5,244 results match your criteria hyperthermia increase


Effects of passive heat stress and recovery on human cognitive function: An ERP study.

PLoS One 2021 20;16(7):e0254769. Epub 2021 Jul 20.

Department of Health Sciences Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara City, Japan.

Using event-related potentials (ERPs), we investigated the effects of passive heat stress and recovery on the human cognitive function with Flanker tasks, involving congruent and incongruent stimuli. We hypothesized that modulation of the peak amplitude and latency of the P300 component in ERP waveforms would differ with task difficulty during passive heat stress and recovery. Subjects performed the Flanker tasks before (Pre), at the end of whole body heating (Heat: internal temperature increase of ~1. Read More

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Negative relationship between dry matter intake and the temperature-humidity index with increasing heat stress in cattle: a global meta-analysis.

Int J Biometeorol 2021 Jul 20. Epub 2021 Jul 20.

University of Tasmania, Hobart, TAS, 7001, Australia.

Changes in frequency and severity of heat waves due to climate change pose a considerable challenge to livestock production systems. Although it is well known that heat stress reduces feed intake in cattle, effects of heat stress vary between animal genotypes and climatic conditions and are context specific. To derive a generic global prediction that accounts for the effects of heat stress across genotypes, management and environments, we conducted a systematic literature review and a meta-analysis to assess the relationship between dry matter intake (DMI) and the temperature-humidity index (THI), two reliable variables for the measurement of feed intake and heat stress in cattle, respectively. Read More

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The effects of endurance exercise combined with high-temperature head-out water immersion on serum concentration of brain-derived neurotrophic factor in healthy young men.

Int J Hyperthermia 2021 ;38(1):1077-1085

Department of Rehabilitation Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan.

Objectives: To evaluate acute changes in serum brain-derived neurotrophic factor (BDNF) concentration following combined endurance exercise and heat stress through head-out water immersion (HOI).

Setting: Observational study with crossover design.

Methods: Ten healthy young male participants performed HOI at 40 °C (40 °C HOI) or continuous cycling at 60% of maximal oxygen uptake while immersed in 40 °C (40 °C HOI-ex) or 23 °C water (23 °C HOI-ex) for 15 min. Read More

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January 2021

Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis.

Int J Nanomedicine 2021 5;16:4559-4577. Epub 2021 Jul 5.

Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People's Republic of China.

Purpose: Reactive oxygen species (ROS) are a group of signaling biomolecules that play important roles in the cell cycle. When intracellular ROS homeostasis is disrupted, it can induce cellular necrosis and apoptosis. It is desirable to effectively cascade-amplifying ROS generation and weaken antioxidant defense for disrupting ROS homeostasis in tumor microenvironment (TME), which has been recognized as a novel and ideal antitumor strategy. Read More

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Impact of Cutaneous Blood Flow on NIR-DCS Measures of Skeletal Muscle Blood Flow Index.

J Appl Physiol (1985) 2021 Jul 15. Epub 2021 Jul 15.

Department of Kinesiology, grid.267315.4The University of Texas at Arlington, Arlington, TX, United States.

Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an optical technique for estimating relative changes in skeletal muscle perfusion during exercise, but may be affected by changes in cutaneous blood flow, as photons emitted by the laser must first pass through the skin. Accordingly, the purpose of this investigation was to examine how increased cutaneous blood flow affects NIR-DCS blood flow index (BFI) at rest and during exercise using a passive whole-body heating protocol that increases cutaneous, but not skeletal muscle, perfusion in the uncovered limb. BFI and cutaneous perfusion (laser Doppler flowmetry) were assessed in 15 healthy young subjects before (e. Read More

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Effect of Heat Stimulation on Circulating Irisin in Humans.

Front Physiol 2021 28;12:675377. Epub 2021 Jun 28.

Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, South Korea.

High temperatures lead to oxidative stress. The aim of the study was to determine whether heat stimulation-induced hyperthermia can increase the level of circulating irisin. Twenty-one healthy female subjects (age, 26. Read More

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Serotonin toxicity of serotonergic psychedelics.

Psychopharmacology (Berl) 2021 Jul 12. Epub 2021 Jul 12.

Touro University California, Vallejo, CA, 94590, USA.

Rationale: In recent years, psychedelic substances with serotonergic mechanisms have accumulated substantial evidence that they may provide therapeutic benefits for people suffering with psychiatric symptoms. Psychiatric disorders targeted by these psychedelic-assisted therapies are managed with serotonergic drugs like selective serotonin reuptake inhibitors (SSRIs) as the current standard of care, so it is important to evaluate the potential risks of drug-drug interactions and serotonin toxicity (ST) between these agents.

Objectives: A critical evaluation of the scientific literature is necessary to delineate the risks of ST when combining psychedelics with available serotonergic pharmacotherapy options. Read More

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Postoperative oxaliplatin-based hyperthermic intraperitoneal chemotherapy: an effective and safe palliative treatment option for colorectal cancer with peritoneal metastasis.

World J Surg Oncol 2021 Jul 6;19(1):200. Epub 2021 Jul 6.

Department of Surgical Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Yanta west street No.277, Xi'an, 710061, Shaanxi, China.

Background: The prognosis of patients with colorectal cancer and peritoneal metastasis (CRC-PM) after incomplete cytoreductive surgery (CRS) or palliative surgery is poor. Novel and effective therapies are urgently needed. This study aimed to assess the effects of palliative postoperative hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with CRC-PM. Read More

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Sunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates.

Cochrane Database Syst Rev 2021 Jul 6;7:CD013277. Epub 2021 Jul 6.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.

Background: Acute bilirubin encephalopathy (ABE) and the other serious complications of severe hyperbilirubinemia in the neonate occur far more frequently in low- and middle-income countries (LMIC). This is due to several factors that place babies in LMIC at greater risk for hyperbilirubinemia, including increased prevalence of hematologic disorders leading to hemolysis, increased sepsis, less prenatal or postnatal care, and a lack of resources to treat jaundiced babies. Hospitals and clinics face frequent shortages of functioning phototherapy machines and inconsistent access to electricity to run the machines. Read More

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Multifunctional theranostic nanoparticles for biomedical cancer treatments - A comprehensive review.

Mater Sci Eng C Mater Biol Appl 2021 Aug 24;127:112199. Epub 2021 May 24.

Department of Chemical Engineering, University of Petroleum and Energy Studies, Dehradun, India. Electronic address:

Modern-day search for the novel agents (their preparation and consequent implementation) to effectively treat the cancer is mainly fuelled by the historical failure of the conventional treatment modalities. Apart from that, the complexities such as higher rate of cell mutations, variable tumor microenvironment, patient-specific disparities, and the evolving nature of cancers have made this search much stronger in the latest times. As a result of this, in about two decades, the theranostic nanoparticles (TNPs) - i. Read More

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Recognition in Emergency Department of Septic Patients at Higher Risk of Death: Beware of Patients without Fever.

Medicina (Kaunas) 2021 Jun 12;57(6). Epub 2021 Jun 12.

Infectious Disease Unit, Azienda Sanitaria Universitaria Integrata di Udine (ASU FC), 33100 Udine, Italy.

: Chances of surviving sepsis increase markedly upon prompt diagnosis and treatment. As most sepsis cases initially show-up in the Emergency Department (ED), early recognition of a septic patient has a pivotal role in sepsis management, despite the lack of precise guidelines. The aim of this study was to identify the most accurate predictors of in-hospital mortality outcome in septic patients admitted to the ED. Read More

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Distinct Modulatory Effects of Fever-Range Hyperthermia on the Response of Breast Cancer Cells and Macrophages to Mistletoe ( L.) Extract.

Pharmaceuticals (Basel) 2021 Jun 8;14(6). Epub 2021 Jun 8.

Department of Immunology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 1 Lwowska Str., 87-100 Torun, Poland.

Heat utility as a critical component of fever is often ignored, although the symptom is observed in many medical conditions. Mistletoe extract (ME) is an adjunctive medication prescribed to cancer patients. The increase in body temperature is frequently observed in patients following ME administration. Read More

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The Effect of Statins on RyR and RyR- Associated Disease.

J Appl Physiol (1985) 2021 06 24. Epub 2021 Jun 24.

Division of Cardiology, Hartford Hospital, Hartford, CT, United States.

Objective: We sought to review the effects of statins on the ryanodine receptor (RyR) and on RyR-associated diseases, with an emphasis on catecholaminergic polymorphic ventricular tachycardia (CPVT).

Background: Statins can affect skeletal muscle and produce statin associated muscle symptoms (SAMS), but have no adverse effects on cardiac muscle. These contrasting effects may be due to differences in how statins affect the skeletal (RyR1) and cardiac (RyR2) RyR. Read More

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Effects of Surface Charge, PEGylation and Functionalization with Dipalmitoylphosphatidyldiglycerol on Liposome-Cell Interactions and Local Drug Delivery to Solid Tumors via Thermosensitive Liposomes.

Int J Nanomedicine 2021 14;16:4045-4061. Epub 2021 Jun 14.

Department of Internal Medicine III, University Hospital, Ludwig Maximilian University, Munich, Germany.

Purpose: Previous studies demonstrated the possibility of targeting tumor-angiogenic endothelial cells with positively charged nanocarriers, such as cationic liposomes. We investigated the active targeting potential of positively charged nanoparticles in combination with the heat-induced drug release function of thermosensitive liposomes (TSL). This novel dual-targeted approach via cationic TSL (CTSL) was thoroughly explored using either a novel synthetic phospholipid 1,2-dipalmitoyl--glycero-3-phosphodiglycerol (DPPG) or a conventional polyethylene glycol (PEG) surface modification. Read More

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Closed-loop trans-skull ultrasound hyperthermia leads to improved drug delivery from thermosensitive drugs and promotes changes in vascular transport dynamics in brain tumors.

Theranostics 2021 24;11(15):7276-7293. Epub 2021 May 24.

School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA.

Effective drug delivery in brain tumors remains a major challenge in oncology. Although local hyperthermia and stimuli-responsive delivery systems, such as thermosensitive liposomes, represent promising strategies to locally enhance drug delivery in solid tumors and improve outcomes, their application in intracranial malignancies remains unexplored. We hypothesized that the combined abilities of closed-loop trans-skull Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS) hyperthermia with those of thermosensitive drugs can alleviate challenges in drug delivery and improve survival in gliomas. Read More

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Quantitative ultrasound characterization of therapy response in prostate cancer in vivo.

Am J Transl Res 2021 15;13(5):4437-4449. Epub 2021 May 15.

Imaging Research and Physical Sciences, Sunnybrook Health Sciences Centre Toronto, Ontario, Canada.

Quantitative ultrasound (QUS) is a non-invasive imaging modality that permits the detection of tumor response following various cancer therapies. Based on ultrasound signal scattering from the biological system, scatterer size, and concentration of microscopic scatterers, QUS enables the rapid characterization of tumor cell death. In this study, tumor response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) in tumor-bearing mice, with prostate cancer xenografts (PC3), was examined using QUS. Read More

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Short-term heat acclimation preserves knee extensor torque but does not improve 20 km self-paced cycling performance in the heat.

Eur J Appl Physiol 2021 Jun 19. Epub 2021 Jun 19.

School of Exercise and Nutrition Sciences, Queensland University of Technology (QUT), Brisbane, Australia.

Purpose: This study investigated the effect of 5 days of heat acclimation training on neuromuscular function, intestinal damage, and 20 km cycling (20TT) performance in the heat.

Methods: Eight recreationally trained males completed two 5-day training blocks (cycling 60 min day at 50% peak power output) in a counter-balanced, cross-over design, with a 20TT completed before and after each block. Training was conducted in hot (HA: 34. Read More

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A recombinant protein (MyxoTLm) for the serological diagnosis of acute and chronic Trypanosoma vivax infection in cattle.

Vet Parasitol 2021 Aug 15;296:109495. Epub 2021 Jun 15.

Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Human trypanosomiases and animal trypanosomoses are caused by distinct protozoan parasites of the genus Trypanosoma. The etiological agents of bovine trypanosomosis (BT) are T. vivax, T. Read More

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Enhanced Near-Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite-Based P-N Heterojunction.

Adv Sci (Weinh) 2021 Jun 19:e2002211. Epub 2021 Jun 19.

Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.

Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections after orthopedic implant increase the risk of failure and potentially cause amputation of limbs or life-threatening sepsis in severe cases. Additionally, satisfactory bone-implant integration is another important indicator of an ideal implant. Here, an antibiotic-free antibacterial nanofilm based on oxide perovskite-type calcium titanate (CTO)/fibrous red phosphorus (RP) on titanium implant surface (Ti-CTO/RP) in which the P-N heterojunction and internal electric field are established at the heterointerface, is designed. Read More

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HIPEC Methodology and Regimens: The Need for an Expert Consensus.

Ann Surg Oncol 2021 Jun 17. Epub 2021 Jun 17.

Department of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France.

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) is performed with a wide variation in methodology, drugs, and other elements vital to the procedure. Adoption of a limited number of regimens could increase the collective experience of peritoneal oncologists, make comparison between studies more meaningful, and lead to a greater acceptance of results from randomized trials. This study aimed to determine the possibility of standardizing HIPEC methodology and regimens and to identify the best method of performing such a standardization. Read More

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A multicenter randomized phase II trial of hyperthermia combined with TPF induction chemotherapy compared with TPF induction chemotherapy in locally advanced resectable oral squamous cell carcinoma.

Int J Hyperthermia 2021 ;38(1):939-947

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Hyperthermia has been reported to cause cancer stage regression, thus providing surgical opportunities in patients with unresectable tumors and improving the quality of life of patients by preserving certain organs.

Methods: A prospective open-label phase II trial was conducted to evaluate the efficacy of hyperthermia combined with induction chemotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC). Patients received hyperthermia combined with two cycles of 5-fluorouracil, cisplatin, and docetaxel (TPF) induction chemotherapy regimens or TPF induction chemotherapy alone, followed by radical surgery with postoperative radiotherapy. Read More

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Effects of rumen-protected choline supplementation in Holstein dairy cows during electric heat blanket-induced heat stress.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Animal and Dairy Sciences, University of Wisconsin-Madison 53706. Electronic address:

Dairy cows experiencing heat stress (HS) attempt to thermoregulate through multiple mechanisms, such as reducing feed intake and milk production and altering blood flow to increase heat dissipation. Effects of choline on energy metabolism and immune function may yield it a viable nutritional intervention to mitigate negative effects of HS. The primary objective of this experiment was to determine if supplementation of rumen-protected choline during, or before and during, an increased heat load would ameliorate the negative effects of HS on production and immune status. Read More

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Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia.

Adv Mater 2021 Jun 12:e2100077. Epub 2021 Jun 12.

Nanomaterials for Bioimaging Group (nanoBIG), Universidad Autónoma de Madrid, Madrid, 28049, Spain.

Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. Read More

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General method to stabilize mesophilic proteins in hyperthermal water.

iScience 2021 May 2;24(5):102503. Epub 2021 May 2.

Clinical Translational Center for Targeted Drug, School of Medicine, Jinan University, Guangzhou 510632, China.

The stability of protein structures and biological functions at normal temperature is closely linked with the universal aqueous environment of organisms. Preserving bioactivities of proteins in hyperthermia water would expand their functional capabilities beyond those in native environments. However, only a limited number of proteins derived from hyperthermophiles are thermostable at elevated temperatures. Read More

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Image-guided High-Intensity Focused Ultrasound, A Novel Application for Interventional Nuclear Medicine?

J Nucl Med 2021 Jun 4. Epub 2021 Jun 4.

Innovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, Leipzig, Germany, Germany.

Image-guided high-intensity focused ultrasound (HIFU) has been increasingly used in medicine over the past few decades, and several systems for such have become commercially available. HIFU has passed regulatory approval for the ablation of various solid tumors, the treatment of neurological diseases, and the palliative management of bone metastases around the world. The mechanical and thermal effects of focused ultrasound provide a possibility for histotripsy, support radiation therapy, and targeted drug delivery. Read More

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Nanotherapeutic approach to tackle chemotherapeutic resistance of cancer stem cells.

Life Sci 2021 Aug 2;279:119667. Epub 2021 Jun 2.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address:

Estimates indicate that cancer will become the leading cause of mortality worldwide in the future. Tumorigenesis is a complex process that involves self-sufficiency in signs of growth, insensitivity to anti-growth signals, prevention of apoptosis, unlimited replication, sustained angiogenesis, tissue invasion, and metastasis. Cancer stem cells (CSCs) have an important role in tumor development and resistance. Read More

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In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments.

Int J Hyperthermia 2021 ;38(1):846-861

IMDEA Nanoscience, Madrid, Spain.

Bearing partially or fully metallic passive implants represents an exclusion criterion for patients undergoing a magnetic hyperthermia procedure, but there are no specific studies backing this restrictive decision. This work assesses how the secondary magnetic field generated at the surface of two common types of prostheses affects the safety and efficiency of magnetic hyperthermia treatments of localized tumors. The paper also proposes the combination of a multi-criteria decision analysis and a graphical representation of calculated data as an initial screening during the preclinical risk assessment for each patient. Read More

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Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells.

Int J Mol Sci 2021 May 6;22(9). Epub 2021 May 6.

Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.

Ethanol has been shown to exhibit therapeutic properties as an ablative agent alone and in combination with thermal ablation. Ethanol may also increase sensitivity of cancer cells to certain physical and chemical antitumoral agents. The aim of our study was to assess the potential influence of nontoxic concentrations of ethanol on hyperthermia therapy, an antitumoral modality that is continuously growing and that can be combined with classical chemotherapy and radiotherapy to improve their efficiency. Read More

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The Use of Silica Microparticles to Improve the Efficiency of Optical Hyperthermia (OH).

Int J Mol Sci 2021 May 11;22(10). Epub 2021 May 11.

Centro de Tecnología Biomédica (CTB), Campus de Montegancedo, Universidad Politécnica de Madrid (UPM), Pozuelo de Alarcón, 28223 Madrid, Spain.

Although optical hyperthermia could be a promising anticancer therapy, the need for high concentrations of light-absorbing metal nanoparticles and high-intensity lasers, or large exposure times, could discourage its use due to the toxicity that they could imply. In this article, we explore a possible role of silica microparticles that have high biocompatibility and that scatter light, when used in combination with conventional nanoparticles, to reduce those high concentrations of particles and/or those intense laser beams, in order to improve the biocompatibility of the overall procedure. Our underlying hypothesis is that the scattering of light caused by the microparticles would increase the optical density of the irradiated volume due to the production of multiple reflections of the incident light: the nanoparticles present in the same volume would absorb more energy from the laser than without the presence of silica particles, resulting either in higher heat production or in the need for less laser power or absorbing particles for the same required temperature rise. Read More

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Collagen/kerateine multi-protein hydrogels as a thermally stable extracellular matrix for 3D models.

Int J Hyperthermia 2021 ;38(1):830-845

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

To determine whether the addition of kerateine (reduced keratin) in rat tail collagen type I hydrogels increases thermal stability and changes material properties and supports cell growth for use in cellular hyperthermia studies for tumor treatment. Collagen type I extracted from rat tail tendon was combined with kerateine extracted from human hair fibers. Thermal, mechanical, and biocompatibility properties and cell behavior was assessed and compared to 100% collagen type I hydrogels to demonstrate their utility as a tissue model for 3D testing. Read More

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