4,096 results match your criteria hscrp hospitalization

Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV. Read More

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September 2021

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection.

Ren Fail 2021 Dec;43(1):1329-1337

Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19.

Methods: In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Read More

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December 2021

Atorvastatin therapy in COVID-19 adult inpatients: A double-blind, randomized controlled trial.

Int J Cardiol Heart Vasc 2021 Oct 14;36:100875. Epub 2021 Sep 14.

Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: Efficacious therapies are urgently required to tackle the coronavirus disease 2019 (COVID-19). This trial aims to evaluate the effects of atorvastatin in comparison with standard care for adults hospitalized with COVID-19.

Methods: We conducted a randomized controlled clinical trial on adults hospitalized with COVID-19. Read More

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October 2021

Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort.

Front Immunol 2021 1;12:700921. Epub 2021 Sep 1.

Grupo Enfermedades Emergentes, Universidad Científica del Sur, Lima, Peru.

Cytokines, chemokines and growth factors present different expression profiles related to the prognosis of COVID-19. We analyzed clinical parameters and assessed the expression of these biomarkers in patients with different disease severity in a hospitalized Peruvian cohort to determine those associated with worse prognosis. We measured anti-spike IgG antibodies by ELISA and 30 cytokines by quantitative suspension array technology in 123 sera samples. Read More

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September 2021

Association Between Psychological Distress, Cognitive Complaints, and Neuropsychological Status After a Severe COVID-19 Episode: A Cross-Sectional Study.

Front Psychiatry 2021 3;12:725861. Epub 2021 Sep 3.

Université de Paris, AP-HP, Hôpital Hôtel-Dieu, DMU Psychiatrie et Addictologie, Service de Psychiatrie de l'adulte, INSERM, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, Paris, France.

Cognitive complaints are frequent after COVID-19 but their clinical determinants are poorly understood. This study aimed to explore the associations of objective cognitive performances and psychological distress with cognitive complaints in COVID-19 survivors. Patients previously hospitalized for COVID-19 in a university hospital during the first wave of COVID-19 pandemic in France were followed-up at 1 month after their admission. Read More

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September 2021

Prognostic nutritional index as indicator of immune nutritional status of patients with COVID-19.

Int J Vitam Nutr Res 2021 Sep 20. Epub 2021 Sep 20.

Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences University, Istanbul, Turkey.

This study aimed to investigate the effect of the nutritional status, as assessed by the prognostic nutritional index (PNI) on the disease prognosis of patients with COVID-19. This retrospective study included 282 patients with COVID-19. The PNI score of all patients, 147 of whom were male, with a mean age of 56. Read More

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September 2021

Effect of urban air pollution on CRP and coagulation: a study on inpatients with acute exacerbation of chronic obstructive pulmonary disease.

BMC Pulm Med 2021 Sep 18;21(1):296. Epub 2021 Sep 18.

Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an important event in the course of chronic obstructive pulmonary disease that negatively affects patients' quality of life and leads to higher socioeconomic costs. While previous studies have demonstrated a significant association between urban air pollution and hospitalization for AECOPD, there is a lack of research on the impact of particulate matter (PM) on inflammation and coagulation in AECOPD inpatients. Therefore, this study investigated the association of changes in coagulation function and C-reactive protein (CRP) with PM levels in the days preceding hospitalization. Read More

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September 2021

Clinical features and prognosis of severe meconium aspiration syndrome with acute respiratory distress syndrome.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):903-908

Department of Neonatology, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan, Guangdong 523325, China (Email: com).

Objectives: To study the clinical features and prognosis of neonates with severe meconium aspiration syndrome (MAS) and acute respiratory distress syndrome (ARDS).

Methods: A retrospective analysis was performed on the medical data of 60 neonates with severe MAS who were admitted from January 2017 to December 2019. According to the presence or absence of ARDS, they were divided into two groups: ARDS (=45) and non-ARDS (=15). Read More

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September 2021

Lung Ultrasound in Patients With SARS-COV-2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade.

J Ultrasound Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiology, Istituto Auxologico Italiano IRCCS, Ospedale S. Luca, Milan.

Objectives: Lung ultrasound (LUS) might be comparable to chest computed tomography (CT) in detecting parenchymal and pleural pathology, and in monitoring interstitial lung disease. We aimed to describe LUS characteristics of patients during the hospitalization for COVID-19 pneumonia, and to compare the extent of lung involvement at LUS and chest-CT with inflammatory response and the severity of respiration impairment.

Methods: During a 2-week period, we performed LUS and chest CT in hospitalized patients affected by COVID-19 pneumonia. Read More

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September 2021

International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: a 4CE Consortium Study.

J Med Internet Res 2021 Sep 2. Epub 2021 Sep 2.

Institute for Biomedical Informatics, University of Kentucky, Lexington, US.

Background: Many countries have experienced two predominant waves of COVID-19-related hospitalizations. Comparing the clinical trajectories of patients hospitalized in separate waves of the pandemic enables further understanding of the evolving epidemiology, pathophysiology, and healthcare dynamics of the COVID-19 pandemic.

Objective: In this retrospective cohort study, we analyzed electronic health record (EHR) data from patients with SARS-CoV-2 infections hospitalized in participating healthcare systems representing 315 hospitals across six countries. Read More

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September 2021

Evaluation of hematological parameters and inflammatory markers in children with COVID-19.

Ir J Med Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey.

Background: The aim of this study was to evaluate hematological parameters in children with COVID-19 and determine the effects of inflammatory biomarkers on the assessment of hospitalization.

Methods: This retrospective single-center study was performed on 633 children with COVID-19 between March 2020 and January 2021. The study population was separated into two groups: inpatients (n = 83) and outpatients (n = 550). Read More

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September 2021

Inflammation/coagulopathy/fibrinolysis: Dynamic indicators of COVID-19 progression in patients with moderate COVID-19 in Wenzhou, China.

Clin Immunol 2021 Sep 11:108852. Epub 2021 Sep 11.

School of Basic Medical Science, Wenzhou Medical University, Wenzhou, China. Electronic address:

Background: Majority of coronavirus disease 2019 (COVID-19) non-survivors meet the criteria for disseminated intravascular coagulation (DIC). Although timely monitoring of clotting hemorrhagic development during the natural course of COVID-19 is critical for understanding pathogenesis, diagnosis, and treatment of the disease, however, limited data are available on the dynamic processes of inflammation/coagulopathy/fibrinolysis (ICF).

Methods: We monitored the dynamic progression of ICF in patients with moderate COVID-19. Read More

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September 2021

Efficacy of Combination Therapy With The JAK Inhibitor Baricitinib In The Treatment of COVID-19.

Res Sq 2021 Sep 8. Epub 2021 Sep 8.

Background: Coronavirus disease-19 (COVID-19), resulting from infection with SARS-CoV-2, spans a wide spectrum of illness. In severely ill patients, highly elevated serum levels of certain cytokines and considerable cytolytic T cell infiltrates in the lungs have been observed. These same patients may bear low to negligible viral burdens suggesting that an overactive immune response, often termed cytokine storm, contributes to the severity of COVID-19. Read More

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September 2021

Multifunctional Irrigation-Assisted Vacuum Drainage versus Traditional Drainage in the Treatment of Odontogenic Deep Fascial Infection: A Retrospective Cohort Study.

Infect Drug Resist 2021 2;14:3571-3580. Epub 2021 Sep 2.

Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, People's Republic of China.

Purpose: Odontogenic deep fascial space infection in the head and neck is a common potentially fatal clinical problem. Traditional drainage method is considered laborious and gravity-dependent. In this study, we aimed to evaluate the clinical effect of a modified multifunctional irrigation-assisted vacuum drainage (MIVD) by comparing it with the traditional drainage method in the treatment of odontogenic deep fascial infection. Read More

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September 2021

Systemic Inflammation in the First 2 Weeks After Birth as a Determinant of Physical Growth Outcomes in Hospitalized Infants With Extremely Low Gestational Age.

J Pediatr 2021 Sep 8. Epub 2021 Sep 8.

Division of Neonatal-Perinatal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

Objective: To examine associations of systemic inflammation with growth outcomes at neonatal intensive care unit (NICU) discharge/transfer among infants with extremely low gestational ages.

Study Design: We studied 850 infants at born 23-27 weeks of gestation. We defined inflammatory protein elevation as the highest quartile of c-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-∝), or interleukin 8 (IL-8) on postnatal days 1, 7, and 14. Read More

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September 2021

Clinical and CT findings of adenovirus pneumonia in immunocompetent adults.

Clin Respir J 2021 Sep 9. Epub 2021 Sep 9.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.

Introduction: Adenovirus pneumonia is not uncommon in children and immunocompromised patients. However, the study of the clinical and computed tomography (CT) characteristics of Adenovirus pneumonia in immunocompetent adults is still limited.

Objective: The objective of this study was to retrospectively observe the clinical and CT characteristics as well as their dynamic change of Adenovirus pneumonia in immunocompetent adults. Read More

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September 2021

[Effect of acupuncture on analgesia and sedation in elderly patients with severe pneumonia during invasive mechanical ventilation].

Zhongguo Zhen Jiu 2021 Sep;41(9):971-8

Department of Emergency, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Objective: To observe the analgesic and sedative effects of acupuncture in elderly patients with severe pneumonia during invasive mechanical ventilation.

Methods: A total of 188 elderly patients with severe pneumonia were randomly divided into an observation group and a control group, 94 cases in each group. Both groups were treated with routine nursing and treatment of severe pneumonia such as invasive mechanical ventilation, analgesia and sedation. Read More

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September 2021

Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave versus the second wave.

J Med Virol 2021 Sep 7. Epub 2021 Sep 7.

Department of Rheumatology, Istanbul Gaziosmanpasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID-19), the outcome of COVID-19 patients with severe/critical illness would be expected to be better in the second wave compared with the first wave. As our hospitalization criteria changed in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID-19 patients with only severe/critical illness. Among 642 laboratory-confirmed hospitalized COVID-19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow-up were surveyed. Read More

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September 2021

Frequency of deep vein thrombosis at admission for acute stroke and associated factors: a cross-sectional study.

Thromb J 2021 Sep 6;19(1):62. Epub 2021 Sep 6.

Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, 247-8533, Kamakura City, Kanagawa, Japan.

Background: Intermittent pneumatic compression (IPC) is commonly used to prevent deep vein thrombosis (DVT) during hospitalization in patients with acute stroke. However, if DVT exists at admission, IPC of the legs with DVT may cause migration of the thrombi, resulting in pulmonary emboli. Whole-leg ultrasonography (wl-US) is a practical tool to detect DVT; however, wl-US is not always performed at admission in all stroke patients. Read More

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September 2021

Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

BMC Infect Dis 2021 Sep 4;21(1):908. Epub 2021 Sep 4.

Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.

Background: Pre-existing comorbidities have been linked to SARS-CoV-2 infection but evidence is sparse on the importance and pattern of multimorbidity (2 or more conditions) and severity of infection indicated by hospitalisation or mortality. We aimed to use a multimorbidity index developed specifically for COVID-19 to investigate the association between multimorbidity and risk of severe SARS-CoV-2 infection.

Methods: We used data from the UK Biobank linked to laboratory confirmed test results for SARS-CoV-2 infection and mortality data from Public Health England between March 16 and July 26, 2020. Read More

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September 2021

Incidence, Risk Factors and Outcome of COVID-19 Associated AKI- A Study from South India.

J Assoc Physicians India 2021 Jun;69(6):11-12

Department of Intensive Respiratory Care, Meenakshi Mission Hospital and Research Centre, Madurai, Tamil Nadu.

Background: Acute Kidney Injury (AKI) is a dreaded complication of Covid-19 infection with high morbidity and mortality. Limited data exists on Indian experience. In a tertiary care hospital situated in South India, we analysed the incidence, clinical profile and outcomes of patients diagnosed with AKI due to COVID-19. Read More

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Fostamatinib for the treatment of hospitalized adults with COVD-19 A randomized trial.

Clin Infect Dis 2021 Sep 1. Epub 2021 Sep 1.

National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.

Background: Coronavirus Disease 2019 (Covid-19) requiring hospitalization is characterized by robust antibody production, dysregulated immune response and immunothrombosis. Fostamatinib, is a novel spleen tyrosine kinase inhibitor we hypothesize will ameliorate Fc activation and attenuate harmful effects of the anti-COVID-19 immune response.

Methods: We conducted a double-blind, randomized, placebo-controlled trial in hospitalized adults requiring oxygen with Covid-19 where patients receiving standard of care were randomized to receive fostamatinib or placebo. Read More

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September 2021

Predictors of severity and in-hospital mortality in patients with influenza.

Monaldi Arch Chest Dis 2021 Aug 10. Epub 2021 Aug 10.

Department of Internal Medicine, Centro Hospitalar Universitário de São João, E.P.E., Porto.

Influenza virus is a common agent of acute respiratoty infections during epidemic periods. It is a major cause of morbidity and mortality and represent a significant burden on the healthcare system. We aimed to evaluate predictors of severity and of in-hospital mortality in patients hospitalized with influenza infection. Read More

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Biomarkers of Inflammation and Inflammation-Related Indexes upon Emergency Department Admission Are Predictive for the Risk of Intensive Care Unit Hospitalization and Mortality in Acute Poisoning: A 6-Year Prospective Observational Study.

Dis Markers 2021 19;2021:4696156. Epub 2021 Aug 19.

Internal Medicine and Clinical Toxicology Department, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.

Patients poisoned with drugs and nonpharmaceutical substances are frequently admitted from the emergency department (ED) to a medical or ICU department. We hypothesized that biomarkers of inflammation and inflammation-related indexes based on the complete blood cell (CBC) count can identify acutely poisoned patients at increased risk for ICU hospitalization and death. We performed a 6-year prospective cohort study on 1548 adult patients. Read More

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Systemic inflammation induced by exacerbation of COPD or pneumonia in patients with COPD induces cardiac troponin elevation.

BMJ Open Respir Res 2021 Aug;8(1)

Institute for Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Troponin is a biomarker of myocardial injury. In chronic obstructive pulmonary disease (COPD), troponin is an important determinant of mortality after acute exacerbation. Whether acute exacerbation of COPD (AECOPD) causes troponin elevation is not known. Read More

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Usefulness of Easy-to-Use Risk Scoring Systems Rated in the Emergency Department to Predict Major Adverse Outcomes in Hospitalized COVID-19 Patients.

J Clin Med 2021 Aug 18;10(16). Epub 2021 Aug 18.

Immunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, Mexico City 14080, Mexico.

Background: Several easy-to-use risk scoring systems have been built to identify patients at risk of developing complications associated with COVID-19. However, information about the ability of each score to early predict major adverse outcomes during hospitalization of severe COVID-19 patients is still scarce.

Methods: Eight risk scoring systems were rated upon arrival at the Emergency Department, and the occurrence of thrombosis, need for mechanical ventilation, death, and a composite that included all major adverse outcomes were assessed during the hospital stay. Read More

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Predictors of Hypoxemia and Related Adverse Outcomes in Patients Hospitalized with COVID-19: A Double-Center Retrospective Study.

J Clin Med 2021 Aug 14;10(16). Epub 2021 Aug 14.

Heart Institute, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Hypoxemia is a hallmark of coronavirus disease 2019 (COVID-19) severity. We sought to determine predictors of hypoxemia and related adverse outcomes among patients hospitalized with COVID-19 in the two largest hospitals in Jerusalem, Israel, from 9 March through 16 July 2020. Patients were categorized as those who developed reduced (<94%) vs. Read More

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High neutrophil to lymphocytes ratio is associated with nutritional risk in hospitalised, unselected cancer patients: a cross-sectional study.

Sci Rep 2021 Aug 24;11(1):17120. Epub 2021 Aug 24.

Faculty of Nutrition, Federal University of Goiás, Rua 227, Quadra 68 s/n°, Setor Leste Universitário, Goiânia, GO, 74605080, Brasil.

Cancer patients possess metabolic and pathophysiological changes and an inflammatory environment that leads to malnutrition. This study aimed to (i) determine whether there is an association between neutrophil-to-lymphocyte ratio (NLR) and nutritional risk, and (ii) identify the cut-off value of NLR that best predicts malnutrition by screening for nutritional risk (NRS 2002). This cross-sectional study included 119 patients with unselected cancer undergoing chemotherapy and/or surgery. Read More

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New Scoring System for Predicting Mortality in Patients with COVID-19.

Yonsei Med J 2021 Sep;62(9):806-813

Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Purpose: We aimed to develop a novel mortality scoring system for inpatients with COVID-19 based on simple demographic factors and laboratory findings.

Materials And Methods: We reviewed and analyzed data from patients who were admitted and diagnosed with COVID-19 at 10 hospitals in Daegu, South Korea, between January and July 2020. We randomized and assigned patients to the development and validation groups at a 70% to 30% ratio. Read More

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September 2021

Post-implantation syndrome after frozen elephant trunk is associated with the volume of new-onset aortic thrombus.

J Thorac Dis 2021 Jul;13(7):4311-4321

Department of Vascular and Endovascular Surgery, University Hospital Münster, Münster, Germany.

Background: Post-implantation syndrome (PIS) is defined as non-infectious continuous fever and a concomitant rise in inflammatory markers shortly after endovascular aortic repair. PIS occurrence after hybrid procedures, such as the frozen elephant trunk (FET) technique, has not been adequately investigated. The current study aims to define the incidence of PIS after the FET and to identify possible risk factors associated with its occurrence. Read More

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