96,169 results match your criteria hyperinsulinism

Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events.

Front Pediatr 2021 16;9:699129. Epub 2021 Jul 16.

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Focal hyperinsulinism (HI) comprises nearly 50% of all surgically treated HI cases and is cured if the focal lesion can be completely resected. Pre-operative localization of the lesion is thus critical. Few cases of hyperinsulinism with multiple focal lesions have been reported, and assessment of the molecular mechanisms driving this rare occurrence has been limited. Read More

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Response to Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women".

Science 2021 07;373(6554)

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63105, USA.

In evaluating any randomized clinical trial, it is important to determine whether baseline differences between groups could have affected the primary outcome. In our study, muscle insulin sensitivity, which was identical in both groups at baseline, improved after nicotinamide mononucleotide (NMN), not placebo, therapy. Differences in baseline intrahepatic triglyceride content between groups do not negate the effects of NMN observed in muscle. Read More

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Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women".

Charles Brenner

Science 2021 07;373(6554)

Department of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA.

Yoshino (Reports, 11 June 2021, p. 1224) have reported that nicotinamide mononucleotide (NMN) increases muscle insulin sensitivity in prediabetic women. However, the 13 women who received NMN had hepatic lipid content of 6. Read More

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Advances in paediatric nonalcoholic fatty liver disease: Role of lipidomics.

World J Gastroenterol 2021 Jul;27(25):3815-3824

Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy.

Due its close relationship with obesity, nonalcoholic fatty liver disease (NAFLD) has become a major worldwide health issue even in childhood. The most accepted pathophysiological hypothesis is represented by the "multiple hits" theory, in which both hepatic intracellular lipid accumulation and insulin resistance mainly contribute to liver injury through several factors. Among these, lipotoxicity has gained particular attention. Read More

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Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.

Reprod Health 2021 Jul 26;18(1):156. Epub 2021 Jul 26.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. Read More

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Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: a meta-analysis.

J Int Med Res 2021 Jul;49(7):3000605211031758

Department of TCM Gynaecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Objective: This meta-analysis evaluated the effect of probiotics and synbiotics on insulin resistance in patients with polycystic ovary syndrome (PCOS).

Methods: A systematic search was performed to identify all relevant publications listed on the electronic databases (PubMed®, Web of Science, Embase® and China National Knowledge Infrastructure) between inception and 30 October 2020. All statistical analyses were performed on randomized controlled trials (RCTs) using RevMan version 5. Read More

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[Effect of metformin and rosiglitazone in non-obese polycystic ovary syndrome women with insulin resistance].

Zhonghua Fu Chan Ke Za Zhi 2021 Jul;56(7):467-473

Center for Reproductive Medicine, Key Laboratory of Birth Defects and Women Children's Diseases, Ministry of Education, West China Second Hospital of Sichuan University, Chengdu 610041, China.

To investigate effects of metformin and rosiglitazone in non-obese polycystic ovary syndrome (PCOS) women with insulin resistance. Totally 200 non-obese PCOS women with insulin resistance in West China Second Hospital of Sichuan University were enrolled into this study from Sep. 2013 to Jun. Read More

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Sirolimus in infants with congenital hyperinsulinism (CHI) - a single-centre experience.

Eur J Pediatr 2021 Jul 24. Epub 2021 Jul 24.

Department of Pediatrics Endocrinology Rainbow Children's Hospital, 500034, Hyderabad, India.

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in neonates and infants. Medical treatment includes the use of high concentrations of glucose and combinations of diazoxide, octreotide and glucagon. We report our experience of using sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in the treatment of CHI in seven newborns who are poorly responding to standard medical therapy. Read More

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Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance.

Int J Mol Sci 2021 Jul 11;22(14). Epub 2021 Jul 11.

Department of Medical Biology, Medical University of Bialystok, 15-089 Białystok, Poland.

Adipose tissue (AT) is an endocrine organ involved in the management of energy metabolism via secretion of adipokines, hormones, and recently described secretory microvesicles, i.e., exosomes. Read More

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Burnout and metabolic syndrome among healthcare workers: Is subclinical hypothyroidism a mediator?

J Occup Health 2021 Jan;63(1):e12252

Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taiwan.

Objectives: Evidence suggests that subclinical hypothyroidism (SCH) is associated with burnout and metabolic syndrome (MetS). We examined the relationship between burnout and MetS among healthcare workers (HCWs) and investigated the potential mediation of SCH.

Methods: This cross-sectional study included HCWs from a tertiary medical center; demographic data were obtained using a questionnaire. Read More

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January 2021


Acta Clin Croat 2020 Dec;59(4):696-702

1Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4University of Applied Health Sciences, Zagreb, Croatia; 5Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6School of Medicine, University of Zagreb, Zagreb, Croatia; 7Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia.

Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. Read More

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December 2020

Insulin resistance and need for a lifestyle change to eliminate it.

Bratisl Lek Listy 2021 ;122(8):567-571

The AIM of our work is to point out the relationship between insulin resistance and metabolic compensation of diabetes mellitus, as well as to explore the possibilities of improving these parameters by non-drug measures. The rising incidence of insulin resistance associated with many comorbidities, especially due to the increase in obesity and unhealthy lifestyles, is a serious medical problem today. It is therefore necessary to be able to recognize and evaluate the presence of insulin resistance, prevent its occurrence, and ensure its elimination in high-risk individuals. Read More

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Protective Effects of Ethanolic Extract from Rhizome of against Renal Fibrosis and Inflammation in a Diabetic Nephropathy Model.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Jeollabuk-do, Iksan 54538, Korea.

Progressive diabetic nephropathy (DN) in diabetes leads to major morbidity and mortality. The major pathological alterations of DN include mesangial expansion, extracellular matrix alterations, tubulointerstitial fibrosis, and glomerular sclerosis. is widely used in traditional oriental medicine and has long been used as a diuretic, astringent, insecticide and antihypertensive. Read More

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Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Urinary acrolein adduct levels have been reported to be increased in both habitual smokers and type-2 diabetic patients. The impairment of glucose transport in skeletal muscles is a major factor responsible for glucose uptake reduction in type-2 diabetic patients. The effect of acrolein on glucose metabolism in skeletal muscle remains unclear. Read More

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Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress.

Int J Mol Sci 2021 Jul 4;22(13). Epub 2021 Jul 4.

Department of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of Re-Public of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. Read More

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Association Between Diet Quality and Prevalence of Obesity, Dyslipidemia, and Insulin Resistance Among Filipino Immigrant Women in Korea: The Filipino Women's Diet and Health Study.

Front Public Health 2021 1;9:647661. Epub 2021 Jul 1.

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.

Diet quality may be a key modifiable factor for the prevention of non-communicable disease. We aimed to investigate the association between diet quality and prevalence of obesity, dyslipidemia, and insulin resistance among Filipino immigrant women in Korea. A total of 413 participants from the 2014-2016 baseline population of the Filipino Women's Diet and Health Study (FiLWHEL) were examined. Read More

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Effect of laparoscopic RouxenY gastric bypass on improvement of insulin resistance in Type 2 diabetic patients evaluated by hyperinsulinemiceuglycemic clamp.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Jun;46(6):609-614

Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objectives: With the increase of people's living standards increasing year by year, Type 2 diabetes has brought great economic and living burden to the society and patients. Bariatric surgery can improve metabolic indicators in patients with diabetes, but specific mechanisms are still under study. This study aims to evaluate the effect of Roux-en-Y gastric bypass (RYGB) on insulin resistance in patients with Type 2 diabetes by hyperinsulinemic-euglycemic clamp. Read More

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Navigating the U.S. health insurance landscape for children with rare diseases: a qualitative study of parents' experiences.

Orphanet J Rare Dis 2021 Jul 15;16(1):313. Epub 2021 Jul 15.

Department of Health Promotion and Policy, School of Public Health and Health Sciences, University of Massachusetts Amherst, 715 North Pleasant Street, Amherst, MA, United States.

Background: Parents of children with rare diseases often face uncertainty about diagnosis, treatment, and costs associated with healthcare for their child. Health insurance status impacts each of these areas, but no U.S. Read More

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Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double-blind, phase 2 trial.

Diabetes Obes Metab 2021 Jul 15. Epub 2021 Jul 15.

Novartis Institutes for BioMedical Research, Translational Medicine, Basel, Switzerland.

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. The dual sodium-glucose co-transporter 1/2 inhibitor (SGLT1/2i) licogliflozin (LIK066) ameliorates hyperinsulinism in patients with diabetes and obesity. This study examines the effect of licogliflozin on androgens in women with PCOS. Read More

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Congenital hyperinsulinism in Gran Canaria, Canary Isles.

An Pediatr (Engl Ed) 2021 Jul 10. Epub 2021 Jul 10.

Unidad de Genética Clínica, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain.

Introduction: Congenital hyperinsulinism (CH) is a severe disorder characterised by the appearance of severe hypoglycaemia. Pathogenic mutations in the ABCC8 and KCNJ11 genes are the most frequent cause, although its appearance also been associated to mutations in other genes (GCK, GLUD1, HADH, HNF1A, HNF4A, SLC16A1, UCP2, HK1), and with different syndromes.

Materials And Methods: Retrospective review of patients diagnosed with CH in this unit during the last 18 years (2001-2018). Read More

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Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis.

J Agric Food Chem 2021 Jul 12;69(28):7884-7897. Epub 2021 Jul 12.

College of Animal Science and Veterinary Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, People's Republic of China.

This study investigated the effects of oleanolic acid (OA) on hepatic lipid metabolism and gut-liver axis homeostasis in an obesity-related non-alcoholic fatty liver disease (NAFLD) nutritional animal model and explored possible molecular mechanisms behind its effects. The results revealed that OA ameliorated the development of metabolic disorders, insulin resistance, and hepatic steatosis in obese rats. Meanwhile, OA restored high-fat-diet (HFD)-induced intestinal barrier dysfunction and endotoxin-mediated induction of toll-like-receptor-4-related pathways, subsequently inhibiting endotoxemia and systemic inflammation and balancing the homeostasis of the gut-liver axis. Read More

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[Analysis of genetic variants in four children with congenital hyperinsulinemia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jul;38(7):635-638

Laboratory of Genetics and Metabolism, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530033, China.

Objective: To explore the genetic basis of four children with congenital hyperinsulinemia (CHI).

Methods: The four children were subjected to high-throughput whole exome sequencing (WES). Candidate variants were validated by Sanger sequencing. Read More

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A spontaneously hypertensive diet-induced atherosclerosis-prone mouse model of metabolic syndrome.

Biomed Pharmacother 2021 Jul 8;139:111668. Epub 2021 May 8.

Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; The University of Melbourne, Melbourne, VIC, Australia; Monash University, Melbourne, VIC, Australia. Electronic address:

Metabolic Syndrome (MetS) is a complex and multifactorial condition often characterised by obesity, hypertension, hyperlipidaemia, insulin resistance, glucose intolerance and fasting hyperglycaemia. Collectively, MetS can increase the risk of atherosclerotic-cardiovascular disease, which is the leading cause of death worldwide. However, no animal model currently exists to study MetS in the context of atherosclerosis. Read More

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Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs.

Biomed Pharmacother 2021 Jul 7;139:111662. Epub 2021 May 7.

Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Metformin is one of the most prescribed drugs in type II diabetes (T2DM) which has recently found new applications in the prevention and treatment of various illnesses, from metabolic disorders to cardiovascular and age-related diseases. Metformin improves insulin resistance (IR) by modulating metabolic mechanisms and mitochondrial biogenesis. Alternation of microRNAs (miRs) in the treatment of IR-related illnesses has been observed by metformin therapy. Read More

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Testosteronmangel stark mit metabolischem Syndrom assoziiert.

MMW Fortschr Med 2021 07;163(13):34-35

DKD Helios Klinik Wiesbaden, Fachbereich Endokrinologie, Diabetes u. Stoffwechsel, Aukammallee 33, 65191, Wiesbaden, Deutschland.

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[Puerarin alleviates insulin resistance in type 2 diabetic mice by modulating fetuin B-AMPK/ACC signaling pathway in the liver].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jun;41(6):839-846

Cooperation Research Center of Shanghai University of Traditional Chinese Medicine//Department of Endocrinology, Traditional Chinese Medicine Hospital of Jiading District, Shanghai 201899, China.

Objective: To explore the role of fetuin B-AMPK/ACC signaling pathway in mediating the effect of puerarin on hepatic insulin resistance in mice with type 2 diabetes mellitus (T2DM).

Objective: Forty C57BL/6J mouse models of T2DM induced by high-fat diet and intraperitoneal injection of streptozotocin were randomized into diabetic model (HFD) group and 3 puerarin groups for treatment with low-, moderate- and high- dose puerarin (50, 100 and 200 mg/kg, respectively), with another 10 mice fed a normal diet as the control group. After treatment for 8 weeks, the mice were examined for fasting blood glucose (FBG), fasting insulin (FINS), liver triglycerides (TG), cholesterol (TC) and free fatty acids (FFA) levels. Read More

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Hypothalamic microinflammation.

Handb Clin Neurol 2021 ;181:311-322

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.

Over the past decade, hypothalamic microinflammation has been studied and appreciated as a core mechanism involved in the advancement of metabolic syndrome and aging. Accumulating evidence suggests that atypical microinflammatory insults disturb hypothalamic regulation resulting in metabolic imbalance and aging progression, establishing a common causality for these two pathophysiologic statuses. Studies have causally linked these changes to activation of key proinflammatory pathways, especially NF-κB signaling within the hypothalamus, which leads to hypothalamic neuronal dysregulation, astrogliosis, microgliosis, and loss of adult hypothalamic neural stem/progenitor cells. Read More

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Efficacy of omega-3 fatty acid supplementation on cardiovascular risk factors in patients with polycystic ovary syndrome: a systematic review and meta-analysis.

Ann Palliat Med 2021 Jun;10(6):6425-6437

Department of Gynecology and Obstetrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: There is a close relationship between cardiovascular risk factors and polycystic ovary syndrome (PCOS), and omega-3 fatty acids may have a key role in improving cardiovascular risk factors. We conducted the current systematic review and meta-analysis to evaluate the effect of omega-3 fatty acid supplementation on cardiovascular risk factors in patients with PCOS.

Methods: We searched 4 databases including PubMed (MEDLINE), Cochrane Library, Embase, and Web of Science from inception to February 2021. Read More

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Role of Various Gene Expressions in Etiopathogenesis of Type 2 Diabetes Mellitus.

Adv Mind Body Med 2021 Summer;35(3):31-39

Context: Diabetes is a metabolic disease, with high mortality, and is characterized by increased glucose levels in the blood occurring due to poor pancreatic insulin secretion or development of insulin resistance in the body. Type 2 DM (T2DM) represents 90% of diabetic cases, and its pathogenesis involves a genetic correlation with insulin resistance, β-cell dysfunction, lifestyle, and environmental factors.

Objective: The current study intended to examine the pathophysiology of T2DM, including factors influencing insulin resistance and beta (β)-cell dysfunction as well as the genetic factors that indicate susceptibility to T2DM. Read More

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