1,468 results match your criteria hu-a

Trends and Variation in the Use of Observation Stays at Children's Hospitals.

J Hosp Med 2021 Jul 21. Epub 2021 Jul 21.

Surgical Outcomes Quality Improvement Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Background: Observation status could improve efficiency of healthcare resource use but also might shift financial burdens to patients and hospitals. Although the use of observation stays has increased for adult patient populations, the trends are unknown among hospitalized children.

Objective: The goal of this study was to describe recent trends in observation stays for pediatric populations at children's hospitals. Read More

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A natural acylphloroglucinol triggered antiproliferative possessions in HEL cells by impeding STAT3 signaling and attenuating angiogenesis in transgenic zebrafish model.

Biomed Pharmacother 2021 Jul 10;141:111877. Epub 2021 Jul 10.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address:

Leukemia is responsible for a reason of death, globally. Even though there are several treatment regimens available in the clinics against this disease, a perfect chemotherapeutic agent for the same is still under investigation. Natural plant-derived secondary metabolites are used in clinics to treat leukemia for better benefits with reduced side-effects. Read More

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[Animal Experimental Study of the Role of Menthol and Cineole, Two Tobacco Additives, on Nicotine Dependence].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):649-654

Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To establish a nicotine intravenous self-administration rat model, and to examine, with this model, the effects of two flavoring additives, menthol and cineole, on nicotine dependence.

Methods: Thirty male Sprague-Dawley (SD) rats were included in the study. After jugular venous catheterization was performed, fixed concentration of nicotine was administered in order to train the rats and establish the rat model of intravenous self-administration groups, receiving intraperitoneal injection of menthol, cineole, and dimethyl sulfoxide (DMSO), the vehicle that was used for the control group. Read More

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Periodic Colonoscopies Are Associated with Improved Survival and Prognosis of Colorectal Cancer in Ulcerative Colitis.

Dig Dis Sci 2021 Jul 27. Epub 2021 Jul 27.

Department of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute, McMaster University, McMaster University Medical Centre, 1280 Main St West, Unit 3V28, Hamilton, ON, L8S 4K1, Canada.

Background And Study Aims: This study aimed to identify whether ulcerative colitis (UC) patients who develop colorectal cancer (CRC) present at earlier stages of CRC and have improved survival if prior to their CRC diagnosis, they underwent intermittent follow-up colonoscopies compared to those who have no follow-up colonoscopies.

Methods: Patients with UC who developed primary CRC were identified using data provided by the Institute for Clinical Evaluative Sciences. We defined low-risk CRC stage as estimated 5-year survival ≥ 80% compared to high-risk CRC as 5-year survival < 80%. Read More

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Quantitative stable isotope probing technique and its applications in microbial ecology.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2615-2622

Fujian Normal University, Fuzhou 350007, China.

Quantitative stable isotope probing (qSIP) is a powerful tool, which links microbial taxon with functional metabolism in ecosystems and quantitatively determines the metabolic activity or growth rate of individual microbial taxa exposed to isotope tracers in the environment. qSIP technique employs quantitative PCR, high-throughput sequencing and stable isotope probing (SIP) techniques. The procedure involves adding labeled substrates to environmental samples for cultivation, separating labeled heavy fraction from unlabeled light fraction via isopycnic ultracentrifugation, making absolute quantification and sequencing analysis for microbial populations in all fractions, and then quantifying the isotope abundance of DNA involved in uptake and transformation based on the DNA density curve of unlabeled treatment and GC content. Read More

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Coupling enhancement mechanisms, materials, and strategies for surface-enhanced Raman scattering devices.

Analyst 2021 Jul 23. Epub 2021 Jul 23.

State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, P. R. China.

Surface-enhanced Raman scattering (SERS) has become one of the most sensitive analytical techniques for identifying the chemical components, molecular structures, molecular conformations, and the interactions between molecules. However, great challenges still need to be addressed until it can be widely accepted by the absolute quantification of analytes. Recently, many efforts have been devoted to addressing these issues via various electromagnetic (EM), chemical (CM), and EM-CM hybrid coupling enhancement strategies. Read More

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Risk factors of medical device-related pressure injury in intensive care units.

J Clin Nurs 2021 Jul 26. Epub 2021 Jul 26.

The Third Affilated Hospital of Sun Yat-sen University, Lingnan Hospital, Guangzhou, China.

Objectives: Intensive care unit (ICU) patients are at high risk of medical device related pressure injury (MDRPI). This study aims to ascertain the MDRPI prevalence in ICU patients and analyse the risk factors of MDRPI.

Background: The occurrence of MDRPI not only increases hospitalisation time with pain and economic burden, but also causes medical disputes. Read More

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An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells.

J Exp Clin Cancer Res 2021 Jul 24;40(1):242. Epub 2021 Jul 24.

State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, Guizhou Province, People's Republic of China.

Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer types. However, the usage of immunotherapy is limited due to its low response rate, suggesting that tumor cells escape the immune surveillance. Read More

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Comments on Computed Tomography for Evaluating Appendicitis.

JAMA Surg 2021 Jul 21. Epub 2021 Jul 21.

Division of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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Association between Human Genetic Variants and the Vaginal Bacteriome of Pregnant Women.

mSystems 2021 Jul 20:e0015821. Epub 2021 Jul 20.

Department of Epidemiology, Fudan Universitygrid.8547.e, Shanghai, China.

The influence of human genetic variants on the vaginal bacterial traits (VBTs) of pregnant women is still unknown. Using a genome-wide association approach based on the 16S rRNA bacteriome analysis, a total of 72 host genetic variant (single nucleotide polymorphisms [SNPs], indels, or copy number variations [CNVs])-VBT associations were found that reached the genome-wide significance level ( < 5 × 10) with an acceptable genomic inflation factor λ of <1.1. Read More

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Surgical management of female genital mutilation-related morbidity: A scoping review.

J Plast Reconstr Aesthet Surg 2021 Jun 6. Epub 2021 Jun 6.

Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, 675N. Saint Clair St, 19-250, Chicago, IL 60611, United States; Buehler Center for Health Policy and Economics, Northwestern University Feinberg School of Medicine. Chicago, IL, United States. Electronic address:

Background: Over 200 million women and girls worldwide have suffered from the partial to total removal of external female genitalia for nonmedical purposes, referred to as female genital mutilation (FGM). Survivors of FGM may develop debilitating physical and psychological long-term sequelae. This is the first study to examine the scope of the extant surgical literature on the management of FGM-related morbidity. Read More

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Integrated assessment of major and trace elements in surface and core sediments from an urban lagoon, China: Potential ecological risks and influencing factors.

Mar Pollut Bull 2021 Jun 30;170:112651. Epub 2021 Jun 30.

CAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Marine sediments serve as a sink for contaminants of anthropogenic origin. Here, 25 major and trace elements were determined in surface and core sediments from an urban lagoon (Yundang Lagoon), China. The median concentrations of Pb, Cd, Cu, and Zn in both surface and core sediments exceeded global and crustal averages. Read More

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A facile and fast strategy for cathodic electroactive-biofilm assembly via magnetic nanoparticle bioconjugation.

Biosens Bioelectron 2021 Oct 24;190:113464. Epub 2021 Jun 24.

Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

Microbial electrosynthesis is a promising electricity-driven technology for converting carbon dioxide into value-added compounds, but the formation of cathodic electroactive-biofilms (CEBs) is challenging. Herein, we have demonstrated an innovative strategy for CEBs assembly via magnetic nanoparticle bioconjugation, which lies in the synergistic interactions among a bonder (Streptavidin, SA), conductive nanomaterials (FeO), and a methanogen (M. barkeri). Read More

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October 2021

Alterations of oral microbiota in patients with obstructive sleep apnea-hypopnea syndrome treated with continuous positive airway pressure: a pilot study.

Sleep Breath 2021 Jul 1. Epub 2021 Jul 1.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, No. 34, Zhongshanbei Rd, Licheng District, Quanzhou, 362000, Fujian Province, China.

Purpose: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an independent risk factor for cardiovascular diseases, including hypertension. In our previous study, it was demonstrated that oral microbiota alteration in patients with OSAHS, particularly in the genera Aggregatibacter and Porphyromonas, may influence the development of hypertension. Continuous positive airway pressure (CPAP) is the main therapy for OSAHS and OSAHS-associated hypertension. Read More

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Py-Macrodipa: A Janus Chelator Capable of Binding Medicinally Relevant Rare-Earth Radiometals of Disparate Sizes.

J Am Chem Soc 2021 Jul 30;143(27):10429-10440. Epub 2021 Jun 30.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.

Nuclear medicine leverages different types of radiometals for disease diagnosis and treatment, but these applications usually require them to be stably chelated. Given the often-disparate chemical properties of these radionuclides, it is challenging to find a single chelator that binds all of them effectively. Toward addressing this problem, we recently reported a macrocyclic chelator macrodipa with an unprecedented "dual-size-selectivity" pattern for lanthanide (Ln) ions, characterized by its high affinity for both the large and the small Ln ( , 2020, 142, 13500). Read More

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Rationally integrating peptide-induced targeting and multimodal therapies in a dual-shell theranostic platform for orthotopic metastatic spinal tumors.

Biomaterials 2021 Jun 18;275:120917. Epub 2021 Jun 18.

Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Department of Orthopaedic Surgery, Shanghai Baoshan District Wusong Central Hospital, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, 200940, PR China. Electronic address:

Metastatic tumors present great challenges in diagnosis and treatment. Herein, a proof-of-concept theranostic nanoplatform composed of an Au nanoparticle core and a double-shell of metal-organic framework (MOF) and mesoporous silica (MS) is developed for combating spinal metastasis of lung cancer in an orthotopic model. Two drugs, Alpelisib (BYL719) as an inhibitor and cisplatin as a chemotherapeutic drug, are separately loaded into the double-shell with high loading content. Read More

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Dichroic Photoelasticity in Black Phosphorus Revealed by Ultrafast Coherent Phonon Dynamics.

J Phys Chem Lett 2021 Jul 18;12(25):5871-5878. Epub 2021 Jun 18.

State Key Laboratory of Surface Physics and Department of Physics, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan University, Shanghai 200433, China.

Coherent longitudinal lattice vibrations of black phosphorus provide unique access to the out-of-plane strain coupled in-plane optical properties. In this work, polarization-resolved femtosecond transient absorption microscopy is applied to study the anisotropic coherent phonon responses. Multiorder phonon harmonics were observed with thickness dependence well explained by the linear chain model, allowing rapid optical mapping of phonon frequency distributions. Read More

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Enhanced Potassium-Ion Storage of the 3D Carbon Superstructure by Manipulating the Nitrogen-Doped Species and Morphology.

Nanomicro Lett 2020 Oct 27;13(1). Epub 2020 Oct 27.

College of Materials Science and Engineering, Hunan University, Changsha, 410082, People's Republic of China.

Potassium-ion batteries (PIBs) are attractive for grid-scale energy storage due to the abundant potassium resource and high energy density. The key to achieving high-performance and large-scale energy storage technology lies in seeking eco-efficient synthetic processes to the design of suitable anode materials. Herein, a spherical sponge-like carbon superstructure (NCS) assembled by 2D nanosheets is rationally and efficiently designed for K storage. Read More

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October 2020

Changes in molecular structure of extracellular polymeric substances (EPS) with temperature in relation to sludge macro-physical properties.

Water Res 2021 May 31;201:117316. Epub 2021 May 31.

School of Environmental Studies, China University of Geosciences, Wuhan 430074, Hubei, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Extracellular polymeric substances (EPS) are important components of activated sludge, whose content and composition have important effects on the macro-physical properties of sludge. In this study, the response of EPS in sludge to temperature (-40-200 °C) was systematically investigated using XAD resin fractionation, variable-temperature infrared spectra (VTIS) and two-dimensional correlation spectroscopy (2D-COS). The relationships between the molecular structure of EPS and the macro-physical properties (rheological property and dewatering performance) of waste activated sludge (WAS) at varying temperature were also established. Read More

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MS device: smartphone-facilitated mobile nucleic acid analysis on microfluidic device.

Analyst 2021 Jun;146(12):3823-3833

Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, PR China.

Mobile sensing based on the integration of microfluidic devices and smartphones, so-called MS2 technology, has enabled many applications over recent years and continues to stimulate growing interest in both research communities and industries. In particular, MS2 technology has been proven to be able to be applied to molecular diagnostic analysis and can be implemented for basic research and clinical testing. However, the currently reported MS2-based nucleic acid analysis system has limited use in practical applications, because it is not integrated with quantitative PCR, multiplex PCR, and isothermal amplification functions, and lacks temperature control, image acquisition and real-time processing units with excellent performance. Read More

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Hybrid AI-assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears.

Nat Commun 2021 06 10;12(1):3541. Epub 2021 Jun 10.

Department of Pathology, Guangdong Provincial Women's and Children's Dispensary, Shenzhen, Guangdong Province, PR China.

Technical advancements significantly improve earlier diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various factors. We develop an artificial intelligence assistive diagnostic solution, AIATBS, to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria. We train AIATBS with >81,000 retrospective samples. Read More

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ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes.

BMC Cancer 2021 Jun 9;21(1):680. Epub 2021 Jun 9.

State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Province Science City, High Tech Zone, Baiyun District, Guiyang, 550014, Guizhou Province, People's Republic of China.

Background: Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mechanisms are largely unknown. The limonoid compounds A1542 and A1543 stimulate ERK/MAPK by direct binding, leading to leukemic cell death and suppression of leukemia in mouse models. Read More

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-Mediated Active Responses of Plant Growth under Salt and Temperature Stress in .

Plants (Basel) 2021 May 31;10(6). Epub 2021 May 31.

College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

The transcription factor NF-YB (nuclear factor-YB) family is a subfamily of the nuclear factor Y (NF-Y), which plays an important role in regulating plant growth, development and participates in various stress responses. Although the NF-Y family has been studied in many species, it is still obscure in . In this study, 23 genes in eucalyptus were identified and unevenly distributed on 11 chromosomes. Read More

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[Advances and Challenges in Biosafety Research for Urban Environments].

Huan Jing Ke Xue 2021 Jun;42(6):2565-2572

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

The global emergence of infectious diseases significantly threatens biosafety and human health. Anthropogenic activities, including rapid urbanization, agricultural intensification, global trade, and travel, are major drivers of zoonotic disease emergence. Emphasizing on the nexus of human, animal, and environmental health, the 'One Health' approach has been widely accepted for managing and preventing zoonoses. Read More

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Synthesis of maleimide-based enediynes with cyclopropane moieties for enhanced cytotoxicity under normoxic and hypoxic conditions.

J Mater Chem B 2021 Jun;9(22):4502-4509

Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Myers-Saito cycloaromatization (MSC) is the working mechanism of many natural enediyne antibiotics with high antitumor potency. However, the presence of the equilibrium between diradical and zwitterionic intermediates in MSC severely hinders further improvement in cytotoxicity toward tumor cells. To this end, a series of maleimide-based enediynes with cyclopropane moieties were synthesized for enhanced cytotoxicity toward tumor cells. Read More

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A retrospective analysis of pleural effusion specimens based on the newly proposed International System for Reporting Serous Fluid Cytopathology.

Diagn Cytopathol 2021 May 21. Epub 2021 May 21.

Department of Pathology, Yueyang integrated traditional Chinese and Western Medicine Hospital, Shanghai University of traditional Chinese Medicine, Shanghai, China.

Background: Recently, the International System for Reporting Serous Fluid Cytopathology (TIS) has been established, with an aim to standardize reporting and guide clinical decision making.

Methods: The cytological and clinicopathological data of pleural effusions were retrieved from the pathology database and electronic medical records. All specimens were evaluated and reclassified in accordance with the TIS recommendations. Read More

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Safety and efficacy of His-bundle pacing/left bundle branch area pacing versus right ventricular pacing: a systematic review and meta-analysis.

J Interv Card Electrophysiol 2021 May 21. Epub 2021 May 21.

Department of Cardiology, Shandong Provincial Hospital, Shandong, 250021, Jinan, China.

Background: Recent studies have demonstrated that right ventricular pacing (RVP) has deleterious effects on non-synchronized ventricular contraction, while His-bundle pacing (HBP) or left bundle branch area pacing (LBBaP) contribute to improvements in patients' mid- and long-term outcomes. This meta-analysis aimed to compare the safety and efficacy of physiologic pacing (HBP/LBBaP) versus those of RVP.

Methods: A systematic search of PubMed, Cochrane Library, and Embase was conducted for studies that compared the effects of physiologic pacing and RVP. Read More

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N-Terminal Extensions Appear to Frustrate HU Heterodimer Formation by Strengthening Intersubunit Contacts and Blocking the Formation of a Heterotetrameric Intermediate.

Biochemistry 2021 Jun 21;60(23):1836-1852. Epub 2021 May 21.

Centre for Protein Science, Design and Engineering (CPSDE), Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector-81, SAS Nagar, Punjab 140306, India.

HU is a bacterial nucleoid-associated protein. Two homologues, known as HU-A, and HU-B, are found in within which the early, late, and stationary phases of growth are dominated by HU-AA, HU-BB, and HU-AB dimers, respectively. Here, using genetic manipulation, mass spectrometry, spectroscopy, chromatography, and electrophoretic examination of glutaraldehyde-mediated cross-linking of subunits, in combination with experiments involving mixing, co-expression, unfolding, and refolding of HU chains, we show that the spontaneous formation of HU-AB heterodimers that is reported to occur upon mixing of wild-type HU-AA and HU-BB homodimers does not occur if chains possess N-terminal extensions. Read More

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Natural Self-Confined Structure Effectively Suppressing Volume Expansion toward Advanced Lithium Storage.

ACS Appl Mater Interfaces 2021 Jun 19;13(21):24634-24642. Epub 2021 May 19.

Hirano Institute for Materials Innovation, Shanghai Jiao Tong University, Shanghai 200240, PR China.

Volume expansion hinders conversion-type transition-metal oxides (TMOs) as potential anode candidates for high-capacity lithium-ion batteries. While nanostructuring and nanosizing have been employed to improve the cycling stability of TMOs, we show here that both high initial Coulombic efficiency (ICE) and stable cycling reversibility are achieved in the layered compound LiNbMoO (L0.9NMO) by inherent properties of the bulk crystal structure. Read More

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Comprehensive assessment of the impact of horticultural activities on salivary stress biomarkers, psychological status, and the autonomic nervous system response visualized using a wearable biosensor.

Neuro Endocrinol Lett 2021 Mar;42(1):55-60

Department of Palliative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Objectives: This study aims to comprehensively investigate the changes of salivary stress biomarkers, psychological status, and autonomic nervous system (ANS) response due to horticultural activities (HAs).

Design And Methods: A prospective observational study was conducted in twenty Japanese healthy adults (mean age, 58.4 years). Read More

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