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Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019), a Dutch population based study.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Radboud university medical centre, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.

Aim: Anastomotic leakage (AL) after colon cancer (CC) and rectal cancer (RC) surgery often requires reintervention. Prevalence and morbidity may change over time with evolutions in treatment strategies and changes in patient characteristics. This nationwide study aimed to evaluate changes in the incidence, risk factors and mortality from AL during the past nine years. Read More

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September 2021

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood.

Acta Paediatr 2021 Sep 18. Epub 2021 Sep 18.

University of Iceland, Faculty of Medicine, Reykjavík, Iceland.

Aims: The prevalence of allergic diseases is high and increasing in many countries. The aim of this study was to describe the prevalence of allergic diseases and changes in clinical expression in a birth cohort followed for three decades.

Methods: We followed Icelandic citizens born in 1987 for allergic diseases when they were two, four, eight, 15, 21 and 29 years of age. Read More

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September 2021

LncRNA DLGAP1-AS1 accelerates glioblastoma cell proliferation through targeting miR-515-5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway.

Brain Behav 2021 Sep 18:e2321. Epub 2021 Sep 18.

Department of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Introduction: Glioblastoma (GBM), the primary malignant tumor in the central nervous system, features high aggressiveness and mortality. Long noncoding RNAs (lncRNAs) can exert the crucial function in regulating various human diseases, including GBM. However, the function and mechanism of lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) in GBM remain still unknown. Read More

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September 2021

Neural shifts in alpha rhythm's dual functioning during empathy.

Brain Behav 2021 Sep 18:e32355. Epub 2021 Sep 18.

Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.

Introduction: Alpha oscillations are unique in their capacity to relay neuronal information through a dual-process named "gating by inhibition": rhythmic enhancement inhibits task-irrelevant regions while rhythmic suppression engages task-relevant regions in the brain. A social-cognitive process that operates by relying on the suppression of the alpha rhythm in the primary somatosensory cortex (S1) is the ability to generate empathy. This phenomenon has been evidenced in dozens of electrophysiological studies targeting adult human subjects. Read More

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September 2021

Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model.

Bipolar Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, University of California Irvine, Irvine, 92697, CA, USA.

Objective: The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non-invasive, requires less processing, and can be done without the need for trained personnel. This study investigated the utility of longitudinal salivary lithium level monitoring. Read More

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September 2021

Early Versus Delayed Feeding After Therapeutic Endoscopic Procedures: A Meta-Analysis of Randomized Controlled Trials.

Dig Endosc 2021 Sep 18. Epub 2021 Sep 18.

Division of Emergency Medicine, Department of Emergency and Critical Care, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

Introduction: Early feeding was previously considered to increase the risk of postprocedural bleeding. However, many trials have demonstrated the benefits of early feeding after therapeutic endoscopic procedures. We conducted a meta-analysis of randomized controlled trials to evaluate the safety and outcomes between early feeding and delayed feeding after therapeutic endoscopic procedures. Read More

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September 2021

High-speed stretch-shortening cycle exercises as a strategy to provide eccentric overload during resistance training.

Scand J Med Sci Sports 2021 Sep 18. Epub 2021 Sep 18.

Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027 WA, Australia.

Resistance exercises eliciting eccentric overload (EO) are considered to strongly promote muscular hypertrophy and broad neuromuscular adaptations, but typically require specialized equipment. The aims of these experiments were to assess whether EO is achieved during common high-speed stretch-shortening cycle (SSC) exercises (rebound bench press throw [RBPT] and squat jump [SJ]), and to test the effect of the external load on the EO achieved. Twenty-nine under-18 handball players and fifteen physically active males (24. Read More

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September 2021

Pelvic inflammatory disease is associated with ovarian cancer development in women with endometriosis: A cohort study in Taiwan.

Int J Gynaecol Obstet 2021 Sep 18. Epub 2021 Sep 18.

Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Tzyou, Taiwan.

Objective: Endometriosis and pelvic inflammatory disease are considered to be risk factors for ovarian cancer, as dysbiosis likely contributes to ovarian cancer development via chronic inflammation and immune response alteration. Therefore, we hypothesized that pelvic inflammatory disease predisposes to ovarian cancer development in women with endometriosis.

Methods: We selected patients who were diagnosed with endometriosis or pelvic inflammatory disease between January 1, 2000, and December 31, 2015 in a 2-million longitudinal health and welfare database in Taiwan, with cancer and death registries. Read More

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

Observations and report of incidents on how birthing persons are treated during childbirth in two public facilities of Argentina.

Int J Gynaecol Obstet 2021 Sep 18. Epub 2021 Sep 18.

Department of Mother and Child Health. Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina.

Objective: This study sought to estimate the frequency and types of mistreatment during childbirth and explore health professionals´ opinions on barriers/facilitators to providing respectful childbirth care.

Methods: This prospective mixed-methods investigation consisted of direct observations of childbirth (N=250), at-home surveys with birthing individuals (N=45), and qualitative in-depth health staff interviews (N=6); conducted January-July 2019, in two public facilities in Argentina. Frequencies of clinical practices and mistreatment and 5% confidence intervals were calculated. Read More

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September 2021

Phylogenetic conservation of behavioral variation and behavioral syndromes.

J Evol Biol 2021 Sep 18. Epub 2021 Sep 18.

Department of Biological Sciences, North Dakota State University.

Individuals frequently differ consistently from one another in their average behaviors (i.e. "animal personality") and in correlated suites of consistent behavioral responses (i. Read More

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September 2021

Recent improvement in survival outcomes and reappraisal of prognostic factors in pediatric living donor liver transplantation.

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University Ulsan College of Medicine, Seoul, Korea.

Background: Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end-stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LT is to achieve complete donor safety and zero recipient mortality.

Methods: We conducted a retrospective, single center assessment of the outcomes as well as the clinical factors that may influence graft and patient survival after primary LDLTs conducted between 1994 and 2020. Read More

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September 2021

The Use of Radiomic Analysis of Magnetic Resonance Imaging in Predicting Distant Metastases of Rectal Carcinoma following Surgical Resection - A Systematic Review & Meta-Analysis.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Discipline of Surgery, Galway University Hospitals, Galway, H91 YR71, Ireland.

Background: Estimating prognosis in rectal carcinoma (RC) is challenging, with distant recurrence (DR) occurring in up to 30% of cases. Radiomics is a novel field using diagnostic imaging to investigate the tumour heterogeneity of cancers and may have the potential to predict DR.

Aims: To perform a systematic review of current literature evaluating the use of radiomics in predicting DR in patients with resected RC. Read More

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September 2021

Very preterm infants admitted to a tertiary neonatal unit in central Vietnam showed poor postnatal growth.

Acta Paediatr 2021 Sep 18. Epub 2021 Sep 18.

Department of Paediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Aim: We aimed to evaluate the postnatal growth of very preterm infants.

Methods: This was a cross-sectional observational study of neonates born before 32 weeks of gestation and admitted to the neonatal unit at Da Nang Hospital for Women and Children, Vietnam, between 1 February 2020 and 30 September 2020. Morbidities, therapies, nutrition modalities and growth status were recorded from admission to discharge. Read More

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September 2021

Can zirconia crowns be the first restorative choice after endodontic treatment of primary teeth?

Int J Clin Pract 2021 Sep 18:e14888. Epub 2021 Sep 18.

Department of Pediatric Dentistry, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.

Objective: Early loss of primary teeth due to caries can cause temporary or permanent problems, such as occlusion disorders, aesthetic problems, nutritional problems, abnormal habits, and speech disorders. Although the development of restorative materials has led to significant improvements, failures are still frequent. The purpose of this study was to evaluate the success rates of zirconia crown with compare to other crowns for the restoration of endodonticly treated teeth with excessive loss of material. Read More

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September 2021

Acute Kidney Injury is a Common and Significant Complication Following Ileostomy Formation.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.

Aim: To characterize the incidence and short-term prognostic value of an acute kidney injury (AKI) during the admission where an ileostomy is formed.

Methods: Adults with a baseline creatinine discharged alive after ileostomy formation from 2014-2016 were included. All patients had daily basic metabolic panels (BMP) and the Kidney Diseases Improving Global Outcomes criteria were used to determine the presence and severity of any AKI. Read More

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September 2021

Digital contact-tracing in France: uptake by COVID-19 risk factor and by exposure risk.

Authors:
M Guillon

J Public Health (Oxf) 2021 Sep 17. Epub 2021 Sep 17.

Université de Montpellier, Montpellier Recherche en Economie, Avenue Raymond Dugrand, 34960 Cedex 2, Montpellier, France.

Background: Few studies have investigated the influence of COVID-19 conspiracy theories on digital contact-tracing adoption and the differentiated uptake of digital contact-tracing by COVID-19 risk factor and by exposure risk.

Methods: Using a cross-sectional survey conducted in France in November 2020 (N = 1042), we investigate the factors associated with the use of the French 'TousAntiCovid' contact-tracing application. Our independent variables of interest include COVID-19 and 'TousAntiCovid' perceptions, trust in the government, time and risk preferences and the level of adherence to COVID-19 conspiracy theories. Read More

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September 2021

Abiraterone acetate plus prednisone in non-metastatic biochemically recurrent castration-naïve prostate cancer.

Eur J Cancer 2021 Sep 15;157:259-267. Epub 2021 Sep 15.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Intermittent androgen deprivation therapy (ADT) in biochemically recurrent castration-naïve prostate cancer is non-inferior to continuous therapy. We hypothesised that finite-duration abiraterone acetate plus prednisone (Abi +P) added to ADT will further reduce the duration of treatment exposure by prolonging time to prostate-specific antigen (PSA) recurrence without impacting eugonad state recovery.

Methods: This phase II, randomised, open-label trial enrolled patients with rising PSA ≥ 0. Read More

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September 2021

Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.

Eur J Cancer 2021 Sep 15;157:250-258. Epub 2021 Sep 15.

University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, Italy. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) has an overall favourable outcome, except for patients with an advanced stage disease. The programmed death protein-1 (PD-1) inhibitor cemiplimab has been approved for use in advanced cSCC. We report clinical outcomes from the named patient programme-compassionate use of cemiplimab for patients with advanced cSCC in Italy. Read More

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September 2021

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Eur J Cancer 2021 Sep 15;157:214-224. Epub 2021 Sep 15.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irAEs). We sought to determine the activity of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in treatment or prevention of auto-immune irAE in ICI-treated patients.

Methods: Institutional databases from 2 melanoma centers were reviewed for patients treated with ICIs and tocilizumab. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Hydrated electrons mediated in-situ construction of cubic phase CdS/Cd thin layer on a millimeter-scale support for photocatalytic hydrogen evolution.

J Colloid Interface Sci 2021 Sep 8;607(Pt 1):769-781. Epub 2021 Sep 8.

TJU-NIMS International Collaboration Laboratory, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, People's Republic of China; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

In this study, non-noble metal Cd decorated cubic phase CdS (CdS/Cd) thin layer on a millimeter-scale chitosan-Mg(OH) xerogel beads (CMB) were elaborately designed and successfully synthesized via facile hydrated electrons (e) assistant strategy. The in-situ formation of metallic Cd was driven by e generated from UV/NaSO process. Owing to metallic Cd, [email protected]/Cd exhibited better visible-light absorption ability and more efficient separation capability for photo-induced carriers, its hydrogen production efficiency was about threefold improved compared to [email protected] Read More

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September 2021

4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.

Bioorg Chem 2021 Sep 11;116:105349. Epub 2021 Sep 11.

College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address:

A series of fluorinated and hydroxylated 2,4-diphenyl indenopyridinols were designed and synthesized using l-proline-catalyzed and microwave-assisted synthetic methods for the development of new anticancer agents. Adriamycin and etoposide were used as reference compounds for the evaluation of topo IIα inhibitory and anti-proliferative activity of the synthesized compounds. Exploring the structure-activity relationships of 36 prepared compounds and biological results, most of the compounds with ortho- and para-fluorophenyl at 4-position of indenopyridinol ring displayed strong topo IIα inhibition. Read More

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September 2021

Complications and prognosis associated with intra-tympanic steroid injection to treat sudden sensorineural hearing impairment.

Am J Otolaryngol 2021 Sep 10;43(1):103221. Epub 2021 Sep 10.

Division of Otology, Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, Chang Gung University, Taiwan. Electronic address:

Purpose: The purpose of this study was to measure the incidence of complications in sudden sensorineural hearing loss (SSNHL) patients treated with intra-tympanic steroid injection (ITSI) and compare hearing recovery rates.

Materials And Methods: 123 patients with unilateral SSNHL receiving ITSIs were included in this study. Post-ITSI complications were documented including otalgia, dysgeusia, vertigo (duration>1 h), and persistent eardrum perforation. Read More

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September 2021

Extracranial temporal bone paragangliomas: Re-defining the role of otologic surgery within the scope of function-preserving multimodal concepts.

Am J Otolaryngol 2021 Sep 12;43(1):103212. Epub 2021 Sep 12.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Introduction: The aim of this study was to present our concept in the management of extracranial temporal bone paragangliomas and demonstrate the outcome after primary surgical management of the middle ear component, with an individualized indication for adjuvant radiotherapy.

Materials And Methods: The records of all patients treated for extracranial jugulotympanic paragangliomas by means of primary surgical management between 2010 and 2021 were studied retrospectively.

Results: Twenty-nine patients made up our study sample (mean age 58. Read More

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September 2021

Virtual reality surgical planning for endoscopic endonasal approaches to the craniovertebral junction.

Am J Otolaryngol 2021 Sep 11;43(1):103219. Epub 2021 Sep 11.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Otolaryngology Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Purpose: To demonstrate the utility of virtual reality (VR) for preoperative surgical planning of endoscopic endonasal craniovertebral junction (CVJ) surgery.

Materials And Methods: Five patients who had undergone endoscopic endonasal surgery of the craniovertebral junction with preoperative virtual reality surgical planning were identified and described.

Results: The anterior approach to the CVJ has been traditionally accomplished transorally. Read More

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September 2021

Defining the microbiome of the head and neck: A contemporary review.

Am J Otolaryngol 2021 Sep 11;43(1):103224. Epub 2021 Sep 11.

University of Connecticut Health Center Department of Otolaryngology-Head and Neck Surgery, United States of America. Electronic address:

Objective: The purpose of this paper is to define the microbiome of the head and neck by characterizing and distinguishing the commensal bacteria from pathogenic species.

Study Design: Literature review.

Methods: Pubmed and Google scholar databases were queried for relevant articles. Read More

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September 2021

F-FDG-PET/CT interpretation pitfalls in patients with head and neck cancer.

Am J Otolaryngol 2021 Sep 10;43(1):103209. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Aim: The aim of the present study is to raise awareness of ENT Surgeons on the limitations of F-FDG PET/CT in head and neck cancer by presenting illustrative cases from our department archives.

Materials And Methods: A retrospective chart review was conducted for all patients with head and neck cancer treated in our ENT department from 2015 to 2020. Cases with various interpretation pitfalls due to false-positive and false-negative PET/CT results that lead to diagnostic dilemmas and treatment delays either in their pre-therapeutic work-up or in their post-therapeutic monitoring were included. Read More

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September 2021

Facial nerve sacrifice in lateral approaches to the skull base: Simultaneous reconstruction by graft interposition.

Am J Otolaryngol 2021 Sep 10;43(1):103210. Epub 2021 Sep 10.

Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy.

Purpose: To evaluate the outcome of facial nerve (FN) cable graft interposition in lateral skull base surgery.

Materials And Methods: A group of 16 patients who underwent FN graft interposition procedure was retrospectively considered. Postoperative FN function was evaluated using the House-Brackmann (HB) grading system, the Sunnybrook Facial Grading System (SFGS), the Facial Disability Index (FDI) and the Oral Functioning Scale (OFS) questionnaires. Read More

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September 2021

Evaluation of the impact of deep neuromuscular blockade on surgical conditions for laryngeal microsurgery with High Frequency Jet Ventilation. A comparison with no block during intravenous general anesthesia with topical lidocaine.

Am J Otolaryngol 2021 Sep 4;43(1):103187. Epub 2021 Sep 4.

Université catholique de Louvain, CHU UCL Namur, Department of Anesthesiology, Avenue Dr G Thérasse 1, 5530 Yvoir, Belgium.

Objective: Laryngeal transoral surgery classically requires a neuromuscular block (NMB) to facilitate tracheal intubation and to improve surgical conditions. However, the short duration of most procedures and the potential complications of residual NMB lead to consider a no block approach. The hypothesis that intravenous anesthesia (remifentanil and propofol infusions) without NMB but including glottis topical lidocaine anesthesia would allow clinically acceptable laryngeal exposure and good surgical conditions was tested in the specific context of procedures undergone with High Frequency Jet Ventilation (HFJV). Read More

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September 2021