19,944,911 results match your criteria human gamma-b-crystallin

Independent and joint associations between leisure time physical activity and strength activities with mortality outcomes in older adults ≥65 years-of-age: a prospective cohort study.

J Gerontol A Biol Sci Med Sci 2021 Apr 15. Epub 2021 Apr 15.

Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.

Scientific evidence regarding the combined effect of both aerobic leisure time physical activity (LTPA) and muscle strengthening activities on all-cause, CVD or cancer mortality in older adults is scant. The aim of the study was to investigate the associations between recommended physical activity and mortality in older adults ≥65 years-of-age. This prospective cohort study used data from the National Health Interview Surveys from 1997-2013 linked with mortality files through December 31, 2015 (n=89,962). Read More

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Predicting influenza and rhinovirus infections in airway cells utilizing volatile emissions.

J Infect Dis 2021 Apr 15. Epub 2021 Apr 15.

VA Northern California Health Care System, 10535 Hospital Way, Mather, CA, United States of America.

Background: Respiratory viral infections are common and potentially devastating to patients with underlying lung disease. Diagnosing viral infections often requires invasive sampling, and interpretation often requires specialized laboratory equipment. Here, we test the hypothesis that a breath test could diagnose influenza and rhinovirus infections using an in vitro model of the human airway. Read More

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In Response.

Anesth Analg 2021 May;132(5):e85-e86

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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Effect of Inadequate Sleep on Clinician Performance.

Haleh Saadat

Anesth Analg 2021 May;132(5):1338-1343

From the Department of Anesthesiology, Frank H Netter School of Medicine, Quinnipiac University, Hartford Health Care, St. Vincent's Medical Center, Bridgeport, Connecticut.

The negative impacts of sleep deprivation and fatigue have long been recognized. Numerous studies have documented the ill effects of impaired alertness associated with the disruption of the sleep-wake cycle; these include an increased incidence of human error-related accidents, increased morbidity and mortality, and an overall decrement in social, financial, and human productivity. While there are multiple studies on the impact of sleep deprivation and fatigue in resident physicians, far fewer have examined the effects on attending physicians, and only a handful addresses the accumulated effects of chronic sleep disturbances on acute sleep loss during a night call-shift. Read More

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Addressing Suffering in Patients With Psychiatric Disorders.

Joel Yager

J Nerv Ment Dis 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychiatry, MC A011-04, University of Colorado School of Medicine, Aurora, Colorado.

Background: Patients with psychiatric disorders (as well as general medical conditions) often describe their lives in terms of suffering. Although suffering is honored as a central focus of physicians' concerns, it is not even indexed in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Generally connoting severe, prolonged distress, suffering can be distinguished from pain, depression, and anxiety. Read More

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Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions.

J Innate Immun 2021 Apr 15:1-17. Epub 2021 Apr 15.

Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, Germany.

A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically used as biomarker of inflammatory processes. However, the effects of IL-8 on cellular key regulators of neutrophil properties such as the intracellular pH (pHi) in dependence of ion transport proteins and during inflammation remain to be elucidated. Read More

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Cabergoline in Treatment of Methamphetamine-Dependent Patients and Its Effect on Serum Level of Glial Cell-Derived Neurotrophic Factor: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Eur Addict Res 2021 Apr 15:1-12. Epub 2021 Apr 15.

Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Methamphetamine use disorder is an important public health problem, especially in the younger generation, and associated with various psychiatric, cognitive, social, economic, and legal issues. Cabergoline, a drug with dopaminergic properties and long half-life, has been considered for the treatment of stimulant dependence. The systemic use of cabergoline has been shown to increase glial cell-derived neurotrophic factor (GDNF) expression. Read More

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Analysis of cerebral blood flow entropy when listening music with emotional content.

Physiol Meas 2021 Apr 15. Epub 2021 Apr 15.

University of Santiago, Santiago, CHILE.

Music is one of the most sublime stimulus that human beings can experience. Despite being just an acoustic wave that exert little physical action on a subject, it triggers profound changes in emotions and physiological states. This study explores the possibility of detecting subtle changes in cerebral blood flow velocity in response to emotional reactions produced by different musical stimuli using multiscale entropy analysis. Read More

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A novel calibration for L-shell x-ray fluorescence measurements of bone lead concentration using the strontium Kβ/Kα ratio.

Physiol Meas 2021 Apr 15. Epub 2021 Apr 15.

Physics, California State University Fresno, Fresno, California, UNITED STATES.

: Lead (Pb) is a well-known toxic element.bone Pb concentration measurement is a long-term exposure metric complementary to blood Pb concentration measurement which is a metric of recent exposure.human tibia bone Pb measurements using Pb K-shell or L-shell x-ray fluorescence (KXRF or LXRF) emissions were developed in the 1980s. Read More

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Qualitative distribution of endogenous sphingolipids in plasma of human and rodent species by UPLC-Q-Exactive-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 2;1173:122684. Epub 2021 Apr 2.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Sphingolipids (SLs) are endogenously bioactive molecules with diverse structures, and its metabolic disorders are involved in the progression of many diseases. In this study, an ultra-performance liquid chromatography quadrupole exactive mass spectrometry (UPLC-Q-Exactive-MS) method was established to comprehensively profile SLs in plasma. First, the fragment patterns of SL standards of each subclass were investigated. Read More

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Spatio-temporal variations and input patterns on the legacy and novel brominated flame retardants (BFRs) in coastal rivers of North China.

Environ Pollut 2021 Apr 7;283:117093. Epub 2021 Apr 7.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), CAS, Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China. Electronic address:

Decabromodiphenyl ether (BDE209) has been subject to restrictions since 2018 in developed countries but is still manufacturing in China. Decabromodiphenyl ethane (DBDPE) is widely used as a replacement for BDE209. To better understand the behaviors and fates of these legacy and novel brominated flame retardants (BFRs), water samples were collected from the estuaries of 36 rivers that drain into the Bohai Sea (BS) and North Yellow Sea (NYS) in 2017 and 2018. Read More

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Textile-based sandwich scaffold using wet electrospun yarns for skin tissue engineering.

J Mech Behav Biomed Mater 2021 Apr 8;119:104499. Epub 2021 Apr 8.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

One of the key elements in tissue engineering is to design and fabricate scaffolds with tissue-like properties. However, mimicking the strain-stiffening property of human tissues by using synthetic materials is still a challenge in scaffold fabrication since most synthetic materials exhibit strain-softening behavior. To address this challenge, we propose a textile-based sandwich scaffold to mimic strain-stiffening behavior observed in human tissues. Read More

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Effects of genipin crosslinking on mechanical cell-matrix interaction in 3D engineered tendon constructs.

J Mech Behav Biomed Mater 2021 Apr 12;119:104508. Epub 2021 Apr 12.

Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Bispebjerg-Frederiksberg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark; Department of Physical and Occupational Therapy, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.

It is well known that cells can generate endogenous forces onto the extracellular matrix, but to what extent the mechanical properties of the matrix influences these endogenous cellular forces remains unclear. We therefore sought to quantify the influence of matrix rigidity on cell-matrix interactions by inducing cross-links using increasing concentrations of genipin (0.01-1 mM) or by blocking cross-link formation using beta-aminopropionitrile (BAPN) in engineered human tendon tissue constructs. Read More

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The effectiveness of physical activity interventions in Asian children and adolescents: a systematic review.

Public Health 2021 Apr 12;194:48-59. Epub 2021 Apr 12.

School of Health & Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Objective: The objective of this review is to investigate the effectiveness of interventions to promote physical activity (PA) among children and adolescents in Asian countries.

Study Design: Systematic review.

Methods: A systematic search of eight electronic databases was performed to retrieve articles published between January 1990 and August 2019, in English language, including any interventions to promote PA outcomes among children (aged 3-12 years) and adolescents (aged 13-18 years) in Asian countries. Read More

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Critical oxygenation: Can muscle oxygenation inform us about critical power?

Med Hypotheses 2021 Mar 23;150:110575. Epub 2021 Mar 23.

Institute of Sport Science, University of Bern, Bern Bremgartenstrasse 145, 3012 Bern, Switzerland.

The power-duration relationship is well documented for athletic performance and is formulated out mathematically in the critical power (CP) model. The CP model, when applied properly, has great predictive power, e.g. Read More

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Clinicopathologic features of unexpectedly HER2 positive breast carcinomas: An institutional experience.

Pathol Res Pract 2021 Apr 9;222:153441. Epub 2021 Apr 9.

Department of Pathology, Breast Pathology Section, Northwestern University Feinberg School of Medicine, 251 East Huron St., Chicago, IL, 60611, United States.

Human epidermal growth factor receptor 2 (HER2) overexpression occurs in 15-20 % of all breast carcinomas. These tumors are usually high-grade which often correlates with reduced overall survival and increased rates of recurrence. In a retrospective review, we identified 19 cases of unexpectedly HER2 positive (by immunohistochemistry and/or fluorescence in-situ hybridization) invasive breast carcinomas on core needle biopsies from a registry at Northwestern Memorial Hospital. Read More

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Bioactivity-guided discovery of quality control markers in rhizomes of Curcuma wenyujin based on spectrum-effect relationship against human lung cancer cells.

Phytomedicine 2021 Mar 27;86:153559. Epub 2021 Mar 27.

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. Electronic address:

Background: Due to the diversity of the ingredients, the complexity of the mechanism of action, the uncertainty of the effective ingredients, coupled with the multiple species and multiple growing areas, the quality control (QC) of Traditional Chinese Medicines (TCMs) is challenging. Discovering and identifying effective compounds from the complex extracts of TCMs and then establishing a scientific QC method is the key to the holistic QC of TCMs.

Purpose: To develop an anti-lung-cancer-guided spectrum-effect relationship approach for the discovery of QC markers of the rhizome of Curcuma wenyujin (WEZ) and establish a bioactive compounds-based holistic QC method. Read More

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Pitch accents create dissociable syntactic and semantic expectations during sentence processing.

Cognition 2021 Apr 12;212:104702. Epub 2021 Apr 12.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

The language system uses syntactic, semantic, as well as prosodic cues to efficiently guide auditory sentence comprehension. Prosodic cues, such as pitch accents, can build expectations about upcoming sentence elements. This study investigates to what extent syntactic and semantic expectations generated by pitch accents can be dissociated and if so, which cues take precedence when contradictory information is present. Read More

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The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.

Biochem Biophys Res Commun 2021 Apr 12;557:20-25. Epub 2021 Apr 12.

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, National Pesticide Engineering Research Center (Tianjin), Nankai University, 94 Weijin Road, Tianjin, 300071, China. Electronic address:

Protoporphyrinogen IX oxidase (PPO) is the last common enzyme in chlorophyll and heme biosynthesis pathways. In human, point mutations on PPO are responsible for the dominantly inherited disorder disease, Variegate Porphyria (VP). Of the VP-causing mutation site, the Arg59 is by far the most prevalent VP mutation residue identified. Read More

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Generation of a human induced pluripotent stem cell line from a Bietti crystalline corneoretinal dystrophy patient with CYP4V2 mutations.

Stem Cell Res 2021 Apr 7;53:102330. Epub 2021 Apr 7.

Department of Ophthalmology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessively inherited progressive retinal disease. Here, we describe the generation and characterization of a human induced pluripotent stem cell (hiPSC) line of BCD patient with CYP4V2 mutations. The reprogramming of this iPSC line was performed from skin fibroblast by using the Sendai-virus based approach. Read More

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Histogram analysis of quantitative parameters from synthetic MRI: Correlations with prognostic factors and molecular subtypes in invasive ductal breast cancer.

Eur J Radiol 2021 Apr 8;139:109697. Epub 2021 Apr 8.

Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Purpose: To evaluate intra-tumoral heterogeneity through a histogram analysis of quantitative parameters obtained from synthetic MRI (magnetic resonance imaging), and determine correlations of these histogram characteristics with prognostic factors and molecular subtypes of invasive ductal carcinoma (IDC).

Methods: A total of 122 IDC from 122 women who underwent preoperative synthetic MRI and DCE (dynamic contrast enhancement)-MRI were investigated. The synthetic MRI parameters (T1, T2, and PD (proton density)) were obtained. Read More

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Interweaving social and manipulative development in early infancy: Some direction for infant caregiving.

Infant Behav Dev 2021 Apr 12;63:101564. Epub 2021 Apr 12.

School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil. Electronic address:

Early infancy has been neglect not having the best opportunities to promote social motor and cognitive development. The maturational concept considering young infants as passive beings provide a misguided view of the developmental process. The human infant is an active being from the very beginning of life. Read More

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Placentation and embryo death in the plains viscacha (Lagostomus maximus).

Placenta 2021 Apr 1;108:97-102. Epub 2021 Apr 1.

Laboratory of Descriptive, Experimental and Comparative, Histology and Embryology, Argentina.

Caviomorpha are an exceptional group among rodents due to their extended gestational period and the delivery of precocial offspring. Among them, Lagostomus maximus is characterized by its polyovulation, polyembryony, and the highest embryonic death known in mammals. Its chorioallantoic placenta is hemomonochorial, an ancestral character among rodents. Read More

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Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorate collagen-induced arthritis via immunomodulatory T lymphocytes.

Mol Immunol 2021 Apr 12;135:36-44. Epub 2021 Apr 12.

Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, China. Electronic address:

Background: Rheumatoid arthritis (RA) is an autoimmune disease for which there are currently no effective therapies. Although mesenchymal stem cells (MSCs) can prevent arthritis through immunomodulatory mechanisms, there are several associated risks. Alternatively, MSC-derived small extracellular vesicles (sEVs) can mimic the effects of MSCs, while reducing the risk of adverse events. Read More

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Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction.

Mol Immunol 2021 Apr 12;135:21-27. Epub 2021 Apr 12.

Department of Traditional Chinese Medicine Pain Area of Orthopedic, Honghui Hospital, Xi'an Jiaotong University, Xianyang, Shaanxi 710064, China. Electronic address:

Ultraviolet A (UVA) irradiation caused skin keratinocytes to accumulate reactive oxygen species (ROS) leading to the skin injury. Thymoquinone (TQ) was identified as the prominent bioactive ingredient in Nigella sativa seeds which was applied in therapying various human diseases. This study aimed to illustrate the role and mechanism of TQ in UVA-induced skin injury. Read More

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Injury pattern according to player position in Japanese youth handball: A cross-sectional study among 2377 players.

Phys Ther Sport 2021 Apr 5;50:7-14. Epub 2021 Apr 5.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.

Objective: Although the incidence and pattern of injuries in youth handball have widely been investigated, it is unclear whether the characteristics of injuries differ on the basis of player position. This study aimed at revealing the player position-based injury profile in Japanese youth handball players.

Design: Cross-sectional. Read More

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Proteome profiling reveals the efficacy and targets of sophocarpine against asthma.

Int Immunopharmacol 2021 Apr 12;96:107348. Epub 2021 Apr 12.

Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China. Electronic address:

Sophocarpine (SPC) as a quinolizidine alkaloid displays powerful effects on inflammatory diseases through regulating multiple targets. Asthma is a complex heterogeneous and inflammatory disease with an increasing incidence worldwide. Here we established a mice asthma model and investigated the effect of SPC. Read More

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Inflammatory mediators in various molecular pathways involved in the development of pulmonary fibrosis.

Int Immunopharmacol 2021 Apr 12;96:107608. Epub 2021 Apr 12.

Yenepoya Research Centre, Yenepoya University, Deralakatte, Mangalore 575018, Karnataka, India. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease (ILD) that is marked by scarring of lung tissue, ultimately leading to respiratory failure. The survival rate of IPF is disappointing and to date demonstrates a clinical quandary. The exact etiology of the disease remains under discussion. Read More

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RFID Track for Tray Optimization: An Instrument Utilization Pilot Study in Surgical Oncology.

J Surg Res 2021 Apr 12;264:490-498. Epub 2021 Apr 12.

Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina; Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Background: Surgical instrument tray reduction attempts to minimize intraoperative inefficiency and processing costs. Previous reduction methods relied on trained observers manually recording instrument use (i.e. Read More

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A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.

J Psychiatr Res 2021 Apr 7;138:163-175. Epub 2021 Apr 7.

King's College London, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, London, UK; National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, King's College London, London, UK. Electronic address:

Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.

Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence. Read More

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