740 results match your criteria human abeta1-40

Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation.

Mol Cell Neurosci 2021 May 20;114:103631. Epub 2021 May 20.

School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK; Centre for Human Brain Health (CHBH), University of Birmingham, Edgbaston, Birmingham, UK. Electronic address:

Introduction: Presenilin-1 (PSEN1) gene mutations are the most common cause of familial Alzheimer's disease (fAD) and are known to interfere with activity of the membrane imbedded γ-secretase complex. PSEN1 mutations have been shown to shift Amyloid-β precursor protein (AβPP) processing toward amyloid-β (Aβ) 1-42 production. However, less is known about whether PSEN1 mutations may alter the activity of enzymes such as ADAM10, involved with non-amyloidogenic AβPP processing, and markers of oxidative stress. Read More

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Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.

Alzheimers Dement 2021 May 18. Epub 2021 May 18.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Introduction: There is increasing interest in plasma amyloid beta (Aβ) as an endophenotype of Alzheimer's disease (AD). Identifying the genetic determinants of plasma Aβ levels may elucidate important biological processes that determine plasma Aβ measures.

Methods: We included 12,369 non-demented participants from eight population-based studies. Read More

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Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

Department of Psychiatry, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer's disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. Read More

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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.

Acta Neuropathol 2021 Jun 21;141(6):823-839. Epub 2021 Apr 21.

INSERM, CNRS, IPMC, Team Labelled "Laboratory of Excellence (LABEX) DistAlz", Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, 660 route des Lucioles, Sophia-Antipolis, 06560, Valbonne, France.

One of the main components of senile plaques in Alzheimer's disease (AD)-affected brain is the Aβ peptide species harboring a pyroglutamate at position three pE3-Aβ. Several studies indicated that pE3-Aβ is toxic, prone to aggregation and serves as a seed of Aβ aggregation. The cyclisation of the glutamate residue is produced by glutaminyl cyclase, the pharmacological and genetic reductions of which significantly alleviate AD-related anatomical lesions and cognitive defects in mice models. Read More

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A Comparative Study of the Effects of Platinum (II) Complexes on β-Amyloid Aggregation: Potential Neurodrug Applications.

Int J Mol Sci 2021 Mar 16;22(6). Epub 2021 Mar 16.

Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

Herein the effects of three platinum complexes, namely (-4-2)-(2,2'-bipyridine)dichloridoplatinum(II), Pt-bpy, (-4-2)-dichlorido(1,10-phenanthroline) platinum(II), Pt-phen, and (-4-2)-chlorido(2,2':6',2''-terpyridine)platinum(II) chloride, Pt-terpy, on the aggregation of an amyloid model system derived from the C-terminal domain of Aβ peptide (Aβ) were investigated. Thioflavin T (ThT) binding assays revealed the ability of Pt(II) compounds to repress amyloid aggregation in a dose-dependent way, whereas the ability of Aβ peptide to interfere with ligand field of metal complexes was analyzed through UV-Vis absorption spectroscopy and electrospray ionization mass spectrometry. Spectroscopic data provided micromolar EC values and allowed to assess that the observed inhibition of amyloid aggregation is due to the formation of adducts between Aβ peptide and complexes upon the release of labile ligands as chloride and that they can explore different modes of coordination toward Aβ with respect to the entire Aβ polypeptide. Read More

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Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.

Int J Mol Sci 2021 Mar 13;22(6). Epub 2021 Mar 13.

Department of Biomedical Sciences, Macquarie University, North Ryde, NSW 2109, Australia.

Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre-symptomatic Dutch-type hereditary CAA (D-CAA) mutation-carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre-symptomatic members of a D-CAA pedigree were assembled and followed up 3-4 years later (NC = 8; MC = 9). Read More

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Onset of Preclinical Alzheimer Disease in Monozygotic Twins.

Ann Neurol 2021 05 4;89(5):987-1000. Epub 2021 Mar 4.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

Objective: The present work was undertaken to study the genetic contribution to the start of Alzheimer's disease (AD) with amyloid and tau biomarkers in cognitively intact older identical twins.

Methods: We studied in 96 monozygotic twin-pairs relationships between amyloid-beta (Aβ) aggregation as measured by the Aβ1-42/1-40 ratio in cerebrospinal fluid (CSF; n = 126) and positron emission tomography (PET, n = 194), and CSF markers for Aβ production (beta-secretase 1, Aβ1-40, and Aβ1-38) and CSF tau. Associations among markers were tested with generalized estimating equations including a random effect for twin status, adjusted for age, gender, and apolipoprotein E ε4 genotype. Read More

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Gut Inflammation Induced by Dextran Sulfate Sodium Exacerbates Amyloid-β Plaque Deposition in the AppNL-G-F Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2021 ;79(3):1235-1255

Department of Biomedical Sciences, University of North Dakota School of Medicine & Health Sciences, Grand Forks, ND, USA.

Background: Although it is known that the brain communicates with the gastrointestinal (GI) tract via the well-established gut-brain axis, the influence exerted by chronic intestinal inflammation on brain changes in Alzheimer's disease (AD) is not fully understood. We hypothesized that increased gut inflammation would alter brain pathology of a mouse model of AD.

Objective: Determine whether colitis exacerbates AD-related brain changes. Read More

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January 2021

Development of an Immunoassay for the Detection of Amyloid Beta 1-42 and Its Application in Urine Samples.

J Immunol Res 2020 28;2020:8821181. Epub 2020 Dec 28.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Amyloid beta peptides (A1-42) have been found to be associated with the cause of Alzheimer's disease (AD) and dementia. Currently, methods for detecting A1-42 are complicated and expensive. The present study is aimed at developing an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) to detect A1-42 by using a polyclonal antibody from alpaca, an application used in urine samples. Read More

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December 2020

Ionic Environment Affects Biomolecular Interactions of Amyloid-β: SPR Biosensor Study.

Int J Mol Sci 2020 Dec 20;21(24). Epub 2020 Dec 20.

Institute of Photonics and Electronics of the Czech Academy of Sciences, Chaberská 1014/57, 182 51 Prague, Czech Republic.

In early stages of Alzheimer's disease (AD), amyloid beta (Aβ) accumulates in the mitochondrial matrix and interacts with mitochondrial proteins, such as cyclophilin D (cypD) and 17β-hydroxysteroid dehydrogenase 10 (17β-HSD10). Multiple processes associated with AD such as increased production or oligomerization of Aβ affect these interactions and disbalance the equilibrium between the biomolecules, which contributes to mitochondrial dysfunction. Here, we investigate the effect of the ionic environment on the interactions of Aβ (Aβ, Aβ) with cypD and 17β-HSD10 using a surface plasmon resonance (SPR) biosensor. Read More

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December 2020

Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease.

Eur J Med Chem 2021 Feb 16;212:113096. Epub 2020 Dec 16.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Based on our previous work, a series of N-phenyl-3-methoxy-4-pyridinone derivatives were designed as orally bioavailable dual functional agents for therapy of Alzheimer's disease, through introducing alkyloxy moiety into 4-pyridinone ring to avoid the possible phase II metabolism of 3-hydroxy-4-pyridinone in lead compound 3-hydroxy-2-methyl-1-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-pyridin-4(1H)-one (4). In vitro studies indicated that most of these compounds exhibit excellent H receptor antagonistic activities and potent self-induced Aβ/Aβ aggregation inhibitory activities. In particular, 3-methoxy-1-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-pyridin-4(1H)-one (7i) demonstrated IC value of 0. Read More

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February 2021

From Brain to Heart: Possible Role of Amyloid-β in Ischemic Heart Disease and Ischemia-Reperfusion Injury.

Int J Mol Sci 2020 Dec 17;21(24). Epub 2020 Dec 17.

Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) and University of Trieste, 34100 Trieste, Italy.

Ischemic heart disease (IHD) is among the leading causes of death in developed countries. Its pathological origin is traced back to coronary atherosclerosis, a lipid-driven immuno-inflammatory disease of the arteries that leads to multifocal plaque development. The primary clinical manifestation of IHD is acute myocardial infarction (AMI),) whose prognosis is ameliorated with optimal timing of revascularization. Read More

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December 2020

Real-Time Analysis of Specific Binding between Apolipoprotein E Isoforms and Amyloid β-Peptide by Dual Polarization Interferometry.

Anal Chem 2021 01 21;93(3):1472-1479. Epub 2020 Dec 21.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China.

One of the pathogenesis hypotheses of Alzheimer's disease (AD) is amyloid depositions and neurofibrillary tangles. Apolipoprotein E (Apo E) acts a vital part in the development of AD by affecting the aggregation and clearance of amyloid-β (Aβ). In this paper, a dual polarization interferometry (DPI) technique was employed for a real-time investigation toward the binding events of Apo E isoforms, for instance, Apo E2, Apo E3, and Apo E4, with Aβ. Read More

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January 2021

Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2).

Cells 2020 12 11;9(12). Epub 2020 Dec 11.

Department of Ophthalmology, Kanazawa Medical University, Ishikawa 920-0293, Japan.

The prevalence of nuclear cataracts was observed to be significantly higher among residents of tropical and subtropical regions compared to those of temperate and subarctic regions. We hypothesized that elevated environmental temperatures may pose a risk of nuclear cataract development. The results of our in silico simulation revealed that in temperate and tropical regions, the human lens temperature ranges from 35. Read More

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December 2020

Neuroprotective effects of miR-331-3p through improved cell viability and inflammatory marker expression: Correlation of serum miR-331-3p levels with diagnosis and severity of Alzheimer's disease.

Exp Gerontol 2021 02 3;144:111187. Epub 2020 Dec 3.

Department of Clinical Laboratory, Zibo Central Hospital, Gongqingtuan West Road, Zibo 255036, China. Electronic address:

Background: Alzheimer's disease (AD) is a common neurodegenerative disease with an increasing incidence rate. Numerous microRNAs (miRNAs) have been found to be involved in AD progression. This study aimed to investigate the expression and diagnostic value of microRNA-331-3p (miR-331-3p) in AD patients and to explore the effects of miR-331-3p on neuronal viability and neuroinflammation. Read More

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February 2021

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression.

J Steroid Biochem Mol Biol 2021 01 7;205:105785. Epub 2020 Nov 7.

Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland; Department of Psychiatry, University Hospital of Lausanne, Switzerland; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zürich, Switzerland. Electronic address:

Background And Purpose: Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD pathology, i.e. Read More

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January 2021

Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease: associated beta amyloid protein.

Sci Rep 2020 10 23;10(1):18150. Epub 2020 Oct 23.

GAIA Research Center, Bioanalytical Department, The Goulandris Natural History Museum, 14562, Kifissia, Greece.

Natural products have played a dominant role in the discovery of lead compounds for the development of drugs aimed at the treatment of human diseases. This electrospray ionization-ion mobility spectrometry-mass spectrometry (ESI-IMS-MS)-based study demonstrates that dietary antioxidants, isolated components from the stigmas of saffron (Crocus sativus L.) may be effective in inhibiting Aβ fibrillogenesis, a neuropathological hallmark of Alzheimer's Disease (AD). Read More

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October 2020

Immunomagnetic Reduction Detects Plasma Aβ Levels as a Potential Dominant Indicator Predicting Cognitive Decline.

Neurol Ther 2020 Dec 22;9(2):435-442. Epub 2020 Oct 22.

MagQu LLC, Surprise, AZ, 85378, USA.

Although the concentrations of Alzheimer's disease (AD) biomarkers Aβ, Aβ and tau protein are very low in human plasma, ultrasensitive assays such as immunomagnetic reduction (IMR) are able to precisely quantify them. Review articles have described the detailed working mechanism of IMR and revealed the feasibility of detecting early-stage AD by assaying these plasma biomarkers with IMR. In this review, we aimed to compare the significance of these plasma biomarkers in predicting cognitive decline in patients with Down syndrome, stroke, or amnestic mild cognitive impairment based on findings in the literature. Read More

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December 2020

ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22 activation in Aβ-induced retinal pigment epithelial cell injury.

Theranostics 2020 19;10(25):11637-11655. Epub 2020 Sep 19.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Amyloid β (Aβ) deposition, an essential pathological process in age-related macular degeneration (AMD), causes retinal pigment epithelium (RPE) degeneration driven mostly by oxidative stress. However, despite intense investigations, the extent to which overoxidation contributes to Aβ-mediated RPE damage and its potential mechanism has not been fully elucidated. We performed tandem mass-tagged (TMT) mass spectrometry (MS) and bioinformatic analysis of the RPE-choroid complex in an Aβ-induced mouse model of retinal degeneration to obtain a comprehensive proteomic profile. Read More

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Computational Investigation of Gantenerumab and Crenezumab Recognition of Aβ Fibrils in Alzheimer's Disease Brain Tissue.

ACS Chem Neurosci 2020 10 9;11(20):3233-3244. Epub 2020 Oct 9.

Basic Science Program, Leidos Biomedical Research, Inc., Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States.

Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases without effective therapies. Immunotherapies using antibodies to lower assembled Aβ provide a promising approach and have been widely studied. Anti-amyloid antibodies are often selective to amyloid conformation, and the lack of amyloid-antibody structural information limits our understanding of these antibodies' conformation selection. Read More

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October 2020

Development and Technical Validation of an Immunoassay for the Detection of APP (Aβ) in Biological Samples.

Int J Mol Sci 2020 Sep 8;21(18). Epub 2020 Sep 8.

Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D37075 Göttingen, Germany.

The ratio of amyloid precursor protein (APP) (Aβ)/Aβ in blood plasma was reported to represent a novel Alzheimer's disease biomarker. Here, we describe the characterization of two antibodies against the N-terminus of Aβ and the development and "fit-for-purpose" technical validation of a sandwich immunoassay for the measurement of Aβ. Antibody selectivity was assessed by capillary isoelectric focusing immunoassay, Western blot analysis, and immunohistochemistry. Read More

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September 2020

Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.

Exp Cell Res 2020 11 6;396(1):112266. Epub 2020 Sep 6.

Institute of Neuroscience, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China; Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, China. Electronic address:

The aggregation of β-amyloid (Aβ) peptide in Alzheimer's disease (AD) is characterized by mitochondrial dysfunction and mitophagy impairment. Mitophagy is a homeostatic mechanism by which autophagy selectively eliminates damaged mitochondria. Valinomycin is a respiratory chain inhibitor that activates mitophagy via the PINK1/Parkin signaling pathway. Read More

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November 2020

Effect of Times to Blood Processing on the Stability of Blood Proteins Associated with Dementia.

Dement Geriatr Cogn Disord 2020 12;49(3):303-311. Epub 2020 Aug 12.

MagQu Co., Ltd., New Taipei City, Taiwan,

Background: The stability of proteins in the collecting tubes after blood draw is critical to the measured concentrations of the proteins. Although the guidelines issued by the Clinical and Laboratory Standards Institute (CLSI) suggest centrifugation should take place within 2 h of drawing blood, it is very difficult to follow these guidelines in hospitals or clinics. It is necessary to study the effect of times to blood processing on the stability of the proteins of interest. Read More

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Association of CSF Aβ, amyloid PET, and cognition in cognitively unimpaired elderly adults.

Neurology 2020 10 5;95(15):e2075-e2085. Epub 2020 Aug 5.

From the Helen Wills Neuroscience Institute (T.G., W.J.J., S.M.L.), University of California; Molecular Biophysics and Integrated Bioimaging (T.G., W.J.J., S.M.L.), Lawrence Berkeley National Laboratory, Berkeley, CA; and Department of Pathology and Laboratory Medicine (L.M.S., J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Objective: To compare CSF β-amyloid (Aβ) and florbetapir PET measurements in cognitively unimpaired (CU) elderly adults in order to detect the earliest abnormalities and compare their predictive effect for cognitive decline.

Methods: A total of 259 CU individuals were categorized as abnormal (+) or normal (-) on CSF Aβ/Aβ analyzed with mass spectrometry and Aβ PET measured with F-florbetapir. Simultaneous longitudinal measurements of CSF and PET were compared for 39 individuals who were unambiguously Aβ-negative at baseline (CSF-/PET-). Read More

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October 2020

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer's Disease Transgenic Mouse Model.

Front Cell Neurosci 2020 3;14:200. Epub 2020 Jul 3.

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, United States.

Aging is a major risk factor for Alzheimer's disease (AD). Insulin-like growth factor-1 receptor (IGF-1R) regulates general aging and lifespan. However, the contribution of IGF-1 to age-related AD pathology and progression is highly controversial. Read More

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Modulating Aβ aggregation by tyrosol-based ligands: The crucial role of the catechol moiety.

Biophys Chem 2020 10 17;265:106434. Epub 2020 Jul 17.

Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, I-80126 Napoli, Italy. Electronic address:

The abnormal deposition of Aβ amyloid deposits in the brain is a hallmark of Alzheimer's disease (AD). Based on this evidence, many current therapeutic approaches focus on the development of small molecules halting Aβ aggregation. However, due to the temporary and elusive structures of amyloid assemblies, the rational design of aggregation inhibitors remains a challenging task. Read More

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October 2020

Atorvastatin Improves Mitochondrial Function and Prevents Oxidative Stress in Hippocampus Following Amyloid-β Intracerebroventricular Administration in Mice.

Mol Neurobiol 2020 Oct 18;57(10):4187-4201. Epub 2020 Jul 18.

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Trindade, Florianópolis, SC, 88040-900, Brazil.

Amyloid-β (Aβ) peptides play a significant role in the pathogenesis of Alzheimer's disease (AD). Neurotoxic effects promoted by Aβ peptides involve glutamate transmission impairment, decrease of neurotrophic factors, mitochondrial dysfunction, oxidative stress, synaptotoxicity, and neuronal degeneration. Here, we assessed the early events evoked by Aβ on the hippocampus. Read More

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October 2020

From monomer to fibril: Abeta-amyloid binding to Aducanumab antibody studied by molecular dynamics simulation.

Proteins 2020 12 3;88(12):1592-1606. Epub 2020 Aug 3.

Physics Department T38, Technical University of Munich, Garching, Germany.

Alzheimer's disease is one of the most common causes of dementia. It is believed that the aggregation of short Aβ-peptides to form oligomeric and protofibrillar amyloid assemblies plays a central role for disease-relevant neurotoxicity. In recent years, passive immunotherapy has been introduced as a potential treatment strategy with anti-amyloid antibodies binding to Aβ-amyloids and inducing their subsequent degradation by the immune system. Read More

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December 2020

The Effect of Polysaccharides on Pyroptosis-Associated Amyloid β Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Age-related macular degeneration (AMD) is a sight-threatening disease with limited treatment options. We investigated whether amyloid β (Aβ) could cause pyroptosis and evaluated the effects of polysaccharides (LBP) on Aβ oligomers-induced retinal pigment epithelium 19 (ARPE-19) damage, which is an in vitro AMD model. Aβ oligomers verified by Western blot were added to ARPE-19 cells with or without 24 h LBP treatment. Read More

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Indicators of rapid cognitive decline in amnestic mild cognitive impairment: The role of plasma biomarkers using magnetically labeled immunoassays.

J Psychiatr Res 2020 10 9;129:66-72. Epub 2020 Jun 9.

Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Plasma levels of biomarkers change with the progression of Alzheimer's disease (AD), which involves the accumulation of pathological amyloid β (Aβ) and Tau protein tangles. However, few studies have investigated the association between plasma biomarkers and rapid cognitive decline in patients with amnestic mild cognitive impairment (aMCI) and AD. A total of 10 healthy controls, 24 patients with aMCI, and 19 patients with AD were enrolled. Read More

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October 2020