108,073 results match your criteria human hepatoma


[Corrigendum] MicroRNA‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma.

Oncol Rep 2021 Jul 13;46(1). Epub 2021 May 13.

Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China.

Following the publication of the above article, an interested reader drew to the authors' attention that Figs. 6C and 7A apparently contained overlapping panels, suggesting that these data for purportedly different experiments had been derived from the same original source. The wound‑healing result for the anti‑miR‑122+siRNA PKM2 experiment in the lower panel of Fig. Read More

View Article and Full-Text PDF

Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal-Derived Endophytic Fungus sp.

Front Pharmacol 2021 26;12:542891. Epub 2021 Apr 26.

Department of Biochemistry, Indian Institute of Science, Bangalore, India.

The endophytic fungal community in the marine ecosystem has been demonstrated to be relevant source of novel and pharmacologically active secondary metabolites. The current study focused on the evaluation of cytotoxic and apoptosis induction potential in the culture extracts of endophytic fungi associated with , a marine brown alga. The cytotoxicity of the four marine endophytes, sp. Read More

View Article and Full-Text PDF

Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2).

J Nanosci Nanotechnol 2021 Nov;21(11):5414-5428

US Environmental Protection Agency, Retired from EPA, Durham NC 27709, USA.

In order to understand toxicity of nano silver, human hepatocellular carcinoma (HepG2) cells were treated either with silver nitrate (AgNO₃) or with nano silver capped with glutathione (Ag-S) at various concentration. Differentially expressed genelists for mRNA and microRNA were obtained through Illumina RNA sequencing and DEseq data analyses. Both treatments showed non-linear dose response relationships for mRNA and microRNA. Read More

View Article and Full-Text PDF
November 2021

and Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue.

Visc Med 2021 Mar 12;37(2):110-115. Epub 2021 Jan 12.

Department of Medicine II, Saarland University Medical Center, Homburg, Germany.

Introduction: The endoplasmic reticulum transmembrane proteins Sec61, Sec62, and Sec63 are responsible for the intracellular trafficking of precursor proteins and affect intracellular signaling. overexpression has been linked to various human cancers. Our aim was to investigate and expression in hepatocellular carcinoma (HCC) and surrounding liver tissue. Read More

View Article and Full-Text PDF

[A Case of Metachronous Quintuple Cancer Involving the Stomach, Rectum, Colon, Liver and Prostate].

Gan To Kagaku Ryoho 2021 Apr;48(4):608-611

Dept. of Surgery, Kansai Rosai Hospital.

Advances and improvements in cancer diagnosis and treatment have made it possible to find multiple primary cancers. We report here a rare case of metachronous quintuple cancer involving the stomach, rectum, colon, liver and prostate. An 80s‒ year‒old male was referred to our hospital with abnormality on upper GI series. Read More

View Article and Full-Text PDF

[A Case of Intrahepatic Cholangiocarcinoma Confused with a Recurrent Hepatocellular Carcinoma Treated by RFA at Diagnosis].

Gan To Kagaku Ryoho 2021 Apr;48(4):543-545

Dept. of Surgery, Chiba Rosai Hospital.

Intrahepatic cholangiocarcinoma(ICC)is the second most common malignant liver tumor after hepatocellular carcinoma (HCC). ICC is usually ischemic; however, it has variable findings and may be difficult to differentiate from HCC. We report about a case of ICC that was difficult to distinguish from HCC treated by radiofrequency ablation(RFA). Read More

View Article and Full-Text PDF

[A Case of Hepatocellular Carcinoma Complicated by Liver Metastasis of Colon Cancer during the Course of Treatment].

Gan To Kagaku Ryoho 2021 Apr;48(4):531-535

Dept. of Gastroenterology, National Hospital Organization Takasaki General Medical Center.

A 72‒year‒old man with hepatocellular carcinoma(HCC)was treated with transarterial chemoembolization(TACE)and radiofrequency ablation(RFA). Six months after RFA, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd‒ EOB‒DTPA)‒enhanced magnetic resonance imaging(MRI)revealed multiple metastatic recurrences in the liver. TACE was performed for the recurrent HCC. Read More

View Article and Full-Text PDF

The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms.

RNA 2021 May 11. Epub 2021 May 11.

Life and Medical Sciences Institute (LIMES), University of Bonn.

The stem cell-specific RNA-binding protein TRIM71/LIN-41 was the first identified target of the pro-differentiation and tumor suppressor miRNA let-7. TRIM71 has essential functions in embryonic development and a proposed oncogenic role in several cancer types, such as hepatocellular carcinoma. Here, we show that TRIM71 regulates let-7 expression and activity via two independent mechanisms. Read More

View Article and Full-Text PDF

Differential effects of androgens and estrogens over cellular GH sensitivity in HEPG2 cells.

Growth Horm IGF Res 2021 May 4;57-58:101390. Epub 2021 May 4.

Institute of Maternal and Child Research (IDIMI), School of Medicine, University of Chile, Santiago, Chile.

Testosterone and estrogen concentrations progressively increase during puberty, and in association with growth hormone (GH), lead to the increase in height velocity known as the pubertal growth spurt. Very limited information is available however, regarding the possible effects of sex steroids over GH cellular sensitivity.

Objective: To investigate the effects of different concentrations of testosterone, estradiol and dihydrotestosterone over the GH intracellular signaling pathway. Read More

View Article and Full-Text PDF

Hepatic hilar and celiac plexus nerve blocks as analgesia for doxorubicin-eluting bead embolization procedures for hepatocellular carcinoma: A non-blinded randomized clinical trial.

J Vasc Interv Radiol 2021 May 8. Epub 2021 May 8.

Department of Radiodiagnosis, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Purpose: To investigate whether hepatic hilar and celiac plexus nerve blocks provide safe and effective analgesia to patients undergoing doxorubicin-eluting embolics embolization for hepatocellular carcinoma MATERIALS AND METHODS: In this prospective, randomized trial, 92 patients undergoing drug-eluting embolics transarterial chemoembolization (TACE) for hepatocellular carcinoma were enrolled. The control group received standard intraprocedural local anesthetic, intraarterial lidocaine, and intravenous analgesia; the study group (HHCB) underwent hepatic hilar and celiac plexus nerve blockade in addition. Intraarterial lidocaine, intravenous and postprocedural oral narcotics and antiemetics requirements, pain, patient satisfaction, adverse events, and hospital stay were compared. Read More

View Article and Full-Text PDF

Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma.

Bosn J Basic Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, Nanning, China; Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, China.

Hepatocellular carcinoma (HCC) is a highly malignant tumor. In this study, we sought to identify a novel biomarker for HCC by analyzing transcriptome and clinical data. The R software was used to analyze the differentially expressed genes (DEGs) in the datasets GSE74656 and GSE84598 downloaded from the Gene Expression Omnibus database, followed by a functional annotation. Read More

View Article and Full-Text PDF

Deregulation of cell cycle and related microRNA expression induced by vinyl chloride monomer in hepatocytes of rats.

Toxicol Ind Health 2021 May 11:7482337211015591. Epub 2021 May 11.

Department of Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, China.

Vinyl chloride (VC) is a confirmed human carcinogen associated with hepatocellular carcinoma and angiosarcoma. However, the role of microRNAs (miRNAs) in liver cell cycle changes under VC exposure remains unclear, which prevents research on the mechanism of VC-induced carcinogenesis. In this study, male rats were injected intraperitoneally with VC (0, 5, 25, and 125 mg/kg body weight) for 6, 8, and 12 weeks. Read More

View Article and Full-Text PDF

TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.

Cancer Sci 2021 May 10. Epub 2021 May 10.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

Ten-eleven translocation 1 (TET1) is an essential methylcytosine dioxygenase of the DNA demethylation pathway. Despite its dysregulation being known to occur in human cancer, the role of TET1 remains poorly understood. In this study, we report that TET1 promotes cell growth in human liver cancer. Read More

View Article and Full-Text PDF

The Comparative Effect of Nisin and Thioridazine as Potential Anticancer Agents on Hepatocellular Carcinoma.

Rep Biochem Mol Biol 2021 Jan;9(4):452-462

Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University.

Background: Hepatocellular carcinoma is a major health problem worldwide especially in Egypt. It accounts for the fifth common cancer and the second cause of death among different cancers. This study investigated the efficacy and molecular mechanism of Nisin and/or Thioridazine as anticancer treatment on human liver cancer HepG2 cell line. Read More

View Article and Full-Text PDF
January 2021

The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma.

Front Oncol 2021 21;11:649107. Epub 2021 Apr 21.

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hepatocellular carcinoma (HCC) is among the utmost deadly human malignancies. This type of cancer has been associated with several environmental, viral, and lifestyle risk factors. Among the epigenetic factors which contribute in the pathogenesis of HCC is dysregulation of long non-coding RNAs (lncRNAs). Read More

View Article and Full-Text PDF

Computer-aided diagnosis of hepatocellular carcinoma fusing imaging and structured health data.

Health Inf Sci Syst 2021 Dec 4;9(1):20. Epub 2021 May 4.

Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245-Porto Alegre, Rio Grande do Sul, Brazil.

Introduction: Hepatocellular carcinoma is the prevalent primary liver cancer, a silent disease that killed 782,000 worldwide in 2018. Multimodal deep learning is the application of deep learning techniques, fusing more than one data modality as the model's input.

Purpose: A computer-aided diagnosis system for hepatocellular carcinoma developed with multimodal deep learning approaches could use multiple data modalities as recommended by clinical guidelines, and enhance the robustness and the value of the second-opinion given to physicians. Read More

View Article and Full-Text PDF
December 2021

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice.

Endocr J 2021 May 7. Epub 2021 May 7.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Nonalcoholic fatty liver disease (NAFLD) is a clinical spectrum that encompasses simple steatosis to nonalcoholic steatohepatitis (NASH), the latter of which is characterized by chronic inflammation and fibrosis. NASH is now becoming the leading cause of cirrhosis and hepatocellular carcinoma worldwide. The pathophysiology of NASH is multifactorial and, therefore, not yet completely understood, although it is pointed out that hepatocyte death and subsequent inflammation play a central roles in disease pathogenesis. Read More

View Article and Full-Text PDF

[Genetic analysis of hepatocellular cancer towards the genome medicine].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):428-436

Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo.

View Article and Full-Text PDF

[Late line systemic therapy for advanced hepatocellular carcinoma].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):418-427

Department of Gastroenterology, Graduate School of Medicine, Chiba University.

View Article and Full-Text PDF

[The paradigm shifts in the treatment of the intermediate stage hepatocellular carcinoma].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):407-417

Department of Gastroenterology, Kanazawa University Hospital.

View Article and Full-Text PDF

[Efficacy and safety of systemic treatments using immune checkpoint inhibitors for advanced hepatocellular carcinoma].

Authors:
Junji Furuse

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):400-406

Department of Medical Oncology, Kyorin University Faculty of Medicine.

View Article and Full-Text PDF

[Systemic therapy for hepatocellular carcinoma:recent advances and future perspective].

Authors:
Masatoshi Kudo

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(5):379-399

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine.

View Article and Full-Text PDF

Phthalates promote the invasion of hepatocellular carcinoma cells by enhancing the interaction between Pregnane X receptor and E26 transformation specific sequence 1.

Pharmacol Res 2021 May 6;169:105648. Epub 2021 May 6.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address:

Phthalates (PAEs) are considered endocrine-disrupting chemicals (EDCs), a series of compounds able to disrupt the normal regulation of the human endocrine-system. In the present study, we investigated the roles of four PAEs, butyl benzyl phthalate (BBP), dibutyl phthalate (DBP), dimethyl phthalate (DMP), and diethyl phthalate (DEP), in hepatocellular carcinoma (HCC) cells. We define novel roles for the PAEs on the migration of HCC cells via their enhancing of the interaction between the pregnane X receptor (PXR) and E26 transformation specific sequence 1 (ETS-1). Read More

View Article and Full-Text PDF

Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.

J Hepatol 2021 May 5. Epub 2021 May 5.

Department of Medicine, Duke University, Duke University Health System, Durham, NC, USA. Electronic address:

Background & Aims: Nonalcoholic Fatty Liver Disease (NAFLD), the hepatic correlate of the metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic inflammation is thought to be the root cause of all these diseases, the mechanism whereby it promotes HBC in NAFLD remains poorly understood. Here we aim to evaluate the hypothesis that inflammation-related dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes HB carcinogenesis. Read More

View Article and Full-Text PDF

A mutation in SLC37A4 causes a dominantly inherited congenital disorder of glycosylation characterized by liver dysfunction.

Am J Hum Genet 2021 May 4. Epub 2021 May 4.

Complex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

SLC37A4 encodes an endoplasmic reticulum (ER)-localized multitransmembrane protein required for transporting glucose-6-phosphate (Glc-6P) into the ER. Once transported into the ER, Glc-6P is subsequently hydrolyzed by tissue-specific phosphatases to glucose and inorganic phosphate during times of glucose depletion. Pathogenic variants in SLC37A4 cause an established recessive disorder known as glycogen storage disorder 1b characterized by liver and kidney dysfunction with neutropenia. Read More

View Article and Full-Text PDF

Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas.

J Immunother Cancer 2021 May;9(5)

Department of Paediatric Haematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy

Background: Pediatric high-grade gliomas (pHGGs) are among the most common and incurable malignant neoplasms of childhood. Despite aggressive, multimodal treatment, the outcome of children with high-grade gliomas has not significantly improved over the past decades, prompting the development of innovative approaches.

Methods: To develop an effective treatment, we aimed at improving the suboptimal antitumor efficacy of oncolytic adenoviruses (OAs) by testing the combination with a gene-therapy approach using a bispecific T-cell engager (BiTE) directed towards the erythropoietin-producing human hepatocellular carcinoma A2 receptor (EphA2), conveyed by a replication-incompetent adenoviral vector (EphA2 adenovirus (EAd)). Read More

View Article and Full-Text PDF

Prevention of hepatitis B mother-to-child transmission in Namibia: A cost-effectiveness analysis.

Vaccine 2021 May 4. Epub 2021 May 4.

Health Economics Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

Despite access to a safe and effective vaccine, mother-to-child transmission (MTCT) of hepatitis B virus (HBV) persists in Africa. This is of concern since perinatally-infected infants are at highest risk of developing hepatocellular carcinoma, a life-threatening consequence of chronic HBV infection. While tools to prevent HBV MTCT are available, the cost implications of these interventions need consideration prior to implementation. Read More

View Article and Full-Text PDF

Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.

Life Sci 2021 May 5;278:119588. Epub 2021 May 5.

Department of Environmental Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. Electronic address:

Aims: The elevation of arginase in vascular tissues decreases nitric oxide production, which is considered as an early step of atherosclerosis in obesity. Previously, we found that arginase-1, one of arginase isozymes, was elevated in the blood plasma of obese adults. The purpose of this study is to elucidate the mechanism by which obesity increases arginase-1 levels in the blood. Read More

View Article and Full-Text PDF

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.

Autophagy 2021 May 7:1-13. Epub 2021 May 7.

Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.

The small non-coding (vault RNA 1-1) is known to confer resistance to apoptosis in several malignant cell lines and to also modulate the macroautophagic/autophagic flux in hepatocytes, thus highlighting its pro-survival role. Here we describe a new function of in regulating and tumor cell proliferation, tumorigenesis and chemoresistance. Knockout (KO) of in human hepatocellular carcinoma cells reduced nuclear localization of TFEB (transcription factor EB), leading to a downregulation of the coordinated lysosomal expression and regulation (CLEAR) network genes and lysosomal compartment dysfunction. Read More

View Article and Full-Text PDF

Apigenin Inhibits the Growth of Hepatocellular Carcinoma Cells by Affecting the Expression of microRNA Transcriptome.

Front Oncol 2021 6;11:657665. Epub 2021 Apr 6.

Department of Pathology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Chinese Medicine, Shanghai, China.

Background: Apigenin, as a natural flavonoid, has low intrinsic toxicity and has potential pharmacological effects against hepatocellular carcinoma (HCC). However, the molecular mechanisms involving microRNAs (miRNAs) and their target genes regulated by apigenin in the treatment of HCC have not been addressed.

Objective: In this study, the molecular mechanisms of apigenin involved in the prevention and treatment of HCC were explored and using miRNA transcriptomic sequencing to determine the basis for the clinical applications of apigenin in the treatment of HCC. Read More

View Article and Full-Text PDF