Viruses 2021 04 28;13(5). Epub 2021 Apr 28.
110 Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey, NJ 11 08544-101, USA.
Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC). Even though current approved antiviral therapies, including pegylated type I interferon (IFN) and nucleos(t)ide analogs, can effectively suppress viremia, HBV infection is rarely cured. Since HBV exhibits a narrow species tropism and robustly infects only humans and higher primates, progress in HBV research and preclinical testing of antiviral drugs has been hampered by the scarcity of suitable animal models. Read More