61 results match your criteria hyperperfused areas

Hypoxia and perfusion in breast cancer: simultaneous assessment using PET/MR imaging.

Eur Radiol 2021 Jan 28;31(1):333-344. Epub 2020 Jul 28.

Department of Radiology, School of Clinical Medicine, University of Cambridge, Box 218, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

Objectives: Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined F-fluoromisonidazole ( F-FMISO) PET/MRI, with simultaneous assessment circumventing the effect of temporal variation in hypoxia and perfusion. Read More

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January 2021

Is bone marrow edema syndrome a precursor of hip or knee osteonecrosis? Results of 49 patients and review of the literature.

Diagn Interv Radiol 2020 Jul;26(4):355-362

Department of Radiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

Purpose: Diagnosis of bone marrow edema syndrome (BMES) can be challenging. There is sometimes uncertainty about the correct diagnosis of BMES on morphologic magnetic resonance imaging (MRI), since subchondral findings like lines and spots can be misinterpreted as "beginning" or "possible" avascular osteonecrosis (AVN). The aim of our study was to systematically assess the temporal course of BMES from first diagnosis on MRI until the end of clinical symptoms and the full disappearance of bone marrow edema (BME) to determine whether subchondral lines and spots detected in these patients can develop into osteonecrosis. Read More

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A rare case of a spontaneous abscess of the corpus cavernosum: the role of contrast-enhanced ultrasound in diagnosis and post-therapeutic follow-up.

J Ultrasound 2020 May 14. Epub 2020 May 14.

Ospedale Santa Maria Delle Grazie, Asl Na2 Nord, Pozzuoli, NA, Italy.

In this paper, we describe the pattern of an idiopathic corpus cavernosum (CC) abscess using contrast-enhanced ultrasound (CEUS) and compare this to the lesion characterization achieved using preliminary baseline ultrasound/color doppler (ECD). In a 43-year-old man, who arrived at our emergency department for a penile swelling and hematopyuria, ECD examination showed equivocal mucosal and subcutaneous tissue swelling, an inhomogeneous hypoechoic area in the left CC, and a suspected millimetric interruption of the albuginea. CEUS showed multiple avascular areas wrapped in a hyperperfused rim representing abscesses and a not-perfused balanopreputial-oriented fistula. Read More

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Super-early images of brain perfusion SPECT using I-IMP for the assessment of hyperperfusion in stroke patients.

Ann Nucl Med 2018 Dec 1;32(10):695-701. Epub 2018 Sep 1.

Department of Radiology, Kitasato University Hospital, Sagamihara, Japan.

Objective: With the advancement of reperfusion therapy in stroke patients, assessment of perfusion status after therapy is gaining importance. Hyperperfusion tends to be underestimated by the conventional early imaging of I-IMP brain perfusion SPECT. We evaluated the utility of super-early imaging as an adjunct to early imaging for the assessment of postischemic hyperperfusion in stroke patients. Read More

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December 2018

Arterial Spin Labeling Cerebral Perfusion Magnetic Resonance Imaging in Migraine Aura: An Observational Study.

J Stroke Cerebrovasc Dis 2018 May 10;27(5):1262-1266. Epub 2018 Jan 10.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany; Department of Neurology, Klinikum Kempten, Kempten, Germany.

Background: Changes in cerebral perfusion during migraine with aura (MA) have been assessed mainly using dynamic susceptibility contrast (DSC) magnetic resonance perfusion imaging. A contrast agent-free method to assess these changes would be desirable. We assessed changes in cerebral perfusion during MA using arterial spin labeling (ASL) perfusion magnetic resonance imaging. Read More

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Vasa 2018 Feb 4;47(2):91-97. Epub 2018 Jan 4.

2 Poliklinik, Funktionsbereich und Hiller Forschungszentrum für Rheumatologie, Medizinische Fakultät, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Erythromelalgia is a rare syndrome characterized by the intermittent or, less commonly, by the permanent occurrence of extremely painful hyperperfused skin areas mainly located in the distal extremities. Primary erythromelalgia is nowadays considered to be a genetically determined neuropathic disorder affecting SCN9A, SCN10A, and SCN11A coding for NaV1.7, NaV1. Read More

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February 2018

Connectivity in ictal single photon emission computed tomography perfusion: a cortico-cortical evoked potential study.

Brain 2017 Jul;140(7):1872-1884

Epilepsy Center, Cleveland Clinic Foundation, Cleveland, OH, USA.

Subtraction ictal and interictal single photon emission computed tomography can demonstrate complex ictal perfusion patterns. Regions with ictal hyperperfusion are suggested to reflect seizure onset and propagation pathways. The significance of ictal hypoperfusion is not well understood. Read More

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Different Perfusion Patterns in a Patient with Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2017 May 11;26(5):e83-e84. Epub 2017 Mar 11.

Functional Unit of Cerebrovascular Diseases, Hospital Clínic, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

A 29-year-old male patient with aphasia and mild weakness of the right arm arrived at the emergency room 4 hours after symptom onset. The computed tomography perfusion showed a typical delay in the time-based maps in the left occipital lobe and another hyperperfused area in the left frontal lobe. The follow-up magnetic resonance imaging confirmed cortical ischemic lesions in both areas. Read More

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Utility of gray-matter segmentation of ictal-Interictal perfusion SPECT and interictal F-FDG-PET in medically refractory epilepsy.

Epilepsy Res 2017 02 30;130:93-100. Epub 2017 Jan 30.

Departments of Pediatrics and Neurology, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA. Electronic address:

Purpose: We present a method of gray-matter segmentation of functional neuroimaging for localization of seizure onset zone (SOZ) in epilepsy surgery. F-FDG-PET hypometabolism and ictal SPECT hyperperfusion may correspond to SOZ. We hypothesize that limiting functional images to gray matter improves identification of small, subtle, or obscure cortical volumes of F-FDG-PET hypometabolism and eliminates hyperperfused seizure propagation pathways within white matter in ictal perfusion SPECT. Read More

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February 2017

Differentiation of Glioblastoma from Brain Metastasis: Qualitative and Quantitative Analysis Using Arterial Spin Labeling MR Imaging.

PLoS One 2016 18;11(11):e0166662. Epub 2016 Nov 18.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

Purpose: To evaluate the diagnostic performance of cerebral blood flow (CBF) by using arterial spin labeling (ASL) perfusion magnetic resonance (MR) imaging to differentiate glioblastoma (GBM) from brain metastasis.

Materials And Methods: The institutional review board of our hospital approved this retrospective study. The study population consisted of 128 consecutive patients who underwent surgical resection and were diagnosed as either GBM (n = 89) or brain metastasis (n = 39). Read More

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Do perfusion and diffusion MRI predict glioblastoma relapse sites following chemoradiation?

J Neurooncol 2016 10 8;130(1):181-192. Epub 2016 Aug 8.

INSERM UMR 1214, TONIC (Toulouse NeuroImaging Centre), 31059, Toulouse, France.

To assess the value of T2* dynamic-susceptibility contrast MRI (DSC-MRI) and diffusion-weighted imaging (DWI) to predict the glioblastoma relapse sites after chemoradiation. From a cohort of 44 patients, primarily treated with radiotherapy (60 Gy) and concomitant temozolomide for glioblastoma, who were included in the reference arm of a prospective clinical trial (NCT01507506), 15 patients relapsed and their imaging data were analyzed. All patients underwent anatomical MRI, DSC-MRI and DWI before radiotherapy and every 2 months thereafter until relapse. Read More

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October 2016

[Nonconvulsive Status Epilepticus].

Brain Nerve 2016 Apr;68(4):451-62

Epilepsy Center, Department of Neurology, Nakamura Memorial Hospital.

Nonconvulsive status epilepticus (NCSE) is a type of status epilepticus (SE) lacking a predominant motor manifestation. The annual prevalence of NCSE is estimated to reach 10 to 20 cases in every 100,000 people. While almost half of all SE cases are nonconvulsive, there are several different types of NCSE: 1) epileptic absence SE, 2) epileptic focal seizure SE with consciousness disturbance (complex partial SE), 3) de novo NCSE of late onset, 4) NCSE due to acute brain injury or prolonged consciousness disturbance after convulsive SE. Read More

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OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy.

Invest Ophthalmol Vis Sci 2015 Aug;56(9):5229-37

Department of Ophthalmology Radboud University Medical Center, Nijmegen, The Netherlands.

Purpose: Abnormal choroidal blood flow is considered important in the pathogenesis of chronic central serous chorioretinopathy (CSC). Optical coherence tomography (OCT) angiography can image ocular blood cell flow and could thus provide novel insights in disease mechanisms of CSC. We evaluated depth-resolved flow in chronic CSC by OCT angiography compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA). Read More

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Patient-specific detection of cerebral blood flow alterations as assessed by arterial spin labeling in drug-resistant epileptic patients.

PLoS One 2015 6;10(5):e0123975. Epub 2015 May 6.

Clinical Neurology Unit, Department of Medical Science, Surgery and Health, University of Trieste, Trieste, Italy.

Electrophysiological and hemodynamic data can be integrated to accurately and precisely identify the generators of abnormal electrical activity in drug-resistant focal epilepsy. Arterial Spin Labeling (ASL), a magnetic resonance imaging (MRI) technique for quantitative noninvasive measurement of cerebral blood flow (CBF), can provide a direct measure of variations in cerebral perfusion associated with the epileptic focus. In this study, we aimed to confirm the ASL diagnostic value in the identification of the epileptogenic zone, as compared to electrical source imaging (ESI) results, and to apply a template-based approach to depict statistically significant CBF alterations. Read More

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February 2016

Three-tesla functional MR language mapping: comparison with direct cortical stimulation in gliomas.

Neurology 2015 Feb;84(6):560-8

Objective: To evaluate the accuracy of functional MRI (fMRI) at 3T, as currently used in the preoperative mapping of language areas, compared with direct cortical stimulation (DCS) during awake surgery, in patients with supratentorial gliomas; and to identify clinical, histopathologic,and radiologic factors associated with fMRI/DCS discrepancies.

Methods: Language mapping with fMRI and DCS of 40 consecutive patients with gliomas(24 low-grade, 16 high-grade) in functional areas were retrospectively analyzed. Three block designed tasks were performed during fMRI (letter word generation, category word generation,semantic association). Read More

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February 2015

Classification of tumor area using combined DCE and DSC MRI in patients with glioblastoma.

J Neurooncol 2015 Jan 5;121(2):349-57. Epub 2014 Nov 5.

Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizman St, 64239, Tel Aviv, Israel.

This study proposes an automatic method for identification and quantification of different tissue components: the non-enhanced infiltrative tumor, vasogenic edema and enhanced tumor areas, at the subject level, in patients with glioblastoma (GB) based on dynamic contrast enhancement (DCE) and dynamic susceptibility contrast (DSC) MRI. Nineteen MR data sets, obtained from 12 patients with GB, were included. Seven patients were scanned before and 8 weeks following bevacizumab initiation. Read More

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January 2015

Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI).

Eur Radiol 2014 Nov 6;24(11):2980-8. Epub 2014 Aug 6.

University Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland.

Objective: To investigate pathological findings in the susceptibility weighted imaging (SWI) of patients experiencing convulsive (CSE) or non-convulsive status epilepticus (NCSE) with focal hyperperfusion in the acute setting.

Methods: Twelve patients (six with NCSE confirmed by electroencephalogram (EEG) and six patients with CSE with seizure event clinically diagnosed) underwent MRI in this acute setting (mean time between onset of symptoms and MRI was 3 h 8 min), including SWI, dynamic susceptibility contrast MR imaging (DSC) and diffusion-weighted imaging (DWI). MRI sequences were retrospectively evaluated and compared with EEG findings (10/12 patients), and clinical symptoms. Read More

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November 2014

Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients.

Mitochondrion 2013 Nov 2;13(6):676-80. Epub 2013 Oct 2.

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaiduki, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan.

In stroke-like episodes (SEs) of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), the detection of preclinically latent lesions is a challenge. We report regional cerebral hyperperfusion observed on arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in the preclinical phase more than 3 months before the clinical onset of SEs in 3 MELAS patients. These hyperperfused areas were not detected by conventional MRI in the preclinical phase and developed into acute lesions at the clinical onset of SEs, suggesting that ASL imaging has the potential for predicting the emergence of SEs. Read More

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November 2013

Hyperperfusion in progressive multifocal leukoencephalopathy is associated with disease progression and absence of immune reconstitution inflammatory syndrome.

Brain 2013 Nov 1;136(Pt 11):3441-50. Epub 2013 Oct 1.

1 Division of Neurovirology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.

We sought to characterize perfusion patterns of progressive multifocal leukoencephalopathy lesions by arterial spin labelling perfusion magnetic resonance imaging and to analyse their association with immune reconstitution inflammatory syndrome, and survival. A total of 22 patients with progressive multifocal leukoencephalopathy underwent a clinical evaluation and magnetic resonance imaging of the brain within 190 days of symptom onset. The presence of immune reconstitution inflammatory syndrome was determined based on clinical and laboratory criteria. Read More

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November 2013

Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy.

Neuroimage 2014 Nov 17;102 Pt 1:49-59. Epub 2013 Jun 17.

Department of Neurological, and Movement Sciences, Section of Neurology, University of Verona, Italy; Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, Venice, Italy; Clinical Neurophysiology and Functional Neuroimaging Unit, AOUI of Verona, Verona, Italy.

When localization of the epileptic focus is uncertain, the epileptic activity generator may be more accurately identified with non-invasive imaging techniques which could also serve to guide stereo-electroencephalography (sEEG) electrode implantation. The aim of this study was to assess the diagnostic value of perfusion magnetic resonance imaging with arterial spin labeling (ASL) in the identification of the epileptogenic zone, as compared to the more invasive positron-emission tomography (PET) and other established investigation methods for source imaging of electroencephalography (EEG) data. In 6 patients with drug-resistant focal epilepsy, standard video-EEG was performed to identify clinical seizure semeiology, and high-density EEG, ASL and FDG-PET to non-invasively localize the epileptic focus. Read More

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November 2014

Clinical patterns and pathophysiology of hypermotor seizures: an ictal SPECT study.

Epileptic Disord 2012 Mar;14(1):32-40

Department of Neurosurgery, Nishi-Niigata Chuo National Hospital, Niigata, Japan.

Hypermotor seizures (HMS) can include different forms of hypermotor behaviour due to various mechanisms associated with generation of ictal automatisms. Despite the varied location of seizure onset, similar semiologic features during seizures may exist. Ictal single-photon emission tomography (SPECT) apparently reflects not only the origin of epileptic discharge but also the spread to adjacent cortical areas. Read More

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Ictogenesis and symptomatogenesis of gelastic seizures in hypothalamic hamartomas: an ictal SPECT study.

Epilepsia 2010 Nov 30;51(11):2270-9. Epub 2010 Sep 30.

Department of Functional Neurosurgery, Epilepsy Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan.

Purpose: To topographically localize the ictogenic zone within hypothalamic hamartomas (HHs) and the symptomatogenic zone for gelastic seizure (GS), we analyzed data from both interictal and ictal single photon emission computed tomography (SPECT).

Methods: Ictal SPECT was performed immediately after GS onset in 21 patients with HH (aged 2-36 years, mean 13.8 years) who underwent stereotactic radiofrequency thermocoagulation (SRT). Read More

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November 2010

Fractal features for localization of temporal lobe epileptic foci using SPECT imaging.

Comput Biol Med 2010 May 25;40(5):469-77. Epub 2010 Mar 25.

Inserm U, Parc EuraSanté, Loos, France.

Single photon emission computed tomography (SPECT) is an accurate imaging method for the diagnosis of refractory partial epilepsy. Two scans are carried out: interictal and ictal. The interest of this method is to provide an image in the ictal period, which allows hyperperfused areas linked to the seizure to be localized. Read More

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[Imaging of gliomas].

Cancer Radiother 2008 Nov 14;12(6-7):669-75. Epub 2008 Oct 14.

Service de neuroradiologie, groupe hospitalier de la Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013 Paris, France.

The imaging of gliomas, as well as diffuse infiltrative gliomas or as more recently individualized entities, has been profoundly modified these last years. Correlated with the classic morphological MRI, numerous new sequences have appeared that allowed a more metabolic approach of the tumors, such as diffusion, perfusion--related to angiogenesis--and spectroscopy--reflecting metabolic data. Their development in daily practice allows to precise the diagnostic, to definite the more active areas (correlated with the hyperperfused or more metabolic active areas in relation with the Ki67 index) and so optimize the biopsy and/or evaluate the evolution of the lesion. Read More

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November 2008

Assessment of SPM in perfusion brain SPECT studies. A numerical simulation study using bootstrap resampling methods.

IEEE Trans Biomed Eng 2008 Jul;55(7):1849-53

Unitat de Biofisica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.

Statistical parametric mapping (SPM) has become the technique of choice to statistically evaluate positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and single photon emission computed tomography (SPECT) functional brain studies. Nevertheless, only a few methodological studies have been carried out to assess the performance of SPM in SPECT. The aim of this paper was to study the performance of SPM in detecting changes in regional cerebral blood flow (rCBF) in hypo- and hyperperfused areas in brain SPECT studies. Read More

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Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state.

Cereb Cortex 2009 Feb 4;19(2):375-82. Epub 2008 Jun 4.

Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

Although most functional neuroimaging studies examine task effects, interest intensifies in the "default" resting brain. Resting conditions show consistent regional activity, yet oxygen extraction fraction constancy across regions. We compared resting cerebral metabolic rates of glucose (CMRgl) measured with 18F-labeled 2-fluoro-2-deoxy-D-glucose to cerebral blood flow (CBF) 15O-H2O measures, using the same positron emission tomography scanner in 2 samples (n = 60 and 30) of healthy right-handed adults. Read More

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February 2009

Gender differences in methamphetamine use and responses: a review.

Gend Med 2008 Mar;5(1):24-35

Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272-0095, USA.

Background: Men and women differ markedly with regard to their use of, and responses to, methamphetamine (MA) and related amphetamines. However, these gender differences oftentimes are given only a cursory consideration in the analyses of these MA effects.

Objective: In this brief review, we summarize the data on gender differences in various parameters of MA use and responses. Read More

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Drowning--post-mortem imaging findings by computed tomography.

Eur Radiol 2008 Feb 29;18(2):283-90. Epub 2007 Aug 29.

Institute of Diagnostic Radiology, University Hospital, Freiburgstrasse, 3010 Bern, Switzerland.

The aim of this study was to identify the classic autopsy signs of drowning in post-mortem multislice computed tomography (MSCT). Therefore, the post-mortem pre-autopsy MSCT- findings of ten drowning cases were correlated with autopsy and statistically compared with the post-mortem MSCT of 20 non-drowning cases. Fluid in the airways was present in all drowning cases. Read More

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February 2008

[Nodular lesions of liver parenchyma caused by pathological vascularisation/perfusion].

H-P Fischer H Zhou

Pathologe 2006 Jul;27(4):273-83

Institut für Pathologie, Universität Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn.

Nodular regenerative hyperplasia (NRH) is characterized by a non-cirrhotic micronodular transformation of the liver parenchyma. It is based on the obliteration of small portal veins. Macroregenerative nodules (MRN) develop in areas of favourable blood flow in otherwise hypoperfused liver tissue. Read More

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Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats.

Epilepsy Res 2006 May 28;69(2):100-18. Epub 2006 Feb 28.

INSERM U398, Université Louis Pasteur, Strasbourg, France.

Rationale: Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in the generation and spread of seizures in epileptic patients. Since the spatial distribution and extent of ictal LCBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a rat model of amygdala kindled seizures to follow time-dependent changes in the distribution of seizure-induced LCBF changes.

Methods: Rats were implanted with a left amygdala electrode and were stimulated until reaching stage 1. Read More

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