5,095 results match your criteria huge economic


Transcriptome analysis revealed inhibition of lipid metabolism in 2-D porcine enteroids by infection with porcine epidemic diarrhea virus.

Vet Microbiol 2022 Aug 5;273:109525. Epub 2022 Aug 5.

Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya, 572000, China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China; Zhejiang Provincial Key Lab of Preventive Veterinary Medicine, MOA Key Laboratory of Animal Virology, Center for Veterinary Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address:

Porcine epidemic diarrhea virus (PEDV) is a swine enterovirus that causes huge economic losses to the swine industry. It is of great interest to understand the gene expression patterns of host responses to PEDV infection and the mechanistic insights. Here, we report the differences of gene expression profiles by RNA-seq in the porcine small intestinal 2-D enteroids cells infected with low-passage (16 passages, P16) and high-passage (120 passages, P120) PEDV strains for 12, 24 and 36 h. Read More

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Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment.

Stem Cell Res Ther 2022 Aug 12;13(1):410. Epub 2022 Aug 12.

Departments of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, People's Republic of China.

Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic growth, and threatening people's lives and health. At present, some therapeutic regimens are available for treatment of COVID-19 pneumonia, including antiviral therapy, immunity therapy, anticoagulant therapy, and others. Among them, injection of mesenchymal stem cells (MSCs) is currently a promising therapy. Read More

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Antidepressant-like activity of oroxylin A in mice models of depression: A behavioral and neurobiological characterization.

Front Pharmacol 2022 26;13:921553. Epub 2022 Jul 26.

Department of Neurosurgery, Rudong People's Hospital, Nantong, China.

Depression is a mood disorder which causes a huge economic burden to both families and societies. However, those monoamine-based antidepressants used in clinical practice have been found to have various limitations. Therefore, currently it is very necessary to explore novel antidepressant targets and medications. Read More

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Maize Stalk Obtained after Acid Treatment and Its Use for Simultaneous Removal of Cu, Pb, Ni, Cd, Cr and Fe.

Polymers (Basel) 2022 Aug 2;14(15). Epub 2022 Aug 2.

National Research and Development Institute for Industrial Ecology ECOIND, Street Podu Dambovitei No. 57-73, District 6, 060652 Bucharest, Romania.

In this research, eco-friendly material represented by maize stalk (MS) obtained after acid treatment was employed for simultaneous removal of Cu, Pb, Ni, Cd, Cr and Fe (M) from simulated textile aqueous matrix and tannery wastewater produced by the leather industry. The acid treatment of MS was done with 4 M HCl. The influence of experimental parameters was evaluated in order to optimize the adsorption process for simulated textile matrix. Read More

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Analysis of Tissue-Specific Defense Responses to in .

Plants (Basel) 2022 Jul 31;11(15). Epub 2022 Jul 31.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs of the PRC, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China.

Sclerotinia stem rot (SSR) caused by () is the main disease threat of oilseed rape (), resulting in huge economic losses every year. SSR resistance manifests as quantitative disease resistance (QDR), and no gene with complete SSR resistance has been cloned or reported so far. Transcriptome analysis has revealed a large number of defense-related genes and response processes. Read More

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Village chicken production and food security: a two-decade bibliometric analysis of global research trends.

Agric Food Secur 2022 2;11(1):40. Epub 2022 Aug 2.

Small-Scale Agribusiness and Rural Non-Farm Enterprise, Niche Area, Walter Sisulu University, P/Bag X1, Mthatha, 5117 South Africa.

Background: The present study aimed to reveal outputs of research works on village chicken production as a tool to combat food insecurity, taking into account the recurring challenge posed by food shortage and high rise in hunger among vulnerable people of several countries.

Results: On aggregate, 104 publications were obtained in a BibTeX design for analysis using bibliometric package in R studio. The obtained data comprised, but not limited to authors, citations, institutions, key words and journals. Read More

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Combined Antibody Tagged HRP Gold Nanoparticle Probe for Effective PCV2 Screening in Pig Farms.

Int J Nanomedicine 2022 29;17:3361-3369. Epub 2022 Jul 29.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, People's Republic of China.

Introduction: Porcine circovirus type 2 (PCV2) causes immune repression and intercurrent infections in pigs, resulting in a huge economic loss to the pig breeding industry. Additionally, the spread of PCV2 in pig farms can pollute the living environment of the residents in the farm's vicinity, which increases the rate of infections. Therefore, rapid and sensitive detection methods are needed for disease prevention and timely environmental cleaning. Read More

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Effectiveness of physical activity on immunity markers and quality of life in cancer patient: a systematic review.

PeerJ 2022 2;10:e13664. Epub 2022 Aug 2.

Department of General Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Background: Cancer is a huge group of diseases that can affect various body parts of humans but also has a psychological, societal, and economic impact. Physical activity can improve the quality of life (QOL) and immunity, while moderate intensity exercise can reduce the probability of this lethal disease. The current study aimed to determine the effect of physical activity on immune markers and QOL in cancer patients as well as to evaluate cancer-related fatigue (CRF) and its association with physical activity. Read More

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Enhancing epitope of PEDV spike protein.

Front Microbiol 2022 22;13:933249. Epub 2022 Jul 22.

Center of Research Excellence in Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Porcine epidemic diarrhea virus (PEDV) is the causative agent of a highly contagious enteric disease of pigs characterized by diarrhea, vomiting, and severe dehydration. PEDV infects pigs of all ages, but neonatal pigs during the first week of life are highly susceptible; the mortality rates among newborn piglets may reach 80-100%. Thus, PEDV is regarded as one of the most devastating pig viruses that cause huge economic damage to pig industries worldwide. Read More

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A highly adaptable platform powered by CRISPR-Cas12a to diagnose lumpy skin disease in cattle.

Anal Chim Acta 2022 Aug 27;1221:340079. Epub 2022 Jun 27.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; China Pharmaceutical University, Nanjing, 211198, China.

Lumpy skin disease (LSD) in cattle, a transboundary viral disease of cattle once restricted to Africa, has been spreading to many European and Asian countries in the past decade with huge economic losses. This emerging worldwide threat to cattle warrants the development of diagnostic methods for accurate disease screening of suspected samples to effectively control the spread of LSD. In this study, we integrated pre-amplification and three kinds of sensor systems with CRISPR and therefore established an LSD diagnosis platform with highly adaptable and ultra-sensitive advantages. Read More

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Prevalence and risk factors analysis for low back pain among occupational groups in key industries of China.

BMC Public Health 2022 08 5;22(1):1493. Epub 2022 Aug 5.

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: With the acceleration of industrialization and population aging, low back pain (LBP) has become the leading cause of life loss years caused by disability. Thus, it places a huge economic burden on society and is a global public health problem that needs urgent solution. This study aimed to conduct an epidemiological investigation and research on a large sample of workers in key industries in different regions of China, determine the incidence and distribution characteristics of LBP, explore the epidemic law, and provide a reference basis for alleviating global public health problems caused by LBP. Read More

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Energy, exergy, and economic analysis of solar still using coal cylinder fins: an experimental study.

Environ Sci Pollut Res Int 2022 Aug 6. Epub 2022 Aug 6.

Department of Electrical and Electronics Engineering, Kongu Engineering College (Autonomous), Perundurai, Erode, Tamil Nadu, India.

The phenomenon of drinking water scarcity has turned into the foremost issue that the world's populace is facing today. The Algerian desert regions, including the El Oued region (southeastern Algeria), also suffer from drinking water shortages, despite the presence of huge quantities of underground salty water. Solar distillation is among the easy and cheap solutions to solve this problem because this method relies on renewable energy (solar energy) as a key factor in providing drinking water from saltwater. Read More

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DYRK1a Inhibitor Mediated Rescue of Models of Alzheimer's Disease-Down Syndrome Phenotypes.

Front Pharmacol 2022 19;13:881385. Epub 2022 Jul 19.

School of Physiology, Pharmacology and Neuroscience, Faculty of Life Science, University of Bristol, Bristol, United Kingdom.

Alzheimer's disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of genes such as () into Amyloid-β and () gene, into hyperphosphorylated Tau tangles being known for decades, there remains no treatments to halt disease progression. One population with increased risk of AD are people with Down syndrome (DS), who have a 90% lifetime incidence of AD, due to trisomy of human chromosome 21 (HSA21) resulting in three copies of and other AD-associated genes, such as (Dual specificity tyrosine-phosphorylation-regulated kinase 1A) overexpression. Read More

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Land, buildings, and equipment acquisitions in U.S. hospitals: A fifteen-year perspective.

PLoS One 2022 4;17(8):e0272370. Epub 2022 Aug 4.

Professor of Accounting, Johns Hopkins Carey Business School, Professor of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Washington, DC, United States of America.

Hospitals acquire and maintain long-term operating assets such as land, buildings, and equipment. In this study, we analyzed hospitals' long-term assets acquisitions data extracted from the Medicare Cost Report, a mandatory annual filing for all Medicare-certified hospitals. The first objective of this study is to examine the time trend of land, buildings, and equipment acquisitions of all general acute care hospitals in the U. Read More

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The Potential Role of Digital Health in Obesity Care.

Adv Ther 2022 Aug 4. Epub 2022 Aug 4.

The College of Contemporary Health, Technopark, 90 London Road, London, SE1 6LN, UK.

Obesity is a complex, multi-factorial, chronic condition which increases the risk of a wide range of diseases including type 2 diabetes mellitus, cardiovascular disease and certain cancers. The prevalence of obesity continues to rise and this places a huge economic burden on the healthcare system. Existing approaches to obesity treatment tend to focus on individual responsibility and diet and exercise, failing to recognise the complexity of the condition and the need for a whole-system approach. Read More

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Clinicopathological and molecular studies on cattle naturally infected with lumpy skin diseases in selected districts of Wolaita Zone, Southern Ethiopia.

BMC Vet Res 2022 Aug 3;18(1):297. Epub 2022 Aug 3.

National Animal Health Investigation and Diagnostic Center, Sebeta, Ethiopia.

Background: Lumpy skin disease is a contagious viral disease of cattle caused by LSDV that results in huge economic losses in the cattle industry. This study characterizes LSDV in cattle through clinicopathological and molecular techniques in selected districts of Wolaita Zone, Southern Ethiopia.

Methods: A crossectional study was conducted from November 2020 to June 2021 using Real-time polymerase chain reaction and Histopathological techniques to confirm LSDV. Read More

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Characterization of the pathogenesis and immune response to a highly virulent Edwardsiella tarda strain responsible for mass mortality in the hybrid snakehead (Channa maculate ♀ × Channa argus ♂).

Microb Pathog 2022 Jul 30;170:105689. Epub 2022 Jul 30.

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. Electronic address:

Edwardsiella tarda is reported as the causative agent of the systemic disease Edwardsiellosis in fish, which lead to huge economic losses in aquaculture. The pathogenicity and immune response to a highly virulent E. tarda isolate responsible for mass mortality in hybrid snakehead were performed. Read More

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The need for screening, early diagnosis, and prediction of chronic kidney disease in people with diabetes in low- and middle-income countries-a review of the current literature.

BMC Med 2022 08 2;20(1):247. Epub 2022 Aug 2.

Non-Communicable Diseases Research Unit, South African Medical Research Council, Francie van Zijl Drive, Parow Valley, PO Box 19070, Cape Town, South Africa.

Chronic kidney disease (CKD) in people with diabetes is becoming an increasing major public health concern, disproportionately burdening low- and middle-income countries (LMICs). This rising burden is due to various factors, including the lack of disease awareness that results in late referral and the cost of screening and consequent treatment of the comorbid conditions, as well as other factors endemic to LMICs relating to inadequate management of risk factors. We critically assessed the extant literature, by performing searches of Medline via PubMed, EBSCOhost, Scopus, and Web of Science, for studies pertaining to screening, diagnosis, and prediction of CKD amongst adults with diabetes in LMICs, using relevant key terms. Read More

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Analysis of the Geographic Transmission Differences of COVID-19 in China Caused by Population Movement and Population Density.

Bull Math Biol 2022 Aug 1;84(9):94. Epub 2022 Aug 1.

School of mathematics and statistics, Southwest University, Chongqing, 400715, People's Republic of China.

The coronavirus disease (COVID-19) has led to a global pandemic and caused huge healthy and economic losses. Non-pharmaceutical interventions, especially contact tracing and social distance restrictions, play a vital role in the control of COVID-19. Understanding the spatial impact is essential for designing such a control policy. Read More

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RNA-seq Based Transcriptome Analysis Reveals The Cross-Talk of Macrophage and Adipocyte of Chicken Subcutaneous Adipose Tissue during The Embryonic and Post-Hatch Period.

Front Immunol 2022 15;13:889439. Epub 2022 Jul 15.

College of Animal Science and Technology, Northwest A&F University, Yangling, China.

With high fecundity and short production cycle, poultry is one of the important sources of meat. During the embryonic and post-hatch period, the higher death rate caused huge economic losses in poultry production. Our previous study showed that chick subcutaneous adipose tissue is an important energy supply tissue besides yolk. Read More

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Classification of Effect on Real Estates in Mumbai During Covid-19.

SN Comput Sci 2022 26;3(5):399. Epub 2022 Jul 26.

School of Management, ITM University, Gwalior, Madhya Pradesh India.

At the point when the global pandemic hit, we saw one of the greatest monetary accidents in late history. With crashes in the securities exchange and irregularities in all business sectors and ventures, one thing that never appears to change is the increment in worth of homes. This pandemic had made the land area take a significant misfortune. Read More

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Does It Matter to Establish a Strategic Partnership for COVID-19 Prevention and Control? The Perspective of Multiple Distances in Emerging Economies.

Front Public Health 2022 14;10:894816. Epub 2022 Jul 14.

School of Economics and Management, Beijing University of Posts and Telecommunications, Beijing, China.

The rapid spread of the COVID-19 pandemic in early 2020 has impacted the politics, economy and society of countries around the world. The public health diplomacy system through which developed countries in Europe and America used to provide vertical one-way assistance to developing countries faces huge challenges. How emerging economies can cooperate to fight the pandemic on the basis of mutual trust and mutual benefit has become an urgent issue. Read More

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Reverse transcription recombinase-aided amplification assay for H5 subtype avian influenza virus.

Virol J 2022 Jul 30;19(1):129. Epub 2022 Jul 30.

China Animal Health and Epidemiology Center, 369 Nanjing Road, Qingdao, Shandong Province, China.

Background: The H5 subtype avian influenza virus (AIV) has caused huge economic losses to the poultry industry and is a threat to human health. A rapid and simple test is needed to confirm infection in suspected cases during disease outbreaks.

Methods: In this study, we developed a reverse transcription recombinase-aided amplification (RT-RAA) assay for the detection of H5 subtype AIV. Read More

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Uncovering the Research Gaps to Alleviate the Negative Impacts of Climate Change on Food Security: A Review.

Front Plant Sci 2022 11;13:927535. Epub 2022 Jul 11.

National Institute for Genomics and Advanced Biotechnology, Islamabad, Pakistan.

Climatic variability has been acquiring an extensive consideration due to its widespread ability to impact food production and livelihoods. Climate change has the potential to intersperse global approaches in alleviating hunger and undernutrition. It is hypothesized that climate shifts bring substantial negative impacts on food production systems, thereby intimidating food security. Read More

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Modeling innovation in the cryptocurrency ecosystem.

Sci Rep 2022 Jul 28;12(1):12942. Epub 2022 Jul 28.

Complexity Science Hub Vienna, Josefstaedter Strasse 39, 1080, Vienna, Austria.

Blockchains are among the most relevant emerging technologies of recent times and, according to many, they will have a central role in shaping the future of our society. Since the introduction of Bitcoin in 2009, the first notorious blockchain system bound to a cryptocurrency, the blockchain ecosystem has experienced a huge growth, driven by innovations both in conceptual and algorithmic terms, and in the creation of a large number of new cryptocoins. New blockchains and their associated cryptocoins, emerge mostly as the result of forking already existing projects. Read More

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Inhibitory effect of Buddlejasaponin IVb on porcine epidemic diarrhea virus in vivo and in vitro.

Vet Microbiol 2022 Sep 19;272:109516. Epub 2022 Jul 19.

College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, China. Electronic address:

Porcine epidemic diarrhea virus (PEDV) is one of the main pathogens causing severe diarrhea in piglets. Infection of the host induces apoptosis, causing huge economic losses to the pig industry. At present, the preventive and therapeutic effects of commercial vaccines are not satisfactory, and it is necessary to develop new anti-PEDV drugs. Read More

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September 2022

Proposing a Robust Model to Reduce Employees' Turnover Intentions in an Ethical Leadership Framework: Empirical Evidence from the Healthcare Sector.

Int J Environ Res Public Health 2022 Jul 22;19(15). Epub 2022 Jul 22.

Department of Business Administration, College of Business and Administration, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

Employee turnover is expensive and disruptive for an organization. Studies have already mentioned that the economic cost of turnover is huge, ranging from 90% to 200% of the existing employee's salary. With an increase in turnover rate, the social fabric of an enterprise may be disrupted. Read More

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Ethylene Plays a Dual Role during Infection by of .

Genes (Basel) 2022 Jul 22;13(8). Epub 2022 Jul 22.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling 712100, China.

infection leads to hypertrophy of host roots and subsequent formation of galls, causing huge economic losses to agricultural producers of plants. Ethylene (ET) has been reported to play a vital role against necrotrophic pathogens in the classic immunity system. More clues suggested that the defense to pathogens in roots may be different from the acrial. Read More

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GMMA as an Alternative Carrier for a Glycoconjugate Vaccine against Group A .

Vaccines (Basel) 2022 Jun 28;10(7). Epub 2022 Jun 28.

GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, 53100 Siena, Italy.

Group A (GAS) causes about 500,000 annual deaths globally, and no vaccines are currently available. The Group A Carbohydrate (GAC), conserved across all GAS serotypes, conjugated to an appropriate carrier protein, represents a promising vaccine candidate. Here, we explored the possibility to use Generalized Modules for Membrane Antigens (GMMA) as an alternative carrier system for GAC, exploiting their intrinsic adjuvant properties. Read More

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Lights and Shadows on the Therapeutic Use of Antimicrobial Peptides.

Molecules 2022 Jul 18;27(14). Epub 2022 Jul 18.

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.

The emergence of antimicrobial-resistant infections is still a major concern for public health worldwide. The number of pathogenic microorganisms capable of resisting common therapeutic treatments are constantly increasing, highlighting the need of innovative and more effective drugs. This phenomenon is strictly connected to the rapid metabolism of microorganisms: due to the huge number of mutations that can occur in a relatively short time, a colony can "adapt" to the pharmacological treatment with the evolution of new resistant species. Read More

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