909 results match your criteria hypersensitive bladder


Granulomatous Hepatitis Following Intra-Vesical Instillation of Bacillus Calmette-Guérin for Treatment of Bladder Cancer.

Infect Dis Rep 2021 Jul 1;13(3):611-618. Epub 2021 Jul 1.

Infectious Diseases Department, Centro Hospitalar e Universitário de São João, 4099-002 Porto, Portugal.

Intra-vesical instillation of bacillus Calmette-Guérin (BCG) is an important treatment modality of superficial bladder cancer. It is usually well tolerated, although some adverse reactions can occur. One possible yet rare complication is granulomatous hepatitis, that is thought to be caused either by BCG infection or a hypersensitivity reaction to the bacillus. Read More

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Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats.

Am J Physiol Renal Physiol 2021 06 21. Epub 2021 Jun 21.

Department of Biomedical Engineering, Duke University, Durham, NC, United States.

The spontaneously hypertensive rat (SHR), a genetic model of high blood pressure, has also been studied as a potential model of overactive bladder (OAB). In vivo studies confirmed the presence of surrogate markers of OAB, including detrusor overactivity (DO), increased urinary frequency, decreased bladder capacity and voided volume, and afferent hypersensitivity to bladder irritation. However, these observations were during awake cystometry (CMG) using implanted bladder catheters tethered to an infusion pump and artificially filled. Read More

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Chronic psychological stress and lower urinary tract symptoms.

Low Urin Tract Symptoms 2021 Jun 16. Epub 2021 Jun 16.

Centre for Urology Research, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland, Australia.

It is well established that lower urinary tract symptoms (LUTS), particularly urinary urgency and incontinence, cause stress and anxiety for patients. However, there is mounting evidence that the relationship between these two factors is bidirectional and that chronic psychological stress itself can result in the development of symptoms such as urinary frequency, urgency, incontinence, and pelvic pain. This review considers the evidence that such a relationship exists and reviews the literature from clinical and animal studies to identify some of the mechanisms that might be involved. Read More

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Noninvasive bladder testing of adolescent females to assess visceral hypersensitivity.

Pain 2021 Apr 12. Epub 2021 Apr 12.

Department of Ob/Gyn, NorthShore University HealthSystem Evanston, IL, United States, Department of Ob/Gyn, University of Chicago, Pritzker School of Medicine, Chicago, IL, United States, Department of Psychology, Loyola University of Chicago, Chicago, IL, United States, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States.

Abstract: Excess pain after visceral provocation has been suggested as a marker for chronic pelvic pain risk in women. However, few noninvasive tests have been validated that could be performed readily on youth in early risk windows. Therefore, we evaluated the validity and reliability of a noninvasive bladder pain test in 124 healthy premenarchal females (median age 11, [interquartile range 11-12]), as previously studied in adult women. Read More

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Efficacy of capacitive resistive monopolar radiofrequency in the physiotherapeutic treatment of chronic pelvic pain syndrome: study protocol for a randomized controlled trial.

Trials 2021 May 20;22(1):356. Epub 2021 May 20.

Rehabilitación Abdomino-Pelviana (RAPbarcelona SL), Barcelona, Spain.

Background: Chronic pelvic pain syndrome (CPPS) is a multifactorial disorder that affects 5.7% to 26.6% of women and 2. Read More

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Voiding dysfunctions in patients with non-Hunner's ulcer interstitial cystitis/bladder pain syndrome do not affect long-term treatment outcome.

Int J Clin Pract 2021 May 17:e14372. Epub 2021 May 17.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan.

Purpose: The role of urodynamic study in the diagnosis and prognostication of interstitial cystitis/bladder pain syndrome (IC/BPS) is still controversial. This study evaluated the correlation of the baseline voiding dysfunctions and long-term treatment outcome in patients with non-Hunner's ulcer IC (NHIC).

Materials And Methods: A total of 211 NHIC patients were enrolled. Read More

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Comparative safety review of current pharmacological treatments for interstitial cystitis/ bladder pain syndrome.

Expert Opin Drug Saf 2021 May 19:1-11. Epub 2021 May 19.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a frustrating disease of chronic bladder pain associated with lower urinary tract symptoms. Although there are many proposed treatment algorithms, the uncertainty as to their etiology has a negative impact on the therapeutic outcome. Oftentimes combination therapy of drugs with different mechanisms of action will be utilized to relieve the symptoms. Read More

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NK cell memory: discovery of a mystery.

Nat Immunol 2021 06;22(6):669-671

Department of Immunology, Harvard Medical School, Boston, MA, USA.

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A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities.

FASEB J 2021 04;35(4):e21430

Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, SA, Australia.

Endometriosis is a painful inflammatory disorder affecting ~10% of women of reproductive age. Although chronic pelvic pain (CPP) remains the main symptom of endometriosis patients, adequate treatments for CPP are lacking. Animal models that recapitulate the features and symptoms experienced by women with endometriosis are essential for investigating the etiology of endometriosis, as well as developing new treatments. Read More

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Case Report: Enfortumab Vedotin for Metastatic Urothelial Carcinoma: A Case Series on the Clinical and Histopathologic Spectrum of Adverse Cutaneous Reactions From Fatal Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis to Dermal Hypersensitivity Reaction.

Front Oncol 2021 4;11:621591. Epub 2021 Mar 4.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Enfortumab vedotin is a Nectin-4 directed antibody-drug conjugate approved in metastatic urothelial carcinoma following progression on a platinum-containing chemotherapy and immune checkpoint blockade. On-target dermatologic toxicity may occur from Nectin-4 expression in the skin. We highlight a case of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis following enfortumab infusions that was ultimately fatal. Read More

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Selective blockade of transient receptor potential vanilloid 4 reduces cyclophosphamide-induced bladder pain in mice.

Eur J Pharmacol 2021 May 15;899:174040. Epub 2021 Mar 15.

Laboratory for Drug Discovery & Disease Research, Shionogi & Co., Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka, 561-0825, Japan. Electronic address:

Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel activated by various physical stimuli such as cell swelling and shear stress. TRPV4 is expressed in bladder sensory nerves and epithelium, and its activation produces urinary dysfunction in rodents. However, there have been few reports regarding its involvement in bladder pain. Read More

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Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.

J Neurosci 2021 Apr 16;41(17):3900-3916. Epub 2021 Mar 16.

Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042 South Australia, Australia

Understanding the sensory mechanisms innervating the bladder is paramount to developing efficacious treatments for chronic bladder hypersensitivity conditions. The contribution of Mas-gene-related G protein-coupled receptors (Mrgpr) to bladder signaling is currently unknown. Using male and female mice, we show with single-cell RT-PCR that subpopulations of DRG neurons innervating the mouse bladder express (14%) and (38%), either individually or in combination, with high levels of coexpression with (81%-89%). Read More

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Epirubicin-induced Kounis syndrome.

BMC Cardiovasc Disord 2021 Mar 12;21(1):133. Epub 2021 Mar 12.

Department of Cardiology, Peking University People's Hospital, Beijing, China.

Background: Kounis syndrome is an acute coronary syndrome that appears in the setting of anaphylactic reaction or hypersensitivity. Many drugs and environmental exposures have been identified as potential offenders, and diagnosis and treatment can be challenging.

Case Presentation: A 62-year-old man with recurrent bladder cancer underwent an intra-iliac artery epirubicin injection. Read More

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Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity.

Eur J Pharmacol 2021 May 3;899:173995. Epub 2021 Mar 3.

Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.

Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including urinary urgency in overactive bladder (OAB). We aimed to investigate a pharmacological effect of KPR-5714, a novel selective TRPM8 antagonist, on TRPM8 channels, M receptors and β-adrenoceptors using the transfected cells of each gene at first. Then, combination effects of KPR-5714 and mirabegron, a β-adrenoceptor agonist, or tolterodine tartrate, an anticholinergic agent, were studied on rhythmic bladder contractions (RBCs) in normal rats and bladder function in frequent-voiding rats. Read More

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Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca Channels, on Visceral Pain in Mice.

Biol Pharm Bull 2021 ;44(3):461-464

Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University.

T-Type Ca channels (T-channels), particularly Ca3.2, are now considered as therapeutic targets for treatment of intractable pain including visceral pain. Among existing medicines, bepridil, a multi-channel blocker, used for treatment of arrhythmia and angina, and pimozide, a dopamine D receptor antagonist, known as a typical antipsychotic, have potent T-channel blocking activity. Read More

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January 2021

Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP-II Research Network Study.

Neurourol Urodyn 2021 03 19;40(3):810-818. Epub 2021 Feb 19.

Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.

Objective: To use the phenotyping data from the MAPP-II Symptom Patterns Study (SPS) to compare the systemic features between urologic chronic pelvic pain syndrome (UCPPS) with Hunner lesion (HL) versus those without HL.

Methods: We performed chart review on 385 women and 193 men with UCPPS who enrolled in the MAPP-II SPS. 223 had cystoscopy and documentation of HL status. Read More

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Beneficial effect of Bletilla striata extract solution on zymosan-induced interstitial cystitis in rat.

Neurourol Urodyn 2021 03 19;40(3):763-770. Epub 2021 Feb 19.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Aims: Interstitial cystitis (IC) is a chronic pain syndrome that is characterized by suprapubic pain upon bladder filling. Bletilla striata, a well-known traditional Chinese herb with established efficacy in wound healing and anti-inflammation, was hypothesized to improve the symptoms of IC possibly though forming a physical barrier that could isolate the bladder tissue from irritants. This study was conducted to evaluate the beneficial effects of intravesical treatment with B. Read More

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[Intravesical Gemcitabine instillations following BCG failure and allergy to Mitomycin: A unique case of a patient with an inverted papilloma of the bladder].

Aktuelle Urol 2021 Feb 1;52(1):43-46. Epub 2021 Feb 1.

University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck.

Intravesical chemotherapy instillation is a unique method of treatment confined to urothelial neoplasia. Within the last decades, the substances Bacillus Calmette-Guerin (BCG) and mitomycin C (MMC) have evolved as the standard regimens for intravesical therapy. However, there are other chemotherapeutic substances, which are used less frequently, such as gemcitabine. Read More

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February 2021

A Practical Approach to Assist Asthmatics to Lose Weight.

J Allergy Clin Immunol Pract 2021 06 28;9(6):2245-2254. Epub 2021 Jan 28.

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, Fla.

Treating patients with obesity, particularly asthmatics, is a complex challenge that requires a unique and individually tailored approach. Obesity, defined by the Centers for Disease Control and Prevention, is a body mass index of 30.0 kg/m or greater. Read More

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Cortical Mechanisms of Visual Hypersensitivity in Women at Risk for Chronic Pelvic Pain.

medRxiv 2021 Jan 18. Epub 2021 Jan 18.

Multisensory hypersensitivity (MSH), which refers to persistent discomfort across sensory modalities, is a risk factor for chronic pain. Developing a better understanding of the neural contributions of disparate sensory systems to MSH may clarify its role in the development of chronic pain. We recruited a cohort of women ( =147) enriched with participants with menstrual pain at risk for developing chronic pain. Read More

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January 2021

Ketamine-induced urological toxicity: potential mechanisms and translation for adults with mood disorders receiving ketamine treatment.

Psychopharmacology (Berl) 2021 Apr 23;238(4):917-926. Epub 2021 Jan 23.

Mood Disorder Psychopharmacology Unit, University Health Network, 399 Bathurst Street, MP 9-325, Toronto, ON, M5T 2S8, Canada.

Intravenous (IV) ketamine has been shown to have rapid and robust antidepressant effects in adults with treatment-resistant depression (TRD). Urological toxicity has been observed in chronic ketamine abusers as evidenced by dysuria, urgency, and hematuria. The foregoing observation provides the basis for evaluating whether ketamine-induced urological toxicity (KIUT) is associated with sub-anesthetic doses of ketamine (0. Read More

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Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis.

Pharmacol Res Perspect 2021 02;9(1):e00697

Department of Physiology and Anatomy Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Although interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition causing bladder pain and urinary symptoms, effective treatments have not been established. The aim of this study was to adapt a chronic cystitis model in rats using lipopolysaccharide (LPS), which reflects IC/BPS pathology, and characterize the model's histological and behavioral effects. Furthermore, we investigated the effect of an α δ subunit ligand, gabapentin (GBP), on bladder hypersensitivity of rats with chronic cystitis. Read More

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February 2021

A Bladder Mass in a Patient with Henoch-Schönlein Purpura.

J Pediatr 2021 04 13;231:289-290. Epub 2020 Dec 13.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

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Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation.

Front Neurosci 2020 23;14:590871. Epub 2020 Oct 23.

Visceral Pain Research Group, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, SA, Australia.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition characterised by urinary urgency, frequency and pelvic pain, that significantly impacts the quality of life for ∼5% of women. Bladder sensation is coordinated by primary afferent sensory neurons that innervate the bladder wall, translating bladder stretch into signals that travel to the brain via the spinal cord. Whilst the pathophysiology of IC/BPS remains unknown, an increase in the permeability of the bladder urothelium has been proposed as an initiating cause. Read More

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October 2020

[Cellular regulation of the lower urinary tract as a cause of the bladder overactivity and reduced efficiency of pharmacotherapy].

Urologiia 2020 11(5):149-156

Russian Medical Academy of Continuous Postgraduate Education of the Ministry of Health of Russia, Moscow, Russian.

Overactive bladder (OAB) is a polyetiological nosology. Its symptoms are often characterized not only with detrusor hyperactivity, but also with the increased sensitivity of afferent fibers, which is clinically manifested as urgency. In addition, the disorders at the level of receptors expression and the synthesis of mediators lead to the development of bladder pain syndrome (BPS), which also significantly reduces the quality of life of patients. Read More

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November 2020

New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients.

Clin Rheumatol 2021 May 24;40(5):1933-1940. Epub 2020 Oct 24.

Department of Internal Medicine and Clinical Immunology, CHRU Tours, Tours, France.

Objective: IgA vasculitis (IgAV) frequently occurs during or after a mucosal infection; it also rarely occurs in patients with cancer. We hypothesized that cancer could impact the baseline characteristics and/or outcome of vasculitis. We aimed to describe the presentation of IgAV in patients with cancer (IgAV ca+) compared to patients without cancer. Read More

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Spinal neuron-glia-immune interaction in cross-organ sensitization.

Am J Physiol Gastrointest Liver Physiol 2020 12 21;319(6):G748-G760. Epub 2020 Oct 21.

Department of Physiology and Biophysics, Commonwealth University School of Medicine, Richmond, Virginia.

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), historically considered as regional gastrointestinal disorders with heightened colonic sensitivity, are increasingly recognized to have concurrent dysfunction of other visceral and somatic organs, such as urinary bladder hyperactivity, leg pain, and skin hypersensitivity. The interorgan sensory cross talk is, at large, termed "cross-organ sensitization." These organs, anatomically distant from one another, physiologically interlock through projecting their sensory information into dorsal root ganglia (DRG) and then the spinal cord for integrative processing. Read More

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December 2020

Lacking transient receptor potential melastatin 2 attenuates lipopolysaccharide-induced bladder inflammation and its associated hypersensitivity in mice.

Int J Urol 2021 Jan 7;28(1):107-114. Epub 2020 Oct 7.

Department of Continence Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Objective: To study the role of transient receptor potential melastatin 2 in bladder function and inflammation-associated hypersensitivity.

Methods: We evaluated physiological function of the bladder and intravesical lipopolysaccharide-induced inflammatory nociceptive responses in female wild-type and transient receptor potential melastatin 2-knockout mice. In vivo frequency/volume and decerebrated unanesthetized cystometry measurements, as well as in vitro detrusor strip functional studies, were carried out to evaluate bladder function. Read More

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January 2021

Disseminated Bacillus Calmette-Guérin (BCG) infection and acute exacerbation of interstitial pneumonitis: an autopsy case report and literature review.

BMC Infect Dis 2020 Sep 29;20(1):708. Epub 2020 Sep 29.

Department of Neurology, Nitobe Memorial Nakano General Hospital, 4-59-16 Chuo Nakano-ku, Tokyo, 164-8607, Japan.

Background: Intravesical administration of Bacillus Calmette-Guérin (BCG) has proven useful for treatment and prevention of recurrence of superficial bladder cancer and in situ carcinoma. However, fatal side effects such as disseminated infections may occur. Early diagnosis and accurate therapy for interstitial pneumonitis (IP) are important because exacerbation of IP triggered by infections is the major cause of death. Read More

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September 2020

[Interstitial cystitis/bladder pain syndrome (IC/BPS)].

Urologe A 2020 Sep;59(9):1123-1134

Klinik für Urologie, Andrologie und Kinderurologie, Interdisziplinäres Kontinenz- und Beckenbodenzentrum Weiden, Zentrum für Interstitielle Zystitis (IC) und Beckenschmerz, Klinikum Weiden/Kliniken Nordoberpfalz AG, Söllnerstraße 16, 92637, Weiden, Deutschland.

As an orphan disease interstitial cystitis/bladder pain syndrome (IC/BPS) is a frequently underdiagnosed and inadequately treated disease of the urinary bladder, often after years of symptoms. Caused by an unknown etiology, a high variability of symptoms, a lack of biomarkers and a gradual onset, IC/BPS is a diagnosis by exclusion and poses a special challenge to doctors and patients. In addition to conventional and complementary medical treatment, oral medication, intravesical and transurethral procedures are available as treatment options. Read More

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September 2020