90,129 results match your criteria hydrogen peroxide

Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Ecotoxicol Environ Saf 2021 Jun 9;220:112401. Epub 2021 Jun 9.

Department of Botany, S.P. College, Srinagar, Jammu and Kashmir, India. Electronic address:

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0. Read More

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Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.

Bioresour Technol 2021 May 24;337:125327. Epub 2021 May 24.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars. The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency. The optimal pretreatment was with 0. Read More

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Degradation of antibiotic Cephalosporin C in different water matrices by ionizing radiation: Degradation kinetics, pathways, and toxicity.

Sci Total Environ 2021 Jun 4;791:148253. Epub 2021 Jun 4.

Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, PR China; Beijing Key Laboratory of Radioactive Waste Treatment, Tsinghua University, Beijing 100084, PR China. Electronic address:

Cephalosporin antibiotics are ubiquitous emerging pollutants in various aquatic environments due to their extensive production and application. Herein, the radiolytic degradation of antibiotic Cephalosporin C (CEP-C) in different water matrices was comprehensively investigated using gamma radiation at various experimental conditions. The results revealed that CEP-C oxidation obeyed pseudo first-order kinetics, and 100%, 94. Read More

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Oxygen-generating glycol chitosan-manganese dioxide nanoparticles enhance the photodynamic effects of chlorin e6 on activated macrophages in hypoxic conditions.

Int J Biol Macromol 2021 Jun 10;184:20-28. Epub 2021 Jun 10.

Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do 17546, Republic of Korea. Electronic address:

This study aimed to investigate the use of glycol chitosan (GC) for the synthesis of MnO nanoparticles (NPs) and to evaluate whether the prepared GC-MnO NPs enhance the light-triggered photodynamic effects of chlorin e6 (Ce6) via the generation of oxygen and alleviation of hypoxia in lipopolysaccharide (LPS)-activated macrophages (RAW 264.7), which produce excessive amounts of reactive oxygen species (ROS). GC-MnO NPs were synthesized by a simple reaction between GC and KMnO in water. Read More

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A comparison of Prx- and OxyR-based HO probes expressed in S. cerevisiae.

J Biol Chem 2021 Jun 9:100866. Epub 2021 Jun 9.

German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

Genetically encoded fluorescent HO probes continue to advance the field of redox biology. Here we compare the previously established peroxiredoxin-based HO probe roGFP2-Tsa2ΔC with the newly described OxyR-based HO probe HyPer7, using yeast as the model system. While not as sensitive as roGFP2-Tsa2ΔC, HyPer7 is much improved relative to earlier HyPer versions, most notably by ratiometric pH stability. Read More

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Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid.

Methods Mol Biol 2021 ;2275:315-327

Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, USA.

The development of boronic probes enabled reliable detection and quantitative analysis of hydrogen peroxide , other nucleophilic hydroperoxides, hypochlorite , and peroxynitrite . The major product, in which boronate moiety of the probe is replaced by the hydroxyl group, is, however, common for all those oxidants. Here, we describe how ortho-isomer of mitochondria-targeted phenylboronic acid can be used to detect and differentiate peroxynitrite-dependent and independent probe oxidation. Read More

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January 2021

Imaging Mitochondrial Hydrogen Peroxide in Living Cells.

Methods Mol Biol 2021 ;2275:127-140

School of Chemistry, The University of Sydney, Sydney, NSW, Australia.

Hydrogen peroxide (HO) produced from mitochondria is intimately involved in human health and disease, but is challenging to selectively monitor inside living systems. The fluorescent probe MitoPY1 provides a practical tool for imaging mitochondrial HO and has been demonstrated to function in a variety of diverse cell types. In this chapter, we describe the synthetic preparation of the small molecule probe MitoPY1 , methods for validating this probe in vitro and in live cells, and an example procedure for measuring mitochondrial HO in a cell culture model of Parkinson's disease. Read More

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January 2021

Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide.

Methods Mol Biol 2021 ;2275:87-117

School of Chemistry, University of Glasgow, Glasgow, UK.

Small molecules can be physicochemically targeted to the mitochondrial matrix using the lipophilic alkyltriphenylphosphonium (TPP) group. Once in the mitochondria the TPP conjugate can detect or influence processes within the mitochondrial matrix directly. Alternatively, the conjugate can behave as a prodrug, which is activated by release from the TPP group either using an internal or external instruction. Read More

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January 2021

Decontamination of respirators amid shortages due to SARS-CoV-2.

Photochem Photobiol Sci 2021 Jun 12. Epub 2021 Jun 12.

Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294-0022, USA.

The pandemic created by SARS-CoV-2 has caused a shortage in the supplies of N95 filtering facepiece respirators (FFRs), disposable respirators with at least 95% efficiency to remove non-oily airborne particles, due to increasing cases all over the world. The current article reviewed various possible decontamination methods for FFR reuse including ultraviolet germicidal irradiation (UVGI), hydrogen peroxide vapor (HPV), microwave-generated steam (MGS), hydrogen peroxide gas plasma (HPGP), and 70% or higher ethanol solution. HPV decontamination was effective against bacterial spores (6 log reduction of Geobacillus stearothermophilus spores) on FFRs and viruses (> 4 log reduction of various types of viruses) on inanimate surfaces, and no degradation of respirator materials and fit has been reported. Read More

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PREMATURE SENESCENCE LEAF 50 Promotes Heat Stress Tolerance in Rice (Oryza sativa L.).

Rice (N Y) 2021 Jun 12;14(1):53. Epub 2021 Jun 12.

State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, 310006, China.

Background: Heat stress is a major environmental factor that could induce premature leaf senescence in plants. So far, a few rice premature senescent leaf mutants have been reported to involve in heat tolerance.

Findings: We identified a premature senescence leaf 50 (psl50) mutant that exhibited a higher heat susceptibility with decreased survival rate, over-accumulated hydrogen peroxide (HO) content and increased cell death under heat stress compared with the wild-type. Read More

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In-office tooth bleaching with chitosan-enriched hydrogen peroxide gels: in vitro results.

Clin Oral Investig 2021 Jun 12. Epub 2021 Jun 12.

Department of Restorative Dentistry, Piracicaba Dental School, University of Campinas, Av. Limeira, 901, Piracicaba, SP, 13414-903, Brazil.

Objective: This study aimed to evaluate the effects of adding chitosan to 35% hydrogen peroxide gels (for in-office bleaching), with or without calcium gluconate, on tooth properties and bleaching efficacy.

Methods: Bovine enamel/dentin specimens (4 × 4 × 2.5 mm) were randomly allocated into groups (n = 10): negative control (unbleached), bleaching with 35% hydrogen peroxide gel (35% HP, commercial gel); 35% HP with 2% chitosan (% wt) (35% HP + chitosan), 35% HP and calcium (35% HP + Ca, commercial gel), and 35% HP + Ca + 2% chitosan. Read More

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Peroxidasin promotes diabetic vascular endothelial dysfunction induced by advanced glycation end products via NOX2/HOCl/Akt/eNOS pathway.

Redox Biol 2021 Jun 6;45:102031. Epub 2021 Jun 6.

Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, 41008, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Reactive oxygen species (ROS) derived from NADPH oxidases (NOX) plays an essential role in advanced glycation end products (AGEs)-induced diabetic vascular endothelial dysfunction. Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (HO) to hypochlorous acid (HOCl). This present study aimed to elucidate the role of PXDN in promoting vascular endothelial dysfunction induced by AGEs in diabetes mellitus. Read More

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Clinical evaluation of in-office tooth whitening with violet LED (405 nm): A double-blind randomized controlled clinical trial.

Photodiagnosis Photodyn Ther 2021 Jun 8:102385. Epub 2021 Jun 8.

Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. Electronic address:

Background: Although there is little evidence showing the effectiveness of violet LED on in-office tooth whitening, there are some studies which have reported satisfactory results. This double-blind randomized controlled clinical trial aimed to evaluate the effect of a violet light emission diode (LED) (405nm) system, used in-office, on tooth whitening, sensitivity, use of medication after whitening and quality of life.

Methods: Eight patients were randomized into 4 groups (n = 20): G1 - violet LED, G2 - 35% carbamide peroxide (CP) and violet LED, G3 only CP 35% and G4 35% hydrogen peroxide (HP). Read More

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A copper-zinc-superoxide dismutase (CuZnSOD) from redlip mullet, Liza haematocheila: Insights to its structural characteristics, immune responses, antioxidant activity, and potent antibacterial properties.

Dev Comp Immunol 2021 Jun 8:104165. Epub 2021 Jun 8.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address:

Copper-zinc superoxide dismutase (CuZnSOD) is a nuclear-encoded metalloenzyme responsible for scavenging harmful reactive oxygen species (ROS). In this study, the CuZnSOD homolog from redlip mullet (Liza haematochelia) (MuCuZnSOD) was structurally and functionally characterized to evaluate its antioxidant capacity, antibacterial properties, and protective level in various pathogenic stress conditions. Structural characteristics of MuCuZnSOD were evaluated using different bioinformatics tools. Read More

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An effective NIR laser/tumor-microenvironment co-responsive cancer theranostic nanoplatform with multi-modal imaging and therapies.

Nanoscale 2021 Jun 11. Epub 2021 Jun 11.

College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China.

Cancer is still a major threat to human health at present. Developing new types of integrated nanoplatforms for the accurate diagnosis and effective treatment of cancer is very significant. Herein, an intelligent dual-stage core-shell cancer theranostic nanoplatform ([email protected]@PbP) with NIR laser/tumor-microenvironment (TME) co-responsiveness and multi-modal imaging-therapy was successfully prepared, which was composed of the precisely structured oil-soluble Au1Ag24 nanoclusters (NCs) and Fe3+ ions easily assembled within the oil and aqueous phases of the polyethylene glycol (PEG) block grafted polyketal (PK) copolymer (PK-b-PEG, PbP) vesicles, respectively. Read More

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Rhizospheric Protects cv. Geumsugangsan From Multiple Abiotic Stresses Multifarious Plant Growth-Promoting Attributes.

Front Plant Sci 2021 25;12:669693. Epub 2021 May 25.

Department of Applied Biosciences, Kyungpook National University, Daegu, South Korea.

Plant growth-promoting rhizobacteria (PGPR) are beneficial microorganisms that can be utilized to improve plant responses against biotic and abiotic stresses. In this study, we investigated whether PGPR () isolated from the endorhizosphere of have the potential to sustain pepper growth under drought, salinity, and heavy metal stresses. The bacterial strain was determined based on 16S rDNA and gyrB gene sequencing and characterized based on the following biochemical traits: nitrogen fixation; 1-aminocyclopropane-1-carboxylate deaminase activity; indole acetic acid production; inorganic phosphate, potassium, zinc, and silicon solubilization; and siderophore production. Read More

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ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron.

Acta Pharmacol Sin 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.

Ferroptotic cell death is characterized by iron-dependent lipid peroxidation that is initiated by ferrous iron and HO via Fenton reaction, in which the role of activating transcription factor 3 (ATF3) remains elusive. Brucine is a weak alkaline indole alkaloid extracted from the seeds of Strychnos nux-vomica, which has shown potent antitumor activity against various tumors, including glioma. In this study, we showed that brucine inhibited glioma cell growth in vitro and in vivo, which was paralleled by nuclear translocation of ATF3, lipid peroxidation, and increases of iron and HO. Read More

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Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes.

Med Sci Monit 2021 Jun 11;27:e930258. Epub 2021 Jun 11.

Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, China (mainland).

BACKGROUND To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. MATERIAL AND METHODS Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. Liver function, bile secretion, and pathological features of DCD donor livers were detected to evaluate the protective effects of NMP and BMMSCs on DCD donor livers. Read More

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Signal-on photoelectrochemical immunoassay mediated by the etching reaction of oxygen/phosphorus co-doped g-CN/AgBr/MnO nanohybrids.

Anal Chim Acta 2021 Aug 24;1171:338680. Epub 2021 May 24.

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 350108, People's Republic of China. Electronic address:

We designed a signal-on photoelectrochemical (PEC) immunoassay for the sensitive monitoring of prostate-specific antigen (PSA) based on the etching reaction of hydrogen peroxide (HO) toward oxygen/phosphorus co-doped graphitic CN/AgBr/MnO nanosheets (OP-g-CN/AgBr/MnO). Initially, glucose oxidase (GO)-labeled detection antibodies were introduced into the capture antibody-coated microplate with a sandwich-type immunoreaction in the presence of PSA. Then, the as-generated HO from the decomposition of glucose by GO etched the manganese dioxide (MnO) nanosheets into manganese ions (Mn), thereby causing the exposure of the underlying OP-g-CN/AgBr. Read More

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Oxidative biomarkers of exhaled breath condensate in adults exposed to traffic-related air pollution: A case-control study.

J Breath Res 2021 Jun 10. Epub 2021 Jun 10.

Molecular Biology, National Institute for Research in Environmental Health, Kamla Nehru hospital, Bhopal, Madhya Pradesh, 462001, INDIA.

Objective Traffic-related air pollution exposure (TRAP) is a major public health problem. The effects of TRAP exposure on oxidative biomarkers of exhaled breath condensate (EBC) of adults are not much studied. We compared the oxidative EBC biomarkers in a group of individuals exposed to TRAP with those unexposed to TRAP. Read More

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Enhanced dewatering of activated sludge by acid assisted Heat-CaO treatment: Simultaneously removing heavy metals and mitigating antibiotic resistance genes.

J Hazard Mater 2021 May 27;418:126248. Epub 2021 May 27.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

High water content and accumulation of heavy metals and antibiotic resistance genes (ARGs) in sewage sludge limit its application. Fenton process has been widely used in sludge dewatering, but the use of hydrogen peroxide (HO) and generation of acid sludge are the main drawbacks. Here, a novel method of heat-CaO treatment was proposed to enhance sludge dewatering. Read More

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Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and Imaging.

Acc Chem Res 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemistry, Southern Methodist University, Dallas, Texas 75275-0314, United States.

ConspectusChemiluminescence is a fascinating phenomenon that evolved in nature and has been harnessed by chemists in diverse ways to improve life. This Account tells the story of our research group's efforts to formulate and manifest spiroadamantane 1,2-dioxetanes with triggerable chemiluminescence for imaging and monitoring important reactive analytes in living cells, animals, and human clinical samples. Analytes like reactive sulfur, oxygen and nitrogen species, as well as pH and hypoxia can be indicators of cellular function or dysfunction and are often implicated in the causes and effects of disease. Read More

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Characterization and Selection of Lactobacillus plantarum and Lactobacillus paracasei for prevention of oral bacterial infections from Chinese pickle.

AMB Express 2021 Jun 9;11(1):84. Epub 2021 Jun 9.

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, 318 Liuhe Road, Hangzhou, 310023, Zhejiang, China.

The oral infections were mainly caused by Streptococci and Staphylococcus aureus. Antibiotic therapies can eliminate these harmful bacteria. However, it can break beneficial microbes and lead to the persistence of resistant strains. Read More

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CircRNA DOCK1 Regulates miR-409-3p/MCL1 Axis to Modulate Proliferation and Apoptosis of Human Brain Vascular Smooth Muscle Cells.

Front Cell Dev Biol 2021 24;9:655628. Epub 2021 May 24.

Department of Neurosurgery, Shanxi Bethune Hospital, The Third Hospital of Shanxi Medical University, Taiyuan, China.

Background: Intracranial aneurysm is an abnormal expansion in the intracranial arteries, which is associated with growth and apoptosis of vascular smooth muscle cells. Circular RNAs (circRNAs) have implicated in the progression of intracranial aneurysms. The purpose of this paper is to study the function and mechanism of circRNA dedicator of cytokinesis 1 (circ_DOCK1) in regulating proliferation and apoptosis of human brain vascular smooth muscle cells (HBVSMCs). Read More

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Pursuit of the ideal antiseptic irrigation solution in the management of periprosthetic joint infections.

J Bone Jt Infect 2021 26;6(6):189-198. Epub 2021 May 26.

Brigham & Women's Hospital, Department of Orthopedics, Boston, MA, 02115, USA.

Irrigation and debridement in the treatment of periprosthetic joint infection (PJI) serve an integral role in the eradication of bacterial burden and subsequent re-infection rates. Identifying the optimal irrigation agent, however, remains challenging, as there is limited data on superiority. Direct comparison of different irrigation solutions remains difficult because of variability in treatment protocols. Read More

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Role of TRPM2 in brain tumours and potential as a drug target.

Acta Pharmacol Sin 2021 Jun 9. Epub 2021 Jun 9.

Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest category of drug targets, following enzymes and receptors. The transient receptor potential melastatin (TRPM) subfamily of ion channels are important to cell function and survival. Studies have shown upregulation of the TRPM family of ion channels in various brain tumours. Read More

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Visual monitoring and optical recognition of digoxin by functionalized AuNPs and triangular AgNPs as efficient optical nano-probes.

J Mol Recognit 2021 Jun 9:e2917. Epub 2021 Jun 9.

Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In this study, we presented elective, sensitive, and rapid UV-Vis spectrophotometry and calorimetric assay for the recognition of digoxin. Therefore, cysteamine-gold nanoparticles (Cys A-AuNPs) in the presence of cysteine acid amine and Silver nanoparticles in the presence of tetramethyl benzidine and hydrogen peroxide (AgNPs-TMB [3,3',5,5'-tetramethylbenzidine]-H O ) were synthesized and utilized as the desired probe. Finally, color variation of probes was observed in the absence and presence of digoxin. Read More

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Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications.

Appl Microbiol Biotechnol 2021 Jun 9. Epub 2021 Jun 9.

Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1, Hon-cho, 036-8564, Hirosaki, Aomori, Japan.

Mucus layer that covers the body surface of various animal functions as a defense barrier against microbes, environmental xenobiotics, and predators. Previous studies have reported that L-amino acid oxidase (LAAO), present in several animal fluids, has potent properties against pathogenic bacteria, viruses, and parasites. LAAO catalyzes the oxidative deamination of specific L-amino acids with the generation of hydrogen peroxide and L-amino acid metabolites. Read More

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A Zeolitic-Imidazole Framework-Derived Trifunctional Electrocatalyst for Hydrazine Fuel Cells.

ACS Nano 2021 Jun 9. Epub 2021 Jun 9.

School of Chemistry and Chemical Engineering, Key Laboratory of Material Chemistry for Energy Conversion and Storage (Ministry of Education), Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China.

Hydrazine fuel cells are promising sustainable power sources. However, the high price and limited reserves of noble metal catalysts that promote the sluggish cathodic and anodic electrochemical reactions hinder their practical applications. Reflecting the enhanced diffusion and improved kinetics of nanostructured non-noble metal electrocatalysts, we report an efficient zeolitic-imidazole framework-derived trifunctional electrocatalyst for hydrazine oxidation, oxygen, and hydrogen peroxide reduction. Read More

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Nitrogen and copper-doped carbon quantum dots with intrinsic peroxidase-like activity for double-signal detection of phenol.

Analyst 2021 Jun 9. Epub 2021 Jun 9.

Anhui Key Laboratory of Chemo-Biosensing, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, P R China.

Herein, a simple and facile one-step hydrothermal carbonization synthesis procedure for the fabrication of N, Cu-doped carbon quantum dots (N, Cu-CQDs) as a peroxidase-mimicking enzyme was reported. The peroxidase-like performance of N, Cu-CQDs was assessed based on the oxidative coupling reaction of phenol with 4-aminoantipyrine (4-AAP) in the presence of hydrogen peroxide (H2O2). The N, Cu-CQDs/4-AAP/H2O2 system was applied to sensing phenol based on double signals of absorption spectra (or colorimetric visualization) as well as fluorescence spectra. Read More

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