26,070 results match your criteria hybrid models

Performance evaluation of nanotubular halloysites from weathered pegmatites in removing heavy metals from water through novel artificial intelligence-based models and human-based optimization algorithm.

Chemosphere 2021 Jun 3;282:131012. Epub 2021 Jun 3.

Department of Exploration Geology, Faculty of Geosciences and Geoengineering, Hanoi University of Mining and Geology, 18 Vien st., Duc Thang ward, Bac Tu Liem dist., Hanoi, Viet Nam.

The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd, Pb) from water. Read More

View Article and Full-Text PDF

Impact of different nebulizers' connections on aerosol therapy.

Int J Clin Pract 2021 Jun 12:e14493. Epub 2021 Jun 12.

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt.

Background: Aerosol therapy has the advantage of a higher safety due to the local deposition of inhaled medication to the lung, however, the main drawback is the low and variable amount of delivered drug to patients. Hence, this study aimed to investigate the effect of different accessory connections on aerosol delivery from different nebulizers.

Method: this study consisted of three main models in-vitro, in vivo, and ex-vivo models. Read More

View Article and Full-Text PDF

Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.

Nat Commun 2021 Jun 11;12(1):3568. Epub 2021 Jun 11.

Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Bone marrow (BM) chimeric mice are a valuable tool in the field of immunology, with the genetic manipulation of donor cells widely used to study gene function under physiological and pathological settings. To date, however, BM chimera protocols require myeloablative conditioning of recipient mice, which dramatically alters steady-state hematopoiesis. Additionally, most protocols use fluorescence-activated cell sorting (FACS) of hematopoietic stem/progenitor cells (HSPCs) for ex vivo genetic manipulation. Read More

View Article and Full-Text PDF

Automated Medical Avatar Animation for Warfighter Mission Simulation.

J Trauma Acute Care Surg 2021 May 18. Epub 2021 May 18.

CFD Research Corporation, Huntsville, AL Biophysics and Biomedical Modeling Division, US Army Research Institute of Environmental Medicine, Natick, MA Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ.

Background: Virtual representations of human internal anatomy are important for military applications such as protective equipment design, injury severity prediction, thermal analysis, and physiological simulations. High-fidelity volumetric models based on imaging data are typically in static postures, and difficult to utilize in simulations of realistic mission scenarios. This study aimed to investigate a hybrid approach to reposition medical avatars that preserves internal anatomy but allows rapid repositioning of full 3D meshes. Read More

View Article and Full-Text PDF

Stroke Risk Prediction with Hybrid Deep Transfer Learning Framework.

IEEE J Biomed Health Inform 2021 Jun 11;PP. Epub 2021 Jun 11.

Stroke has become a leading cause of death and long-term disability in the world, and there is no effective treatment.Deep learning-based approaches have the potential to outperform existing stroke risk prediction models, they rely on large well-labeled data. Due to the strict privacy protection policy in health-care systems, stroke data is usually distributed among different hospitals in small pieces. Read More

View Article and Full-Text PDF

Evaluation of pro-apoptotic potential of taxifolin against liver cancer.

PeerJ 2021 25;9:e11276. Epub 2021 May 25.

Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.

Liver cancer is the second most common cause of cancer-induced deaths worldwide. Liver cirrhosis and cancer are a consequence of the abnormal angio-architecture formation of liver and formation of new blood vessels. This angiogenesis is driven by overexpression of hypoxia-inducible factor 1-alpha (Hif1-) and vascular endothelial growth factor (VEGF). Read More

View Article and Full-Text PDF

Hybrid AI-assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears.

Nat Commun 2021 06 10;12(1):3541. Epub 2021 Jun 10.

Department of Pathology, Guangdong Provincial Women's and Children's Dispensary, Shenzhen, Guangdong Province, PR China.

Technical advancements significantly improve earlier diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various factors. We develop an artificial intelligence assistive diagnostic solution, AIATBS, to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria. We train AIATBS with >81,000 retrospective samples. Read More

View Article and Full-Text PDF

Predictions of the elastic modulus of trabecular bone in the femoral head and the intertrochanter: a solitary wave-based approach.

Biomech Model Mechanobiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Civil Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi, 127788, UAE.

This paper deals with the numerical prediction of the elastic modulus of trabecular bone in the femoral head (FH) and the intertrochanteric (IT) region via site-specific bone quality assessment using solitary waves in a one-dimensional granular chain. For accurate evaluation of bone quality, high-resolution finite element models of bone microstructures in both FH and IT are generated using a topology optimization-based bone microstructure reconstruction scheme. A hybrid discrete element/finite element (DE/FE) model is then developed to study the interaction of highly nonlinear solitary waves in a granular chain with the generated bone microstructures. Read More

View Article and Full-Text PDF

Towards Uncovering the Intrinsic Data Structures for Unsupervised Domain Adaptation using Structurally Regularized Deep Clustering.

IEEE Trans Pattern Anal Mach Intell 2021 Jun 9;PP. Epub 2021 Jun 9.

Unsupervised domain adaptation (UDA) is to learn classification models that make predictions for unlabeled data on a target domain, given labeled data on a source domain whose distribution diverges from the target one. Mainstream UDA methods strive to learn domain-aligned features. Although impressive results have been achieved, these methods have a potential risk of damaging the intrinsic data structures of target discrimination, raising an issue of generalization particularly for UDA tasks in an inductive setting. Read More

View Article and Full-Text PDF

Easily Available, Amphiphilic Diiron Cyclopentadienyl Complexes Exhibit in Vitro Anticancer Activity in 2D and 3D Human Cancer Cells through Redox Modulation Triggered by CO Release.

Chemistry 2021 Jun 9. Epub 2021 Jun 9.

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, I-56124, Pisa, Italy.

A straightforward two-step procedure via single CO removal allows the conversion of commercial [Fe Cp (CO) ] into a range of amphiphilic and robust ionic complexes based on a hybrid aminocarbyne/iminium ligand, [Fe Cp (CO) {CN(R)(R')}]X (R, R'=alkyl or aryl; X=CF SO or BF ), on up to multigram scales. Their physicochemical properties can be modulated by an appropriate choice of N-substituents and counteranion. Tested against a panel of human cancer cell lines, the complexes were shown to possess promising antiproliferative activity and to circumvent multidrug resistance. Read More

View Article and Full-Text PDF

HIV-1 Nef induces Hck/Lyn-dependent expansion of MDSC associated with elevated IL-17/G-CSF.

J Virol 2021 Jun 9:JVI0047121. Epub 2021 Jun 9.

Laboratory of Molecular Biology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7.

HIV or SIV infection causes myelodysplasia, anemia and accumulation of inflammatory monocytes (CD14 CD16), through largely unknown cellular and molecular pathways. The mouse cells thought to be equivalent to human CD14 CD16 cells are CD11bGr1 myeloid-derived suppressive cells (MDSC). We used HIV transgenic (Tg) mouse models to study MDSC, namely CD4C/Nef Tg mice expressing in dendritic cells (DC), pDC, CD4 T and other mature and immature myeloid cells and CD11c/Nef Tg mice with a more restricted expression, mainly in DC and pDC. Read More

View Article and Full-Text PDF

A single atom change turns insulating saturated wires into molecular conductors.

Nat Commun 2021 Jun 8;12(1):3432. Epub 2021 Jun 8.

Department of Chemistry, National University of Singapore, Singapore, Singapore.

We present an efficient strategy to modulate tunnelling in molecular junctions by changing the tunnelling decay coefficient, β, by terminal-atom substitution which avoids altering the molecular backbone. By varying X = H, F, Cl, Br, I in junctions with S(CH)X, current densities (J) increase >4 orders of magnitude, creating molecular conductors via reduction of β from 0.75 to 0. Read More

View Article and Full-Text PDF

Neurodegenerative Diseases: A Multidisciplinary Approach.

Curr Pharm Des 2021 Jun 8. Epub 2021 Jun 8.

Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Medicine, Faculty of Pharmacy, and Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.

The rapid pattern of population ageing in recent years increases the risk of appearance of associated neurodegenerative diseases. Dementias are one of the most feared disorders, and although not necessarily all elderly people suffer from dementia, the number of people with this disease is increasing rapidly. The causes of dementia are multiple, and the diagnosis of the different types of dementia is complicated since most patients display mixed dementias, and symptoms overlapping. Read More

View Article and Full-Text PDF

Separation of multiphosphorylated cyclopeptides and their positional isomers by hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 25;1177:122792. Epub 2021 May 25.

Université Paris-Saclay, CEA, Service d'Etudes Analytiques et de Réactivité des Surfaces, F-91191 Gif-sur-Yvette, France.

Peptides are efficient models used in different fields such as toxicology to study the interactions of several contaminants at the molecular scale, requiring the development of bio-analytical strategies. In this context, Hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS) was used to separate synthetic multiphosphorylated cyclopeptides and their positional isomers at physiological pH. We assessed (i) the selectivity of eleven HILIC columns, from different manufacturers and packed with diverse polar sorbents, and (ii) the effect of mobile phase composition on the separation selectivity. Read More

View Article and Full-Text PDF

Derivation and validation of Pd/Pa in the assessment of residual ischemia post-intervention: A prospective all-comer registry.

Catheter Cardiovasc Interv 2021 Jun 8. Epub 2021 Jun 8.

John L McClellan Memorial Veterans Hospital, Central Arkansas VA Healthy System, Little Rock, Arkansas, USA.

Background: Measurement of post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) demonstrates residual ischemia in a large percentage of cases deemed angiographically successful which, in turn, has been associated with worse long-term outcomes. It has recently been shown that a resting pressure index, Pd/Pa, has prognostic value post stenting, however, its diagnostic value relative to FFR post-PCI has not been evaluated.

Methods: The diagnostic accuracy of Pd/Pa in identifying ischemia (FFR≤0. Read More

View Article and Full-Text PDF

Treatment alliance and needs of care concerning religiousness and spirituality: A follow-up study among psychiatric inpatients.

Int J Soc Psychiatry 2021 Jun 8:207640211023065. Epub 2021 Jun 8.

Center for Research and Innovation in Christian Mental Health Care, Amersfoort, The Netherlands.

Background: Patient satisfaction with religious/spiritual (R/S) care during mental health treatment has been associated with a better treatment alliance.

Aims: To investigate the longitudinal relations between (un)met R/S care needs and treatment alliance/compliance over a 6-month period.

Method: 201 patients in a Christian (CC) and a secular mental health clinic completed a questionnaire (T0) containing an R/S care needs questionnaire, the Working Alliance Inventory (WAI) and the Service Engagement Scale (SES). Read More

View Article and Full-Text PDF

A hybrid level set model for image segmentation.

PLoS One 2021 7;16(6):e0251914. Epub 2021 Jun 7.

Artificial Intelligence Key Laboratory of Sichuan Province, Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, China.

Active contour models driven by local binary fitting energy can segment images with inhomogeneous intensity, while being prone to falling into a local minima. However, the segmentation result largely depends on the location of the initial contour. We propose an active contour model with global and local image information. Read More

View Article and Full-Text PDF

Real-world use of a new hybrid closed-loop improves glycemic control in youth with type 1 diabetes.

Diabetes Technol Ther 2021 Jun 7. Epub 2021 Jun 7.

University of Colorado Denver, 12226, Barbara Davis Center for Childhood Diabetes, 1775 Aurora Court, A140, Denver, Colorado, United States, 80204;

Objective: To describe real-world outcomes for youth using the Tandem X2 with Control-IQ technology ("Control-IQ") for 6-months at a large pediatric clinic.

Methods: Youth with T1D who started Control-IQ for routine care were prospectively followed. Data on system use and glycemic control were collected prior to Control-IQ start, and at 1, 3, and 6-months after start. Read More

View Article and Full-Text PDF

Hydroxyapatite reinforced inorganic-organic hybrid nanocomposite as high-performance adsorbents for bilirubin removal and in pig models.

Bioact Mater 2021 Dec 24;6(12):4772-4785. Epub 2021 May 24.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.

Highly efficient removal of bilirubin from whole blood directly by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to the low adsorption capacity, poor mechanical strength and low biocompatibility of adsorbents. In this work, a new class of nanocomposite adsorbents was constructed through an inorganic-organic co-crosslinked nanocomposite network between vinyltriethoxysilane (VTES)-functionalized hydroxyapatite nanoparticles (V-Hap) and non-ionic styrene-divinylbenzene (PS-DVB) resins (PS-DVB/V-Hap) using suspension polymerization. Notably, our adsorbent demonstrated substantially improved mechanical performance compared to the pure polymer, with the hardness and modulus increasing by nearly 3 and 2. Read More

View Article and Full-Text PDF
December 2021

A Sight on Single-Cell Transcriptomics in Plants Through the Prism of Cell-Based Computational Modeling Approaches: Benefits and Challenges for Data Analysis.

Front Genet 2021 21;12:652974. Epub 2021 May 21.

Laboratory of Plant Growth Biomechanics, Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk, Russia.

Single-cell technology is a relatively new and promising way to obtain high-resolution transcriptomic data mostly used for animals during the last decade. However, several scientific groups developed and applied the protocols for some plant tissues. Together with deeply-developed cell-resolution imaging techniques, this achievement opens up new horizons for studying the complex mechanisms of plant tissue architecture formation. Read More

View Article and Full-Text PDF

Localizing Clinical Patterns of Blast Traumatic Brain Injury Through Computational Modeling and Simulation.

Front Neurol 2021 20;12:547655. Epub 2021 May 20.

Department of Neurology, Brooke Army Medical Center, Fort Sam Houston, TX, United States.

Blast traumatic brain injury is ubiquitous in modern military conflict with significant morbidity and mortality. Yet the mechanism by which blast overpressure waves cause specific intracranial injury in humans remains unclear. Reviewing of both the clinical experience of neurointensivists and neurosurgeons who treated service members exposed to blast have revealed a pattern of injury to cerebral blood vessels, manifested as subarachnoid hemorrhage, pseudoaneurysm, and early diffuse cerebral edema. Read More

View Article and Full-Text PDF

Data-driven interval credibility constrained quadratic programming model for water quality management under uncertainty.

J Environ Manage 2021 Jun 2;293:112791. Epub 2021 Jun 2.

Department of Civil Engineering, McMaster University, 1280 Main Street West, Hamilton, L8S 4L7, ON, Canada. Electronic address:

Although integrated simulation-optimization modeling can provide a comprehensive and reliable analysis for water quality management (WQM), it is usually not easy to implement in practice. This study proposed a new efficient simulation-optimization modeling approach by leveraging the power of data-driven modeling, to support WQM under various uncertainties. A water quality simulation model is integrated with the optimization model, and then substituted by a series of numerical surrogate models based on inexact linear regression. Read More

View Article and Full-Text PDF

CC-LA: determining optimal switching angles in a cascaded H-bridge multilevel inverter with the aid of binary cat cubpool-based lion algorithm.

Environ Sci Pollut Res Int 2021 Jun 5. Epub 2021 Jun 5.

Institute of Chemical Technology, Mumbai, India.

A multilevel inverter (MLI) is a power electronic device that includes the capability to offer the preferred voltage level (alternating) in the output. Accordingly, selective harmonic elimination (SHE) or pulse width modulation (PWM) methodologies were deployed widely. However, these techniques are not appropriate in a certain situation which involves a huge number of switching angles if an excellent primary guess is not obtainable. Read More

View Article and Full-Text PDF

Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project.

Eur Respir J 2021 Jun 4;57(6). Epub 2021 Jun 4.

Dept of Environmental Science, Aarhus University, Roskilde, Denmark.

Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter <2.5 µm (PM), nitrogen dioxide (NO) and black carbon (BC) with asthma incidence in adults. Read More

View Article and Full-Text PDF

Adsorption performance and mechanism of iron-loaded biochar to methyl orange in the presence of Cr from dye wastewater.

J Hazard Mater 2021 08 26;415:125749. Epub 2021 Mar 26.

School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

Biochar prepared from sludge and liriodendron leaves (SLAC) was modified by Fe (SLAC-Fe), and they were used to remove methyl orange (MO) from single system and aqueous solution with Cr. The physical and chemical properties of biochar were characterized by BET, SEM, TEM, EDS, FTIR and XPS. The influences of initial MO concentration, adsorbent dose, pH, contact time and temperature on the adsorption of MO by biochar were investigated. Read More

View Article and Full-Text PDF

Predicting the sorption efficiency of heavy metal based on the biochar characteristics, metal sources, and environmental conditions using various novel hybrid machine learning models.

Chemosphere 2021 Aug 9;276:130204. Epub 2021 Mar 9.

Division of Computational Mathematics and Engineering, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, 70000, Viet Nam; Faculty of Mathematics and Statistics, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam. Electronic address:

Heavy metals in water and wastewater are taken into account as one of the most hazardous environmental issues that significantly impact human health. The use of biochar systems with different materials helped significantly remove heavy metals in the water, especially wastewater treatment systems. Nevertheless, heavy metal's sorption efficiency on the biochar systems is highly dependent on the biochar characteristics, metal sources, and environmental conditions. Read More

View Article and Full-Text PDF

Hydrothermal synthesis of hydroxyapatite-reduced graphene oxide (1D-2D) hybrids with enhanced selective adsorption properties for methyl orange and hexavalent chromium from aqueous solutions.

Chemosphere 2021 Aug 16;276:130200. Epub 2021 Mar 16.

Department of Environmental Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, Republic of Korea. Electronic address:

The presence of organic dye molecules and heavy metal ions in water causes ecological and public health problems. Therefore, remediation of water/wastewater contaminated with organic dye molecules and toxic metal ions is of importance. Herein, a reduced graphene oxide (RGO)-hydroxyapatite (Hat) (1D-2D) hybrid composite was fabricated through a hydrothermal process and applied for the adsorption of methyl orange (MO) and hexavalent chromium (Cr(VI)) from water. Read More

View Article and Full-Text PDF

A deep cascade of ensemble of dual domain networks with gradient-based T1 assistance and perceptual refinement for fast MRI reconstruction.

Comput Med Imaging Graph 2021 May 24;91:101942. Epub 2021 May 24.

Department of Electrical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India; Healthcare Technology Innovation Centre, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.

Deep learning networks have shown promising results in fast magnetic resonance imaging (MRI) reconstruction. In our work, we develop deep networks to further improve the quantitative and the perceptual quality of reconstruction. To begin with, we propose reconsynergynet (RSN), a network that combines the complementary benefits of independently operating on both the image and the Fourier domain. Read More

View Article and Full-Text PDF

Hybrid Models for the simulation and prediction of chromatographic processes for protein capture.

J Chromatogr A 2021 May 13;1650:462248. Epub 2021 May 13.

DataHow AG, Zurich, Switzerland. Electronic address:

The biopharmaceutical industries are continuously faced with the pressure to reduce the development costs and accelerate development time scales. The traditional approach of heuristic-based or platform process-based optimization is soon getting obsolete, and more generalized tools for process development and optimization are required to keep pace with the emerging trends. Thus, advanced model-based methods that can reduce the can ensure accelerated development of robust processes with minimal experiments are necessary. Read More

View Article and Full-Text PDF

Improving hospital readmission prediction using individualized utility analysis.

J Biomed Inform 2021 Jun 1;119:103826. Epub 2021 Jun 1.

Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Objective: Machine learning (ML) models for allocating readmission-mitigating interventions are typically selected according to their discriminative ability, which may not necessarily translate into utility in allocation of resources. Our objective was to determine whether ML models for allocating readmission-mitigating interventions have different usefulness based on their overall utility and discriminative ability.

Materials And Methods: We conducted a retrospective utility analysis of ML models using claims data acquired from the Optum Clinformatics Data Mart, including 513,495 commercially-insured inpatients (mean [SD] age 69 [19] years; 294,895 [57%] Female) over the period January 2016 through January 2017 from all 50 states with mean 90 day cost of $11,552. Read More

View Article and Full-Text PDF