490 results match your criteria hypertrophy offspring


Identification and validation of the miRNA-mRNA regulatory network in fetoplacental arterial endothelial cells of gestational diabetes mellitus.

Bioengineered 2021 Dec;12(1):3503-3515

Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Gestational diabetes mellitus (GDM) increases the risk of fetal heart malformations, though little is known about the mechanism of hyperglycemia-induced heart malformations. Thus, we aimed to reveal the global landscape of miRNAs and mRNAs in GDM-exposed fetoplacental arterial endothelial cells (dAECs) and establish regulatory networks for exploring the pathophysiological mechanism of fetal heart malformations in maternal hyperglycemia. Gene Expression Omnibus (GEO) datasets were used, and identification of differentially expressed miRNAs (DEMs) and genes (DEGs) in GDM was based on a previous sequencing analysis of dAECs. Read More

View Article and Full-Text PDF
December 2021

Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques ().

Front Vet Sci 2021 2;8:540493. Epub 2021 Jun 2.

Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

In a colony of rhesus macaques at California National Primate Research Center (CNPRC), naturally occurring hypertrophic cardiomyopathy (HCM) classified by left ventricular hypertrophy without obvious underlying diseases has been identified during necropsy over the last two decades. A preliminary pedigree analysis suggested a strong genetic predisposition of this disease with a founder effect. However, the mode of inheritance was undetermined due to insufficient pedigree data. Read More

View Article and Full-Text PDF

Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.

PLoS One 2021 10;16(6):e0252954. Epub 2021 Jun 10.

Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.

The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Read More

View Article and Full-Text PDF

Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction.

Am J Physiol Renal Physiol 2021 Jul 31;321(1):F93-F105. Epub 2021 May 31.

Department of Pediatrics and Adolescent Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.

Intrauterine growth restriction (IUGR) due to an adverse intrauterine environment predisposes to arterial hypertension and loss of kidney function. Here, we investigated whether vascular dysregulation in renal interlobar arteries (RIAs) may contribute to hypertensive glomerular damage after IUGR. In rats, IUGR was induced by bilateral uterine vessel ligation. Read More

View Article and Full-Text PDF

Estrogen normalizes maternal HFD-induced cardiac hypertrophy in offspring by regulating AT2R.

J Endocrinol 2021 06 16;250(1):1-12. Epub 2021 Jun 16.

Department of Pharmacology, Key Laboratory of Molecular Target & Clinical Pharmacology, School of, Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Our previous study has demonstrated maternal high-fat diet (HFD) caused sex-dependent cardiac hypertrophy in adult male, but not female offspring. The present study tested the hypothesis that estrogen normalizes maternal HFD-induced cardiac hypertrophy by regulating angiotensin II receptor (ATR) expression in adult female offspring. Pregnant rats were divided into the normal diet (ND) and HFD (60% kcal fat) groups. Read More

View Article and Full-Text PDF

Gestational and Breastfeeding Low-Protein Intake on Blood Pressure, Kidney Structure, and Renal Function in Male Rat Offspring in Adulthood.

Front Physiol 2021 22;12:658431. Epub 2021 Apr 22.

Fetal Programming and Hydroelectrolyte Metabolism Laboratory, Nucleus of Medicine and Experimental Surgery, Department of Internal Medicine, Faculty of Medical Sciences at State University of Campinas, Campinas, Brazil.

: Our previous studies demonstrated that maternal protein-restricted (low-protein, LP) 16-week-old offspring had pronounced nephron number reduction and arterial hypertension associated with an unchanged glomerular filtration rate (GFR). An enhanced gomerular area may be related to increased glomerular filtration and overflow, which accounts for glomerular filtration barrier breakdown and early glomerulosclerosis. The effect of protein restriction during gestational and breastfeeding periods is unknown. Read More

View Article and Full-Text PDF

Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female mice.

FASEB J 2021 04;35(4):e21299

Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Hyperandrogenism is the main characteristic of polycystic ovary syndrome, which affects placental function and fetal growth, and leads to reproductive and metabolic dysfunction in female offspring. Adiponectin acts on the placenta and may exert endocrine effects on the developing fetus. This study aims to investigate if maternal and/or fetal adiponectin can prevent metabolic and reproductive dysfunction in prenatal androgenized (PNA) female offspring. Read More

View Article and Full-Text PDF

Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study.

Br J Nutr 2021 Feb 23:1-9. Epub 2021 Feb 23.

Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed for the maintenance of neurocognitive health, is associated with cardiac remodelling is unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended the eighth examination cycle and had available dietary and echocardiographic data (mean age 66 years; 55 % women). Read More

View Article and Full-Text PDF
February 2021

Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.

Sci Rep 2021 01 13;11(1):1186. Epub 2021 Jan 13.

Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

We aimed to investigate the effects of maternal tadalafil therapy on fetal programming of metabolic function in a mouse model of fetal growth restriction (FGR). Pregnant C57BL6 mice were divided into the control, L-NG-nitroarginine methyl ester (L-NAME), and tadalafil + L-NAME groups. Six weeks after birth, the male pups in each group were given a high-fat diet. Read More

View Article and Full-Text PDF
January 2021

N-acetylcysteine protects neonatal mice from ventricular hypertrophy induced by maternal obesity in a sex-specific manner.

Biomed Pharmacother 2021 Jan 8;133:110989. Epub 2020 Dec 8.

Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China; MOH Key Laboratory of Neonatal Diseases at Children's Hospital, Fudan University, Shanghai, China. Electronic address:

Background: Maternal obesity induces adverse cardiac programming in offspring, and effective interventions are needed to prevent cardiovascular ill-health. Herein we hypothesized that exposure to maternal obesogenic diet-induced obesity in mice results in left ventricular remodelling and hypertrophy in early childhood, and that maternal N-acetylcysteine (NAC) treatment alleviates these effects in a sex-dependent manner.

Methods And Results: The maternal obesity was induced in mice by the consumption of a Western diet accompanied by a 20 % sucrose solution. Read More

View Article and Full-Text PDF
January 2021

Age-related histological changes in rat tibial.

Folia Morphol (Warsz) 2020 Nov 10. Epub 2020 Nov 10.

china, Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China, 430071 Wuhan, China.

Background: At present, studies on osteochondral morphogenesis only focus on a certain period of time or only provide a pattern diagram, but lack of dynamic tracking observation from the initiation of development to maturity. This study was to dynamically observe the changes of skeleton morphology and structure from embryo to adult, to provide research data for enriching the knowledge of bone and cartilage tissue structure.

Materials And Methods: In the intrauterine experiment, 5 normal pregnant Wistar rats were sacrificed under anesthesia at gestational day (GD) 14, 17, 20, respectively. Read More

View Article and Full-Text PDF
November 2020

Bone tissue morphology of rat offspring lactationally exposed to polychlorinated biphenyl 169 and 155.

Sci Rep 2020 11 4;10(1):19016. Epub 2020 Nov 4.

Institute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, Ljubljana, Slovenia.

Polychlorinated biphenyls (PCBs) are ubiquitous, persistent, organic pollutants also considered endocrine-disrupting chemicals. Our study examined the effects of lactational exposure to nondioxin-like PCB-155 and/or dioxin-like PCB-169 on longitudinal femur growth at the distal epiphyseal growth plate (EGP) in young rats at three different ages [postnatal days (PNDs) 9, 22, and 42]. After delivery, lactating rats were divided into four groups (PCB-169, PCB-155, PCB-155 + 169, and control) and administered PCBs intraperitoneally. Read More

View Article and Full-Text PDF
November 2020

Obesity induction in adult zebrafish leads to negative reproduction and offspring effects.

Reproduction 2020 12;160(6):833-842

Department of Veterinary Medicine, Central Animal Housing, Federal University of Lavras, Lavras, Minas Gerais, Brazil.

Obesity is a transgenerational epigenetic metabolic disturbance. Although the diet-induced obese (DIO) zebrafish model is well established, reproductive parameters and changes in offspring have not yet been evaluated. Thus, the aim of this study was to evaluate possible changes in reproductive parameters, embryos and offspring (F1) generated by the reproduction of diet-induced obese males and females. Read More

View Article and Full-Text PDF
December 2020

Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.

Mol Hum Reprod 2020 11;26(11):866-878

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, 94143, USA.

The preimplantation stage of development is exquisitely sensitive to environmental stresses, and changes occurring during this developmental phase may have long-term health effects. Animal studies indicate that IVF offspring display metabolic alterations, including hypertension, glucose intolerance and cardiac hypertrophy, often in a sexual dimorphic fashion. The detailed nature of epigenetic changes following in-vitro culture is, however, unknown. Read More

View Article and Full-Text PDF
November 2020

Maternal Adenine-Induced Chronic Kidney Disease Programs Hypertension in Adult Male Rat Offspring: Implications of Nitric Oxide and Gut Microbiome Derived Metabolites.

Int J Mol Sci 2020 Sep 30;21(19). Epub 2020 Sep 30.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan.

Maternal chronic kidney disease (CKD) during pregnancy causes adverse fetal programming. Nitric oxide (NO) deficiency, gut microbiota dysbiosis, and dysregulated renin-angiotensin system (RAS) during pregnancy are linked to the development of hypertension in adult offspring. We examined whether maternal adenine-induced CKD can program hypertension and kidney disease in adult male offspring. Read More

View Article and Full-Text PDF
September 2020

Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning.

J Dev Orig Health Dis 2021 Jun 9;12(3):523-529. Epub 2020 Sep 9.

Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

Literature describes breast milk as the best food for the newborn, recommending exclusive breastfeeding for up to 6 months of age. However, it is not available for more than 40% of children worldwide. Pharmacological and non-pharmacological models of 3-day early weaning were developed in rodents to investigate later outcomes related solely to this nutritional insult. Read More

View Article and Full-Text PDF

Both maternal and embryonic exposure to mild hypoxia influence embryonic development of the intertidal gastropod .

J Exp Biol 2020 10 26;223(Pt 20). Epub 2020 Oct 26.

Marine Biology and Ecology Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.

There is growing evidence that maternal exposure to environmental stressors can alter offspring phenotype and increase fitness. Here, we investigate the relative and combined effects of maternal and developmental exposure to mild hypoxia (65 and 74% air saturation, respectively) on the growth and development of embryos of the marine gastropod Differences in embryo morphological traits were driven by the developmental environment, whereas the maternal environment and interactive effects of maternal and developmental environment were the main driver of differences in the timing of developmental events. While developmental exposure to mild hypoxia significantly increased the area of an important respiratory organ, the velum, it significantly delayed hatching of veliger larvae and reduced their size at hatching and overall survival. Read More

View Article and Full-Text PDF
October 2020

Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.

PLoS One 2020 19;15(8):e0236960. Epub 2020 Aug 19.

Division of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Background: Circulating microRNAs may reflect or influence pathological cardiac remodeling and contribute to atrial fibrillation (AF).

Objective: The purpose of this study was to identify candidate plasma microRNAs that are associated with echocardiographic phenotypes of atrial remodeling, and incident and prevalent AF in a community-based cohort.

Methods: We analyzed left atrial function index (LAFI) of 1788 Framingham Offspring 8 participants. Read More

View Article and Full-Text PDF
October 2020

Maternal Nutrient Restriction and Skeletal Muscle Development: Consequences for Postnatal Health.

Adv Exp Med Biol 2020 ;1265:153-165

Department of Animal Science, Texas A&M University, College Station, TX, USA.

Severe undernutrition and famine continue to be a worldwide concern, as cases have been increasing in the past 5 years, particularly in developing countries. The occurrence of nutrient restriction (NR) during pregnancy affects fetal growth, leading to small for gestational age (SGA) or intrauterine growth restricted (IUGR) offspring. During adulthood, SGA and IUGR offspring are at a higher risk for the development of metabolic syndrome. Read More

View Article and Full-Text PDF
September 2020

Could the E/A ratio be included in the cardiological evaluation of the offspring of diabetic mothers? A case-control study in South Sardinia.

J Matern Fetal Neonatal Med 2020 Aug 5:1-10. Epub 2020 Aug 5.

Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari. SS, Monserrato, Italy.

Introduction: Diabetes mellitus (DM) is a chronic disease widespread in the world. Sardinia represents, together with Finland, the region with the highest incidence of type 1 DM (DM1), as well as a high prevalence of gestational DM (GDM). Despite the improvement in obstetric surveillance, perinatal and long-term adverse outcomes are still frequent in the offspring of diabetic mothers. Read More

View Article and Full-Text PDF

Reproduction in the pitviper Bothrops jararacussu: large females increase their reproductive output while small males increase their potential to mate.

Zoology (Jena) 2020 10 17;142:125816. Epub 2020 Jun 17.

Laboratório de Ecologia e Evolução, Instituto Butantan, Avenida Vital Brazil, 1500, CEP 05530-900, São Paulo, SP, Brazil.

Reproductive traits vary widely within and among snake species, and are influenced by a range of factors. However, additional studies are needed on several species, especially on tropical snake faunas, to fully understand the patterns of reproductive variation in snakes. Here, we characterized the reproductive biology of B. Read More

View Article and Full-Text PDF
October 2020

Maternal high-fat diet up-regulates type-1 cannabinoid receptor with estrogen signaling changes in a sex- and depot- specific manner in white adipose tissue of adult rat offspring.

Eur J Nutr 2021 Apr 15;60(3):1313-1326. Epub 2020 Jul 15.

Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Purpose: Obesity and high-fat (HF) diet are associated with over activation of the endocannabinoid system (ECS). We have demonstrated that maternal HF diet induces early obesity and modulates cannabinoid signaling in visceral (VIS) and subcutaneous (SUB) white adipose tissue (WAT) in weanling rat offspring. We hypothesized that perinatal maternal HF diet would program the expression of ECS in adipose tissue in a long-term way in parallel to alterations in epigenetic markers and sex hormone signaling. Read More

View Article and Full-Text PDF

Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood.

Diabetes Care 2020 09 13;43(9):2272-2280. Epub 2020 Jul 13.

Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands

Objective: Gestational diabetes mellitus has been associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models. We assessed the associations of maternal random glucose concentrations across the full range with childhood cardiac ventricular structure and function.

Research Design And Methods: In a population-based prospective cohort among 1,959 women and their offspring, maternal random glucose concentrations were measured at a median 13. Read More

View Article and Full-Text PDF
September 2020

Hypertension Programmed in Adult Hens by Isolated Effects of Developmental Hypoxia In Ovo.

Hypertension 2020 08 15;76(2):533-544. Epub 2020 Jun 15.

From the Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (K.L.S., C.B., N.I., Y.N., C.J.S., D.A.G.).

In mammals, pregnancy complicated by chronic hypoxia can program hypertension in the adult offspring. However, mechanisms remain uncertain because the partial contributions of the challenge on the placenta, mother, and fetus are difficult to disentangle. Here, we used chronic hypoxia in the chicken embryo-an established model system that permits isolation of the direct effects of developmental hypoxia on the cardiovascular system of the offspring, independent of additional effects on the mother or the placenta. Read More

View Article and Full-Text PDF

Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats.

J Dev Orig Health Dis 2020 10 11;11(5):492-498. Epub 2020 Jun 11.

Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.

Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work aims to determine the impact of food restriction (FR) during puberty in early overfed obese and non-obese animals in adult life. Read More

View Article and Full-Text PDF
October 2020

Whole-genome DNA sequencing: The key to detecting a sarcomeric mutation in a 'false genotype-negative' family with hypertrophic cardiomyopathy.

Rev Port Cardiol (Engl Ed) 2020 Apr 22;39(4):227.e1-227.e9. Epub 2020 May 22.

Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, UK; Barts Heart Centre, Barts Health NHS Trust, UK.

The authors report the clinical and genetic investigation of a family with hypertrophic cardiomyopathy (HCM). The individuals described are three affected first-degree relatives (father, daughter and son), one affected niece and unaffected nephew and niece. Those affected all share a very similar phenotype consisting of asymmetric HCM, with hypertrophy particularly affecting the septum and the anterior wall, and similar electrocardiographic features, including a short PR interval. Read More

View Article and Full-Text PDF

Prenatal nicotine exposure affects cardiovascular function and growth of the developing fetus.

J Obstet Gynaecol Res 2020 Jul 19;46(7):1044-1054. Epub 2020 May 19.

Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.

Aim: Effects of nicotine on fetal hemodynamics are not well known, especially in the first trimester fetus. We investigated the acute and chronic effects of nicotine on hemodynamics in pregnant mice and their fetuses using ultrasound. Postnatal health status including growth and hemodynamics was also examined. Read More

View Article and Full-Text PDF

Adipogenic effects of prenatal exposure to bisphenol S (BPS) in adult F1 male mice.

Sci Total Environ 2020 Aug 19;728:138759. Epub 2020 Apr 19.

Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Institute of Health and Environment, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:

Bisphenol S (BPS) has been increasingly used as a substitute for bisphenol A (BPA), a known endocrine disruptor. Early-life exposure to BPA affects fetal development and the risk of obesity in adolescence and adulthood. However, the effects of fetal exposure BPS in later life are unknown. Read More

View Article and Full-Text PDF

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.

Circ Res 2020 07 30;127(4):486-501. Epub 2020 Apr 30.

From the First Affiliated Hospital, School of Public Health (X.F., Z.C., D.H., Q.C., P.Z., Y.Y., Z.S., Q.W., S.H., J.P., J.M., F.W.), Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms. Although ferritin plays a central role in iron metabolism by storing excess cellular iron, the molecular function of ferritin in cardiomyocytes remains unknown. Read More

View Article and Full-Text PDF