115,162 results match your criteria human melanoma


Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.

Cell Metab 2021 May 11. Epub 2021 May 11.

Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

The cell-intrinsic nature of tumor metabolism has become increasingly well characterized. The impact that tumors have on systemic metabolism, however, has received less attention. Here, we used adult zebrafish harboring BRAF-driven melanoma to study the effect of cancer on distant tissues. Read More

View Article and Full-Text PDF

Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target.

Oxid Med Cell Longev 2021 20;2021:6652086. Epub 2021 Apr 20.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Together with nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (HS) is now recognized as a vital gaseous transmitter. The ubiquitous distributions of HS-producing enzymes and potent chemical reactivities of HS in biological systems make HS unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, HS can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. Read More

View Article and Full-Text PDF

Genetic markers for characterization and prediction of prognosis of melanoma subtypes: a 2021 update.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain -

In this article we examine the most important genetic markers involved in melanoma susceptibility, initiation and progression, and their impact on the prognosis of the disease. Current knowledge in melanoma genetics identifies distinct pathways to the development of different melanoma subtypes characterized by specific clinico-pathological features and partially known genetic markers, modulated by high, low or absence of cumulative sun damage. The most prevalent somatic mutations are related to the activation of the MAPK pathway, which are classified into four major subtypes: BRAF mutant, NRAS mutant, NF1 mutant and triple wild-type. Read More

View Article and Full-Text PDF

DUXAP8 knockdown inhibits the development of melanoma by regulating the miR-3182/NUPR1 pathway.

Oncol Lett 2021 Jul 27;22(1):495. Epub 2021 Apr 27.

Department of Dermatology, The Affiliated Changzhou No. 2 People's Hospital with Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.

Double homeobox A pseudogene 8 (DUXAP8) has been reported to regulate the growth of several types of cancers, such as breast cancer and ovarian cancer. However, its role in melanoma remains unclear. In the present study, the mechanism through which DUXAP8 regulates melanoma progression was explored. Read More

View Article and Full-Text PDF

Ultraviolet light-induced collagen degradation inhibits melanoma invasion.

Nat Commun 2021 May 12;12(1):2742. Epub 2021 May 12.

Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.

Ultraviolet radiation (UVR) damages the dermis and fibroblasts; and increases melanoma incidence. Fibroblasts and their matrix contribute to cancer, so we studied how UVR modifies dermal fibroblast function, the extracellular matrix (ECM) and melanoma invasion. We confirmed UVR-damaged fibroblasts persistently upregulate collagen-cleaving matrix metalloprotein-1 (MMP1) expression, reducing local collagen (COL1A1), and COL1A1 degradation by MMP1 decreased melanoma invasion. Read More

View Article and Full-Text PDF

Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis.

Cell Death Dis 2021 May 12;12(5):473. Epub 2021 May 12.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades. During their lifetime, about 8% of CM patients will develop multiple primary melanomas (MPMs), usually at a young age and within 3 years from the first tumor/diagnosis. With the aim of improving our knowledge on MPM biology and pathogenesis, we explored the miRNome of 24 single and multiple primary melanomas, including multiple tumors from the same patient, using a small RNA-sequencing approach. Read More

View Article and Full-Text PDF

[Idiopathic Intrapulmonary Hematoma Need to Differentiate from Pulmonary Metastasis of Malignant Melanoma:Report of a Case].

Kyobu Geka 2021 May;74(5):401-403

Department of Thoracic and Cardiovascular Surgery, University of Saga, Saga, Japan.

A 74-year-old man had previously been treated for primary malignant melanoma of the bladder. Three years after surgery, 8 mm round nodule in the right lower lobe was found on chest computed tomography. The nodule increased to 11 mm after three months, and resected with a diagnosis of metastatic malignant melanoma. Read More

View Article and Full-Text PDF

Dissecting Oncogenic RAS Signaling in Melanoma Development in Genetically Engineered Zebrafish Models.

Methods Mol Biol 2021 ;2262:411-422

Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, UK.

Hyper-activation of RAS signaling pathways causes cancer, including melanoma, and RAS signaling pathways have been successfully targeted using drugs for patient benefit. The available drugs alone cannot cure cancer, however, and so investigation continues into RAS signaling pathways, with the goal of identifying further actionable targets. The zebrafish can be used to model human malignancies, and genetic modification of zebrafish to incorporate selective disease-associated genetic alterations is practicable. Read More

View Article and Full-Text PDF
January 2021

Intratumoral bacteria generate a new class of therapeutically relevant tumor antigens in melanoma.

Cancer Cell 2021 May;39(5):601-603

Department of Bioengineering, University of California San Diego, La Jolla, CA, USA; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA. Electronic address:

The functional repertoire of intratumoral microorganisms and their local effects on the host remain poorly characterized. By revealing potentially immunogenic bacterial peptides on melanoma cells, a Nature paper provides evidence that intratumoral bacteria can directly modulate antitumor immune responses, and it details a new class of therapeutically relevant, non-human tumor antigens. Read More

View Article and Full-Text PDF

Participation of Keratinocyte- and Fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders.

Pigment Cell Melanoma Res 2021 May 11. Epub 2021 May 11.

Department of Dermatology, University of Cincinnati College of Medicine.

Human epidermal melanocytes play a central role in sensing the environment and protecting the skin from the drastic effects of solar ultraviolet radiation and other environmental toxins or inflammatory agents. Melanocytes survive in the epidermis for decades, which subjects them to chronic environmental insults. Melanocytes have a poor self-renewal capacity; therefore, it is critical to ensure their survival with genomic stability. Read More

View Article and Full-Text PDF

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis.

Genome Med 2021 May 10;13(1):81. Epub 2021 May 10.

The Kinghorn Cancer Centre and Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Background: High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing. This hindrance can often introduce technical biases when integrating patient datasets and increase experimental costs. Read More

View Article and Full-Text PDF

Preparation of cerium-curcumin and cerium-quercetin complexes and their LEDs irradiation assisted anticancer effects on MDA-MB-231 and A375 cancer cell lines.

Photodiagnosis Photodyn Ther 2021 May 7:102326. Epub 2021 May 7.

Department of Chemical Engineering, University of Bonab, Bonab, Iran.

Regardless of the numerous studies that have been done on cancer treatment, it is still the most challenging disease to treat especially resistance forms like triple negative breast cancer and melanoma cancer. Curcumin and quercetin as two important polyphenols from plants have different biological roles including anti-cancer effect. But their application is limited due to their poor solubility in aqueous medium. Read More

View Article and Full-Text PDF

A. hierchuntica extract exacerbates genotoxic, cytotoxic, apoptotic and oxidant effects in B16F10 melanoma cells.

Toxicon 2021 May 7;198:73-79. Epub 2021 May 7.

Health Sciences University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey; University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Haydarpasa Numune Health Application and Research Center, Department of Medical Biochemistry, Istanbul, Turkey.

Melanoma is a highly malignant tumor caused by melanocytes. Even though melanoma represents just 3% of all skin malignancies, it represents 75% of deaths. Extracts of A. Read More

View Article and Full-Text PDF

Risk of Ophthalmic Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.

Ocul Immunol Inflamm 2021 May 10:1-11. Epub 2021 May 10.

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

: Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Read More

View Article and Full-Text PDF

Comparative Analysis of Diagnostic Techniques for Melanoma Detection: A Systematic Review of Diagnostic Test Accuracy Studies and Meta-Analysis.

Front Med (Lausanne) 2021 21;8:637069. Epub 2021 Apr 21.

The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.

Melanoma has the highest mortality rate among skin cancers, and early-diagnosis is essential to maximize survival rate. The current procedure for melanoma diagnosis is based on dermoscopy, i.e. Read More

View Article and Full-Text PDF

Development of GATE Monte Carlo Code for Simulation and Dosimetry of New I-125 Seeds in Eye Plaque Brachytherapy.

Nucl Med Mol Imaging 2021 Apr 11;55(2):86-95. Epub 2021 Jan 11.

Department of Physics, Faculty of Science, University of Guilan, Namjoo Avenue, P.O. Box 41635-1914, Rasht, Guilan 4193833697 Iran.

Purpose: Dose distributions are calculated by Monte Carlo (MC) simulations for two low-energy models I brachytherapy source-IrSeed-125 and IsoAid Advantage (model IAI-125A)-loaded in the 14-mm standardized plaque of the COMS during treatment of choroid melanoma.

Methods: In this study, at first, the radial dose function in water around I brachytherapy sources was calculated based on the recommendations of the Task Group No. 43 American Association of Physicists in Medicine (TG-43U1 APPM) using by GATE code. Read More

View Article and Full-Text PDF

Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma.

Cell Cycle 2021 May 9:1-11. Epub 2021 May 9.

Department of Human Science, Georgetown University, Washington, DC, USA.

Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) pathway is dysregulated in more than 90% of melanoma cases. Therefore, tumor cells mainly rely on the G2-M checkpoint to halt the cell cycle in order to repair DNA damage. Read More

View Article and Full-Text PDF

Difficulties encountered in the diagnosis of primary esophageal malignant melanoma by 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a case report.

Ann Palliat Med 2021 Apr;10(4):4975-4981

Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Primary malignant melanoma of the gastrointestinal mucosa is a rare tumor. Here, we report a case of a 60-year-old female patient with esophageal malignant melanoma. Combined with the related literature, the clinical manifestations, imaging, histopathological and immunohistochemical features of primary esophageal malignant melanoma were observed and analyzed. Read More

View Article and Full-Text PDF

Potential Biomarker for Triple-Negative Breast Cancer Invasiveness by Optical Redox Imaging.

Adv Exp Med Biol 2021 ;1269:247-251

Britton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Predicting tumor metastatic potential remains a challenge in cancer research and in clinical diagnosis. Cancer invasion to neighboring tissues is a significant event in cancer progression to metastasis. Optical redox imaging (ORI) is based on detecting the endogenous fluorescence signals of reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavin adenine dinucleotide (FAD). Read More

View Article and Full-Text PDF

NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.

J Biomed Sci 2021 May 7;28(1):35. Epub 2021 May 7.

Department of Pathology, School of Medicine, Boston University Medical Campus, 670 Albany Street, Boston, MA, 02118, USA.

Background: The cell adhesion molecule IGPR-1 regulates various critical cellular processes including, cell-cell adhesion, mechanosensing and autophagy and plays important roles in angiogenesis and tumor growth; however, the molecular mechanism governing the cell surface levels of IGPR-1 remains unknown.

Results: In the present study, we used an in vitro ubiquitination assay and identified ubiquitin E3 ligase NEDD4 and the ubiquitin conjugating enzyme UbcH6 involved in the ubiquitination of IGPR-1. In vitro GST-pulldown and in vivo co-immunoprecipitation assays demonstrated that NEDD4 binds to IGPR-1. Read More

View Article and Full-Text PDF

Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma.

Eur J Cancer 2021 May 4;151:25-34. Epub 2021 May 4.

Department of Chronic Disease Epidemiology, Yale School of Public Health, School of Medicine, Yale Cancer Center, Yale University, New Haven, CT, USA. Electronic address:

Objective: The gut microbiome plays an important role in systemic inflammation and immune response. Microbes can translocate and reside in tumour niches. However, it is unclear how the intratumour microbiome affects immunity in human cancer. Read More

View Article and Full-Text PDF

Detection of cancer metastasis: past, present and future.

Clin Exp Metastasis 2021 May 7. Epub 2021 May 7.

Moffitt Cancer Center, Department of Pathology, 12902 Magnolia Drive, Tampa, FL, 33612, USA.

The clinical importance of metastatic spread of cancer has been recognized for centuries, and melanoma has loomed large in historical descriptions of metastases, as well as the numerous mechanistic theories espoused. The "fatal black tumor" described by Hippocrates in 5000 BC that was later termed "melanose" by Rene Laennec in 1804 was recognized to have the propensity to metastasize by William Norris in 1820. And while the prognosis of melanoma was uniformly acknowledged to be dire, Samuel Cooper described surgical removal as having the potential to improve prognosis. Read More

View Article and Full-Text PDF

Genetics of non-syndromic and syndromic oculocutaneous albinism in human and mouse.

Pigment Cell Melanoma Res 2021 May 7. Epub 2021 May 7.

Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.

Oculocutaneous albinism (OCA) is the most frequent presentation of albinism, a heterogeneous rare genetic condition generally associated with variable alterations in pigmentation and with a profound visual impairment. There are non-syndromic and syndromic types of OCA, depending on whether the gene product affected impairs essentially the function of melanosomes or, in addition, that of other lysosome-related organelles (LROs), respectively. Syndromic OCA can be more severe and associated with additional systemic consequences, beyond pigmentation and vision alterations. Read More

View Article and Full-Text PDF

Validity of claims-based algorithms for selected cancers in Japan: Results from the VALIDATE-J study.

Pharmacoepidemiol Drug Saf 2021 May 7. Epub 2021 May 7.

Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.

Purpose: Real-world data from large administrative claims databases in Japan have recently become available, but limited evidence exists to support their validity. VALIDATE-J validated claims-based algorithms for selected cancers in Japan.

Methods: VALIDATE-J was a multicenter, cross-sectional, retrospective study. Read More

View Article and Full-Text PDF

A GWAS identifies novel gene associations with facial skin wrinkling and mole count in Latin-Americans.

Br J Dermatol 2021 May 6. Epub 2021 May 6.

Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Arica, 1000000, Chile.

Background: Genome-wide association studies (GWAS) have identified genes influencing skin ageing and mole count in Europeans but little is known about the relevance of these (or other genes) in non-Europeans.

Objective: To conduct a GWAS for facial skin ageing and mole count in adults < 40 years old, of mixed European, Native American and African ancestry, recruited in Latin America.

Methods: Skin ageing and mole count scores were obtained from facial photographs of >6,000 individuals. Read More

View Article and Full-Text PDF

Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review.

Clin Pathol 2021 Jan-Dec;14:2632010X211009819. Epub 2021 Apr 20.

Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil.

Pigmented lesions of the oral mucosa encompass several benign and malignant conditions that may be a matter of concern under both clinical and histopathological views. We reported a case of a 62-year-old woman, presenting with an asymptomatic, deeply pigmented lesion on the soft palate. On examination, it appeared asymmetrical, with irregular borders and an area of ulceration. Read More

View Article and Full-Text PDF

Rapamycin Promotes ROS-Mediated Cell Death Functional Inhibition of xCT Expression in Melanoma Under γ-Irradiation.

Front Oncol 2021 20;11:665420. Epub 2021 Apr 20.

Department of Biological Sciences, Kangwon National University, Chuncheon, South Korea.

Although many cancer patients are administered radiotherapy for their treatment, the interaction between tumor cells and macrophages in the tumor microenvironment attenuates the curative effects of radiotherapy. The enhanced activation of mTOR signaling in the tumors promotes tumor radioresistance. In this study, the effects of rapamycin on the interaction between tumor cells and macrophages were investigated. Read More

View Article and Full-Text PDF

Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.

Oncogene 2021 May 6. Epub 2021 May 6.

Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Florence, Italy.

Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to develop more effective treatment regimens. Hedgehog/GLI (HH/GLI) signaling inhibitors targeting the central pathway transducer Smoothened (SMO) have shown to be clinical efficacious in skin cancer; however, several mechanisms of non-canonical HH/GLI pathway activation limit their efficacy. Read More

View Article and Full-Text PDF

Cryptic Biosynthesis of the Berkeleypenostatins from Coculture of Extremophilic sp.

J Nat Prod 2021 May 6. Epub 2021 May 6.

Coculture fermentation of and yielded berkeleypenostatins A-G (-) as well as the previously reported berkeleylactones A-H, the known macrolide A26771B, citrinin, and patulin. As was true with the berkeleylactones, there was no evidence of the berkeleypenostatins in either axenic culture. The structures were deduced from analyses of spectral data, and the absolute configuration of berkeleypenostatin A () was determined by single-crystal X-ray crystallography. Read More

View Article and Full-Text PDF