26,022 results match your criteria hydrophilic structure

Chemical and physical Chitosan modification for designing enzymatic industrial biocatalysts: How to choose the best strategy?

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Instituto de Engenharias e Desenvolvimento Sustentável, Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Campus das Auroras, Redenção CEP 62790970, CE, Brazil; Departamento de Engenharia Química, Universidade Federal do Ceará, Campus do Pici, Bloco 709, Fortaleza CEP 60455760, CE, Brazil. Electronic address:

Chitosan is one of the most abundant natural polymer worldwide, and due to its inherent characteristics, its use in industrial processes has been extensively explored. Because it is biodegradable, biocompatible, non-toxic, hydrophilic, cheap, and has good physical-chemical stability, it is seen as an excellent alternative for the replacement of synthetic materials in the search for more sustainable production methodologies. Thus being, a possible biotechnological application of Chitosan is as a direct support for enzyme immobilization. Read More

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Bioinspired Hydrophilic-Hydrophobic Janus Composites for Highly Efficient Solar Steam Generation.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun, Jilin 130022, China.

Solar energy has received extensive attention as a renewable and sufficient energy source. Herein, inspired by the Janus wettability of lotus leaves, we have constructed a bioinspired hydrophilic-hydrophobic Janus hybrid system of carbonized carrot powder (CC powder)-modified cotton cloth with Nafion coating on one side (cotton cloth-NCC) for highly efficient solar steam generation. In cotton cloth-NCC, CC powder functions as a light absorber to achieve high light absorption, whereas the hydrophilic cotton cloth ensures efficient water transport. Read More

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In-depth site-specific analysis of N-glycoproteome in human cerebrospinal fluid (CSF) and glycosylation landscape changes in Alzheimer's disease (AD).

Mol Cell Proteomics 2021 Apr 13:100081. Epub 2021 Apr 13.

Department of Chemistry, University of Wisconsin, Madison, WI, 53705, USA; School of Pharmacy, University of Wisconsin, Madison, WI, 53705, USA. Electronic address:

As the body fluid that directly interchanges with the extracellular fluid of central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. Read More

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Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process.

Macromol Biosci 2021 Apr 16:e2100048. Epub 2021 Apr 16.

Key Laboratory, of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. Read More

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Highly transparent, writable and photoluminescent foldable polymer film: When fluorescent dyes or pigments join cellulose-based microgel.

Carbohydr Polym 2021 Jul 24;263:117977. Epub 2021 Mar 24.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi Province, 710021, China.

We prepared a self-dispersed cellulose-based microgel via chemically bonding hydrophilic gelatin peptide chain onto cellulose glucose chain. Following, a variety of highly transparent, foldable, and writable photoluminescent polymer films was obtained through loading organic dyes and inorganic pigments onto cellulose-based microgel matrix, respectively. Benefiting from the coupling sites and network effect of microgel as well as the abundant hydroxyl, amino, and imino groups in its structure, the microgel containing organic dyes and inorganic pigments exhibit good dispersion and stability, and the resultant photoluminescent films emit bright yellow, orange, yellow-green, and blue-green fluorescence under UV light, respectively, especially the cellulose-based microgel stabilized inorganic alkaline earth aluminate hybrids exhibit continuous luminescence for a long time in the dark. Read More

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Mechanisms by which different polar fractions of dissolved organic matter affect sorption of the herbicide MCPA in ferralsol.

J Hazard Mater 2021 Mar 31;416:125774. Epub 2021 Mar 31.

Institute of Environment and Plant Protection, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Danzhou Scientific Observing and Experimental Station of Agro-Environment, Ministry of Agriculture, Danzhou 571737, PR China; Hainan Key Laboratory of Tropical Eco-Circuling Agriculture, Haikou 571101, PR China. Electronic address:

Exogenous dissolved organic matter (DOM) modifies the sorption of 4-chloro-2-methylphenoxyacetic acid (MCPA, a polar herbicide) in soil. However, how the chemodiversity and diverse fractions of DOM affect MCPA sorption is still unknown. Here, DOM was extracted from compost and rice straw; the structure-activity correlations between DOM chemodiversity and their effects on MCPA sorption were investigated by redundancy analysis. Read More

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Solvation parameter model: Tutorial on its application to separation systems for neutral compounds.

Colin F Poole

J Chromatogr A 2021 Mar 26;1645:462108. Epub 2021 Mar 26.

Department of Chemistry, Wayne State University, Detroit, MI, 48202, USA. Electronic address:

The solvation parameter model affords a useful tool to model distribution properties of neutral compounds in biphasic separation systems. Common applications include column characterization and method development in gas chromatography; reversed-phase, micellar and hydrophilic interaction liquid chromatography; supercritical fluid chromatography; and micellar electrokinetic chromatography. The characterization of the distribution properties of liquid-liquid partition systems is another major application of this model. Read More

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Development of polyoxyethylene (2) oleyl ether-gliadin nanoparticles: characterization and in vitro cytotoxicity.

Eur J Pharm Sci 2021 Apr 12:105849. Epub 2021 Apr 12.

Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S Venuta", I-88100, Catanzaro, Italy. Electronic address:

Natural polymers have been widely investigated as materials for the delivery of active compounds as a consequence of their biocompatibility, low-cost and the opportunity they furnish to obtain micro- and nanostructures. In this investigation, commercial wheat gliadin was used as raw material with the aim of obtaining a vegetal protein-based nanoformulation to be used for various applications. The influence of non-ionic and anionic surfactants on the physico-chemical properties of gliadin nanoparticles was evaluated in order to propose a suitable candidate able to stabilize the colloidal structure. Read More

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Colloidal Particles in Tuna Head Soup: Chemical Localization, Structural Change, and Antioxidant Property.

Front Nutr 2021 29;8:638390. Epub 2021 Mar 29.

College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China.

In this work, chemical localization, structural changes, and antioxidant properties of tuna colloidal particles (TCPs) in boiling tuna head soup were examined. The results demonstrated that TCPs might be core-shell colloidal spherical structures. The hydrophobic core consisted of triglycerides and chloride ions. Read More

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Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications.

Front Bioeng Biotechnol 2021 29;9:646554. Epub 2021 Mar 29.

Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. Read More

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3D cell sheet structure augments mesenchymal stem cell cytokine production.

Sci Rep 2021 Apr 14;11(1):8170. Epub 2021 Apr 14.

Cell Sheet Tissue Engineering Center (CSTEC), Department of Pharmaceutics and Pharmaceutical Chemistry, Health Sciences, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112, USA.

Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like microenvironments. Toward this end, this study explored scaffold-free cell sheet technology as a new 3D platform. Read More

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In silico  structural and functional analysis of cold shock protein in Pseudomonas fluorescens  PF08 from marine fish.

J Food Prot 2021 Apr 14. Epub 2021 Apr 14.


Pseudomonas fluorescens is a specific spoilage microorganism of refrigerated marine fish, which possesses strong adaptability to low temperature. Cold shock proteins (CSPs) play an important role in bacterial cold adaptation. In this study, the CSP genes were obtained from the genome of P. Read More

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Gradient Heating Effect Modulated by Hydrophobic/Hydrophilic Carbon Nanotube Network Structures for Ultrafast Solar Steam Generation.

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230000, China.

The emerging interface solar-thermal water evaporation has been widely studied to solve fresh water shortage because of its high solar-thermal conversion efficiency, environmental friendliness, and low cost. However, traditional water evaporation systems inevitably lose heat to the environment, which not only greatly affects the water evaporation rate but also hinders their practical applications. In this work, an interface solar-thermal water evaporation system with enhanced heat localization, which is combined by a hydrophobic carbon nanotube (CNT) film (heating layer) and hydrophilic polyvinyl alcohol (PVA)/CNT foam (evaporating layer), is demonstrated. Read More

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Self-contained Janus Aerogel with Antifouling and Salt-Rejecting Properties for Stable Solar Evaporation.

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing 210009, China.

Janus structural interfacial vaporization by separating the solar absorber from the bulk working fluid has attracted tremendous attention due to its low heat losses and high solar conversion efficiency for desalination, water purification, energy generation, etc. However, a totally separated double-deck structure with a discontinuous interfacial transition and inefficient photothermic materials undermines its long-term use and large-scale practical exploitation. Herein, a low-cost Janus monolithic chitosan aerogel with continuous aligned run-through microchannels has been demonstrated to have a highly efficient photothermic effect on seawater desalination and wastewater purification. Read More

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Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review.

Curr Pharm Des 2021 Apr 12. Epub 2021 Apr 12.

Cellular and Molecular Endocrine Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Bacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as "bacterial nanocellulose OR bacterial cellulose OR BNC" AND "cancer OR carcinoma OR tumor". Read More

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Interaction energy between neuronal cell receptors and peptoid ligands.

J Biomech 2021 Mar 15;121:110381. Epub 2021 Mar 15.

Multiscale Materials Modeling Lab, Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, USA; Institute for Nanoscience and Engineering, 731 W. Dickson Street, University of Arkansas, Fayetteville, AR, USA. Electronic address:

Peptoids as an extracellular matrix (ECM) material is gaining importance in in vitro neuronal cell culture studies due to their biocompatibility, self-assembling structure, and stability. Mechanotransduction between a neuronal cell and an ECM is mediated by neuronal cell receptors such as integrin and neural cellular adhesion molecule. In this study, using molecular dynamics, we investigate the interaction energies between peptoid and neuronal cell receptors, and also study the effect of peptoid bundle size. Read More

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Crystal structures of zinc(II) complexes with β-hydroxypyridinecarboxylate ligands: examples of structure-directing effects used in inorganic crystal engineering.

Acta Crystallogr B Struct Sci Cryst Eng Mater 2021 Apr 27;77(Pt 2):193-204. Epub 2021 Feb 27.

Centre for Structural Sciences, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary.

The coordination properties of four hydroxypyridinecarboxylates, designed for the treatment of iron-overloading conditions as bidentate O,O'-donor ligands, have been studied with Zn in the solid state. The coordination compounds [Zn(A1)(HO)] (1), [Zn(A2)(HO)] (2), [Zn(A3)(HO)]·2HO (3) and [Zn(B1)(HO)]·4HO (4), where the ligands are 1-methyl-4-oxidopyridinium-3-carboxylate (A1, CHNO), 1,6-dimethyl-4-oxidopyridinium-3-carboxylate (A2, CHNO), 1,5-dimethyl-4-oxido-pyridinium-3-carboxylate (A3, CHNO) and 1-methyl-3-oxidopyridinium-4-carboxylate (B1, CHNO), have been synthesized and analysed by single-crystal X-ray diffraction. The ligands were chosen to probe (i) the electronic effects of inverting the positions of the O-atom donor groups (i. Read More

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MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration.

Front Bioeng Biotechnol 2021 25;9:668428. Epub 2021 Mar 25.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Electrospinning technique has attracted considerable attention in fabrication of cellulose nanofibrils or nanocellulose membranes, in which polycaprolactone (PCL) could be used as a promising precursor to prepare various cellulose nanofibril membranes for periodontal tissue regeneration. Conventional bio-membranes and cellulose films used in guided tissue regeneration (GTR) can prevent the downgrowth of epithelial cells, fibroblasts, and connective tissue in the area of tooth root but have limitations related to osteogenic and antimicrobial properties. Cellulose nanofibrils can be used as an ideal drug delivery material to encapsulate and carry some drugs. Read More

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Comparative Genomics, Evolutionary and Gene Regulatory Regions Analysis of Casein Gene Family in .

Front Genet 2021 23;12:662609. Epub 2021 Mar 23.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China.

Buffalo is a luxurious genetic resource with multiple utilities (as a dairy, draft, and meat animal) and economic significance in the tropical and subtropical regions of the globe. The excellent potential to survive and perform on marginal resources makes buffalo an important source for nutritious products, particularly milk and meat. This study was aimed to investigate the evolutionary relationship, physiochemical properties, and comparative genomic analysis of the casein gene family (, and ) in river and swamp buffalo. Read More

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Directly Patterning Conductive Polymer Electrodes on Organic Semiconductor via In Situ Polymerization in Microchannels for High-Performance Organic Transistors.

ACS Appl Mater Interfaces 2021 Apr 7. Epub 2021 Apr 7.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, 300072 Tianjin, China.

Conductive polymers are considered promising electrode materials for organic transistors, but the reported devices with conductive polymer electrodes generally suffer from considerable contact resistance. Currently, it is still highly challenging to pattern conductive polymer electrodes on organic semiconductor surfaces with good structure and interface quality. Herein, we develop an in situ polymerization strategy to directly pattern the top-contacted polypyrrole (PPy) electrodes on hydrophobic surfaces of organic semiconductors by microchannel templates, which is also applicable on diverse hydrophobic and hydrophilic surfaces. Read More

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Establishment of validated stability indicating purity method based on the stress degradation behavior of gonadotropin-releasing hormone antagonist (ganirelix) in an injectable formulation using HPLC and LC-MS-QTOF.

Eur J Mass Spectrom (Chichester) 2021 Apr 7:14690667211005335. Epub 2021 Apr 7.

Department of Chemistry, 207673Koneru Lakshmaiah Education Foundation, Guntur, India.

Stress study of a drug substance or pharmaceutical drug product provides a vision into degradation pathways and degradation products of the active pharmaceutical ingredient and helps in interpretation of the chemical structure of the degradation impurities. In the current study, Ganirelix active ingredient presented in the Orgalutran® was stressed with acidic and alkali hydrolysis, photolysis, thermal and oxidation conditions as per the guidelines of International Conference on Harmonization (ICH) Q1A (R2). Ganirelix was found to be labile under thermal and alkali hydrolytic stress conditions, while it was stable to acid hydrolytic, oxidative and photolytic stress. Read More

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Simple and efficient preparation of high-purity trehalulose from the waste syrup of isomaltulose production using solid-phase extraction followed by hydrophilic interaction chromatography.

J Sep Sci 2021 Apr 6. Epub 2021 Apr 6.

School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, P. R. China.

A simple and efficient method was developed for the preparation of high-purity trehalulose from the waste syrup of isomaltulose production. The waste syrup was pre-treated with C18 solid-phase extraction, where 98% decolorization and 97% reducing sugar recovery were obtained, followed by hydrophilic interaction liquid chromatography separation on a cysteine-bonded zwitterionic column. Under optimized conditions, trehalulose was separated from isomaltulose isomer and prepared on a semi-preparative scale with more than 99% purity. Read More

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Insight into the bioactive hydrogels for wound healing and drug delivery systems.

Curr Med Chem 2021 Apr 5. Epub 2021 Apr 5.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061. China.

Hydrogel is a hydrophilic but water-soluble polymer system with a three-dimensional network structure. Hydrogel can absorb large amounts of water and maintain its shape and remain soft. The high-moisturizing properties, good biocompatibility and controlled biodegradability of hydrogels have allowed them to be widely used in wound dressing, tissue engineering, controlled drug delivery systems and other fields. Read More

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Study of the interaction mechanism between hydrophilic thiol capped gold nanoparticles and melamine in aqueous medium.

Colloids Surf B Biointerfaces 2021 Mar 26;203:111727. Epub 2021 Mar 26.

Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. Electronic address:

In the last years, intense efforts have been made in order to obtain colloidal-based systems capable of pointing out the presence of melamine in food samples. In this work, we reported about the recognition of melamine in aqueous solution, using gold nanoparticles stabilized with 3-mercapto-1-propanesulfonate (AuNPs-3MPS), with the aim of deepening how the recognition process works. AuNPs were synthesized using a wet chemical reduction method. Read More

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Investigation on conformational variation and activity of trypsin affected by black phosphorus quantum dots via multi-spectroscopy and molecular modeling.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 26;256:119746. Epub 2021 Mar 26.

Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, PR China. Electronic address:

Binding interaction between black phosphorus quantum dots (BPQDs) and trypsin was researched deeply to illustrate the variations on conformation and activity of trypsin affected by BPQDs via multi-spectroscopy and molecular modeling. Experimental results implied that inherent fluorescence of trypsin was quenched by BPQDs via static fluorescence quenching mode. BPQDs bound with trypsin to construct ground-state complex under the binding forces of van der Waal interaction and hydrophobic interaction, resulting in the conformational change of trypsin to be more hydrophilic and incompact. Read More

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Micellization of Sequence-Controlled Polyurethane Ionomers in Mixed Aqueous Solvents.

Macromolecules 2021 Mar 25;54(5):2376-2382. Epub 2021 Feb 25.

Laboratory of Self-Organizing Soft Matter, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600MB Eindhoven, The Netherlands.

While the impact of compositional parameters such as block length and ionic content on the micellization of (polymeric) amphiphiles is widely investigated, the influence of monomer sequence has received far less attention until recently. Here, we report the synthesis of two sequence-controlled polyurethane ionomers (PUIs) prepared via a stepwise coupling-deprotection strategy, and compare their solution association in aqueous-organic mixtures. The two PUIs are highly similar in mass and overall composition, yet differ markedly in the sequence of building blocks. Read More

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Small Molecule and Macrocyclic Pyrazole Derived Inhibitors of Myeloperoxidase (MPO).

Bioorg Med Chem Lett 2021 Mar 31:128010. Epub 2021 Mar 31.

Research and Development, Bristol-Myers Squibb Company, P. O. Box 5400, Princeton, NJ 08543 USA.

Myeloperoxidase (MPO), a critical enzyme in antimicrobial host-defense, has been implicated in chronic inflammatory diseases such as coronary artery disease. The design and evaluation of MPO inhibitors for the treatment of cardiovascular disease is reported herein. Starting with the MPO and triazolopyridine 3 crystal structure, novel inhibitors were designed incorporating a substituted pyrazole, which allowed for substituents to interact with hydrophobic and hydrophilic patches in the active site. Read More

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Biodegradable and Biocompatible Silatrane Polymers.

Molecules 2021 Mar 26;26(7). Epub 2021 Mar 26.

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russia.

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. Read More

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In-Vitro Application of Magnetic Hybrid Niosomes: Targeted siRNA-Delivery for Enhanced Breast Cancer Therapy.

Pharmaceutics 2021 Mar 16;13(3). Epub 2021 Mar 16.

Institute for Particle Technology, Technische Universität Braunschweig, 38104 Braunschweig, Germany.

Even though the administration of chemotherapeutic agents such as erlotinib is clinically established for the treatment of breast cancer, its efficiency and the therapy outcome can be greatly improved using RNA interference (RNAi) mechanisms for a combinational therapy. However, the cellular uptake of bare small interfering RNA (siRNA) is insufficient and its fast degradation in the bloodstream leads to a lacking delivery and no suitable accumulation of siRNA inside the target tissues. To address these problems, non-ionic surfactant vesicles (niosomes) were used as a nanocarrier platform to encapsulate Lifeguard (LFG)-specific siRNA inside the hydrophilic core. Read More

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Huntingtin: A Protein with a Peculiar Solvent Accessible Surface.

Int J Mol Sci 2021 Mar 12;22(6). Epub 2021 Mar 12.

Biocomputing Group, University of Bologna, Via San Giacomo 9/2, 40126 Bologna, Italy.

Taking advantage of the last cryogenic electron microscopy structure of human huntingtin, we explored with computational methods its physicochemical properties, focusing on the solvent accessible surface of the protein and highlighting a quite interesting mix of hydrophobic and hydrophilic patterns, with the prevalence of the latter ones. We then evaluated the probability of exposed residues to be in contact with other proteins, discovering that they tend to cluster in specific regions of the protein. We then found that the remaining portions of the protein surface can contain calcium-binding sites that we propose here as putative mediators for the protein to interact with membranes. Read More

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