 U/L) were documented prior to the initiation of therapy. Read More

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Study of transfusion-related iron overload (trio) in pediatric patients with hematological malignancy and bone marrow failure syndromes.

Am J Blood Res 2021 15;11(4):384-390. Epub 2021 Aug 15.

Department of Pediatrics, VMMC and Safdarjung Hospital New Delhi, India.

Background: Pediatric patients with hematological malignancy and bone marrow failure syndrome receive multiple transfusions before diagnosis and treatment. Iron overload leads to damage to vital organs like the heart, liver, thyroid, Gonads, Pancreas.

Materials And Methods: A prospective study was done from June 2017-December 2019 in a tertiary care pediatric hematology oncology unit in northern India on children diagnosed with hematological malignancy and bone marrow failure syndromes receiving packed cell transfusion. Read More

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Recall Rate in Congenital Hypothyroidism Screening: Influence of the Day of Sample Collection and Lower Cutoff.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):22-25

University of Medicine and Pharmacy - Clinical Biochemistry and Immunology.

Introduction: The recall rate in congenital hypothyroidism (CH) newborn screening programs depends on several factors such as primary screening strategy, sample collection guidelines, and cut-off. A recall rate of 0.05% is recommended but recall rates of 0. Read More

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October 2021

Clinical Characteristics and Follow-Up of 19 Children With Hashimoto's Thyroiditis Aged Below 3 Years: A Single-Center Retrospective Analysis.

Front Endocrinol (Lausanne) 2021 3;12:737527. Epub 2021 Sep 3.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Aim: To analyze the clinical characteristics of Hashimoto's thyroiditis (HT) in children below 3 years of age in order to improve the understanding of the disease, avoid misdiagnosis, and achieve early diagnosis and treatment.

Methods: The study retrospectively analyzed the clinical data of 19 patients diagnosed with HT in the first three years of life.

Results: The patients (12 female, 7 male) had an average age of 26. Read More

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September 2021

Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study.

Front Endocrinol (Lausanne) 2021 2;12:719225. Epub 2021 Sep 2.

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Thyroid function can be influenced by external stimuli such as light and temperature. However, it is currently unknown whether there is seasonal variation of thyroid function in women of reproductive age. Adequate thyroid function in reproductive-aged women is necessary for optimal fetal-maternal outcomes. Read More

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September 2021

Genetic and Phenotypic Characteristics of Congenital Hypothyroidism in a Chinese Cohort.

Front Endocrinol (Lausanne) 2021 3;12:705773. Epub 2021 Sep 3.

Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.

Background: The molecular etiology and the genotype-phenotype correlation of congenital hypothyroidism (CH) remain unclear.

Methods: We performed genetic analysis in 42 newborns with CH using whole-exome sequencing. Patients were divided into a single-gene group and a multi-gene group according to the number of affected genes, or divided into a monoallelic group, a biallelic group, and an oligogenic group according to the pattern of the detected variants. Read More

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September 2021

Hyponatremia and Fever in a Patient on Ipilimumab and Nivolumab (Immune Checkpoint Inhibitors): A Case Report.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211045249

Adventist Health, Hanford, CA, USA.

Immune checkpoint inhibitors (ICIs) are novel anticancer therapy approved in multiple tumors and their use is rapidly increasing. They are associated with various systemic side effects that are immune-mediated and clinically coined as "immune-related adverse effects" (irAE). Hyponatremia is a possible side effect in patients receiving ICIs. Read More

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September 2021

Insulin-Induced Edema in a Patient with Type 2 Diabetes Mellitus.

Am J Case Rep 2021 Sep 19;22:e931960. Epub 2021 Sep 19.

Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

BACKGROUND The strong association between type 2 diabetes and obesity has been well recognized. Insulin treatment is usually needed at some point in the treatment of patients with type 2 diabetes and obesity to achieve the targeted glycemic control goal. CASE REPORT A 35-year-old woman who had gastric banding for morbid obesity 1 year prior presented to the outpatient clinic with recent onset of shortness of breath and bilateral ankle edema, which were thought to be of cardiac origin. Read More

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September 2021