16 results match your criteria hyperinsulinism smell

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What's in a name? That which we call perinatal stress hyperinsulinism by any other name would smell so bitter.

J Perinatol 2021 Apr 30. Epub 2021 Apr 30.

Division Chief and Director Congenital Hyperinsulinism Center, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.

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Obesity in Midlife Hampers Resting and Sensory-Evoked Cerebral Blood Flow in Mice.

Obesity (Silver Spring) 2021 01 10;29(1):150-158. Epub 2020 Nov 10.

Université de Paris, Unit of Functional and Adaptive Biology (BFA), UMR 8251 CNRS, Paris, France.

Objective: This study aimed to investigate the effects of a high-fat diet (HFD) and aging on resting and activity-dependent cerebral blood flow (CBF).

Methods: To run a comparison between obese and age-matched control animals, 6-week-old mice were fed either with regular chow or an HFD for 3 months or 8 months. Glucose tolerance and insulin sensitivity were assessed for metabolic phenotyping. Read More

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January 2021

Insulin Resistance Is Associated with Reduced Food Odor Sensitivity across a Wide Range of Body Weights.

Nutrients 2020 Jul 24;12(8). Epub 2020 Jul 24.

IFB Adiposity Diseases, Leipzig University Medical Center, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany, (K.W.).

The worldwide obesity epidemic is a major health problem driven by the modern food environment. Recently, it has been shown that smell perception plays a key role in eating behavior and is altered in obesity. However, the underlying mechanisms of this phenomenon are not well understood yet. Read More

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste.

Am J Physiol Endocrinol Metab 2020 08 23;319(2):E276-E290. Epub 2020 Jun 23.

Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, University of Colorado, Aurora, Colorado.

Intake of sugars, especially the fructose component, is strongly associated with the development of obesity and metabolic syndrome, but the relative role of taste versus metabolism in driving preference, intake, and metabolic outcome is not fully understood. We aimed to evaluate the preference for sweet substances and the tendency to develop metabolic syndrome in response to these sugars in mice lacking functional taste signaling [P2X2 (P2X purinoreceptor 2)/P2X3 (P2X purinoreceptor 3) double knockout mice (DKO)] and mice unable to metabolize fructose (fructokinase knockout mice). Of interest, our data indicate that despite their inability to taste sweetness, P2X2/3 DKO mice still prefer caloric sugars (including fructose and glucose) to water in long-term testing, although with diminished preference compared with control mice. Read More

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Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model.

Am J Physiol Renal Physiol 2019 02 28;316(2):F372-F381. Epub 2018 Nov 28.

Department of Physiology, Johns Hopkins University School of Medicine , Baltimore, Maryland.

Olfactory receptors are G protein-coupled receptors that serve to detect odorants in the nose. Additionally, these receptors are expressed in other tissues, where they have functions outside the canonical smell response. Olfactory receptor 1393 (Olfr1393) was recently identified as a novel regulator of Na-glucose cotransporter 1 (Sglt1) localization in the renal proximal tubule. Read More

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February 2019

High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.

J Nutr 2018 08;148(8):1380-1386

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Background: Combined omega-3 fatty acid and vitamin D supplementation may improve multiple sclerosis (MS) by correcting metabolic abnormalities and attenuating oxidative stress and inflammation.

Objective: This study aimed to determine the effects of ω-3 fatty acid and vitamin D cosupplementation on the disability score and metabolic status of patients with MS.

Methods: This was a randomized, placebo-controlled clinical trial with Expanded Disability Status Scale (EDSS) score and inflammation as primary outcomes and oxidative stress biomarkers and metabolic profile as secondary outcomes. Read More

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Insulin resistance and the increased risk for smell dysfunction in US adults.

Laryngoscope 2018 09 13;128(9):1992-1996. Epub 2018 Jan 13.

Department of Preventive Medicine, Colleague of Medicine, Seoul National University, Seoul, Republic of Korea.

Objective: Over 24% of older American adults (approximately 14 million) are estimated to have reduced olfactory sensitivity. Previous studies have provided evidence that patients with diabetes mellitus (DM) or its complications are at increased risk of olfactory dysfunction. We therefore investigated whether smell dysfunction was associated with DM-related biomarkers, including fasting blood glucose, glycohemoglobin, serum insulin, and homeostasis model assessment of insulin sensitivity (HOMA-IR), in older US adults. Read More

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September 2018

The Sense of Smell Impacts Metabolic Health and Obesity.

Cell Metab 2017 Jul;26(1):198-211.e5

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; The Paul F. Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA, USA. Electronic address:

Olfactory inputs help coordinate food appreciation and selection, but their role in systemic physiology and energy balance is poorly understood. Here we demonstrate that mice upon conditional ablation of mature olfactory sensory neurons (OSNs) are resistant to diet-induced obesity accompanied by increased thermogenesis in brown and inguinal fat depots. Acute loss of smell perception after obesity onset not only abrogated further weight gain but also improved fat mass and insulin resistance. Read More

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Taste and smell function in testicular cancer survivors treated with cisplatin-based chemotherapy in relation to dietary intake, food preference, and body composition.

Appetite 2016 10 10;105:392-9. Epub 2016 Jun 10.

Top Institute Food and Nutrition, Wageningen, The Netherlands; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Background: Chemotherapy can affect taste and smell function. This may contribute to the high prevalence of overweight and metabolic syndrome in testicular cancer survivors (TCS). Aims of the study were to evaluate taste and smell function and possible consequences for dietary intake, food preference, and body composition in TCS treated with cisplatin-based chemotherapy. Read More

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October 2016

Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey.

PLoS One 2016 9;11(2):e0148813. Epub 2016 Feb 9.

Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, Seoul, Korea.

Metabolic syndrome (MetS) is associated with a higher risk of morbidity and/or mortality for various chronic diseases. The aim of this study was to investigate the relationships of MetS and its components with olfactory dysfunction in a representative Korean population. We analyzed the data from the Korean National Health and Nutrition Examination Survey (2008-2010). Read More

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[Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus II. Fenugreek (Trigonella foenum-graecum)].

Ceska Slov Farm 2015 Jun;64(3):67-71

Fenugreek seeds are known for their characteristic smell of soup seasoning and as an ingredient of Indian curry. Traditionally the seeds are used as macerate for the treatment of diabetes, cough, and flatulence, to increase breast milk secretion, and for anti-inflammatory and aphrodisiac effects. The use is limited by its unpleasant smell and bitter taste which can be modified by adding mint leaves to the macerate. Read More

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A pilot study investigating the effect of Caralluma fimbriata extract on the risk factors of metabolic syndrome in overweight and obese subjects: a randomised controlled clinical trial.

Complement Ther Med 2013 Jun 23;21(3):180-9. Epub 2013 Feb 23.

Biomedical and Lifestyle Diseases (BioLED) Unit, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.

Objectives: Central obesity is a key component of metabolic syndrome and it is often associated with other risk factors such as dyslipidemia, elevated plasma glucose levels and elevated blood pressure (BP). In this pilot study, the effect of Caralluma fimbriata (an edible succulent) extract in combination with controlled dietary intake and physical activity on these risk factors was assessed in overweight and obese Australian subjects.

Design: This was a randomised, double blind placebo controlled clinical trial. Read More

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Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?

J Appl Physiol (1985) 2010 May 18;108(5):1041-51. Epub 2010 Feb 18.

Center for Cardiovascular and Respiratory Sciences, Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26505, USA.

As chronic stress and depression have become recognized as significant risk factors for peripheral vascular disease in patients with no prior history of vasculopathy, we interrogated this relationship utilizing an established mouse model of chronic stress/depressive symptoms from behavioral research. Male mice were exposed to 8 wk of unpredictable chronic mild stress (UCMS; e.g. Read More

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[Selected risk factors of metabolic syndrome and disorders of taste perception].

Wiad Lek 2010 ;63(4):358-68

Katedra i Zakład Bromatologii Uniwersytetu Medycznego w Poznaniu.

The sense of taste, apart from the sense of smell and sight, is one of the most important senses that play crucial role in the transmission of information regarding the food and its usefulness for consumption. Alarming is an increasing number of people with the taste dysfunction. This kind of dysfunction is serious problem especially among the elderly that arise not only from unavoidable and natural processes of ageing but also from health problems and taken medications. Read More

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November 2011

Effect of genetic variation in Kv1.3 on olfactory function.

Diabetes Metab Res Rev 2009 Sep;25(6):523-7

Medical Clinic, Department of Diabetes, Endocrinology, Nephrology and Angiology, Clinical Chemistry, Eberhard-Karls-University, Tuebingen, Germany.

Background: Olfactory function is reduced in aged humans and diabetes mellitus patients. However, little is known about the pathogenic mechanisms leading to olfactory dysfunction. Recently, it has been shown that the voltage-gated potassium channel Kv1. Read More

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September 2009
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