17,567 results match your criteria hyperplasia observed

Molecular Docking and Dynamic Studies of a Potential Therapeutic Target Inhibiting Glyoxalase System: metabolic action of the 3, 3 '- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model.

Chem Biol Interact 2021 May 11:109511. Epub 2021 May 11.

QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Methylglyoxal is a dicarbonyl compound recruited as a potential cytotoxic marker, initially presents in cells and considered as a metabolite of the glycolytic pathway. Our aim is to demonstrate the inhibitory effect of 3, 3'-[3-(5-chloro-2-hydroxyphenyl)-3-oxopropane-1, 1-diyl] Bis (4-hydroxycoumarin) on the glyoxalase system, and indirectly its anticancer activity. The docking of OT-55 was conducted by using Flexible docking protocol, ChiFlex and libdock tools inside the active site of Glo-I indicated that both hydrogen bonding and hydrophobic interactions contributed significantly in establishing potent binding with the active site which is selected as a strong inhibitor with high scoring values and maximum Gibbs free energy. Read More

View Article and Full-Text PDF

Lethal infection caused by Tetratrichomonas gallinarum in black swans (Cygnus atratus).

BMC Vet Res 2021 May 13;17(1):191. Epub 2021 May 13.

National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, 1-5 Beichenxilu, Chaoyang District, Beijing, 100101, PR China.

Background: Tetratrichomonas gallinarum is parasitic protozoa with a wide host range. However, its lethal infection is rare reported.

Case Presentation: Here, we described the first lethal cases of T. Read More

View Article and Full-Text PDF

Antioxidants resveratrol and SkQ1 attenuate praziquantel adverse effects on the liver in Opisthorchis felineus infected hamsters.

Acta Trop 2021 May 9:105954. Epub 2021 May 9.

Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Lavrentiev Ave., Novosibirsk 630090, Russia; Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia; Institute of Molecular Biology and Biophysics, 2/12, Timakov Str., Novosibirsk, 630117, Russia. Electronic address:

Anthelmintic praziquantel (PZQ) is the drug of the choice for opisthorchiasis, schistosomiasis and other trematodiases therapy for several decades. Despite its good therapeutic performance and effective control of trematode infections, PZQ has some shortcomings; its inability to counteract disease sequelae necessitates novel therapeutic strategies. Testing of antioxidants that have proven themselves in clinical practice, in combination with this anthelmintic drug, offers new opportunities for developing alternatives to PZQ monotherapy. Read More

View Article and Full-Text PDF

Aggravation of airway inflammation in RSV-infected asthmatic mice following infection-induced alteration of gut microbiota.

Ann Palliat Med 2021 May 10. Epub 2021 May 10.

Department of Traditional Chinese Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study aimed to confirm the relationship between asthma, respiratory syncytial virus (RSV) infection, and the gut environment by analyzing the alterations in the gut microbiota of RSV-infected asthmatic mice.

Methods: Twenty-four male BALB/c mice were randomly separated into a control group (CON), ovalbumin (OVA) group, and an OVA + RSV group, (n=8 mice/group). At the end of experiments, we evaluated the RSV-infected asthma model using Wright-Giemsa staining, histopathology and immunoglobulin E (IgE) level using enzyme-linked immunosorbent assays (ELISA). Read More

View Article and Full-Text PDF

Bone marrow adiposity in premenopausal women with type 2 diabetes with observations on peri-trabecular adipocytes.

J Clin Endocrinol Metab 2021 May 11. Epub 2021 May 11.

Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil.

Context: No study has evaluated the relationships among of bone marrow adiposity(BMA), bone histomorphometry(BH) and glycemic control in premenopausal women with type 2 diabetes(T2DM).

Objectives: Assess the effect of glycemic control on BMA;correlate the parameters of BH with BMA and correlate BMA with the use of hypoglycemic agents and with BMD.

Design, Settings And Patients: This was a cross-sectional study that evaluated 26 premenopausal women with T2DM were divided into groups with HbA1c<7% (GC,n=10) and HbA1c>7% (PC,n=16). Read More

View Article and Full-Text PDF

Architecture-Dependent Mechano-Adaptation in Single Vascular Smooth Muscle Cells.

J Biomech Eng 2021 May 11. Epub 2021 May 11.

University of Minnesota - Department of Biomedical Engineering, Nils Hasselmo Hall, Room 7-105, 312 Church St. SE, Minneapolis, MN 55455.

Arteries grow and remodel following mechanical perturbation. Vascular smooth muscle cells (VSMCs) within the artery undergo hyperplasia, hypertrophy, or change their contractility following sustained changes in loading. Experimental evidence suggests that VSMCs grow and remodel to maintain a constant transmural stress, or "target" stress. Read More

View Article and Full-Text PDF

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging.

Front Oncol 2021 22;11:669066. Epub 2021 Apr 22.

Department of Biological Sciences, School of Dental Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

An increased accumulation of immune-dysfunction-associated CD4Foxp3 regulatory T cells (T) is observed in aging oral mucosa during infection. Here we studied the function of T during oral cancer development in aging mucosa. First, we found heightened proportions of T and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Read More

View Article and Full-Text PDF

Prognostic relevance and putative histogenetic role of cytokeratin 7 and MUC5AC expression in Crohn's disease-associated small bowel carcinoma.

Virchows Arch 2021 May 8. Epub 2021 May 8.

Unit of Anatomic Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Via Carlo Forlanini 16 -, 27100, Pavia, Italy.

Most Crohn's disease-associated small bowel carcinomas (CrD-SBCs) are diagnosed in advanced stage and have poor prognosis. To improve diagnosis and therapy, a better knowledge of tumour precancerous lesions, histotypes and prognostic factors is needed. We investigated histologically and immunohistochemically 52 CrD-SBCs and 51 small bowel carcinomas unrelated to inflammatory disease, together with their tumour-associated mucosa, looking for Crohn-selective changes. Read More

View Article and Full-Text PDF

Myomixer is expressed during embryonic and post-larval hyperplasia, muscle regeneration and differentiation of myoblats in rainbow trout (Oncorhynchus mykiss).

Gene 2021 May 4:145688. Epub 2021 May 4.

INRAE, UR1037 Laboratory of Fish Physiology and Genomics, 35000 Rennes, France. Electronic address:

In contrast to mice or zebrafish, trout exhibits post-larval muscle growth through hypertrophy and formation of new myofibers (hyperplasia). The muscle fibers are formed by the fusion of mononucleated cells (myoblasts) regulated by several muscle-specific proteins such as Myomaker or Myomixer. In this work, we identified a unique gene encoding a Myomixer protein of 77 amino acids (aa) in the trout genome. Read More

View Article and Full-Text PDF

Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial.

Epilepsia 2021 May 5. Epub 2021 May 5.

Department of Neuropathology, Institute of Neurology, University College London, London, UK.

Objective: Focal cortical dysplasia (FCD) is a major cause of difficult-to-treat epilepsy in children and young adults, and the diagnosis is currently based on microscopic review of surgical brain tissue using the International League Against Epilepsy classification scheme of 2011. We developed an iterative histopathological agreement trial with genetic testing to identify areas of diagnostic challenges in this widely used classification scheme.

Methods: Four web-based digital pathology trials were completed by 20 neuropathologists from 15 countries using a consecutive series of 196 surgical tissue blocks obtained from 22 epilepsy patients at a single center. Read More

View Article and Full-Text PDF

Inhomogeneity of stiffness and density of the extracellular matrix within the leukoplakia of human oral mucosa as potential physicochemical factors leading to carcinogenesis.

Transl Oncol 2021 May 1;14(7):101105. Epub 2021 May 1.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland; Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University in Kielce, PL-25317 Kielce, Poland. Electronic address:

Oral leukoplakia is a clinical term relating to various morphological lesions, including squamous cell hyperplasia, dysplasia and carcinoma. Leukoplakia morphologically manifested as hyperplasia with epithelial dysplasia is clinically treated as precancerous condition. Nevertheless, there is a lack of good markers indicating the transformation of premalignancies towards cancer. Read More

View Article and Full-Text PDF

Changes in prolactin receptor location in prostate tumors.

Arch Esp Urol 2021 May;74(4):419-426

Instituto de Medicina y Biología Experimental de Cuyo (IMBECU). Centro Científico y Tecnológico Mendoza. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Mendoza. Argentina.

Introduction: Prolactin (PRL) binds its receptor (PRLR) and stimulates cell proliferation, differentiation and survival in prostate cancer (PCa) cell lines via STAT5a, MAPK and AKT.

Objective: To evaluate the expression of PRL and PRLR in normal and tumor prostate tissues with different Gleason patterns.

Methods: Samples of normal, benign prostatic hyperplasia and PCa with different Gleason patterns were selected from radical prostatectomy. Read More

View Article and Full-Text PDF

Surgical resection of extremely rare primary giant splenic angiomyolipoma: a case report.

Surg Case Rep 2021 May 3;7(1):110. Epub 2021 May 3.

Department of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi, 981-8563, Japan.

Background: Angiomyolipoma is a benign mesenchymal tumor that develops commonly in the kidney and rarely in other organs. The involvement of the spleen in angiomyolipoma is extremely rare, and only one such case has been reported in the English literature.

Case Presentation: A 27-year-old man presented with adenoid hyperplasia and bilateral palatal tonsillar hyperplasia. Read More

View Article and Full-Text PDF

Comprehensive mutational analysis of background mucosa in patients with Lugol-voiding lesions.

Cancer Med 2021 May 2. Epub 2021 May 2.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Somatic mutations including the background mucosa in patients with Lugol-voiding lesions (LVLs) are still not well known. The aim of this study was to evaluate the somatic mutations of the background mucosa in patients with LVLs (Squamous cell carcinoma (SCC), intraepithelial neoplasia (IN), and hyperplasia). Twenty-five patients with LVLs (9 with SCC, 6 with IN, and 10 with hyperplasia) were included. Read More

View Article and Full-Text PDF

Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13.

Pharmacol Res Perspect 2021 May;9(3):e00770

Discovery Immunology, Janssen Research & Development, LLC, Spring House, PA, USA.

We conducted a systematic evaluation of lung inflammation indued by repeated intranasal exposure (for 10 consecutive days) to a human aeroallergen, house dust mite (HDM) in BALB/c mice. Peak influx of neutrophils, monocytes/lymphocytes, and eosinophils was observed in bronchoalveolar lavage (BAL) on days 1, 7 and 11, respectively, and normalized to baseline by day 21. Peak elevations of Th2, myeloid-derived cytokines/chemokines and serum IgE were seen both in BAL and lung tissue homogenates between days 7 and 11, and declined thereafter; however, IL-33 levels remained elevated from day 7 to day 21. Read More

View Article and Full-Text PDF

Age-Related Changes in Zinc, Copper and Selenium Levels in the Human Prostate.

Nutrients 2021 Apr 21;13(5). Epub 2021 Apr 21.

Department of Toxicology, Medical University of Lodz, 90-151 Lodz, Poland.

Pathophysiological changes in the prostate gland-benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma (PCa)-are closely related to the age of men. In the prostate gland, zinc is of particular importance for its proper functioning, especially with regard to the effects of hormonal disorders. The aim of this study was to evaluate zinc, copper and selenium concentrations in different parts of the prostate gland in relation to age and the nature of pathological changes. Read More

View Article and Full-Text PDF

SARS-CoV-2 and Placenta: New Insights and Perspectives.

Viruses 2021 04 21;13(5). Epub 2021 Apr 21.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.

The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal-placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. Read More

View Article and Full-Text PDF

Immune Cells and Immunoglobulin Expression in the Mammary Gland Tumors of Dog.

Animals (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.

Inflammatory cells have a role in tumor progression and have prognostic and therapeutic potential. The immunohistochemical expression for Mast Cell Tryptase, Macrophage Marker, CD79a, IgA, IgM and IgG on 43 cases of canine mammary gland lesions was analyzed. In hyperplasia, a few B cells (BCs) and Tumor-Associated Macrophages (TAMs) were observed, while the number of Tumor-Associated Mast Cells (TAMCs) was the highest. Read More

View Article and Full-Text PDF

Investigation of the Initial Host Response of Naïve Atlantic Salmon () Inoculated with .

Microorganisms 2021 Apr 2;9(4). Epub 2021 Apr 2.

Marine and Freshwater Research Centre, Galway Mayo Institute of Technology, Dublin Road, H91 TRNW Galway, Ireland.

Amoebic Gill Disease (AGD), caused by the ectoparasite is characterised by hyperplasia of the gill epithelium and lamellar fusion. In this study, the initial host response of naïve Atlantic salmon () inoculated with was investigated. Using gel-free proteomic techniques and mass spectrometry gill and serum samples were analysed at 7 timepoints (2, 3, 4, 7, 9, 11 and 14 days) post-inoculation with . Read More

View Article and Full-Text PDF

Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation.

Biology (Basel) 2021 Apr 6;10(4). Epub 2021 Apr 6.

Department of Sociology, Social Work and Public Health, Faculty of Labour Sciences, University of Huelva, 21007 Huelva, Spain.

The use of a loop ileostomy as the defunctioning procedure of choice to protect a distal colonic anastomosis causes histological and endoscopic changes in the intestinal mucosal architecture, which have been related to chronic inflammation and changes in the microflora that consequently impact the intestinal structure and function following fecal stream diversion. The aim of this study was to evaluate the histological and endoscopic changes on the colonic mucosa in patients with diversion colitis after stimulation of the efferent loop with probiotics prior to closure of the protective ileostomy. A prospective, randomized, double-blind, controlled study was designed. Read More

View Article and Full-Text PDF

Scanning Electron Microscopic Findings on Respiratory Organs of Some Naturally Infected Dromedary Camels with the Lineage-B of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Saudi Arabia-2018.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

The currently known animal reservoir for MERS-CoV is the dromedary camel. The clinical pattern of the MERS-CoV field infection in dromedary camels is not yet fully studied well. Some pathological changes and the detection of the MERS-CoV antigens by immunohistochemistry have been recently reported. Read More

View Article and Full-Text PDF

Risk of Breast Cancer in Selected Women with Atypical Ductal Hyperplasia Who do not Undergo Surgical Excision.

Ann Surg 2021 Mar 4. Epub 2021 Mar 4.

*Department of Clinical Cancer Prevention, University of Texas, MD Anderson Cancer Center, Houston, TX †Radiology, Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX ‡Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX.

Objective: To review breast cancer incidence in women with atypical ductal hyperplasia (ADH) diagnosed by core needle biopsy (CNB) and managed non-operatively.

Background: ADH found on CNB is associated with an upgrade to carcinoma in 10-50% of women, thus surgical excision remains the standard of care. Safety of non-operative management is unknown. Read More

View Article and Full-Text PDF

Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions.

Sci Adv 2021 Apr 28;7(18). Epub 2021 Apr 28.

Institute of Women's Life Medical Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. Read More

View Article and Full-Text PDF

Topical formulations containing Dwyer oleoresin improve cutaneous wound healing.

Avicenna J Phytomed 2021 Mar-Apr;11(2):120-133

Department of Sciences, Universidade de Franca, Franca (SP), Brazil.

Objective: Evaluation of the healing and toxicological effects of Dwyer oleoresin (CDO).

Materials And Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days.

Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Read More

View Article and Full-Text PDF

Common Femoral Artery Stenting: Computed Tomography Angiography Based Long-Term Patency.

Vasc Endovascular Surg 2021 Apr 28:15385744211010447. Epub 2021 Apr 28.

Department of Endovascular Therapy, 37533Hospiten Hospital Group, Santa Cruz de Tenerife, Canary Island, Spain.

Background: Despite considerable morbid-mortality rates, common femoral endarterectomy is still considered the gold standard for atherosclerotic common femoral artery (CFA) disease. The aim of this study was to demonstrate computed tomography angiography based long-term patency after CFA stent placement and to analyze associated risk factors for restenosis.

Methods: A retrospective and observational study was carried out in consecutive patients treated with endovascular stent placement in CFA lesions. Read More

View Article and Full-Text PDF

Perioperative and Postoperative Outcomes of Robot-Assisted Radical Prostatectomy in Prostate Cancer Patients with Prior Transurethral Subvesical Deobstruction: Results of a High-Volume Center.

J Urol 2021 Apr 27:101097JU0000000000001776. Epub 2021 Apr 27.

Prostate Center Northwest, Department of Urology, Pediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Purpose: Prostate cancer patients who are scheduled for robot-assisted radical prostatectomy often have a history of transurethral resection or laser enucleation of the prostate as treatment of benign prostatic hyperplasia. We examined if these patients have impaired surgical, functional and oncologic outcomes compared to those who have no symptom burden of moderate to severe benign prostatic hyperplasia and no previous transurethral resection or laser enucleation of the prostate.

Materials And Methods: We compared 368 robot-assisted radical prostatectomy patients with previous transurethral resection or laser enucleation of the prostate (group A) to 4,945 robot-assisted radical prostatectomy patients without transurethral resection or laser enucleation of the prostate and without moderate or severe benign prostatic hyperplasia symptoms (group B) at a high-volume robot-assisted radical prostatectomy center. Read More

View Article and Full-Text PDF

Morphological changes in bitches endometrium affected by cystic endometrial hyperplasia - pyometra complex - the value of histopathological examination.

BMC Vet Res 2021 Apr 26;17(1):174. Epub 2021 Apr 26.

Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Toruń, Poland.

Background: Cystic endometrial hyperplasia-pyometra complex (CEH-P) is one of the most common uteropathies in bitches. In diseases with mild or obscure clinical signs and normal uterine size, a diagnosis based on a clinical assessment might be incorrect. The main aim of the research was to determine the morphological variables accompanying uterine diseases in bitches in microscopic evaluation. Read More

View Article and Full-Text PDF

Generalized Multinucleate Cell Angiohistiocytoma: Histopathological and Immunohistochemical Analyses of 10 Lesions.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA; and Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

Abstract: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon fibrohistiocytic disorder that usually presents as a localized solitary papule or multiple grouped papules. Generalized presentation is very rare with less than 20 cases reported in the literature. In this article, we present histopathological and immunohistochemical studies of 10 lesions from a patient with generalized MCAH. Read More

View Article and Full-Text PDF

Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra.

Acta Vet Hung 2021 Apr 22. Epub 2021 Apr 22.

1Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ondokuz Mayis,Samsun, Turkey.

The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)-pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. Read More

View Article and Full-Text PDF

Pro-angiogenic effect of exosomal microRNA-103a in mice with rheumatoid arthritis via the downregulation of hepatocyte nuclear factor 4 alpha and activation of the JAK/STAT3 signaling pathway.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2):629-640

Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, P.R. China.

Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane, accompanied by hyperplasia and neo-angiogenesis, which promote local inflammation. Macrophage-derived exosomes have been reported to enhance inflammation and the immune response. In the present study, we identified a novel exosomal microRNA (miR)-103a, which aids in the regulation of inflammation and angiogenesis in mice with RA, and attempted to identify the underlying mechanism. Read More

View Article and Full-Text PDF