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Bioorg Chem 2021 Apr 1;111:104885. Epub 2021 Apr 1.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address:

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs. Thus, in the present investigation, a novel series of 1,2,4-oxadiazole-chalcone/oxime (6a-f) and (7a-f) were synthesized and characterized by IR, NMR (H and C) and elemental analyses. Read More

Int J Syst Evol Microbiol 2021 Apr;71(4)

Medical Laser Research Center, Dankook University, Cheonan 31116, Republic of Korea.

Soybean pods, separated and enclosed from the outside environment, are considered a suitable place to find new microbes. A Gram-stain-negative, aerobic bacterium, bacterial strain (YB22) was isolated from the pod of (soybean) collected from a rural area in Republic of Korea and characterized by using polyphasic taxonomy. Cells of the strain were rod-shaped (approximately 0. Read More

Int J Syst Evol Microbiol 2021 Apr;71(4)

Institut für Mikrobiologie, Veterinärmedizinische Universität, A-1210 Wien, Austria.

A beige-pigmented, oxidase-positive bacterial isolate, Wesi-4, isolated from charcoal in 2012, was examined in detail by applying a polyphasic taxonomic approach. Cells of the isolates were rod shaped and Gram-stain negative. Examination of the 16S rRNA gene sequence of the isolate revealed highest sequence similarities to the type strains of and (both 97. Read More

Arch Microbiol 2021 Apr 8. Epub 2021 Apr 8.

Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Open Laboratory of Applied Microbiology, Guangdong Microbial Culture Collection Center (GDMCC), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, People's Republic of China.

The two novel bacterial strains designated 1Y17 and 4Y10 from aquaculture water were characterized using a polyphasic taxonomic approach. Phylogenetic analysis of 16S rRNA gene sequences revealed that strains 1Y17 and 4Y10 belonged to the genus Inhella and were close to Inhella crocodyli CCP-18, Inhella inkyongensis IMCC1713 and Inhella fonticola TNR-25. Strains 1Y17 and 4Y10 shared 98. Read More

Arch Microbiol 2021 Apr 8. Epub 2021 Apr 8.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 Let Vladivostoku, 159, Vladivostok, 690022, Russia.

An aerobic, Gram-negative, non-pigmented non-motile bacterium designed КMM 8518 was isolated from a seawater sampled from the Sea of Japan seashore. Strain КMM 8518 grew at 7-42 °C and in the presence of 1-7% NaCl. The phylogenetic analyses based on 16S rRNA gene and whole-genome sequences placed the novel strain КMM 8518 into the genus Thalassobius as a separate lineage. Read More

Arch Microbiol 2021 Apr 7. Epub 2021 Apr 7.

Department of Biological Science, College of Science and Engineering, Sangji University, Wonju, 26339, Republic of Korea.

A yellow-colored bacterial strain, designated S2 was isolated from soil in South Korea. Cells of strain S2 were strictly aerobic, Gram-stain-negative, motile with single polar flagellum, rod-shaped, oxidase and catalase-negative. Growth occurs at 10-37 °C (optimum, 28 °C), pH 5. Read More

J Mol Model 2021 Apr 6;27(5):123. Epub 2021 Apr 6.

Department of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, 826004, India.

The structural, electronic, and optical properties of hydrofluorinated germanene have been studied with different occupancy ratios of fluorine and hydrogen. The hybridization of H-1 s and Ge-4p orbitals in hydrogenated germanene and F-2p and Ge-4p orbitals in fluorinated germanene plays a significant role in creating an energy bandgap. The binding energy and phonon calculations confirm the stability of hydrofluorinated germanene decreases with the increase of the F to H ratio. Read More

Pathogens 2021 Mar 19;10(3). Epub 2021 Mar 19.

Ecole de Médecine Dentaire, Faculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385 Marseille, France.

The genus currently counts a unique species, , isolated from periodontal pockets and associated with periodontitis and endodontic infections. This study contributed to the taxonomical and clinical knowledge of this genus by describing a novel species isolated from a saliva sample from a man in clinical gingival health following successful treatment of periodontitis. Morphological and chemotaxonomic characteristics were investigated using different growth conditions, pH, and temperature. Read More

Plants (Basel) 2021 Mar 23;10(3). Epub 2021 Mar 23.

Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia.

is a cosmopolitan medicinal plant from the Lamiaceae family, which produces structurally highly diverse groups of secondary metabolites. A total of 160 compounds were determined in the volatiles from Serbia during two investigated years (2019 and 2020). The main components were -caryophyllene, followed by germacrene D, -humulene and -copaene. Read More

Healthcare (Basel) 2021 Mar 3;9(3). Epub 2021 Mar 3.

Department of Microbiology, Parasitology and Virology, Faculty of Medicine, Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Background: We investigated the correlation between the androgen receptor (AR) and immunohistochemistry (IHC) as a prognostic factor in breast cancer (BC). AR is expressed in 60-80% of BC.

Methods: We evaluated the prognostic values of AR expression among 143 patients with BC for 36 months. Read More

Int J Environ Res Public Health 2021 Mar 27;18(7). Epub 2021 Mar 27.

Department of Physical Activity and Sport, CEI Campus Mare Nostrum, University of Murcia, 30720 Santiago de la Ribera, Spain.

Increasing physical activity (PA) and personal and social values are two of the greatest demands in the current educational system. This study examined the effects of a program based on the hybridization of the Personal and Social Responsibility Model and gamification. A total of 58 students (13. Read More

Eur J Med Chem 2021 Mar 20;218:113384. Epub 2021 Mar 20.

Institute for Interdisciplinary Research, Jianghan University, Wuhan Economic and Technological Development Zone, Wuhan, 430056, China; Institut Parisien de Chimie Moléculaire, CNRS UMR 8232, Sorbonne Université, 4 Place Jussieu, 75005, Paris, France. Electronic address:

Herein we reported the synthesis of twenty new organoselenium compounds (2a-2j and 3a-3j) based on the hybridization of nonsteroidal antiinflammatory drugs (NSAIDs) skeleton and organoselenium motif (-SeCN and -SeCF), the anticancer activity was evaluated against four types of cancer cell lines, Caco-2 (human colon adenocarcinoma cells), BGC-823 (human gastric cancer cells), MCF-7 (human breast adenocarcinoma cells), PC-3 (human prostatic cancer cells). Interestingly, the introduction of the -SeCN or -SeCF moiety in corresponding parent NSAIDs results in the significant effect on cancer cell lines. Moreover, the most active compound 3a showed IC values lower than 5 μM against the four cancer cell lines, particularly to BGC-823 and MCF-7 with IC values of 2. Read More

Antonie Van Leeuwenhoek 2021 Apr 1. Epub 2021 Apr 1.

Life Sciences Institute, Zunyi Medical University, Zunyi, 563006, People's Republic of China.

A novel, aerobic, moderately halophilic Gram-positive actinomycete, strain MASK1Z-5 was isolated from a surface-sterilized branch of Bruguiera gymnoirhiza in Shankou Mangrove Nature Reserve, Guangxi, China. The taxonomic position of the strain was investigated using a polyphasic approach. Strain MASK1Z-5 tolerated up to 20% (w/v) NaCl (optimum 0-7%), and grew at pH 5. Read More

Klin Lab Diagn 2021 Mar;66(3):154-159

National Research Center for hematology.

Telomere length can be measured by polymerase chain reaction (PCR), allowing to obtain the absolute length of telomeres (ALT) in base pair, and by flow cytometry, which can only estimate the relative telomere length. The aim of the study was to compare the results of the two methods and to develop an accurate and reliable way of converting the relative telomere length to absolute. The peripheral blood from 21 donors was analyzed. Read More

Curr Microbiol 2021 Apr 1. Epub 2021 Apr 1.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.

A Gram-stain-negative, aerobic, non-motile, white-pigmented, short rod-shaped, and alginate-degrading bacterium, designated B1Z28, was isolated from the gut of the abalone Haliotis rubra obtained at Weihai, China. Strain B1Z28 was found to grow at 4-35 °C, pH 6.5-9. Read More

Front Microbiol 2021 15;12:639396. Epub 2021 Mar 15.

Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, United States.

Four strains belonging to the family of were isolated from different locations on the International Space Station (ISS) across two consecutive flights. Of these, three were identified as Gram-negative, rod-shaped, catalase-positive, oxidase-positive, motile bacteria, designated as IF7SW-B2, IIF1SW-B5, and IIF4SW-B5, whereas the fourth was identified as . The sequence similarity of these three ISS strains, designated as IF7SW-B2, IIF1SW-B5, and IIF4SW-B5, was <99. Read More

Antonie Van Leeuwenhoek 2021 Mar 29. Epub 2021 Mar 29.

State Key Laboratory of Microbial Technology, Institute of Marine Science and Technology, Marine Biotechnology Research Center, Shandong University, Qingdao, 266237, China.

Two Gram-stain-negative bacterial strains, SM1969 and SM1979, were isolated from coastal surface seawater of Qingdao, China. They were taxonomically characterized by the phylogenetic, genomic, chemotaxonomic and phenotypic analyses. The two strains shared 97. Read More

Antimicrob Agents Chemother 2021 Mar 29. Epub 2021 Mar 29.

Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

HIV persistence in tissue reservoirs is a major barrier to HIV cure. While antiretrovirals (ARVs) suppress viral replication, antiretroviral therapy (ART) interruption results in rapid rebound viremia that may originate from lymphoid tissues. To understand the relationship between anatomic distribution of ARV exposure and viral expression in lymph nodes, we performed mass spectrometry imaging (MSI) of 6 ARVs, RNAscope hybridization for viral RNA, and immunohistochemistry of collagen in mesenteric lymph nodes from 8 uninfected and 10 reverse transcriptase-simian/human immunodeficiency virus (RT-SHIV) infected rhesus macaque nonhuman primates (NHPs) dosed to steady-state with combination ART. Read More

Transbound Emerg Dis 2021 Mar 29. Epub 2021 Mar 29.

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, 50011, USA.

Porcine Sapovirus (SaV) was first identified by electron microscopy in the United States in 1980 and has since been reported from both asymptomatic and diarrheic pigs usually in mixed infection with other enteric pathogens. SaV as the sole etiological agent of diarrhea in naturally infected pigs has not previously been reported in the United States. Here, we used four independent lines of evidence including metagenomics analysis, real-time RT-PCR (rRT-PCR), histopathology, and in situ hybridization to confirm porcine SaV genogroup III (GIII) as the sole cause of enteritis and diarrhea in pigs. Read More

Antonie Van Leeuwenhoek 2021 Mar 27. Epub 2021 Mar 27.

Key Laboratory of Agriculture Biological Functional Gene of Heilongjiang Provincial Education Committee, Northeast Agricultural University, Harbin, 150030, China.

A novel endophytic actinomycete with antagonistic activity against various phytopathogenic fungi, designated strain p1417, was isolated from the root of cattail (Typha angustifolia L.) collected from Yunnan Province, Southwest China. A polyphasic taxonomic study was carried out to establish the taxonomic status of this strain. Read More

J AOAC Int 2021 Mar 27. Epub 2021 Mar 27.

AOAC INTERNATIONAL, 2275 Research Blvd. #300, Rockville, MD, 20850, USA.

Background: The GENE-UP®  Salmonella (SLM) assay (Performance Tested Method  SM 121802) is a PCR detection method that utilizes Fluorescence Resonance Energy Transfer hybridization probes for the rapid detection of Salmonella species in foods and on environmental surfaces.

Objective: The purpose of this validation was to evaluate the method's interlaboratory performance for submission to AOAC INTERNATIONAL for adoption as First Action Official Method of Analysis  SM.

Method: The GENE-UP method was evaluated in a multi-laboratory study using unpaired test portions for one food matrix, raw ground beef (80% lean). Read More

Antonie Van Leeuwenhoek 2021 Mar 26. Epub 2021 Mar 26.

Department of Marine Chemistry, Zhejiang Ocean University, Zhoushan, China.

During the study into the microbial biodiversity and bioactivity of the Microcystis phycosphere, a new yellow-pigmented, non-motile, rod-shaped bacterium containing polyhydroxybutyrate granules designated as strain Z10-6 was isolated from highly-toxic Microcystis aeruginosa Kützing M.TN-2. The new isolate produces active bioflocculating exopolysaccharides. Read More

Ecol Evol 2021 Mar 7;11(6):2782-2795. Epub 2021 Feb 7.

Department of Biology Ball State University Muncie IN USA.

The invasion of freshwater ecosystems by non-native species can constitute a significant threat to native species and ecosystem health. Non-native trouts have long been stocked in areas where native trouts occur and have negatively impacted native trouts through predation, competition, and hybridization. This study encompassed two seasons of sampling efforts across two ecoregions of the western United States: The Great Basin in summer 2016 and the Yellowstone River Basin in summer 2017. Read More

Arch Microbiol 2021 Mar 24. Epub 2021 Mar 24.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.

A novel Gram-staining negative, crescent-like or rod-shaped, non-motile bacterium, designated strain CUG 91378, was isolated from a sediment sample of Qinghai Lake, Qinghai Province, China. The strain was red-colored, and catalase- and oxidase-positive. Strain CUG 91378 was able to grow at 15-37 °C (optimum, 28 °C), pH 7-9 (pH 7. Read More

Sci Rep 2021 Mar 23;11(1):6695. Epub 2021 Mar 23.

Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.

An ivory-coloured, motile, Gram-stain-negative bacterium, designated TW-1 was isolated from oil-contaminated experimental soil in Kyonggi University. The phylogenetic analysis based on 16S rRNA gene sequence revealed, strain TW-1 formed a lineage within the family Oxalobacteraceae and clustered as members of the genus Massilia. The closest members were M. Read More

Braz J Microbiol 2021 Mar 19. Epub 2021 Mar 19.

ABI Group of GPM Project, Department of Marine Chemistry, College of Marine Science and Technology, Zhejiang Ocean University, Zhoushan, 316022, China.

During our conveying the microbial structures of phycosphere microbiota (PM) derived from diverse marine harmful algal bloom (HAB) dinoflagellates, a new rod-sharped, white-colored cultivable bacterial strain, designated as LZ-15-2, was isolated from the PM of highly toxic Alexandrium catenella LZT09. Phylogenetic analysis of 16S rRNA gene sequence indicated that strain LZ-15-2 belonged to the genus Marivita within the family Rhodobacteraceae, and demonstrated the highest gene similarity of 99.2% to M. Read More

Antonie Van Leeuwenhoek 2021 Mar 19. Epub 2021 Mar 19.

Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.

A novel marine hydrogen- and sulfur-oxidizing bacterium, designated strain S2-6, was isolated from the deep-sea sediment samples at the Longqi hydrothermal system, southwestern Indian Ocean. Cells were Gram-stain-negative, motile, short rods with a single polar flagellum. Growth was observed at 10-45 °C (optimum 33 °C), pH 5. Read More

Vavilovskii Zhurnal Genet Selektsii 2020 Nov;24(7):738-746

Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

The creation of varieties adapted to changing environmental conditions, resistant to various pathogens, and satisfying various grain purposes is impossible without using the genetic diversity of wheat. One of the ways to expand the genetic diversity of wheat is to introduce new variants of genes from the genetic pool of congeners and wild relatives into the genotypes of existing varieties. In this study, we used 10 lines from the Arsenal collection created on the genetic basis of the spring variety 'Rodina' and the diploid species Aegilops speltoides in the Federal Research Center "Nemchinovka" in 1994. Read More

Bioorg Chem 2021 Mar 5;110:104794. Epub 2021 Mar 5.

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, 11884 Cairo, Egypt. Electronic address:

A new series of 1,3,4-thiadiazolo-adamantane derivatives were synthesized through molecular hybridization approach, then used as starting material to synthesize chloro and cyano acetamide-thiadiazole derivatives 2, 3. The newly designed compounds 1-3 were treated with different reagents to design 5-adamantyl thiadiazole derivatives 4-17 and evaluate their in vitro anti-proliferative activity against three cancer cell lines (MCF-7, HepG-2 and A549). Doxorubicin was used as a positive control. Read More

Int J Syst Evol Microbiol 2019 Jun 18;71(3). Epub 2021 Mar 18.

Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources of PR China, Xiamen 361005, PR China.

A novel mesophilic, hydrogen-, and sulfur-oxidizing bacterium, designated strain ST-419, was isolated from a deep-sea hydrothermal vent plume on the Carlsberg Ridge of the Northwestern Indian Ocean. The isolate was a Gram-staining-negative, non-motile and coccoid to oval-shaped bacterium. Growth was observed at 4-50 °C (optimum 37 °C), pH 5. Read More