4,725 results match your criteria hyperkalaemia diagnosis


Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients.

Cureus 2021 Jun 14;13(6):e15648. Epub 2021 Jun 14.

Internal Medicine, Jinnah Postgraduate Medical Center, Karachi, PAK.

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020. Read More

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Brugada Pattern Manifesting During Hyperkalemia, Diabetic Ketoacidosis, and Acute Alcohol Intoxication.

Am J Case Rep 2021 Jul 8;22:e932048. Epub 2021 Jul 8.

Department of Emergency Medicine, Marietta Memorial Hospital, Marietta, OH, USA.

BACKGROUND Brugada syndrome is a rare ion channelopathy that can lead to sudden cardiac death and lethal arrhythmias in patients without a structural cardiac defect, the most common of which being the gain-of-function mutation of the SCN5a sodium ion channel involving phase 0 of the cardiac action potential. In 2012, BrS electrocardiogram findings were redefined and classified as either congenital Brugada syndrome (BrS) or Brugada phenocopies (BrP). Several etiologies of BrP have been reported, such as metabolic derangements, electrolyte abnormalities, cardiovascular diseases, and pulmonary embolism. Read More

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Prognostic implications of hypo and hyperkalaemia in acute heart failure with reduced ejection fraction. Analysis of cardiovascular mortality and hospital readmissions.

Med Clin (Barc) 2021 Jul 3. Epub 2021 Jul 3.

Unidad de Insuficiencia Cardíaca y Trasplante, Hospital Universitari i Politècnic La Fe, Valencia, España; Servicio de Cardiología, Hospital Universitari i Politècnic La Fe. Valencia, España; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Valencia, España; Facultad de Medicina, Universidad de Valencia, Valencia, España.

Background And Objectives: Potassium alterations constitute a major clinical problem in decompensated heart failure (HF). This study aims to assess the prognostic implications of hypo and hyperkalaemia on admission for acute HF in cardiovascular mortality and hospital readmissions.

Material And Method: From January 2016 to June 2020, 1,397 cases with a diagnosis of acute HF were admitted. Read More

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Diagnosis of Ion-Exchange Resin Depositions in Paraffin Sections Using Corrective Light and Electron Microscopy-NanoSuit Method.

Diagnostics (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Institute for NanoSuit Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

Ion-exchange resins are commonly used to treat complications such as hyperkalemia, hyperphosphatemia, and hypercholesterolemia. Gastrointestinal complications may occur as side effects of such treatments. Sodium and calcium polystyrene sulfonate (PS-Ca) are cation-exchange resins comprising an insoluble structure that binds to potassium ions in the digestive tract and exchanges them with sodium and calcium ions, respectively, to promote their elimination. Read More

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Presenting status of children with classical congenital adrenal hyperplasia over two decades (1999-2018) in the absence of newborn screening in Sri Lanka.

J Pediatr Endocrinol Metab 2021 Jun 30. Epub 2021 Jun 30.

Professor in Paediatrics, Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Objectives: Although new-born screening (NBS) for classical congenital adrenal hyperplasia (C-CAH) has been available for decades, it is not widely implemented. We assessed the usefulness of introducing NBS for C-CAH, by analyzing presenting status of infants with C-CAH, over the past two decades, in Sri Lanka.

Methods: This retrospective clinic-based study, from the largest tertiary children's hospital in Sri Lanka, analyzed initial presenting features of children with C-CAH from 1999 to 2018, in the absence of NBS for CAH, and included gender-based comparisons. Read More

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Systemic pseudohypoaldosteronism-1 with episodic dyslipidemia in a Sudanese child.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Departmentof Pediatric Endocrinology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Summary: Systemic pseudohypoaldosteronism type 1 (PHA1) is a rare genetic syndrome of tissue unresponsiveness to aldosterone caused by mutations affecting the epithelial Na channel (ENaC). The classical presentation is life-threatening neonatal/infantile salt-losing crises that mimic congenital adrenal hyperplasia (CAH). Consistently, extra-renal manifestations, including respiratory symptoms that resemble cystic fibrosis, are well reported. Read More

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A rare case of persistent hyperkalaemia.

Ann Clin Biochem 2021 Jul 4:45632211028614. Epub 2021 Jul 4.

Department of Biochemistry & Immunology, University Hospital of Wales, Wales, UK.

Hyperkalaemia is a common biochemical finding that can allude to preanalytical or truly pathological causes. Here, we present a case of a 41-year-old female patient who has regularly presented with incidences of isolated hyperkalaemia since 2012, with otherwise normal renal function and no other associated symptoms. Investigations into the patient's family history revealed similar biochemical findings in her brother and eldest son. Read More

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How important is dietary management in chronic kidney disease progression? A role for low protein diets.

Korean J Intern Med 2021 07 22;36(4):795-806. Epub 2021 Jun 22.

Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California Irvine, School of Medicine, Orange, CA, USA.

High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0. Read More

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Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2-3 study.

Lancet Oncol 2021 07 15;22(7):977-990. Epub 2021 Jun 15.

Live Surgery Ward, Peking Union Medical College Hospital, Beijing, China.

Background: China has a high burden of hepatocellular carcinoma, and hepatitis B virus (HBV) infection is the main causative factor. Patients with hepatocellular carcinoma have a poor prognosis and a substantial unmet clinical need. The phase 2-3 ORIENT-32 study aimed to assess sintilimab (a PD-1 inhibitor) plus IBI305, a bevacizumab biosimilar, versus sorafenib as a first-line treatment for unresectable HBV-associated hepatocellular carcinoma. Read More

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Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town.

Ital J Pediatr 2021 Jun 16;47(1):138. Epub 2021 Jun 16.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Introduction: Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease due to the peripheral resistance to aldosterone. Its clinical spectrum includes neonatal salt loss syndrome with hyponatremia and hypochloraemia, hyperkalemia, metabolic acidosis and increased plasmatic levels of aldosterone. Two genetically distinct forms of disease, renal and systemic, have been described, showing a wide clinical expressivity. Read More

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Association between hyperkalemia, RAASi non-adherence and outcomes in chronic kidney disease.

J Nephrol 2021 Jun 11. Epub 2021 Jun 11.

CliCon S.r.l. Health, Economics and Outcomes Research, Bologna, Italy.

Background: Hyperkalemia is relatively frequent in CKD patients treated with renin-angiotensin-aldosterone-system inhibitors (RAASi).

Aim: The aim of the present study was to estimate the increased risk of cardiovascular events and mortality due to sub-optimal adherence to RAASi in CKD patients with hyperkalemia.

Methods: An observational retrospective cohort study was conducted, based on administrative and laboratory databases of five Local Health Units. Read More

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Double-Positive Anti-GBM and ANCA-MPO Vasculitis Presenting With Crescentic Glomerulonephritis.

Cureus 2021 May 2;13(5):e14806. Epub 2021 May 2.

Internal Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.

We report the case of a 61-year-old man with rapidly progressing glomerulonephritis (RPGN) due to double-positive anti-neutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane antibodies (GBM) vasculitis. The past medical history included stable untreated psoriatic arthritis and arterial hypertension. He presented with asthenia, anorexia, and rapidly deteriorating renal function with metabolic acidosis and hyperkalemia evolving with the need for hemodialysis. Read More

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Potassium Metabolism and Management in Patients with CKD.

Nutrients 2021 May 21;13(6). Epub 2021 May 21.

Kidney Center, Ohno Memorial Hospital, 1-26-10, Minami-Horie, Nishi-ku, Osaka 550-0015, Japan.

Potassium (K), the main cation inside cells, plays roles in maintaining cellular osmolarity and acid-base equilibrium, as well as nerve stimulation transmission, and regulation of cardiac and muscle functions. It has also recently been shown that K has an antihypertensive effect by promoting sodium excretion, while it is also attracting attention as an important component that can suppress hypertension associated with excessive sodium intake. Since most ingested K is excreted through the kidneys, decreased renal function is a major factor in increased serum levels, and target values for its intake according to the degree of renal dysfunction have been established. Read More

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[Update on treatment resistant hypertension and secondary hypertension].

Dtsch Med Wochenschr 2021 Jun 1;146(11):742-746. Epub 2021 Jun 1.

Medizinische Klinik und Poliklinik I, Lehrstuhl Endokrinologie und Diabetologie, Universitätsklinikum Würzburg.

Resistant hypertension (RH) is defined in patients who do not meet their blood pressure targets despite the daily intake of three antihypertensive drugs in maximally tolerated dosages. This triple treatment should comprise (1) an angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB), (2) a calcium channel blocker and (3) a diuretic. RH should also be diagnosed in patients on four or more antihypertensive drug classes. Read More

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2,4-Dinitrophenol: 'diet' drug death following major trauma.

Anaesth Rep 2021 Jan-Jun;9(1):106-109. Epub 2021 May 18.

Department of Anaesthesia and Intensive Care Leeds General Infirmary Leeds UK.

There has been a resurgence in the illicit use of 2,4-dinitrophenol by people wishing to achieve rapid weight loss. Despite its availability, the drug is banned for human consumption as it is toxic and can have fatal consequences. We present the case of a 23-year-old man who regularly consumed 2,4-dinitrophenol to generate fat loss without apparent ill effect. Read More

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Case Report: Severe Hyponatremia in Infants With Urinary Tract Infection.

Front Pediatr 2021 5;9:655010. Epub 2021 May 5.

Paediatric Unit, Hospital Tuanku Ja'afar, Seremban, Malaysia.

Many reports on investigations and treatments in UTI, however little, have been mentioned with regard to electrolyte abnormalities. Secondary pseudohypoaldosteronism (PHA) in UTI, though less common, is a known association. Features include hyponatremia and concomitant hyperkalemia. Read More

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Transient Pseudohypoaldosteronism Secondary to Group B Streptococcus Pyelonephritis.

Cureus 2021 May 17;13(5):e15071. Epub 2021 May 17.

Pediatrics, Children Center, Matsudo City General Hospital, Matsudo, JPN.

Secondary pseudohypoaldosteronism is a condition characterized by aldosterone resistance in renal tubules. It is highly associated with urinary tract infection and urinary tract malformations. Only a few cases of pseudohypoaldosteronism secondary to group B pyelonephritis have been reported to date. Read More

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A case report of pseudohypoaldosteronism type II with a homozygous KLHL3 variant accompanied by hyperthyroidism.

BMC Endocr Disord 2021 May 22;21(1):103. Epub 2021 May 22.

Department of Endocrinology and Metabolism, Peking University People's Hospital, No 11, Xizhimen Nan Street, Xicheng District, 100044, Beijing, China.

Background: Pseudohypoaldosteronism type II (PHAII), also called Gordon syndrome, is a rare hereditary disease caused by variants in the WNK1, WNK4, KLHL3 and CUL3 genes. The combination of PHAII with hyperthyroidism and secondary hyperparathyroidism has not been reported previously.

Case Presentation: A 54-year-old female with recently diagnosed Graves' disease presented hyperkalemia, hypertension, hypercalciuria, elevated levels of parathyroid hormone (PTH) and normal renal function. Read More

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Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction.

Cochrane Database Syst Rev 2021 05 22;5:CD012721. Epub 2021 May 22.

Institute of Health Informatics, University College London, London, UK.

Background: Beta-blockers and inhibitors of the renin-angiotensin-aldosterone system improve survival and reduce morbidity in people with heart failure with reduced left ventricular ejection fraction (LVEF); a review of the evidence is required to determine whether these treatments are beneficial for people with heart failure with preserved ejection fraction (HFpEF).

Objectives: To assess the effects of beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, angiotensin receptor neprilysin inhibitors, and mineralocorticoid receptor antagonists in people with HFpEF.

Search Methods: We updated searches of CENTRAL, MEDLINE, Embase, and one clinical trial register on 14 May 2020 to identify eligible studies, with no language or date restrictions. Read More

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Autosomal dominant tubulointerstitial kidney disease: more than just HNF1β.

Pediatr Nephrol 2021 May 22. Epub 2021 May 22.

Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

Autosomal dominant tubulointerstitial kidney disease (ADTKD) refers to a group of disorders with a bland urinary sediment, slowly progressive chronic kidney disease (CKD), and autosomal dominant inheritance. Due to advances in genetic diagnosis, ADTKD is becoming increasingly recognized as a cause of CKD in both children and adults. ADTKD-REN presents in childhood with mild hypotension, CKD, hyperkalemia, acidosis, and anemia. Read More

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[Effect of serum potassium level on renal function progression in stage Ⅲ-Ⅴ chronic kidney disease patients without dialysis].

Zhonghua Yi Xue Za Zhi 2021 May;101(18):1363-1368

Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China.

To investigate the effect of serum potassium level and hyperkalemia on the renal function decline in chronic kidney disease (CKD) patients. The clinical data at baseline and follow-up in stage Ⅲ-Ⅴ CKD patients without dialysis who were followed up for more than one year in Tianjin First Central Hospital from May 2015 to June 2019 and Teikyo University School of Medicine from January 2008 to July 2013 were retrospectively collected. All patients were divided into stable group (337 cases), slow progression group (337 cases) and rapid progression group (338 cases) according to the tertile of estimated glomerular filtration rate (eGFR) slope (the annual average percentage of eGFR decline). Read More

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A rare cause of salt-wasting in early infancy: Transient pseudohypoaldosteronism.

Turk Arch Pediatr 2021 Jan 1;56(1):75-77. Epub 2021 Jan 1.

Department of Pediatric Endocrinology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

Three infants aged between 38 days and 43 days all presented with poor weight gain, hyponatremia, hyperkalemia, and were diagnosed as having urinary tract infections, which were accompanied by urinary tract malformations in our cases. Hydration and infection treatments were given. A few days after admission, hormonal studies revealed normal cortisol and 17-hydroxy progesterone levels and markedly high aldosterone levels, thus the patients were diagnosed as having transient pseudohypoaldosteronism. Read More

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January 2021

Use of Urine Electrolytes and Urine Osmolality in the Clinical Diagnosis of Fluid, Electrolytes, and Acid-Base Disorders.

Kidney Int Rep 2021 May 13;6(5):1211-1224. Epub 2021 Feb 13.

Renal Division, St. Michael's Hospital and The University of Toronto, Toronto, Ontario, Canada.

We discuss the use of urine electrolytes and urine osmolality in the clinical diagnosis of patients with fluid, electrolytes, and acid-base disorders, emphasizing their physiological basis, their utility, and the caveats and limitations in their use. While our focus is on information obtained from measurements in the urine, clinical diagnosis in these patients must integrate information obtained from the history, the physical examination, and other laboratory data. Read More

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Pseudohyperkalaemia in essential thrombocytosis: an important clinical reminder.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Mater Dei Hospital of Malta, Department of Medicine, Msida, Malta.

Summary: An 82-year-old female was admitted to a general hospital due to progressive bilateral lower limb weakness. A T8-T9 extramedullary meningioma was diagnosed by MRI, and the patient was referred for excision of the tumour. During the patient's admission, she was noted to have persistent hyperkalaemia which was refractory to treatment. Read More

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Rectal ulcer in a hemodialysis patient receiving Kayexalate.

Clin Case Rep 2021 Apr 13;9(4):2385-2389. Epub 2021 Mar 13.

Centre Hospitalier Regional de Huy Huy Belgium.

Kayexalate can cause severe unrecognized GI lesions. Diagnosis of kayexalate crystals in GI biopsy samples is important. Pathologists and clinicians should work hand in hand. Read More

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Acute life-threatening hyperkalaemia in a patient with giant hydronephrosis: a case report.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Department of Emergency Medicine, Catharina Hospital Eindhoven, Eindhoven, Netherlands.

A 52-year-old man with a history of urolithiasis presents to the emergency department with a sudden, sharp, continuous right flank colicky pain. Laboratory workup demonstrates acute kidney injury with a mild hyperkalaemia. During the observation period, the patient develops an atypical broad complex sinus bradycardia and eventually short asystolic periods. Read More

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Atypical presentation of autoimmune polyglandular syndrome type 1 in the fifth decade.

BMJ Case Rep 2021 Apr 26;14(4). Epub 2021 Apr 26.

Endocrinology, Sri Ramachandra University Medical College, Chennai, Tamil Nadu, India.

A 45-year-old woman presented to us with a short-term history of nausea, vomiting and giddiness. On arrival at our hospital, examination revealed postural hypotension. Fluid resuscitation with intravenous normal saline was commenced. Read More

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Transient early-childhood hyperkalemia without salt wasting, physiopathological approach of three cases.

Nefrologia (Engl Ed) 2021 Apr 23. Epub 2021 Apr 23.

Department of Pediatrics, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Two types of early-childhood hyperkalemia had been recognized, according to the presence or absence of urinary salt wasting. This condition was attributed to a maturation disorder of aldosterone receptors and is characterized by sustained hyperkalemia, hyperchloremic metabolic acidosis due to reduced ammonium urinary excretion and bicarbonate loss, and normal creatinine with growth delay. We present three patients of the type without salt wasting, which we will call transient early-childhood hyperkalemia without salt wasting, and discuss its physiopathology according to new insights into sodium and potassium handling by the aldosterone in distal nephron. Read More

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Hyperkalemia in a Patient With Leukemia.

Am J Kidney Dis 2021 05;77(5):A13-A14

Division of Nephrology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

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