Search Our Scientific Publications & Authors

J Pharm Sci 2022 May 20. Epub 2022 May 20.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China; College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Nano/microparticles are widely used as vaccine adjuvants to improve antigen stability and enhance immune response. Conformational stability of a given protein was normally assessed using differential scanning calorimetry (DSC) for the optimization of formulation and for ensuring antigen stability in vaccine products. Here, a higher throughput version, namely the microtiter plate-based differential scanning fluorimetry (DSF) method was developed and optimized for assessing the protein thermal stability in the particulate adjuvant-adsorbed form. Read More

Clin J Oncol Nurs 2022 Jun;26(3):324-327

University of Cincinnati.

Human papillomavirus (HPV) vaccination disparities may exacerbate the substantial racial and ethnic variations in rates of HPV-associated cancers. To reduce these disparities, special attention must be paid to increasing vaccine uptake among subgroups of Asian American men and women who are less likely to engage in primary prevention of HPV-associated cancers. Because nurses are often involved in vaccine discussions, they can play a critical role in improving HPV vaccine uptake by providing culturally appropriate and responsive messages to their patients. Read More

Mol Cell Biochem 2022 May 23. Epub 2022 May 23.

Department of Radiation Oncology, Second Hospital of Jilin University, Changchun, 130022, Jilin, China.

Int J Cancer 2022 May 23. Epub 2022 May 23.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.

Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS-LSIL Triage Study (ALTS), and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high-grade cervical abnormalities at any point during follow-up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged <30 years). Read More

JNCI Cancer Spectr 2022 Mar;6(2)

Center for Health Services Research, Department of Management, Policy, and Community Health, UTHealth School of Public Health, Houston, TX, USA.

Human papillomavirus (HPV)-associated cancer burden is rising in the United States. Trends in the incidence by county-level income and smoking prevalence remain undescribed. We used the Surveillance, Epidemiology, and End Results 21 database to ascertain HPV-associated cancers during 2000-2018. Read More

Math Biosci Eng 2022 Apr;19(6):6013-6039

Department of Mathematics, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

(HPV), which is the main causal factor of cervical cancer, infects normal cervical cells on the specific cell's age interval, i.e., between the G to S phase of cell cycle. Read More

Gynecol Oncol Rep 2022 Jun 15;41:101001. Epub 2022 May 15.

The Ohio State University and Arthur G. James Cancer Hospital and Solove Research Institute, Division of Gynecologic Oncology, Columbus, OH, USA.

Introduction: Eligibility for the human papillomavirus (HPV) vaccine now includes adults 27 through 45 years. It has not been reported how providers are addressing HPV vaccination in patients with existing preinvasive disease. Our objectives were to determine the rates at which vaccination is offered to and received by patients undergoing surgery for high-grade cervical or vulvar dysplasia. Read More

Front Med (Lausanne) 2022 4;9:835254. Epub 2022 May 4.

Molecular and Cell Biology Research Center (MCBRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: Infections in the male genitourinary system with bacterial and viral agents may play a significant role in male infertility. These agents usually infect the urethra, seminal vesicles, prostate, epididymis, vas deferens, and testes retrograde through the reproductive system. A meta-analysis review study was performed to evaluate the presence of bacterial and viral agents in the semen of infertile men and its correlation with infertility. Read More

Front Oral Health 2022 6;3:912861. Epub 2022 May 6.

Department of Otolaryngology Head and Neck Surgery, Centre Intégré Universitaire de Santé et de Services Sociaux West-Central Montreal-Jewish General Hospital, McGill University, Montreal, QC, Canada.

The treatment of oropharyngeal cancer has undergone many paradigms shifts in recent decades. First considered a surgical disease, improvements in radiotherapy led to its popularization in the 1990s. Subsequently, the discovery of the human papillomavirus (HPV) in the pathogenesis of oropharyngeal cancer, as well as the increase in HPV-associated oropharynx cancer incidence, have prompted a reevaluation of its management. Read More

Vaccine X 2022 Aug 29;11:100163. Epub 2022 Apr 29.

Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Vaccines adsorbed to aluminium can induce long-lasting intensely itching subcutaneous nodules (granulomas) at the injection site as well as contact allergy to aluminium. In clinical trials of a new acellular pertussis vaccine performed in the 1990s (Gothenburg, Sweden) with 76 000 participants, itching nodules were reported in 745 children. A positive patch test to aluminium was verified in 77% of the tested children with itchy nodules. Read More

Front Oncol 2022 6;12:838911. Epub 2022 May 6.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

In light of the development of RAS inhibitors, a reliable assessment of the prevalence of RAS mutations and their correlation with the clinical features of patients with HNC is crucially needed. This meta-analysis compiles the findings of 149 studies with over 8500 HNC patients and assesses the global prevalence of mutations in the HRAS, KRAS and NRAS genes. The available data were stratified according to geographical region, clinical features, and tumor characteristics, including human papillomavirus (HPV) infection status and tumor stage. Read More

J Obstet Gynaecol Res 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, Saga, Japan.

Aim: This study aimed to clarify (1) the effectiveness of human papillomavirus (HPV) vaccine against precancerous lesions of uterine cervical cancer and (2) the difference in these effectiveness based on smoking status.

Methods: This retrospective cross-sectional study considered women aged 20-24 who underwent cervical cancer screening in Saga City from April 2014 to March 2020. Cervical cytology and histological diagnosis were compared with or without HPV vaccination and smoking. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):494-500

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan; Gynecologic Cancer Research Center, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: This study (Asian Gynecologic Oncology Group [AGOG]13-001/Taiwanese Gynecologic Oncology Group [TGOG]1006) was to validate human papillomavirus (HPV)16 as an independent good prognostic factor and investigate the impact of treatment modalities to cervical adenocarcinoma and adenosquamous carcinoma (AD/ASC).

Materials And Methods: Patients receiving primary treatment at AGOG and TGOG member hospitals for cervical AD/ASC were retrospectively (1993-2014) and prospectively (since 2014) enrolled. DNA extraction from paraffin-embedded tissue (FFPE) specimens was used for HPV genotyping. Read More

J Clin Oncol 2022 May 20:JCO2200609. Epub 2022 May 20.

University of Michigan, Michigan Institute of Clinical and Health Research, Departments of Family Medicine, Obstetrics and Gynecology, Women's and Gender Studies, Ann Arbor, MI.

J Med Virol 2022 May 20. Epub 2022 May 20.

ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, India.

Killer cell immunoglobulin-like receptors (KIRs) are required for natural killer cell function against virus-infected cells or tumor cells. KIR gene content polymorphisms in Indian women with cervical cancer (CaCx) remain unexplored. Hence, we analyzed the frequencies of KIR genes, KIR haplotypes, and Bx subsets to draw their association with CaCx. Read More

J Med Case Rep 2022 May 20;16(1):196. Epub 2022 May 20.

Department of Obstetrics and Gynecology, Hospital de Denia, Avenida Marina alta, s/n, 03700, Denia, Alicante, Spain.

Background: The spread of cervical squamous cell carcinoma to the inner surface of the uterus with replacement of the endometrium is rare. Continuity of the lesion must be demonstrated to confirm superficial spread and rule out concomitant endometrial cancer.

Case Presentation: We present the case of a 66-year-old white woman with superficial spreading squamous cell carcinoma of the cervix that involved the endometrium. Read More

Zhonghua Liu Xing Bing Xue Za Zhi 2022 May;43(5):702-708

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

We aim to evaluate the morbidity and mortality of cancer attributable to human papillomavirus (HPV) infection in China in 2016. Based on the cancer incidence and mortality rates, national population data, and population attributable fraction () in China, we calculated the number of incidence and death cases attributed to HPV infection in different areas, age groups, and gender in China in 2016. The standardized incidence and mortality rates for cancer attributed to HPV infection were calculated by using Segi's population. Read More

Cancer 2022 May 19. Epub 2022 May 19.

Department of Radiation Oncology, Princess Margaret Cancer Center/University of Toronto, Toronto, Ontario, Canada.

Background: The objective of this study was to describe the clinical presentation and outcomes of human papillomavirus (HPV)-positive nasopharyngeal cancer (NPC) versus Epstein-Barr virus (EBV)-positive NPC and HPV-positive oropharyngeal cancer (OPC).

Methods: Clinical characteristics and presenting signs/symptoms were compared between patients who had viral-related NPC versus viral-related OPC treated with intensity-modulated radiotherapy from 2005 to 2020 and who were matched 1:1 (by tumor and lymph node categories, smoking, age, sex, histology, and year of diagnosis). Locoregional control (LRC), distant control (DC), and overall survival (OS) were compared using the 2005-2018 cohort to maintain 2 years of minimum follow-up. Read More

PLoS One 2022 19;17(5):e0268521. Epub 2022 May 19.

Department of Family Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Background: Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies.

Methods: In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Read More

S Afr Med J 2022 04 29;112(5):335-340. Epub 2022 Apr 29.

School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.

Background: Human papillomavirus (HPV) is a sexually transmitted infection and a causative agent of cervical cancer. It is common in adolescent girls and young women, and the majority of infections are transient and asymptomatic. In Botswana, there are currently no data on the HPV prevalence against which the impact of prophylactic HPV vaccines can be measured. Read More

Nat Commun 2022 May 18;13(1):2889. Epub 2022 May 18.

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

J Vet Med Sci 2022 May 17. Epub 2022 May 17.

Chinese People's Liberation Army Center for Disease Control and Prevention.

Ticks are an important group of arthropod vectors. Ticks pose a profound risk to public health by transmitting many types of microorganisms that are human and animal pathogens. With the development of next-generation sequencing (NGS) technology and viral metagenomics, numerous novel viruses have been discovered in ticks and tick-related hosts. Read More

BMJ Open 2022 May 18;12(5):e059345. Epub 2022 May 18.

Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands.

Introduction: The locoregional failure (LRF) rate in human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) remains disappointingly high and toxicity is substantial. Response prediction prior to or early during treatment would provide opportunities for personalised treatment. Currently, there are no accurate predictive models available for correct OPSCC patient selection. Read More

J Appl Oral Sci 2022 16;30:e20210702. Epub 2022 May 16.

Universidade Federal de Santa Catarina - UFSC, Departamento de Patologia, Florianópolis, SC, Brasil.

Background: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer.

Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection.

Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):551-552

Istinye University, Department of Urology - Istanbul, Turkey.

Nanoscale 2022 May 18. Epub 2022 May 18.

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

As DNA polymerases are even active at ambient temperature, there is inevitable non-specific amplification; to avoid the undesired amplification of analytes, a heat activation-based polymerase chain reaction (PCR), called hot-start PCR, is widely used to be highly precise and quantitative in detection. Unlike thermocycling amplification, isothermal amplification, compatible for point-of-care (PoC) tests, cannot be benefited by the heat-activation technique, making the method qualitative rather than quantitative. In this work, we newly developed a lead ion (Pb) activation technique, called lead-start isothermal amplification, allowing on-demand activation or deactivation of DNA polymerases at room temperature. Read More

Can Oncol Nurs J 2022 1;32(2):233-244. Epub 2022 Apr 1.

Assistant Professor, Faculty of Nursing - University of New Brunswick, Fredericton, New Brunswick.

Nearly all cases of cervical cancer (CC) are caused by persistent infection by human papillomavirus (HPV). CC remains the second most prevalent carcinoma among women and, in 2017, Canada's screening rates were off target by 19%. For example, screening rates as low as 57. Read More

J Transl Med 2022 05 17;20(1):231. Epub 2022 May 17.

Cervical Cancer Screening Coordination Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.

Background: According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) lesions. The study aimed to assess whether HPV Selfy (Ulisse BioMed - Trieste, Italy), a full-genotyping HPV DNA test that detects and differentiates 14 high-risk HPV (HR-HPV) types, meets the criteria for primary cervical cancer screening described in the international guidelines, on clinician-collected as well as on self-collected samples.

Methods: For each participant woman, consecutively referring to Azienda Sanitaria Universitaria Giuliano Isontina (Trieste, Italy) and CRO-National Cancer Institute (Aviano, Italy) for the cervical cancer screening program, the following samples were tested: (a) a clinician-collected cervical specimen, analyzed with the reference test (Hybrid Capture®2 test, HC2) and HPV Selfy; and (b) a self-collected vaginal sample, analyzed with HPV Selfy. Read More

J Med Microbiol 2022 May;71(5)

Department of Pathology, Botucatu Medical School, UNESP, São Paulo State University, São Paulo, Brazil.

Two high-oncogenic-risk human papilomavirus (hrHPV) genotypes - HPV16 and HPV18 - cause most of the cases of cervical cancer worldwide. Bacterial vaginosis is associated with increased hrHPV persistence, although the mechanism underlying this association remains unclear. spp. Read More

Int J Cancer 2022 May 17. Epub 2022 May 17.

IRCCS - Regina Elena National Cancer Institute, Rome, Italy.

As the primary screening test, E6/E7 mRNA has shown similar sensitivity for CIN3+ and lower positivity rate than the HPV DNA test. Nevertheless, the overall mRNA positivity is too high for immediate colposcopy, making a triage test necessary. The aim was to estimate the mRNA performance as a primary test with different triage strategies. Read More