53,946 results match your criteria hypertensive patients


Maternal near-miss attributable to haemorrhagic stroke in patients with hypertensive disorders of pregnancy in Japan: A national cohort study.

Pregnancy Hypertens 2021 Jul 23;25:240-243. Epub 2021 Jul 23.

Department of Gynaecology and Obstetrics, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: To investigate the epidemiologic and clinical characteristics of maternal near-misses attributable to haemorrhagic stroke (HS) occurring in patients with hypertensive disorders of pregnancy (HDP), with a focus on severe neurological morbidity.

Methods: A national retrospective cohort study was conducted using the national database of health insurance claims for the period 2010 to 2017. The subjects were all insured women with a diagnosis of both HDP and HS. Read More

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Effects of enhanced versus reduced vasodilating treatment on brachial and central blood pressure in patients with chronic kidney disease: a randomized controlled trial.

J Hypertens 2021 Jul 23. Epub 2021 Jul 23.

Department of Renal Medicine, Aarhus University Hospital Comparative Medicine Lab, Department of Clinical Medicine, Aarhus University Department of Cardiology, Aarhus University Hospital Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Background: Blood pressure (BP) control is important in chronic kidney disease (CKD), but a reduction in brachial BP may not mirror changes in central aortic BP (cBP) during antihypertensive medication. We hypothesize that a fall in cBP is better reflected during enhanced vasodilation treatment (EVT) compared with reduced vasodilation treatment (RVT) because of different hemodynamic actions of these interventions.

Methods: Eighty-one hypertensive CKD stage 3-4 patients (mean measured glomerular filtration rate 36 ml/min per 1. Read More

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Choroidal structural changes and choroidal vascularity index in patients with systemic hypertension.

Eur J Ophthalmol 2021 Jul 27:11206721211035615. Epub 2021 Jul 27.

Department of Opthalmology, Kırşehir Ahi Evran University School of Medicine, Kirsehir, Turkey.

Purpose: To assess the impact of systemic hypertension on the choroidal structure and choroidal vascularity index (CVI).

Methods: This prospective cross-sectional study comprised 50 eyes of 50 treatment-naive hypertensive patients and 50 eyes of 50 healthy subjects. Choroidal thickness (CT) was measured in the subfoveal region, 1500 µm nasal to the fovea, and 1500 µm temporal to the fovea. Read More

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Hypertensive cerebral hemorrhage with undetectable plasma vascular endothelial growth factor levels in a patient receiving intravitreal injection of aflibercept for bilateral diabetic macular edema: a case report.

J Med Case Rep 2021 Jul 27;15(1):403. Epub 2021 Jul 27.

Department of Ophthalmology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda-ku, Tokyo, 102-8798, Japan.

Background: Intravitreal injections of anti-vascular endothelial growth factor are commonly used to treat macular diseases, including diabetic macular edema. Anti-vascular endothelial growth factor drugs can enter the systemic circulation after intravitreal injections and appear to suppress circulating vascular endothelial growth factor levels. However, whether this can cause any systemic adverse events remains unknown. Read More

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The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.

Clin Sci (Lond) 2021 Jul;135(14):1631-1647

School of Biological Sciences, University of Reading, Reading RG6 2AS, U.K.

Raf kinases signal via extracellular signal-regulated kinases 1/2 (ERK1/2) to drive cell division. Since activating mutations in BRAF (B-Raf proto-oncogene, serine/threonine kinase) are highly oncogenic, BRAF inhibitors including dabrafenib have been developed for cancer. Inhibitors of ERK1/2 signalling used for cancer are cardiotoxic in some patients, raising the question of whether dabrafenib is cardiotoxic. Read More

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Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.

J Pharmacol Sci 2021 Sep 5;147(1):81-85. Epub 2021 Jun 5.

Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan. Electronic address:

Pulmonary arterial hypertension (PAH) is a rare, progressive, and fatal cardiovascular/lung disease. The incidence rate is affected by age. Monocrotaline (MCT, 60 mg/kg)-treated rats are widely used as an experimental PAH model. Read More

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September 2021

Targeting TMEM16A-encoded Ca-activated Cl channels: a new paradigm for antihypertensive therapy?

Authors:
Normand Leblanc

Kidney Int 2021 Aug;100(2):269-272

Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA. Electronic address:

Hypertension is the leading risk factor for the development of heart diseases and stroke. Many hypertensive patients experience undesirable side effects to conventional antihypertensive pharmacotherapy. Cil et al. Read More

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Diagnostic Performance of Office versus Ambulatory Blood Pressure in Kidney Transplant Recipients.

Am J Nephrol 2021 Jul 26:1-11. Epub 2021 Jul 26.

Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, Medical School of Athens, National and Kapodistrian University, Athens, Greece.

Introduction: Hypertension is the most prominent risk factor in kidney transplant recipients (KTRs). No study so far assessed in parallel the prevalence, control, and phenotypes of blood pressure (BP) or the accuracy of currently recommended office BP diagnostic thresholds in diagnosing elevated ambulatory BP in KTRs.

Methods: 205 stable KTRs underwent office BP measurements and 24-h ambulatory BP monitoring (ABPM). Read More

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Risk Factors for Complications Following Lateral Skull Base Surgery and the Utility of ICU Monitoring.

Otol Neurotol 2021 Jul 23. Epub 2021 Jul 23.

Department of Neurotology, Michigan Ear Institute, St. John Providence Hospital and Medical Centers, Farmington Hills Department of Otolaryngology-Head & Neck Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina Department of Otolaryngology-Head and Neck Surgery, Ascension Macomb-Oakland Hospital, Madison Heights Michigan State University College of Osteopathic Medicine, East Lansing, Michigan.

Objective: To examine the role of intensive care unit (ICU) management following lateral skull base surgery for vestibular schwannoma and identify risk factors for complications warranting admission to the ICU.

Study Design: Retrospective review.

Setting: Tertiary referral center. Read More

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Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy.

Ultrasound Obstet Gynecol 2021 Jul 26. Epub 2021 Jul 26.

Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK.

Objectives: Women with hypertensive disorders of pregnancy (HDP) present with evidence of significant myocardial dysfunction on echocardiographic assessment at the time of diagnosis. Birth not only cures the syndrome of HDP, but is also associated with a reduction in cardiovascular (CV) volume and resistance load in the mother due to the delivery of the fetoplacental unit. The impact of this physiological change on maternal myocardial function in women with HDP has not been systematically evaluated. Read More

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Improving services for chronic non-communicable diseases in Samoa: an implementation research study using the care cascade framework.

Aust N Z J Public Health 2021 Jul 26. Epub 2021 Jul 26.

The World Bank Group, Washington DC, USA.

Objective: Samoa needs to intensify the response to the growing non-communicable disease burden. This study aimed to assess bottlenecks in the care continuum and identify possible solutions.

Methods: The mixed-methods study used the cascade framework as an analysis tool and hypertension as a tracer condition for chronic non-communicable diseases. Read More

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Aortic Valve Calcification Score in Patients with Arterial Hypertension Environmentally Exposed to Tobacco Smoke.

Cardiovasc Toxicol 2021 Jul 26. Epub 2021 Jul 26.

Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.

The objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107 non-smokers with AH (mean age 67.16 ± 8. Read More

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Inorganic nitrate attenuates cardiac dysfunction: role for xanthine oxidoreductase and nitric oxide.

Br J Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

Nitric oxide (NO) is a vasodilator and independent modulator of cardiac remodelling. Commonly, in cardiac disease (e.g. Read More

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Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment.

Libyan J Med 2021 Dec;16(1):1949797

Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, Granada, Spain.

Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that could influence the response to the treatment. Single-center, observational, retrospective study. Read More

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December 2021

Hemiplegic migraine episode triggered by regadenoson.

J Nucl Cardiol 2021 Jul 25. Epub 2021 Jul 25.

Division of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.

SPECT and PET myocardial perfusion imaging (MPI) are widely used to evaluate patients for coronary artery disease. Regadenoson (a selective A adenosine receptor agonist) is a commonly used vasodilator agent for stress MPI because of its safety profile and ease of use. Common adverse reactions such as headache, shortness of breath, flushing, and chest and abdominal discomfort are typically mild and can be effectively reversed using methylxanthines such as aminophylline and caffeine. Read More

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Using the Health Belief Model to Explain the Patient's Compliance to Anti-hypertensive Treatment in Three District Hospitals - Dar Es Salaam, Tanzania: A Cross Section Study.

East Afr Health Res J 2021 11;5(1):50-58. Epub 2021 Jun 11.

School of Nursing and Public Health, Department of Clinical Nursing, University of Dodoma, Tanzania.

Background: Hypertension remains a public-health challenge globally. Its prevention, early detection, proper and adequate treatment and control should be given high consideration to prevent occurrence of cardiovascular disease and stroke. This study is guided by the Health Belief Model (HBM) to investigate the influence of treatment compliance using HBM constructs among elderly hypertensive patients in 3 regional hospitals in Dar es Salaam, Tanzania. Read More

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Effects of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors on COVID-19.

World J Clin Cases 2021 Jul;9(20):5462-5469

Translational Medical Research Center, Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, China.

Background: The World Health Organization reported that 28637952 people worldwide had been infected with severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019 (COVID-19), by September 13.

Aim: The aim was to investigate whether long-term use of renin-angiotensin-aldosterone system (RAAS) inhibitors for the treatment of hypertension aggravates the performance of COVID-19 patients with hypertension.

Methods: This was a retrospective analysis of lung computed tomography (CT) data and laboratory values of COVID-19 patients with hypertension who were admitted to Huoshenshan Hospital, Wuhan, Hubei Province, between February 18 and March 31, 2020. Read More

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Usefulness of Stress-Derived E/e' Ratio in Asymptomatic Hypertensive Patients.

Pulse (Basel) 2021 Jun 25;8(3-4):92-98. Epub 2020 Nov 25.

Department of Cardiology, Zagazig University Hospital, Zagazig, Egypt.

Purpose: We sought to investigate the usefulness of stress echocardiography-derived E/e' in predicting subclinical atherosclerosis in asymptomatic hypertensive patients.

Materials And Methods: 71 newly diagnosed untreated hypertensive patients (48 ± 13 years, 65% males) and 30 age- and sex-matched healthy controls were recruited. Resting and exercise echocardiography was performed to assess resting diastolic blood pressure and the diastolic stress parameters. Read More

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The predictive value of microRNA in early hypertensive disorder complicating pregnancy (HDCP).

Am J Transl Res 2021 15;13(6):7288-7293. Epub 2021 Jun 15.

Obstetrics Department III, Cangzhou Central Hospital Cangzhou, China.

Objective: To examine the predictive value of microRNA (miRNA) in hypertensive disorder complicating pregnancy (HDCP).

Methods: 102 pregnant women with HDCP admitted to our hospital from March 2017 to June 2019 were recruited as the study cohort and randomly divided into an HDCP group, a mild preeclampsia group, and a severe preeclampsia group, with 34 patients in each group. In addition, 34 healthy pregnant women who underwent pregnancy tests in our hospital were recruited as the normal group. Read More

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Efficacy of nifedipine tablets plus aspirin in patients with gestational hypertension and the effect on coagulation function and hemorheology.

Am J Transl Res 2021 15;13(6):7059-7064. Epub 2021 Jun 15.

Department of Intervention, Hengshui People's Hospital Hengshui, China.

Objective: This study aimed to investigate the clinical efficacy of Nifedipine tablets plus Aspirin for hypertensive disorder complicating pregnancy and the effect on coagulation function and hemorheology.

Methods: A retrospective analysis of the clinical data from 108 patients with gestational hypertension hospitalized between March 2016 and March 2017 was carried out. These patients were randomly assigned into a research group and a control group, with 54 patients in each group. Read More

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Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension.

Front Neurol 2021 8;12:666632. Epub 2021 Jul 8.

Department of Neurology, Evangelisches Klinikum Bethel, University Hospital OWL of the University Bielefeld, Bielefeld, Germany.

Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of <24 h. Several studies showed differences in vascular risk factors between TGA compared to transient ischemic attack (TIA) or healthy controls with varying results. This retrospective and cross-sectional study compares the cardiovascular risk profile of TGA patients with that of acute stroke patients. Read More

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Impact of the COVID-19 Pandemic on Kidney Diseases Requiring Renal Biopsy: A Single Center Observational Study.

Front Physiol 2021 8;12:649336. Epub 2021 Jul 8.

Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.

Background: The coronavirus disease-2019 (COVID-19) pandemic impacted healthcare services for kidney disease patients. Lockdown and social distancing were mandated worldwide, resulting in closure of medical services. The diagnosis of various kidney diseases may have been delayed during the COVID-19 pandemic because non-urgent tests and visits were postponed due to closure of medical services during the lockdown. Read More

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SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.

Am J Obstet Gynecol 2021 Jul 21. Epub 2021 Jul 21.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA; Detroit Medical Center, Detroit, MI, USA; Department of Obstetrics and Gynecology, Florida International University, Miami, FL, USA. Electronic address:

Objective: To examine the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and the risk of preeclampsia.

Data Sources: MEDLINE, EMBASE, POPLINE, CINAHL, LILACS, and WHO COVID-19, Chinese, and preprint databases (all from December 1, 2019 to May 31, 2021). Google Scholar, bibliographies, and conference proceedings were also searched. Read More

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The Syndromes of Thrombotic Microangiopathy: A Critical Appraisal on Complement Dysregulation.

J Clin Med 2021 Jul 8;10(14). Epub 2021 Jul 8.

Department Nephrology and Clinical Immunology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.

Thrombotic microangiopathy (TMA) is a rare and potentially life-threatening condition that can be caused by a heterogeneous group of diseases, often affecting the brain and kidneys. TMAs should be classified according to etiology to indicate targets for treatment. Complement dysregulation is an important cause of TMA that defines cases not related to coexisting conditions, that is, primary atypical hemolytic uremic syndrome (HUS). Read More

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Salivary Pro-Inflammatory Markers and Smoking Status Influences the Treatment Effectiveness of Periodontal Disease Patients with Hypertension.

Int J Environ Res Public Health 2021 Jul 9;18(14). Epub 2021 Jul 9.

Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Background: Hypertension and periodontal diseases share several risk factors. Inflammation biomarkers in saliva are related to hypertension and periodontal disease. The aim of this study was to explore the role of the salivary inflammatory biomarkers in the treatment effectiveness of patients with hypertension and periodontal disease. Read More

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Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis.

Diabetes Metab Syndr 2021 Jul 16;15(5):102210. Epub 2021 Jul 16.

Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Cardiology and Vascular Medicine, Dr. Soetomo General Hospital, Surabaya, Indonesia.

Aims: This meta-analysis aims to analyze the association of calcium channel blocker (CCB) use with COVID-19 clinical outcomes.

Methods: PubMed, ProQuest, Science Direct, Scopus, and medRxiv databases were searched systematically in a limited period. The primary outcome was mortality. Read More

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Correlation of endoscopic findings with Doppler ultrasound in portal hypertension in children.

Clin Exp Hepatol 2021 Jun 28;7(2):191-195. Epub 2021 May 28.

Department of Pediatric Gastroenterolgy and Hepatology, Bai Jerbai Wadia Hospital of Children, Mumbai, India.

Aim Of The Study: To determine the correlation of the endoscopic findings with portal Doppler and ultrasound (USG) in children with suspected portal hypertension (PHT).

Material And Methods: Eighty children with extrahepatic portal vein obstruction (EHPVO) and chronic liver disease (CLD) were included in this retrospective study conducted over a period of 1 year. All patients underwent upper gastrointestinal (GI) endoscopy and Doppler. Read More

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Lacidipine Ameliorates the Endothelial Senescence and Inflammatory Injury Through CXCR7/P38/C/EBP-β Signaling Pathway.

Front Cardiovasc Med 2021 6;8:692540. Epub 2021 Jul 6.

Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Lacidipine, a third-generation calcium channel blocker, exerts beneficial effects on the endothelium of hypertensive patients in addition to blood pressure lowering. However, the detailed mechanism underlying Lacidipine-related endothelial protection is still elusive. Sixteen spontaneous hypertensive rats (SHRs) were randomly divided into two groups: Lacidipine-treated SHR group and saline-treated control group. Read More

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Mobile health strategies for blood pressure self-management in urban populations with digital barriers: systematic review and meta-analyses.

NPJ Digit Med 2021 Jul 22;4(1):114. Epub 2021 Jul 22.

Division of General Internal Medicine at Zuckerberg San Francisco General Hospital, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Mobile health (mHealth) technologies improve hypertension outcomes, but it is unknown if this benefit applies to all populations. This review aimed to describe the impact of mHealth interventions on blood pressure outcomes in populations with disparities in digital health use. We conducted a systematic search to identify studies with systolic blood pressure (SBP) outcomes located in urban settings in high-income countries that included a digital health disparity population, defined as mean age ≥65 years; lower educational attainment (≥60% ≤high school education); and/or racial/ethnic minority (<50% non-Hispanic White for US studies). Read More

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Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case-control study.

J Clin Hypertens (Greenwich) 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.

The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age-, sex-, race-, diabetes, and body mass index matched). This study is a single-center, retrospective, chart review, case-control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Read More

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