1,497,623 results match your criteria human populations

Prospective association between baseline plasma zinc concentration and development of proteinuria in Chinese hypertensive patients.

J Trace Elem Med Biol 2021 Apr 2;66:126755. Epub 2021 Apr 2.

Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China. Electronic address:

Objective: We aimed to evaluate the association between baseline plasma zinc and the development of proteinuria as well as possible effect modifiers in hypertensive patients.

Methods: This is a subset of the China Stroke Primary Prevention Trial (CSPPT) Renal Sub-Study. In the CSPPT, participants were randomized to receive a daily oral dose of 1 tablet containing 10 mg enalapril and 0. Read More

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Electronic waste generation, recycling and resource recovery: Technological perspectives and trends.

J Hazard Mater 2021 Mar 16;416:125664. Epub 2021 Mar 16.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam; College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address:

The growing population and increased disposal of end-of-life (EoL) electrical and electronic products have caused serious concerns to the environment and human health. Electronic waste (e-waste) is a growing problem because the quantity and the rate at which it is generated has increased exponentially in the last 5 years. The rapid changes or upgradation in technologies, IT requirements for working or learning from home during COVID-19, manufacturers releasing new electronic gadgets and devices that serves the consumers comfort and a declension in services has contributed to an increase in the e-waste or waste of electrical and electronic equipment (WEEE) generation rates. Read More

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Genomic diversity of Listeria monocytogenes isolates from seafood, horticulture and factory environments in New Zealand.

Int J Food Microbiol 2021 Mar 17;347:109166. Epub 2021 Mar 17.

The New Zealand Institute for Plant & Food Research Limited, Auckland, New Zealand.

Listeria monocytogenes is a foodborne human pathogen that causes systemic infection, fetal-placental infection in pregnant women causing abortion and stillbirth and meningoencephalitis in elderly and immunocompromised individuals. This study aimed to analyse L. monocytogenes from different sources from New Zealand (NZ) and to compare them with international strains. Read More

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Self-regulation task in young school age children born preterm: Correlation with early academic achievement.

Early Hum Dev 2021 Mar 26;157:105362. Epub 2021 Mar 26.

Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0115, United States of America; Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, United States of America. Electronic address:

Background: Children born preterm are at risk for difficulties in executive function (EF), however there are limited tools to assess EF in young children and it is not fully understood how these early deficits are related to emerging academic skills.

Aims: To examine (a) early EF differences in young children born preterm, (b) how a measure of behavioral self-regulation correlates with other measures of EF in children born preterm, and (c) how this measure relates to academic outcomes in children born preterm.

Study Design: Longitudinal cohort study. Read More

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Environmental heat-related health symptoms among community in a tropical city.

Sci Total Environ 2021 Mar 30;782:146611. Epub 2021 Mar 30.

Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Due to the changing climate, more frequent and prolonged heatwaves are expected to have a catastrophic consequence on urban human settlement. In tropical cities such as Kuala Lumpur (KL), the quality of the urban environment is made worse by urban heat island (UHI) phenomena due to poor urban planning practices. The prolonged exposure to urban heat is hypothesized to influence human health and well-being, especially in tropical urban areas with high population density. Read More

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Evaluating the impact of the travel ban within mainland China on the epidemic of the COVID-19.

Int J Infect Dis 2021 Apr 7. Epub 2021 Apr 7.

Lamps and Canadian Centre for Disease Modelling (CCDM), Department of Mathematics and Statistics, York University, Toronto, ON, M3J 1P3, Canada. Electronic address:

Objectives: The ongoing COVID-19 pandemic expanded its geographic distribution through the movement of humans and caused subsequent local outbreaks. Hence, it is essential to investigate how human mobility and travel ban affect the transmission and spatial spread while minimizing the impact on social activities and national economics.

Methods: We developed a mobility network model for spatial epidemics, explicitly taking into account time-varying inter-province and inner-province population flows, spatial heterogeneity in terms of disease transmission, as well as the impact of media reports. Read More

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Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension.

Kidney Int 2021 Apr 7. Epub 2021 Apr 7.

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore MD, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore MD, USA; Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore MD, USA.

The genome-wide association study (GWAS) is a powerful means to study genetic determinants of disease traits and generate insights into disease pathophysiology. To date, few GWAS of circulating metabolite levels have been performed in African Americans with chronic kidney disease. Hypothesizing that novel genetic-metabolite associations may be identified in a unique population of African Americans with a lower glomerular filtration rate (GFR), we conducted a GWAS of 652 serum metabolites in 619 participants (mean measured glomerular filtration rate 45 mL/min/1. Read More

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The long-term genetic stability and individual specificity of the human gut microbiome.

Cell 2021 Apr 4. Epub 2021 Apr 4.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands. Electronic address:

By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183 metabolites in 338 individuals after 4 years, we characterize microbial stability and variation in relation to host physiology. Using these individual-specific and temporally stable microbial profiles, including bacterial SNPs and structural variations, we develop a microbial fingerprinting method that shows up to 85% accuracy in classifying metagenomic samples taken 4 years apart. Application of our fingerprinting method to the independent HMP cohort results in 95% accuracy for samples taken 1 year apart. Read More

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Comparison of non-exercise cardiorespiratory fitness prediction equations in apparently healthy adults.

Eur J Prev Cardiol 2021 Apr;28(2):142-148

Fisher Institute of Health and Well-Being, Ball State University, USA.

Aims: A recent scientific statement suggests clinicians should routinely assess cardiorespiratory fitness using at least non-exercise prediction equations. However, no study has comprehensively compared the many non-exercise cardiorespiratory fitness prediction equations to directly-measured cardiorespiratory fitness using data from a single cohort. Our purpose was to compare the accuracy of non-exercise prediction equations to directly-measured cardiorespiratory fitness and evaluate their ability to classify an individual's cardiorespiratory fitness. Read More

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Economic evaluation of differentiated service delivery models for HIV treatment in Lesotho: costs to providers and patients.

J Int AIDS Soc 2021 Apr;24(4):e25692

Kheth'Impilo AIDS Free Living, Cape Town, South Africa.

Introduction: Lesotho, the country with the second-highest HIV/AIDS prevalence (23.6%) in the world, has made considerable progress towards achieving the "95-95-95" UNAIDS targets, but recent success in improving treatment access to all known HIV positive individuals has severely strained existing healthcare infrastructure, financial and human resources. Lesotho also faces the challenge of a largely rural population who incur a significant time and financial burden to visit healthcare facilities. Read More

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Identification of CXCL12-abundant reticular cells in human adult bone marrow.

Br J Haematol 2021 Apr 10. Epub 2021 Apr 10.

Laboratory of Stem Cell Biology and Developmental Immunology, Immunology Frontier Research Center, World Premier International Research Center (WPI), Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Suita, Japan.

A population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells or leptin receptor-expressing cells, are the major cellular component of niches for haematopoietic stem cells (HSCs) in murine bone marrow. CAR cells are characterized by several salient features, including much higher expression of CXCL12, stem cell factor (SCF), forkhead box C1 (FOXC1) and early B-cell factor 3 (EBF3), which are essential for HSC maintenance, than other cells. However, the human counterpart of CAR cells has not been fully described. Read More

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Exploration of spatial-temporal varying impacts on COVID-19 cumulative case in Texas using geographically weighted regression (GWR).

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

School of Resource and Environmental Science, Wuhan University, 129 Luoyu Rd., Wuhan, 430079, Hubei, China.

Since COVID-19 is extremely threatening to human health, it is significant to determine its impact factors to curb the virus spread. To tackle the complexity of COVID-19 expansion on a spatial-temporal scale, this research appropriately analyzed the spatial-temporal heterogeneity at the county-level in Texas. First, the impact factors of COVID-19 are captured on social, economic, and environmental multiple facets, and the communality is extracted through principal component analysis (PCA). Read More

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Future burden of primary and revision hip arthroplasty in Germany: a socio-economic challenge.

Arch Orthop Trauma Surg 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopedics and Traumatology, University Medical Centre of the Johannes Gutenberg-University of Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Introduction: Total hip arthroplasty (THA) rates have increased dramatically in the recent decades worldwide, with Germany being one of the leading countries in the prevalence of THA. Simultaneously, a rising number of revision procedures is expected, which will put an enormous economic burden on future health care systems.

Methods: Nationwide data provided by the Federal Statistical Office of Germany were used to quantify primary and revision arthroplasty rates as a function of age and gender. Read More

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Evaluating causes of current genetic gradients of modern humans of the Iberian Peninsula.

Genome Biol Evol 2021 Apr 10. Epub 2021 Apr 10.

CINBIO, Universidade de Vigo, 36310 Vigo, España.

The history of modern humans in the Iberian Peninsula includes a variety of population arrivals sometimes presenting admixture with resident populations. Genetic data from current Iberian populations revealed an overall east - west genetic gradient that some authors interpreted as a direct consequence of the Reconquista, where Catholic Kingdoms expanded their territories towards the south while displacing Muslims. However, this interpretation has not been formally evaluated. Read More

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Betaherpesvirus assembly and egress: Recent advances illuminate the path.

Adv Virus Res 2020 7;108:337-392. Epub 2020 Oct 7.

Department of Biochemistry, Microbiology & Immunology, Wayne State University School of Medicine, Detroit, MI, United States. Electronic address:

The human betaherpesviruses, human cytomegalovirus (HCMV; species Human betaherpesvirus 5) and human herpesviruses 6A, 6B, and 7 (HHV-6A, -6B, and -7; species Human betaherpesviruses 6A, 6B, and 7) are highly prevalent and can cause severe disease in immune-compromised and immune-naive populations in well- and under-developed communities. Herpesvirus virion assembly is an intricate process that requires viral orchestration of host systems. In this review, we describe recent advances in some of the many cellular events relevant to assembly and egress of betaherpesvirus virions. Read More

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October 2020

Externally added cystatin C reduces growth of A375 melanoma cells by increasing cell cycle time.

FEBS Open Bio 2021 Apr 10. Epub 2021 Apr 10.

Division of Clinical Chemistry & Pharmacology, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Some secreted cysteine protease inhibitors of the cystatin family appear to affect intracellular proteolysis and growth of human cells, as a result of internalization. Here, we studied the effects of external addition of the most abundant human cystatin, cystatin C, on viability and proliferation of cancer cells in culture. A dose-dependent decrease of viable cells was seen for A375 melanoma, MCF-7 breast cancer and PC-3 prostate cancer cells cultured in 1-5 μM cystatin C after 24 h. Read More

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Parameter inference for a stochastic kinetic model of expanded polyglutamine proteins.

Biometrics 2021 Apr 9. Epub 2021 Apr 9.

School of Mathematics, Statistics & Physics, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.

The presence of protein aggregates in cells is a known feature of many human age-related diseases, such as Huntington's disease. Simulations using fixed parameter values in a model of the dynamic evolution of expanded polyglutaime (PolyQ) proteins in cells have been used to gain a better understanding of the biological system. However, there is considerable uncertainty about the values of some of the parameters governing the system. Read More

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Human Induced Pluripotent Stem Cell (iPSC) Handling Protocols: Maintenance, Expansion, and Cryopreservation.

Methods Mol Biol 2021 Apr 10. Epub 2021 Apr 10.

The New York Stem Cell Foundation Research Institute, New York, NY, USA.

Human induced pluripotent stem cells (iPSCs) have emerged as an invaluable resource for basic research, disease modeling, and drug discovery over recent years. Given the numerous advantages of iPSCs over alternative models-including their human origin, their ability to be differentiated into almost any cell type, and the therapeutic potential of patient-specific iPSCs in personalized medicine-many labs are now considering iPSC models for their studies. As the quality of the starting population of iPSCs is a key determinant in the success of any one of these applications, it is crucial to adhere to best practices in iPSC culture. Read More

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Effects of Comorbid Developmental Coordination Disorder and Symptoms of Attention Deficit Hyperactivity Disorder on Physical Activity in Children Aged 4-5 Years.

Child Psychiatry Hum Dev 2021 Apr 9. Epub 2021 Apr 9.

INfant and Child Health (INCH) Lab, Department of Family Medicine, McMaster University, Hamilton, ON, Canada.

Developmental coordination disorder (DCD) is often comorbid with attention-deficit/hyperactivity disorder (ADHD). While children with DCD engage in less moderate-to-vigorous physical activity (MVPA) compared to typically developing (TD) children, research pertaining to how ADHD affects this relationship is limited. We investigated the effect of ADHD on MVPA among children at risk for DCD (DCDr). Read More

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Higher plain water intake is related to lower newly diagnosed nonalcoholic fatty liver disease risk: a population-based study.

Eur J Clin Nutr 2021 Apr 9. Epub 2021 Apr 9.

Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.

Background/objectives: High plain water intake (PWI) lowered body weight, reduced total energy intake, and increased fat oxidation and energy consumption. Because such factors are closely linked to metabolic disorders, which are the main risk factors for nonalcoholic fatty liver disease (NAFLD) onset, it was speculated that higher PWI was associated with a lower risk of NAFLD. However, no prior human studies have examined such relationship. Read More

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Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families.

Mol Psychiatry 2021 Apr 9. Epub 2021 Apr 9.

Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. Read More

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APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.

Mol Psychiatry 2021 Apr 9. Epub 2021 Apr 9.

School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.

Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer's disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk of AD. On the other hand, longitudinal studies have shown that the presence of the APOE2 variant reduces the lifetime risk of developing AD by 40 percent. Read More

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Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry.

Sci Rep 2021 Apr 9;11(1):7822. Epub 2021 Apr 9.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

The aim of this study was to provide definitive reference values for bone mineral density (BMD) and bone turnover markers in the general elderly population. Registered citizens of 50 to 89 years old were targeted for this survey. After random sampling from the resident registry of Obuse town, we established eight groups based on age (50 s, 60 s, 70 s, and 80 s) and gender. Read More

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Interactions between PDA-associated polymorphisms and genetic ancestry alter ductus arteriosus gene expression.

Pediatr Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Background: DNA polymorphisms in PTGIS and TFAP2B have been identified as risk factors for patent ductus arteriosus (PDA) in a population composed of preterm infants with European genetic ancestry but not in more genetically diverse populations.

Goal: To determine if the effects of TFAP2B and PTGIS polymorphisms on ductus arteriosus (DA) gene expression differ based on genetic ancestry.

Methods: DA from 273 human second trimester fetuses were genotyped for TFAP2B and PTGIS polymorphisms and for polymorphisms distributing along genetic ancestry lines. Read More

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Spatio-temporal evolution and influencing mechanism of the COVID-19 epidemic in Shandong province, China.

Sci Rep 2021 Apr 9;11(1):7811. Epub 2021 Apr 9.

College of Urban and Environmental Sciences, Northwest University, Xi'an, 710127, China.

The novel coronavirus pneumonia (COVID-19) outbreak that emerged in late 2019 has posed a severe threat to human health and social and economic development, and thus has become a major public health crisis affecting the world. The spread of COVID-19 in population and regions is a typical geographical process, which is worth discussing from the geographical perspective. This paper focuses on Shandong province, which has a high incidence, though the first Chinese confirmed case was reported from Hubei province. Read More

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COVID-19 and ethnicity:has history repeated itself?

Thorax 2021 Apr 9. Epub 2021 Apr 9.

Lane Fox Respiratory Service, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

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Factors associated with mobile phone usage to access maternal and child healthcare among women of urban slums in Dhaka, Bangladesh: a cross-sectional study.

BMJ Open 2021 Apr 9;11(4):e043933. Epub 2021 Apr 9.

Laboratory of Viral Zoonotics, University of Cambridge, Cambridge, UK.

Introduction: With the acute shortage of human resources and infrastructure, mobile phones can be a critical tool for accessing health services and strengthening health systems in Bangladesh. Yet, there is a scarcity of evidence on the use of mobile phones in this context for accessing health services. In this study, we sought to explore the current use of mobile phones for accessing maternal and child healthcare and its determinants among recently delivered women in urban slums of Bangladesh. Read More

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Early Moves: a protocol for a population-based prospective cohort study to establish general movements as an early biomarker of cognitive impairment in infants.

BMJ Open 2021 Apr 9;11(4):e041695. Epub 2021 Apr 9.

Perth Children's Hospital, Perth, Western Australia, Australia

Introduction: The current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes for these children and support them to reach their full life potential. Early Moves aims to identify early biomarkers, including general movements (GMs), for babies at risk of cognitive impairment, allowing early intervention within critical developmental windows to enable these children to have the best possible start to life. Read More

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Travel-related control measures to contain the COVID-19 pandemic: an evidence map.

BMJ Open 2021 Apr 9;11(4):e041619. Epub 2021 Apr 9.

Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany.

Objectives: To comprehensively map the existing evidence assessing the impact of travel-related control measures for containment of the SARS-CoV-2/COVID-19 pandemic.

Design: Rapid evidence map.

Data Sources: MEDLINE, Embase and Web of Science, and COVID-19 specific databases offered by the US Centers for Disease Control and Prevention and the WHO. Read More

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DNA methylation and gene expression integration in cardiovascular disease.

Clin Epigenetics 2021 Apr 9;13(1):75. Epub 2021 Apr 9.

Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute (IMIM), Dr Aiguader 88, 08003, Barcelona, Spain.

Background: The integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets. Our aim was to integrate DNA methylation and gene expression data in an effort to identify biomarkers related to cardiovascular disease risk in a community-based population. We accessed data from the Framingham Offspring Study, a cohort study with data on DNA methylation (Infinium HumanMethylation450 BeadChip; Illumina) and gene expression (Human Exon 1. Read More

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