39 results match your criteria hyperpyrexia anemia

Prevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan.

PLoS Negl Trop Dis 2021 May 3;15(5):e0009371. Epub 2021 May 3.

Department of Bioscience and Biotechnology, The University of Suwon, Hwaseong City, Gyeonggi-do, Republic of Korea.

Background: Malaria, disproportionately affects poor people more than any other disease of public health concern in developing countries. In resource-constrained environments, monitoring the occurrence of malaria is essential for the success of national malaria control programs. Militancy and military conflicts have been a major challenge in monitoring the incidence and controlling malaria and other emerging infectious diseases. Read More

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Aplastic anemia associated with Crohn's disease: a tertiary center retrospective study.

Ann Hematol 2019 Sep 29;98(9):2053-2061. Epub 2019 Jun 29.

State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China.

Aplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn's disease (CD). We aim to determine the portraits of patients with AA-CD. Read More

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September 2019

Delirium as a complication of the surgical intensive care.

Neuropsychiatr Dis Treat 2016 22;12:2425-2434. Epub 2016 Sep 22.

Department of Psychiatry, Faculty of Medicine and Dentistry, University Hospital Olomouc, Palacky University Olomouc, Czech Republic.

Background: The aim of this study was to examine the impact of somatic illnesses, electrolyte imbalance, red blood cell count, hypotension, and antipsychotic and opioid treatment on the duration of delirium in Central Intensive Care Unit for Surgery.

Patients And Methods: Patients who were admitted to the Department of Central Intensive Care Unit for Surgery in the University Hospital Olomouc from February 2004 to November 2008 were evaluated using Riker sedation-agitation scale. Their blood pressure, heart rate, respiratory rate, and peripheral blood oxygen saturation were measured continually, and body temperature was monitored once in an hour. Read More

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September 2016

Complicated malaria symptoms associated with Plasmodium vivax among patients visiting health facilities in Mendi town, Northwest Ethiopia.

BMC Infect Dis 2016 08 22;16(1):436. Epub 2016 Aug 22.

Department of Biology, College of Natural Sciences, Jimma University, Jimma, Ethiopia.

Background: Malaria is still a major health problem in some parts of the world. Plasmodium falciparum is the common pathogenic parasite and is responsible for majority of malaria associated deaths. Recently the other benign parasite, P. Read More

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The Effect of Intestinal Parasitic Infection on the Clinical Outcome of Malaria in Coinfected Children in Cameroon.

PLoS Negl Trop Dis 2016 Apr 29;10(4):e0004673. Epub 2016 Apr 29.

Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Background: The interaction between intestinal parasites and malaria is still not clear. Data in published literature are conflicting. We studied the effect of intestinal parasitic infection (IPI) on the clinical outcome of malaria in coinfected children. Read More

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Epidemiology and Clinical Burden of Malaria in the War-Torn Area, Orakzai Agency in Pakistan.

PLoS Negl Trop Dis 2016 Jan 25;10(1):e0004399. Epub 2016 Jan 25.

National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.

Background: Military conflict has been a major challenge in the detection and control of emerging infectious diseases such as malaria. It poses issues associated with enhancing emergence and transmission of infectious diseases by destroying infrastructure and collapsing healthcare systems. The Orakzai agency in Pakistan has witnessed a series of intense violence and destruction. Read More

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January 2016

Incidence of Severe Malaria Syndromes and Status of Immune Responses among Khat Chewer Malaria Patients in Ethiopia.

PLoS One 2015 14;10(7):e0131212. Epub 2015 Jul 14.

Department of Environmental Health Sciences and Technology, College of Health Sciences, Jimma University, Jimma, Ethiopia.

Although more emphasis has been given to the genetic and environmental factors that determine host vulnerability to malaria, other factors that might have a crucial role in burdening the disease have not been evaluated yet. Therefore, this study was designed to assess the effect of khat chewing on the incidence of severe malaria syndromes and immune responses during malaria infection in an area where the two problems co-exist. Clinical, physical, demographic, hematological, biochemical and immunological data were collected from Plasmodium falciparum mono-infected malaria patients (age ≥ 10 years) seeking medication in Halaba Kulito and Jimma Health Centers. Read More

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Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos.

Genes Environ 2015 16;37. Epub 2015 Jun 16.

Biochemistry and Nutrition Division, Nigerian Institute of Medical Research, 6 Edmund Crescent, Yaba. PMB. 2013, Lagos, Nigeria.

Introduction: This study determined the association of TLR4 Asp299Gly and Thr399Ile with uncomplicated and severe malaria among Nigerian children of similar ethnic background in Lagos. The association of these SNPs with high parasite density, malnutrition, hyperpyrexia and anaemia was also investigated.

Methods: Genomic DNA of the study participants was screened for the genotypes of TLR4 Asp299Gly and Thr399Ile by PCR-RFLP. Read More

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Prediction of outcome of severe falciparum malaria in Koraput, Odisha, India: A hospital-based study.

Trop Parasitol 2014 Jul;4(2):105-10

Unit of Clinical Epidemiology and Chemotherapy, Vector Control Research Centre (Indian Council of Medical Research), Medical Complex, Indira Nagar, Puducherry, India.

Background And Objectives: Infection with Plasmodium falciparum, caused 627,000 deaths in 2012 in the world. P. falciparum infection causes myriads of clinical manifestations. Read More

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Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study.

Malar J 2014 Jun 16;13:236. Epub 2014 Jun 16.

Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.

Background: Plasmodium falciparum malaria is one of the most widespread and deadliest infectious diseases in children under five years in endemic areas. The disease has been a strong force for evolutionary selection in the human genome, and uncovering the critical host genetic factors that confer resistance to the disease would provide clues to the molecular basis of protective immunity and improve vaccine development initiatives.

Methods: The effect of single nucleotide polymorphisms (SNPs) and plasma transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) levels on malaria pathology was investigated in a case-control study of 1862 individuals from two major ethnic groups in three regions with intense perennial P. Read More

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Clinical profile of severe malaria: study from a tertiary care center in north India.

J Parasit Dis 2014 Mar 21;38(1):11-5. Epub 2012 Nov 21.

Subharti Institute of Medical Sciences, Meerut, Uttar Pradesh India.

One hundred and sixty patients having clinical features of severe malaria reported during monsoon season-August-October 2010 at this tertiary care center of north India. Of these 110 (68.75 %) had Plasmodium vivax infection, 30 (18. Read More

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Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy.

Reumatismo 2013 Dec 18;65(5):253-5. Epub 2013 Dec 18.

Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova.

A 57-year old woman with a history of multiple sclerosis, treated with interferon beta-1a in the last 5 months, was referred for hyperpyrexia (>40°C) that persisted for 15 days. At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1. Read More

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December 2013

Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.

PLoS One 2013 27;8(11):e81071. Epub 2013 Nov 27.

Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.

P. falciparum malaria is one of the most widespread and deadliest infectious diseases in children under five years in endemic areas. The disease has been a strong force for evolutionary selection in the human genome, and uncovering the critical human genetic factors that confer resistance to the disease would provide clues to the molecular basis of protective immunity that would be invaluable for vaccine development. Read More

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September 2014

Safety profile of antiviral medications: a pharmacovigilance study using the Italian spontaneous-reporting database.

Am J Health Syst Pharm 2013 Jun;70(12):1039-46

Department of Neuroscience, Psychology, Drug Research and Child Health, Interuniversity Center of Molecular Medicine and Applied Biophysics (CIMMBA), University of Florence, Florence, Italy.

Purpose: The results of an analysis of suspected antiviral-associated adverse drug reactions (ADRs) in Italy over a 22-year period are presented.

Methods: A case/non-case analysis was conducted using ADR reports compiled in the nationwide spontaneous-reporting database through September 2010. All reported events included in the analysis were evaluated and coded by drug safety experts; causality assessments were performed according to the algorithm of Naranjo et al. Read More

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A primary pulmonary glomus tumor complicated with hyperpyrexia and anemia.

Ann Thorac Surg 2013 Feb;95(2):e29-31

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, PR China.

Pulmonary glomus tumors are extremely rare, with only 19 cases having been reported worldwide. The glomus body is considered to be related to the regulation of body temperature, but the reported cases were not associated with hyperpyrexia. Here, we describe a 28-year-old man with hyperpyrexia and anemia complicated with a coin lesion of the right lung. Read More

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February 2013

Amelanocytic anhidrotic alopecia areata-like phenotype after allogeneic hematopoietic cell transplant.

Arch Dermatol 2012 Aug;148(8):931-4

Section of Dermatology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

Background: Diffuse alopecia areata or canities subita is a rare variant of alopecia in which hair loss is associated with regrowth of white hairs and possible lightening of the skin. Preferential loss of pigmented hair in this disorder may be related to the melanin pigment system and/or melanocytes. Acquired generalized anhidrosis can be associated with autoimmune disease, cancer, graft-vs-host disease, or medications or can be idiopathic. Read More

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Infections from CVC in the pediatric neoplastic patient. Single institution experience.

Minerva Pediatr 2012 Aug;64(4):385-94

Service of Pediatric Oncology, Department of Pediatrics, Second University of the Studies in Naples, Naples, Italy.

Aim: The present clinical study was carried out in order to evaluate in a perspective way the incidence of the infections caused by CVC, the micro-organisms mostly involved in the infectious process, the condition of aplasia in patients when blood cultures show positiveness and the incidence of removals expressed as number of performed removals/number of positive blood culture.

Methods: Between January 2003 and December 2009 452 blood cultures from CVC were carried out on 120 patients affected by acute lymphoblastyic and myelougenous leukemia (38), Hodgkin and non-Hodgkin lymphoma (17) and solid tumors (65), with an average of 65 blood cultures per year showing an average positiveness of 21 cases/year. The blood cultures were performed, in hyperpyrexia, when there was a clinical suspicion of infection from CVC. Read More

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Severe and uncomplicated falciparum malaria in children from three regions and three ethnic groups in Cameroon: prospective study.

Malar J 2012 Jun 24;11:215. Epub 2012 Jun 24.

Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon.

Background: To identify the factors that account for differences in clinical outcomes of malaria as well as its relationship with ethnicity, transmission intensity and parasite density.

Methods: A prospective study was conducted in nine health facilities in the Centre, Littoral and South West regions of Cameroon, and in three ethnic groups; the Bantu, Semi-Bantu and Foulbe. Children aged one month to 13 years, with diagnosis suggestive of malaria, were recruited and characterized using the WHO definition for severe and uncomplicated malaria. Read More

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Oxidative stress in children with severe malaria.

J Trop Pediatr 2012 Apr 20;58(2):147-50. Epub 2011 May 20.

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.

Fifty cases of severe malaria were studied for their oxidant and antioxidant status. Severe anemia (54%) was the most common presentation followed by hyperpyrexia, cerebral malaria and jaundice. Plasma malondialdehyde, protein carbonyl, nitrite, ascorbic acid and copper levels were significantly raised in cases as compared with controls (p < 0. Read More

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Autoimmune hemolytic anemia following MF59-adjuvanted influenza vaccine administration: a report of two cases.

Ann Pharmacother 2011 Jan 28;45(1):e8. Epub 2010 Dec 28.

Tuscan Regional Centre of Pharmacovigilance, Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, School of Medicine and Surgery, Pisa, Italy.

Objective: To describe 2 cases of autoimmune hemolytic anemia (AIHA) following the administration of MF59-adjuvanted influenza vaccine.

Case Summary: An 83-year-old white woman developed persistent hyperpyrexia, polyarthralgia, and lower limb hypostenia about 2 days after receiving influenza vaccine. Clinical signs and laboratory evaluations suggested AIHA. Read More

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January 2011

Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon.

Pak J Biol Sci 2008 Oct;11(20):2401-6

Department of Biochemistry, Faculty of Science, University of Douala, Cameroon.

This study carried out from January to June 2007, was undertaken to describe the clinical presentation of childhood malaria in Douala, a meso-endemic area as far as malaria transmission is concerned. One hundred and seventy eight children were enrolled after informed consent of their parents. The sample characteristics were recorded and clinical as well as preliminary laboratory investigations were performed. Read More

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October 2008

Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana.

Malar J 2007 Jul 27;6:96. Epub 2007 Jul 27.

Navrongo Health Research Centre, Navrongo, Ghana.

Study Design: Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6-59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition for severe malaria.

Results: Of the total children screened, 45. Read More

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Cerebral malaria.

R K Garg

J Assoc Physicians India 2000 Oct;48(10):1004-13

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India.

Cerebral malaria is a rapidly progressive potentially fatal complication of Plasmodium falciparum infection. It is characterized by unarousable and persistent coma along with symmetrical motor signs. Children, pregnant women and non-immune adults are more susceptible to have cerebral malaria. Read More

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October 2000

[Severe and complicated malaria. Report of six cases].

Rev Clin Esp 1998 Aug;198(8):509-13

Unidad de Medicina Intensiva, Hospital La Fe, Valencia.

Six patients with severe and complicated falciparum malaria (6.7 +/- 2.7 WHO criteria) were admitted to our Intensive Care Unit. Read More

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Hypoglycaemia: a major biochemical complication in eclampsia- its risk factors and prognostic value.

J Obstet Gynaecol 1997 Nov;17(6):535-9

University of Maiduguri Teaching Hospital, Nigeria.

In this two year prospective study, random blood glucose levels were determined in 52 eclamptic patients and 38 controls, at the University of Maiduguri Teaching Hospital and Specialist Hospitals in Maiduguri, Nigeria. Eclamptic mothers had lower glucose levels (mean value = 3.5 mmol/l) than controls (mean value = 6. Read More

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November 1997

Is there increased fertility in adult males with the sickle cell trait?

U O Ezeh O Modebe

Hum Biol 1996 Aug;68(4):555-62

Department of Obstetrics and Gynecology, Jessop Hospital for Women, Sheffield, England.

Different proposals have been offered to explain the polymorphism of the sickle cell hemoglobin gene. One of these proposals (Eaton and Mucha 1971) suggested that differential fertility of male subjects with the sickle cell trait contributes to the persistence and stability of the sickle cell gene frequency. Eaton and Mucha claimed that oligospermia, induced by hyperpyrexia, is a less common problem in these subjects because they probably have milder and shorter episodes of fever from malaria infection than subjects with a normal genotype. Read More

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Emergency department presentation and misdiagnosis of imported falciparum malaria.

Ann Emerg Med 1996 Jun;27(6):696-9

Department of Emergency Medicine, Olive View-UCLA Medical Center, Sylmar, USA.

Study Objective: To review the travel history, clinical presentation, laboratory findings, diagnostic accuracy, management, and outcome of the largest reported series of emergency department patients with imported falciparum malaria in the United States.

Methods: This is a retrospective case series at large, inner-city medical center in Los Angeles. Twenty cases of falciparum malaria with initial medical evaluation in the ED were identified from the period 1979 through 1993. Read More

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[Multiple organ failure in Plasmodium falciparum malaria].

Rev Clin Esp 1995 Oct;195(10):688-92

Unidad de Medicina Intensiva, Hospital La Fe, Valencia.

A 44-year-old Spanish woman travelled in Kenya without doing correct malarial prophylaxis. Upon her return to Spain, she suffered from Plasmodium falciparum malaria. She was initially treated with chloroquine for three days, but her state worsened and she was admitted to our intensive care unit. Read More

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October 1995

Complications of seasonal adult malaria at a central hospital.

S K Lutalo C Mabuwa

Cent Afr J Med 1990 Nov;36(11):268-73

Division of Medicine, Harare Central Hospital, Southerton, Zimbabwe.

Recently introduced chloroquine resistant malaria has altered the clinical picture and complicated the overall management of malaria. 113 adults with proved malaria admitted at Harare Central Hospital, Zimbabwe, were evaluated to determine the incidence, nature, relationship to morbidity and mortality and response to treatment of the complications due to malaria. 47. Read More

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November 1990