J Acquir Immune Defic Syndr 2021 May 10. Epub 2021 May 10.
Institute of Population Health Sciences, University of Liverpool, Liverpool, UK Department of Orthopaedic and Trauma Surgery, Liverpool University Teaching Hospital Trust, Liverpool, UK Division of Orthopaedic Surgery, Groote Schuur Hospital, Cape Town, South Africa Orthopaedic Research Unit (ORU), University of Cape Town, Cape Town, South Africa Division of Orthopaedic Surgery, Stellenbosch University, Cape Town, South Africa Department of Orthopaedic and Trauma Surgery, Countess of Chester Hospital, Chester, UK University of Edinburgh, Edinburgh, UK Malawi-Liverpool-Wellcome Trust Clinical Research Programme Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Background: Human immunodeficiency virus (HIV) reduces bone mineral density, mineralisation and turnover, and may impair fracture healing.
Setting: This prospective cohort study in South Africa investigated whether HIV infection was associated with impaired fracture healing following trauma.
Methods: All adults with acute tibia and femur fractures who underwent intermedullary nailing (IM) for fracture fixation between September 2017 and December 2018, at two tertiary hospitals, were followed for a minimum of 12 months post-operatively. Read More