2,672 results match your criteria hybrid scaffold

Herbal hydrogels based encapsulated Enterococcus faecium ABRIINW.N7 improves the resistance of red hybrid tilapia against Streptococcus iniae.

J Appl Microbiol 2021 Apr 5. Epub 2021 Apr 5.

Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aims: The Streptococcal disease has been associated with serious mortality and significant global economic loss in the tilapia farming industry. The overall goal of this work was to test herbal hydrogels based on encapsulated Enterococcus faecium ABRIINW.N7 for potential probiotic anti-microbial activity against Streptococcus iniae in red hybrid tilapia. Read More

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Biomimetic Ti-6Al-4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration.

Bioact Mater 2021 Oct 21;6(10):3437-3448. Epub 2021 Mar 21.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.

Titanium-based scaffolds are widely used implant materials for bone defect treatment. However, the unmatched biomechanics and poor bioactivities of conventional titanium-based implants usually lead to insufficient bone integration. To tackle these challenges, it is critical to develop novel titanium-based scaffolds that meet the bioadaptive requirements for load-bearing critical bone defects. Read More

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October 2021

In vitro and in vivo evaluation of a biomimetic scaffold embedding silver nanoparticles for improved treatment of oral lesions.

Mater Sci Eng C Mater Biol Appl 2021 Apr 5;123:112015. Epub 2021 Mar 5.

University of Bucharest, Faculty of Biology, Splaiul Independentei 91-95, 050095 Bucharest, Romania. Electronic address:

Background: New materials are currently designed for efficient treatment of oral tissue lesions by guided tissue regeneration. The aim of this study was to develop a multifunctional 3D hybrid biomaterial consisting of extracellular matrix components, collagen, chondroitin 4-sulfate and fibronectin, functionalised with silver nanoparticles, intended to improve periodontitis treatment protocols.

Methods: Structural observations were performed by autometallography, scanning and transmission electron microscopy. Read More

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3D printed silica-gelatin hybrid scaffolds of specific channel sizes promote collagen Type II, Sox9 and Aggrecan production from chondrocytes.

Mater Sci Eng C Mater Biol Appl 2021 Apr 12;123:111964. Epub 2021 Feb 12.

Department of Materials, Imperial College London, London SW7 2AZ, UK. Electronic address:

Inorganic/organic hybrids have co-networks of inorganic and organic components, with the aim of obtaining synergy of the properties of those components. Here, a silica-gelatin sol-gel hybrid "ink" was directly 3D printed to produce 3D grid-like scaffolds, using a coupling agent, 3-glycidyloxypropyl)trimethoxysilane (GPTMS), to form covalent bonds between the silicate and gelatin co-networks. Scaffolds were printed with 1 mm strut separation, but the drying method affected the final architecture and properties. Read More

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Low-temperature 3D printing of collagen and chitosan composite for tissue engineering.

Mater Sci Eng C Mater Biol Appl 2021 Apr 12;123:111963. Epub 2021 Feb 12.

Key Laboratory of Medical Information and 3D Bioprinting of Zhejiang Province, Hangzhou Dianzi University, Hangzhou, China; School of Automation, Hangzhou Dianzi University, Hangzhou, China. Electronic address:

Three-dimensional (3D) printing is a promising method to prepare scaffolds for tissue regeneration. Collagen and chitosan composites are superior materials for tissue engineering scaffold but rarely printed due to their poor printability. Here, we prepared a series of tunable hybrid collagen/chitosan bioinks with significantly improved printability through hydrogen bond interaction and printed them into scaffolds by carefully controlling the temperature. Read More

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Hybrid porous zirconia scaffolds fabricated using additive manufacturing for bone tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2021 Apr 6;123:111950. Epub 2021 Feb 6.

Department of Prosthodontics, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea. Electronic address:

For the formation of new bone in critical-sized bone defects, bioactive scaffolds with an interconnected porous network are necessary. Herein, we fabricated three-dimensional (3D) porous hybrid zirconia scaffolds to promote hybrid functionality, i.e. Read More

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Aromatic Rings as Molecular Determinants for the Molecular Recognition of Protein Kinase Inhibitors.

Molecules 2021 Mar 22;26(6). Epub 2021 Mar 22.

Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.

Protein kinases are key enzymes in many signal transduction pathways, and play a crucial role in cellular proliferation, differentiation, and various cell regulatory processes. However, aberrant function of kinases has been associated with cancers and many other diseases. Consequently, competitive inhibition of the ATP binding site of protein kinases has emerged as an effective means of curing these diseases. Read More

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Motility Improvement of Biomimetic Trachea Scaffold via Hybrid 3D-Bioprinting Technology.

Polymers (Basel) 2021 Mar 22;13(6). Epub 2021 Mar 22.

Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.

A trachea has a structure capable of responding to various movements such as rotation of the neck and relaxation/contraction of the conduit due to the mucous membrane and cartilage tissue. However, current reported tubular implanting structures are difficult to impelement as replacements for original trachea movements. Therefore, in this study, we developed a new trachea implant with similar anatomical structure and mechanical properties to native tissue using 3D printing technology and evaluated its performance. Read More

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Silk Fiber-Reinforced Hyaluronic Acid-Based Hydrogel for Cartilage Tissue Engineering.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Clinic for Orthopedic and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, 24015 Kiel, Germany.

A continuing challenge in cartilage tissue engineering for cartilage regeneration is the creation of a suitable synthetic microenvironment for chondrocytes and tissue regeneration. The aim of this study was to develop a highly tunable hybrid scaffold based on a silk fibroin matrix (SM) and a hyaluronic acid (HA) hydrogel. Human articular chondrocytes were embedded in a porous 3-dimensional SM, before infiltration with tyramine modified HA hydrogel. Read More

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Dopamine Self-Polymerization as a Simple and Powerful Tool to Modulate the Viscoelastic Mechanical Properties of Peptide-Based Gels.

Molecules 2021 Mar 4;26(5). Epub 2021 Mar 4.

Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Dopamine is a small versatile molecule used for various biotechnological and biomedical applications. This neurotransmitter, in addition to its biological role, can undergo oxidative self-polymerization to yield polydopamine, a robust universal coating material. Herein, we harness dopamine self-polymerization to modulate the viscoelastic mechanical properties of peptide-based gels, expanding their ever-growing application potential. Read More

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Mechanical and Degradation Properties of Hybrid Scaffolds for Tissue Engineered Heart Valve (TEHV).

J Funct Biomater 2021 Mar 9;12(1). Epub 2021 Mar 9.

Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, UK.

In addition to biocompatibility, an ideal scaffold for the regeneration of valvular tissue should also replicate the natural heart valve extracellular matrix (ECM) in terms of biomechanical properties and structural stability. In our previous paper, we demonstrated the development of collagen type I and hyaluronic acid (HA)-based scaffolds with interlaced microstructure. Such hybrid scaffolds were found to be compatible with cardiosphere-derived cells (CDCs) to potentially regenerate the diseased aortic heart valve. Read More

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New Generation of Hybrid Materials Based on Gelatin and Bioactive Glass Particles for Bone Tissue Regeneration.

Biomolecules 2021 Mar 17;11(3). Epub 2021 Mar 17.

Biomaterials for Health Research Group, ERRMECe, Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules (EA1391), Institut des Matériaux I-MAT (FD4122), CY Tech, CY Cergy Paris Université, Maison Internationale de la Recherche (MIR), rue Descartes, 95001 Neuville sur Oise CEDEX, France.

Hybrid scaffolds based on bioactive glass (BAG) particles (<38 µm), covalently linked to gelatin (G*) using 3-glycidoxypropyltrimethoxysilane (GPTMS), have been studied for bone bioengineering. In this study, two glass compositions (13-93 and 13-93B20 (where 20% of the SiO was replaced with BO)) were introduced in the gelatin matrix. The C (gelatin/GPTMS molar ratio) was kept constant at 500. Read More

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Solar-Powered Photodegradation of Pollutant Dyes Using Silver-Embedded Porous TiO Nanofibers.

Nanomaterials (Basel) 2021 Mar 27;11(4). Epub 2021 Mar 27.

Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore.

Titanium dioxide (TiO) nanomaterials have been ubiquitously investigated as a photocatalyst for organic contaminant treatment in wastewater due to their exemplary semiconductor properties. However, their huge band gap remains a barrier for visible light absorption, limiting their utility in practical applications. The incorporation of noble metals in the TiO scaffold would help mitigate the problem via plasmonic resonance enhancements. Read More

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Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), Faculty of Sciences of Monastir, University of Monastir, 5000 Monastir, Tunisia.

Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In the search for therapeutic alternatives to treat the cancer disease, a series of hybrid pyrazolo[3,4-]pyrimidin-4()-ones tethered with hydrazide-hydrazones, -, was synthesized from condensation reaction of pyrazolopyrimidinone-hydrazide with a series of arylaldehydes in ethanol, in acid catalysis. Read More

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Discovery of pyridine- sulfonamide hybrids as a new scaffold for the development of potential VEGFR-2 inhibitors and apoptosis inducers.

Bioorg Chem 2021 Mar 22;111:104842. Epub 2021 Mar 22.

Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

New sulfonamide derivatives have been synthesized and tested as antitumor agents. All newly synthesized compounds were tested in vitro against 60 lines of human cancer cells. Compound VIIb shows broad-spectrum activity with a mean inhibition value of 91. Read More

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Development of Magnesium Oxide-Silver Hybrid Nanocatalysts for Synergistic Carbon Dioxide Activation to Afford Esters and Heterocycles at Ambient Pressure.

Green Chem 2020 May 24;22(10):3170-3177. Epub 2020 Mar 24.

Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Multi-metallic hybrid nancatalysts consisting of a porous metal oxide host and metal satellite guests serve as a scaffold for multi-step transformations of divergent and energy-challenging substrates. Here we have developed a 3D porous MgO framework (Lewis basic host) with Ag nanoparticles (noble metal guest) for ambient pressure activation and insertion of CO into unsaturated alkyne substrates. The hybrid MgO@Ag-x (x = 2, 5, 7, 8 at % Ag) catalysts are synthesized by impregnating Ag ions in porous MgO cubes followed by reduction using NaBH. Read More

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Engineering a Vascularized 3D Hybrid System to Model Tumor-Stroma Interactions in Breast Cancer.

Front Bioeng Biotechnol 2021 11;9:647031. Epub 2021 Mar 11.

i3S - Instituto de Inovação e Investigação em Saúde, Porto, Portugal.

The stromal microenvironment of breast tumors, namely the vasculature, has a key role in tumor development and metastatic spread. Tumor angiogenesis is a coordinated process, requiring the cooperation of cancer cells, stromal cells, such as fibroblasts and endothelial cells, secreted factors and the extracellular matrix (ECM). models capable of capturing such complex environment are still scarce, but are pivotal to improve success rates in drug development and screening. Read More

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Sustainable and robust graphene cellulose paper decorated with lithiophilic Au nanoparticles to enable dendrite-free and high-power lithium metal anode.

Chemistry 2021 Mar 29. Epub 2021 Mar 29.

Northeast Normal University, Department of international cooperation and exchange, Renmin Street 5268, 130024, Changchun, CHINA.

Lithium metal anodes (LMAs) with high energy density have recently captured increasing attentions for development of next-generation batteries. However, practical viability of LMAs is hindered by the uncontrolled Li dendrite growth and infinite dimension change. Even though constructing 3D conductive skeleton has been regarded as a reliable strategy to prepare low volume stress LMAs, engineering the renewable and lithiophilic conductive scaffold is still a challenge. Read More

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Berberine loaded chitosan nanoparticles encapsulated in polysaccharide-based hydrogel for the repair of spinal cord.

Int J Biol Macromol 2021 Mar 22;182:82-90. Epub 2021 Mar 22.

Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran; Shiraz Molecular Pathology Research Center, Dr Daneshbod Path Lab, Shiraz, Iran; Shefa Neurosciences Research Center, Khatam-Alanbia Hospita, Tehran, Iran.

The potential of berberine loaded in chitosan nanoparticles (BerNChs) within a hybrid of alginate (Alg) and chitosan (Ch) hydrogel was investigated for the substrate which is known as an inhibit activator proteins. The physicochemical properties of the developed Alg-Ch hydrogel were investigated by fourier-transform infrared spectroscopy. The swelling ability and degradation rate of hydrogels were also analyzed in a phosphate-buffered saline solution at physiological pH. Read More

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SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme.

BMC Bioinformatics 2021 Mar 25;22(1):158. Epub 2021 Mar 25.

BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China.

Background: Synthetic long reads (SLR) with long-range co-barcoding information are now widely applied in genomics research. Although several tools have been developed for each specific SLR technique, a robust standalone scaffolder with high efficiency is warranted for hybrid genome assembly.

Results: In this work, we developed a standalone scaffolding tool, SLR-superscaffolder, to link together contigs in draft assemblies using co-barcoding and paired-end read information. Read More

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Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies.

Bioorg Chem 2021 Mar 5;110:104803. Epub 2021 Mar 5.

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt. Electronic address:

One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of quinolines bearing a thiazole moiety were synthesized using thiosemicarbazones 2a-f. Cyclization of 2a-f with ethyl chloroacetate, ethyl 2-chloropropanoate or chloroacetone afforded the corresponding thiazoles 3-5. Read More

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Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model.

Macromol Biosci 2021 Mar 24:e2100002. Epub 2021 Mar 24.

Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.

Aptamers offer excellent potential for replacing antibodies for molecular recognition purposes however their performance can compromise with biological/environmental degradation being a particular problem. Molecularly imprinted Polymers (MIPs) offer an alternative to biological materials and while these offer the robustness and ability to work in extreme environmental conditions, they often lack the same recognition performance. By slightly adapting the chemical structure of a DNA aptamer it is incorporated for use as the recognition part of a MIP, thus creating an aptamer-MIP hybrid or aptaMIP. Read More

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Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin -induced diabetic albino wistar rats.

Bioorg Chem 2021 Mar 10;110:104808. Epub 2021 Mar 10.

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

We have synthesized new hybrid class of indole bearing sulfonamide scaffolds (1-17) as α-glucosidase inhibitors. All scaffolds were found to be active except scaffold 17 and exhibited IC values ranging from 1.60 to 51. Read More

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Comparison of different sequencing strategies for assembling chromosome-level genomes of extremophiles with variable GC content.

iScience 2021 Mar 20;24(3):102219. Epub 2021 Feb 20.

BGI-Qingdao, BGI-Shenzhen, Qingdao, Shandong 266555, China.

In this study, six bacterial isolates with variable GC, including as mesophilic reference strain, were selected to compare hybrid assembly strategies based on next-generation sequencing (NGS) of short reads, single-tube long-fragment reads (stLFR) sequencing, and Oxford Nanopore Technologies (ONT) sequencing platforms. We obtained the complete genomes using the hybrid assembler Unicycler based on the NGS and ONT reads; others were assembled using NGS, stLFR, and ONT reads by using different strategies. The contiguity, accuracy, completeness, sequencing costs, and DNA material requirements of the investigated strategies were compared systematically. Read More

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Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore.

J Am Chem Soc 2021 Mar 18;143(12):4751-4757. Epub 2021 Mar 18.

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

Redox enzymes play a critical role in transforming nascent scaffolds into structurally complex and biologically active natural products. Alchivemycin A (AVM, ) is a highly oxidized polycyclic compound with potent antimicrobial activity and features a rare 2-tetrahydro-4,6-dioxo-1,2-oxazine (TDO) ring system. The scaffold of AVM has previously been shown to be biosynthesized by a hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway. Read More

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Benzimidazole based hybrids against complex diseases: A catalogue of the SAR profile.

Eur J Pharmacol 2021 Mar 14;899:174027. Epub 2021 Mar 14.

Molecular Modelling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, 147002, India. Electronic address:

The fused heterocyclic ring system has been recognized as a privileged structure that is used as a template in medicinal chemistry for drug discovery. Benzimidazole is one of the common scaffolds found in several natural products such as histidine, purines, and an integral part of vitamin B12. This hetero-aromatic bicyclic ring system acts as a pharmacophore in various drugs of therapeutic interest and has a broad spectrum of activity. Read More

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