2,232 results match your criteria hypoperfusion group

The Effectiveness of Ischemia Modified Albumin in Determining Acute Cholecystitis and its Severity.

Clin Lab 2021 Sep;67(9)

Background: Acute cholecystitis (AC) is caused by chemical and bacterial inflammation of the gallbladder. The use of Tokyo guidelines is recommended in determining the diagnosis of AC and its clinical severity. In the early stages of AC, many cytokines are secreted due to the local inflammatory cell activation, leading to exacerbation of inflammation and organ failure. Read More

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September 2021

Discrepancy Between the Degree of Cognitive Impairment and Brain Imaging Abnormalities in Alzheimer's Disease Patients Is Associated with Cognitive Reserve.

J Alzheimers Dis 2021 Sep 10. Epub 2021 Sep 10.

Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.

Background: In Alzheimer's disease (AD) patients, the severity of cognitive impairment is thought to correlate with the degree of brain imaging abnormalities. However, some patients show only mild cognitive deficit, despite severe brain atrophy on magnetic resonance imaging (MRI) or marked hypoperfusion in the cerebral cortices on single-photon emission computed tomography (SPECT). This suggests that cognitive reserve (CR) can compensate for the clinical manifestations of AD in patients with extensive brain pathology. Read More

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September 2021

Carotid artery stenting in patients with chronic internal carotid artery occlusion.

Int Angiol 2021 Aug;40(4):297-305

Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA.

Background: The risk of ischemic stroke in patients with chronic total occlusion (CTO) of the internal carotid artery (ICA) on best medical treatment has been estimated to be 5.5% per year. The purpose of this study was to assess early and mid-term outcome of patients who underwent an attempt at transfemoral carotid artery stenting (CAS) for CTO of the ICA. Read More

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Acute Kidney Injury at the Neurocritical Care Unit.

Neurocrit Care 2021 Sep 13. Epub 2021 Sep 13.

Department of Medicine, Università di Padova, Padua, Italy.

Neurocritical care has advanced substantially in recent decades, allowing doctors to treat patients with more complicated conditions who require a multidisciplinary approach to achieve better clinical outcomes. In neurocritical patients, nonneurological complications such as acute kidney injury (AKI) are independent predictors of worse clinical outcomes. Different research groups have reported an AKI incidence of 11. Read More

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September 2021

Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine.

Eur Neurol 2021 Aug 30:1-12. Epub 2021 Aug 30.

Department of Ophthalmology, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.

Introduction: This study aimed to reveal whether retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) inner plexiform layer, and choroidal layer (CL) thicknesses differed in patients with migraine. Optical coherence tomography (OCT) was used to measure these neurovascular structural changes and determine the relationship between these structures and cranial white matter hyperintensities (WMHs).

Methods: This retrospective comparative registry study included a total of 155 individuals aged 18-55 (mean, 33. Read More

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Decline in executive function in patients with white matter hyperintensities from the static and dynamic perspectives of amplitude of low-frequency fluctuations.

J Neurosci Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Cognitive impairments are characteristics of patients with white matter hyperintensities (WMHs), and hypoperfusion is currently a relatively recognized mechanism of WMHs. Brain activity is closely coupled to the regulation of local blood flow. This study aimed to investigate the abnormal local brain activity of patients with WMHs from the viewpoint of the static amplitude of low-frequency fluctuations (sALFF) and dynamic amplitude of low-frequency fluctuations (dALFF). Read More

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September 2021

Multimodal assessment of regional gray matter integrity in early relapsing-remitting multiple sclerosis patients with normal cognition: a voxel-based structural and perfusion approach.

Br J Radiol 2021 Sep 7:20210308. Epub 2021 Sep 7.

The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy (MIRT), Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.

Objective: There is increasing evidence that gray matter (GM) impairment is strongly associated with clinical performance decline. We aim to perform a voxelwise analysis between regional GM (rGM) perfusion and structural abnormalities in early relapsing-remitting multiple sclerosis patients with normal cognition (RRMS-IC) and explore clinical correlate of early rGM abnormalities.

Methods And Materials: We studied 14 early RRMS-IC patients and 14 healthy age- and sex-matched controls. Read More

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September 2021

Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT.

Int J Retina Vitreous 2021 Sep 3;7(1):51. Epub 2021 Sep 3.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, 203 Lothrop Street, Suite 800, Pittsburg, PA, 15213, USA.

Background: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it.

Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Read More

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September 2021

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model.

Environ Health Perspect 2021 Aug 23;129(8):87006. Epub 2021 Aug 23.

Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.

Background: Exposure to ambient air pollution particulate matter (PM) is associated with increased risk of dementia and accelerated cognitive loss. Vascular contributions to cognitive impairment are well recognized. Chronic cerebral hypoperfusion (CCH) promotes neuroinflammation and blood-brain barrier weakening, which may augment neurotoxic effects of PM. Read More

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Hyponatremia and Renal Venous Congestion in Heart Failure Patients.

Dis Markers 2021 12;2021:6499346. Epub 2021 Aug 12.

Department of Cardiology, University of Medicine and Pharmacy "Victor Babeș" Timișoara, Romania.

Objective: The interrelationship between the heart and kidneys has a great importance in the homeostasis of the cardiovascular system. Heart failure patients present intrarenal arterial hypoperfusion and intrarenal venous congestion due to reduced left ventricle ejection fraction, which triggers numerous neurohormonal factors. The aim of this study was to investigate intrarenal vascularization (arterial and venous), as well as the links between it and systemic congestion and, on the other side, with the mortality in patients with heart failure. Read More

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Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition.

Tohoku J Exp Med 2021 08;254(4):267-273

Department of Obstetrics and Gynecology, Shiga University of Medical Science Hospital.

Ultrasonography and fetal heart rate monitoring are subjective assessments of fetal condition, which warrants the need for objective markers to predict fetal condition. Urinary L-type fatty acid-binding protein (L-FABP) levels correlate with hypoperfusion. Elevated amniotic fluid L-FABP levels may represent fetal tissue hypoperfusion since the amniotic fluid contains fetal urine. Read More

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Ischemic stroke on hormonal contraceptives: Characteristics, mechanisms and outcome.

Eur Stroke J 2021 Jun 21;6(2):205-212. Epub 2021 May 21.

Department of Clinical Neurosciences, Stroke Centre, Neurology Service, Lausanne University Hospital, Lausanne, Switzerland.

Introduction: Systemic contraceptives increase the risk of ischemic stroke but little is known about the characteristics, mechanisms and long-term outcome post stroke of patients on hormonal contraception. We sought to To assess characteristics and outcome of acute ischemic stroke (AIS) in young women using systemic hormonal contraceptives (SHC) and compare them to strokes in non-contraceptive users.

Patients And Methods: Using the Acute STroke Registry and Analysis of Lausanne (ASTRAL), we analyzed demographics, risk factors, clinical, radiological and treatment data of consecutive female patients of <50 years between 2003 to 2015. Read More

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Contrast Bolus Interference in a Multimodal CT Stroke Protocol.

AJNR Am J Neuroradiol 2021 Aug 19. Epub 2021 Aug 19.

Neuroradiology (A.R., T.D., H.U.), Faculty of Medicine, Medical Center, University of Freiburg, University of Freiburg, Freiburg, Germany.

Background And Purpose: Whether CTP is performed before or after CTA varies within multimodal CT stroke protocols. CTA after CTP might show venous filling, and CTP metrics might be disturbed by prior CTA. Therefore, we compared CTP metrics conducted before and after CTA in a large cohort of patients with stroke and analyzed interferences of the CTA bolus with the CTP measurement. Read More

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Reliability and Validity of Visual Estimation of Femoral Head Hypoperfusion on Perfusion MRI in Legg-Calve-Perthes Disease.

J Pediatr Orthop 2021 Oct;41(9):e780-e786

Center for Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children.

Background: Assessing the severity of Legg-Calve-Perthes disease is important for treatment decision-making and determining prognosis. Perfusion magnetic resonance imaging (MRI) scans have improved our ability to assess femoral head hypoperfusion, and the use of an image analysis software called HipVasc (Scottish Rite for Children, Dallas TX) has allowed precise quantification for research purposes. In the clinical setting, using HipVasc software is not practical, and visual estimation is used to assess hypoperfusion. Read More

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October 2021

Acute prolonged motor aura resembling ischemic stroke after COVID - 19 vaccination (CoronaVac): the first case report.

J Headache Pain 2021 Aug 12;22(1):93. Epub 2021 Aug 12.

Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: We report the first case of a patient who suffered transient focal neurological deficit mimicking stroke following CoronaVac vaccination. However, instead of an ischemic stroke, motor aura was suspected.

Case Presentations: A 24 year-old Thai female presented with left hemiparesis fifteen minutes after receiving CoronaVac. Read More

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The association between mean arterial pressure and outcomes in patients with cardiogenic shock: insights from the DOREMI trial.

Eur Heart J Acute Cardiovasc Care 2021 Aug 12. Epub 2021 Aug 12.

CAPITAL Research Group, University of Ottawa Heart Institute, 40 Ruskin Street, H-4238, Ottawa, Ontario K1Y 4W7, Canada.

Aims: Cardiogenic shock (CS) is a state of low cardiac output resulting in end-organ hypoperfusion. Despite high in-hospital mortality rates, little evidence exists regarding the optimal mean arterial pressure (MAP) target in CS. We therefore evaluated the relationship between achieved MAP and clinical outcomes in patients with CS. Read More

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Balloon Test Occlusion of the Carotid Artery: Internal Validation of Predictive Results.

Turk Neurosurg 2021 ;31(5):710-717

Nagoya City University Graduate School of Medical Sciences, Department of Neurosurgery, Nagoya, Japan.

Aim: To develop a protocol of balloon test occlusion (BTO) to perform single-photon emission computed tomography (SPECT) only in cases that require it by using mean stump pressure (MSTP).

Material And Methods: BTO was performed in 52 consecutive patients (derivation group). Using the derivation group data, a protocol was created and applied to 55 consecutive patients (validation group). Read More

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September 2021

Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport.

Aging Dis 2021 Aug 1;12(5):1197-1210. Epub 2021 Aug 1.

1Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Cognitive impairment is closely associated with the slowing of glucose metabolism in the brain. Glucose transport, a rate-limiting step of glucose metabolism, plays a key role in this phenomenon. Previous studies have reported that limb remote ischemic conditioning (LRIC) improves cognitive performance in rats with chronic cerebral hypoperfusion (CCH). Read More

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Quantification of perfusion and metabolism in an autism mouse model assessed by diffuse correlation spectroscopy and near-infrared spectroscopy.

J Biophotonics 2021 Jul 30:e202000454. Epub 2021 Jul 30.

Department of Biomedical, Industrial and Human Factors, Wright State University, Dayton, Ohio, USA.

There is a need for quantitative biomarkers for early diagnosis of autism. Cerebral blood flow and oxidative metabolism parameters may show superior contrasts for improved characterization. Diffuse correlation spectroscopy (DCS) has been shown to be reliable method to obtain cerebral blood flow contrast in animals and humans. Read More

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Processed Multiparameter Electroencephalogram-Guided General Anesthesia Management Can Reduce Postoperative Delirium Following Carotid Endarterectomy: A Randomized Clinical Trial.

Front Neurol 2021 12;12:666814. Epub 2021 Jul 12.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Patients undergoing carotid endarterectomy (CEA) for severe carotid stenosis are vulnerable to postoperative delirium, a complication frequently associated with poor outcome. This study investigated the impact of processed electroencephalogram (EEG)-guided anesthesia management on the incidence of postoperative delirium in patients undergoing CEA. This single-center, prospective, randomized clinical trial on 255 patients receiving CEA under general anesthesia compared the outcomes of patient state index (PSI) monitoring [SEDLine Brain Function Monitor (Masimo, Inc, Irvine, CA)] (standard group, = 128) with PSI combined with density spectral array(DSA) -guided monitoring (intervention group, = 127) to reduce the risk of intraoperative EEG burst suppression. Read More

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The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases.

Sci Rep 2021 Jul 27;11(1):15225. Epub 2021 Jul 27.

Precision Medicine Centre, Hokuto Hospital, Kisen-7-5 Inadacho, Obihiro, Hokkaido, 080-0833, Japan.

Cerebral hypoperfusion impairs brain activity and leads to cognitive impairment. Left and right common carotid arteries (CCA) are the major source of cerebral blood supply. It remains unclear whether blood flow in both CCA contributes equally to brain activity. Read More

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Coincident PAMM and AMN and Insights into a Common Pathophysiology: Coincident PAMM and AMN.

Am J Ophthalmol 2021 Jul 17. Epub 2021 Jul 17.

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States; Greater Los Angeles Veterans Affairs Healthcare Center, Los Angeles, California. Electronic address:

Purpose: To analyze imaging characteristics and the clinical course of patients demonstrating coincident lesions of paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) in the same eye.

Design: Retrospective, observational, case series.

Methods: Lesions from patients presenting with coincident PAMM and AMN in the same eye were evaluated with multimodal imaging including optical coherence tomography (OCT). Read More

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Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care.

Int Heart J 2021 Jul 17;62(4):858-865. Epub 2021 Jul 17.

Department of Cardiovascular Medicine, Nippon Medical School.

The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using the following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [10/μL] × √alanine aminotransferase [U/L]). However, the clinical impact of the FIB4 index in the acute phase of acute heart failure (AHF) has not been sufficiently investigated. Read More

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Haemodynamic frailty - A risk factor for acute kidney injury in the elderly.

Ageing Res Rev 2021 09 13;70:101408. Epub 2021 Jul 13.

Institute of Biomedical Research of Salamanca (IBSAL), and University of Salamanca (USAL), Department of Physiology and Pharmacology, Salamanca, Spain; National Network for Kidney Research REDINREN, RD016/0009/0025, Instituto De Salud Carlos III, Madrid, Spain; Disease and Theranostic Modelling (DisMOD) Working Group, Spain. Electronic address:

Clinical frailty in the elderly is defined by a composite measure of functional psychomotor decline. Herein, we develop the concept of haemodynamic frailty (HDF), a state of increased predisposition to disease prevalent in the elderly and characterised by impairment of the network of compensatory responses governing the defence of circulatory volume and adaptive haemodynamic function. We review the factors predisposing the elderly to HDF, with a focus on the impaired capacity to sustain total body water balance. Read More

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September 2021

A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI.

J Cereb Blood Flow Metab 2021 Jul 14:271678X211031321. Epub 2021 Jul 14.

Paediatric Neurosurgery Department, AP-HP, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France.

Postoperative pediatric cerebellar mutism syndrome (pCMS), characterized mainly by delayed onset transient mutism is a poorly understood complication that may occur after pediatric medulloblastoma (MB) resection. Our aim was to investigate postoperative changes in whole-brain cerebral blood flow (CBF) at rest in pCMS patients using arterial spin labeling (ASL) perfusion imaging. This study compared preoperative and postoperative T2-weighted signal abnormalities and CBF using a voxel-wise, whole-brain analysis in 27 children undergoing MB resection, including 11 patients who developed mutism and 16 who did not. Read More

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Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model.

Mediators Inflamm 2021 23;2021:9985397. Epub 2021 Jun 23.

Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfusion and systemic circulation in a septic shock model.

Methods: Twenty-four beagle dogs were randomly allocated into four groups: (a) sham group: healthy controls, (b) shock group: septic shock induced by , (c) basic therapy group: septic shock animals treated with antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals treated with basic therapy plus UFH. Read More

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Power of Hypoperfusion in Predicting Recurrent Transient Ischemic Attacks: Protocol of a Prospective Cohort Study.

Front Hum Neurosci 2021 24;15:654383. Epub 2021 Jun 24.

Department of Neurology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Transient ischemic attack (TIA) has a high incidence of recurrent vascular events. Hypoperfusion is one of the factors that are closely correlated with 7-day recurrence of TIA. This study aimed to evaluate the power of hypoperfusion shown on magnetic resonance (MR) perfusion imaging in predicting the incidence of 7-day recurrence of ischemic events after TIA. Read More

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Perfusion Imaging and Clinical Outcome in Acute Ischemic Stroke with Large Core.

Ann Neurol 2021 Sep 29;90(3):417-427. Epub 2021 Jul 29.

Acute Stroke Unit, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse and Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

Objective: Mechanical thrombectomy (MT) is not recommended for acute stroke with large vessel occlusion (LVO) and a large volume of irreversibly injured tissue ("core"). Perfusion imaging may identify a subset of patients with large core who benefit from MT.

Methods: We compared two cohorts of LVO-related patients with large core (>50 ml on diffusion-weighted-imaging or CT-perfusion using RAPID), available perfusion imaging, and treated within 6 hours from onset by either MT + Best Medical Management (BMM) in one prospective study, or BMM alone in the pre-MT era from a prospective registry. Read More

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September 2021

Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling.

Evid Based Complement Alternat Med 2021 7;2021:5564246. Epub 2021 Jun 7.

Department of Neurology, Hebei General Hospital, Shijiazhuang, China.

Shikonin (SK) exerts neuroprotective effects; however, to date, its protective effect against chronic cerebral hypoperfusion- (CCH-) induced vascular dementia (VaD) has not been investigated. Therefore, the current study investigated whether SK could mitigate the cognitive deficits caused by CCH. The effects of SK treatment on the PTEN/Akt/CREB/BDNF signaling pathway and apoptosis in hippocampal neurons were examined in a rat model of VaD established via bilateral common carotid artery occlusion (BCCAO). Read More

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ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway.

Neuropsychiatr Dis Treat 2021 16;17:1937-1951. Epub 2021 Jun 16.

Medical Administration Office, Beijing Administration of Traditional Chinese Medicine, Beijing, 100053, People's Republic of China.

Background: ShenmaYizhi decoction (SMYZD) is an effective prescription of traditional Chinese medicine used to treat vascular dementia (VD). Modern research methods have identified its active ingredients clearly as gastrodin, ferulic acid, ginsenosides, and β-sitosterol. Chronic cerebral hypoperfusion is a driving factor or risk factor for VD, which leads to the disturbance of mitochondrial structure and function. Read More

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