Ageing Res Rev 2021 09 13;70:101408. Epub 2021 Jul 13.
Institute of Biomedical Research of Salamanca (IBSAL), and University of Salamanca (USAL), Department of Physiology and Pharmacology, Salamanca, Spain; National Network for Kidney Research REDINREN, RD016/0009/0025, Instituto De Salud Carlos III, Madrid, Spain; Disease and Theranostic Modelling (DisMOD) Working Group, Spain. Electronic address:
Clinical frailty in the elderly is defined by a composite measure of functional psychomotor decline. Herein, we develop the concept of haemodynamic frailty (HDF), a state of increased predisposition to disease prevalent in the elderly and characterised by impairment of the network of compensatory responses governing the defence of circulatory volume and adaptive haemodynamic function. We review the factors predisposing the elderly to HDF, with a focus on the impaired capacity to sustain total body water balance. Read More