14,393 results match your criteria hpv vaccine

Microtiter plate-based differential scanning fluorimetry: a high-throughput method for efficient formulation development.

J Pharm Sci 2022 May 20. Epub 2022 May 20.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China; College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Nano/microparticles are widely used as vaccine adjuvants to improve antigen stability and enhance immune response. Conformational stability of a given protein was normally assessed using differential scanning calorimetry (DSC) for the optimization of formulation and for ensuring antigen stability in vaccine products. Here, a higher throughput version, namely the microtiter plate-based differential scanning fluorimetry (DSF) method was developed and optimized for assessing the protein thermal stability in the particulate adjuvant-adsorbed form. Read More

View Article and Full-Text PDF

Barriers to HPV Vaccination Among Korean Men in the United States.

Minjin Kim

Clin J Oncol Nurs 2022 Jun;26(3):324-327

University of Cincinnati.

Human papillomavirus (HPV) vaccination disparities may exacerbate the substantial racial and ethnic variations in rates of HPV-associated cancers. To reduce these disparities, special attention must be paid to increasing vaccine uptake among subgroups of Asian American men and women who are less likely to engage in primary prevention of HPV-associated cancers. Because nurses are often involved in vaccine discussions, they can play a critical role in improving HPV vaccine uptake by providing culturally appropriate and responsive messages to their patients. Read More

View Article and Full-Text PDF

Different Human Papillomavirus Types Share Early Natural History Transitions in Immunocompetent Women.

Int J Cancer 2022 May 23. Epub 2022 May 23.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.

Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS-LSIL Triage Study (ALTS), and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high-grade cervical abnormalities at any point during follow-up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged <30 years). Read More

View Article and Full-Text PDF

An investigation into human papillomavirus (HPV) vaccination for patients undergoing surgery for high-grade cervical or vulvar dysplasia.

Gynecol Oncol Rep 2022 Jun 15;41:101001. Epub 2022 May 15.

The Ohio State University and Arthur G. James Cancer Hospital and Solove Research Institute, Division of Gynecologic Oncology, Columbus, OH, USA.

Introduction: Eligibility for the human papillomavirus (HPV) vaccine now includes adults 27 through 45 years. It has not been reported how providers are addressing HPV vaccination in patients with existing preinvasive disease. Our objectives were to determine the rates at which vaccination is offered to and received by patients undergoing surgery for high-grade cervical or vulvar dysplasia. Read More

View Article and Full-Text PDF

Long-term clinical course and prognosis of vaccine-related persistent itching nodules (1997-2019): An observational study.

Vaccine X 2022 Aug 29;11:100163. Epub 2022 Apr 29.

Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Vaccines adsorbed to aluminium can induce long-lasting intensely itching subcutaneous nodules (granulomas) at the injection site as well as contact allergy to aluminium. In clinical trials of a new acellular pertussis vaccine performed in the 1990s (Gothenburg, Sweden) with 76 000 participants, itching nodules were reported in 745 children. A positive patch test to aluminium was verified in 77% of the tested children with itchy nodules. Read More

View Article and Full-Text PDF

The difference in the effectiveness of human papillomavirus vaccine based on smoking status.

J Obstet Gynaecol Res 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, Saga, Japan.

Aim: This study aimed to clarify (1) the effectiveness of human papillomavirus (HPV) vaccine against precancerous lesions of uterine cervical cancer and (2) the difference in these effectiveness based on smoking status.

Methods: This retrospective cross-sectional study considered women aged 20-24 who underwent cervical cancer screening in Saga City from April 2014 to March 2020. Cervical cytology and histological diagnosis were compared with or without HPV vaccination and smoking. Read More

View Article and Full-Text PDF

An all-in-one adjuvanted therapeutic cancer vaccine targeting dendritic cell cytosol induces long-lived tumor suppression through NLRC4 inflammasome activation.

Biomaterials 2022 May 10;286:121542. Epub 2022 May 10.

Clinical Vaccine R&D Center, Chonnam National University, Hwasun-gun, Jeonnam, 58128, Republic of Korea; Combinatorial Tumor Immunotherapy MRC, Chonnam National University Medical School, Hwasun-gun, Jeonnam, 58128, Republic of Korea; Department of Microbiology, Chonnam National University Medical School, Hwasun-gun, Jeonnam, 58128, Republic of Korea; Immunotherapy Innovation Center, Hwasun-gun, Jeonnam, 58128, Republic of Korea. Electronic address:

Therapeutic cancer vaccines (TCVs) should induce robust tumor-specific T cell responses. To achieve this, TCVs incorporate T cell epitopes and strong adjuvants. Here, we report an all-in-one adjuvanted cancer vaccine platform that targets the intracellular compartment of dentritic cells and subsequently induces effective cytotoxic T cell responses. Read More

View Article and Full-Text PDF

Human papillomavirus prevalence among unvaccinated young female college students in Botswana: A cross-sectional study.

S Afr Med J 2022 04 29;112(5):335-340. Epub 2022 Apr 29.

School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.

Background: Human papillomavirus (HPV) is a sexually transmitted infection and a causative agent of cervical cancer. It is common in adolescent girls and young women, and the majority of infections are transient and asymptomatic. In Botswana, there are currently no data on the HPV prevalence against which the impact of prophylactic HPV vaccines can be measured. Read More

View Article and Full-Text PDF

[Immunoprevention of HPV-Associated Neoplasias].

Gerd E Gross

MMW Fortschr Med 2022 May;164(10):56-60

, Bahhofstraße 81, 29559, Wrestedt-Stederdorf, Deutschland.

View Article and Full-Text PDF

HPV Vaccination: Does It Have a Role in Preventing Penile Cancer and Other Preneoplastic Lesions?

Semin Oncol Nurs 2022 May 13:151284. Epub 2022 May 13.

Department of Urology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Objectives: Human papillomavirus (HPV) is the most common sexually transmitted infection globally, which causes nearly all cervix carcinomas and contributes to oropharyngeal, penile, vulva, vagina, and anal cancers. Despite the role of HPV in several preneoplastic and cancerous lesions in men, male vaccine coverage is low. This article aims to provide insights into the pathophysiology of HPV-related penile cancer and penile intraepithelial neoplasia (PeIN). Read More

View Article and Full-Text PDF

Increases in human papillomavirus vaccine coverage over 12 months among a community-recruited cohort of gay, bisexual, and other men who have sex with men in Canada.

Vaccine 2022 May 13. Epub 2022 May 13.

University of Toronto, Toronto, Ontario, Canada; Unity Health Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Starting in 2015/16, most Canadian provinces introduced publicly-funded human papillomavirus (HPV) vaccination programs for gay, bisexual, and other men who have sex with men (GBM) aged ≤ 26 years. We estimated 12-month changes in HPV vaccine coverage among community-recruited GBM from 2017 to 2021 and identified baseline factors associated with vaccine initiation (≥1 dose) or series completion (3 doses) among participants who were unvaccinated or partially vaccinated at baseline.

Methods: We recruited sexually-active GBM aged ≥ 16 years in Montreal, Toronto, and Vancouver, Canada, from 02/2017 to 08/2019 and followed them over a median of 12 months (interquartile range = 12-13 months). Read More

View Article and Full-Text PDF

Human Papillomavirus Vaccine Impact and Effectiveness Through 12 Years After Vaccine Introduction in the United States, 2003 to 2018.

Ann Intern Med 2022 May 17. Epub 2022 May 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (J.W.G., L.E.M.).

Background: Human papillomavirus (HPV) vaccination was introduced in 2006 for females and in 2011 for males.

Objective: To estimate vaccine impact and effectiveness against quadrivalent HPV vaccine (4vHPV)-type prevalent infection among sexually experienced U.S. Read More

View Article and Full-Text PDF

Computer-Animated Relational Agents in Human Papillomavirus Vaccination Education.

Obstet Gynecol 2022 May 5;139(5):913-915. Epub 2022 Apr 5.

Division of Gynecologic Oncology, Department of Oncology, the Department of Obstetrics and Gynecology, the Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Department of Oncology, School of Medicine, and the Behavioral and Field Research Core, Department of Oncology, Wayne State University, and the Wayne State University School of Medicine, Detroit, Michigan; the Thomas Jefferson University College of Population Health and Main Line Health Center for Population Health Research at Lankenau Institute for Medical Research, Philadelphia, Pennsylvania; the Department of Obstetrics and Gynecology, the Department of Family and Preventive Medicine, College of Medicine, and the TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and Computer Sciences, Northeastern University, Boston, Massachusetts.

View Article and Full-Text PDF

Global online interest in cervical cancer care in the time of COVID-19: An infodemiology study.

Gynecol Oncol Rep 2022 Jun 10;41:100998. Epub 2022 May 10.

College of Medicine, University of the Philippines, Manila, Philippines.

Introduction: Internet search trends may gauge public awareness and interest in cancer and help identify key areas for improvement in public health interventions and awareness campaigns. During the COVID-19 pandemic, cervical cancer screening significantly decreased, and we hypothesized that this would be mirrored by a decreased online interest in cervical cancer care.

Methods: Using the Google Trends database, we analyzed 2018-2021 global search trends in the following topics: cervical cancer, human papillomavirus, HPV vaccine, Cervarix, Gardasil, Pap test, HPV test, and colposcopy. Read More

View Article and Full-Text PDF

Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination.

Clin Transl Immunology 2022 8;11(5):e1392. Epub 2022 May 8.

Transgene SA Illkirch-Graffenstaden France.

Objective: Antitumor viral vaccines, and more particularly poxviral vaccines, represent an active field for clinical development and translational research. To improve the efficacy and treatment outcome, new viral vectors are sought, with emphasis on their abilities to stimulate innate immunity, to display tumor antigens and to induce a specific T-cell response.

Methods: We screened for a new poxviral backbone with improved innate and adaptive immune stimulation using IFN-α secretion levels in infected PBMC cultures as selection criteria. Read More

View Article and Full-Text PDF

A systematic review with meta-analysis of parental interventions for human papillomavirus vaccine uptake.

J Am Pharm Assoc (2003) 2022 Apr 13. Epub 2022 Apr 13.

Objectives: With the growing ability of pharmacists to vaccinate against HPV, this systematic review with meta-analysis examined the efficacy of interventions targeting parents of children and adolescents in the US to increase HPV vaccine uptake.

Data Sources: A systematic search of PubMed, Web of Science, SCOPUS, CINAHL, and Medline was conducted from January 2006 to January 2022.

Study Selection: We included parent-based randomized controlled trials (RCTs) in the US that measured actual HPV vaccine initiation and completion from patients' medical records. Read More

View Article and Full-Text PDF

Human papillomavirus vaccination related knowledge, and recommendations among healthcare providers in Southern China: a cross-sectional survey.

BMC Womens Health 2022 May 14;22(1):169. Epub 2022 May 14.

The Research Institute of Maternity and Child Medicine, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, No. 2004, Hongli Road, Futian District, Shenzhen, 518000, China.

Background: Little research has been conducted to explore variables associated with the healthcare providers' (HCPs) understanding and recommendation of human papillomavirus vaccine (HPV) since the vaccine was approved for use in China.

Methods: A large-scale cross-sectional survey was conducted in southern China covering Guangdong, Guangxi, and Hainan provinces between April 2019 and October 2019. Firstly, descriptive analysis was used to access awareness, knowledge, barriers, and recommendations toward HPV vaccine among all participants. Read More

View Article and Full-Text PDF

The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss.

J Natl Cancer Inst 2022 May 14. Epub 2022 May 14.

Department of Hematolgy and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA.

Oropharyngeal squamous cell carcinoma (OPSCC) accounts for over half of all head and neck cancers. Since the 1970s, OPSCC has shifted from an environmentally triggered to virally mediated disease due to a sharp rise in human papillomavirus (HPV)-related SCC. Although a highly effective prophylactic vaccine is available, its current implementation is far below national targets and OPSCC incidence is predicted to further increase by 2045. Read More

View Article and Full-Text PDF

Awareness and Knowledge of HPV, HPV Vaccination, and Cervical Cancer among an Indigenous Caribbean Community.

Int J Environ Res Public Health 2022 05 7;19(9). Epub 2022 May 7.

College of Nursing, University of Utah, 10 South 2000 East, Salt Lake City, UT 84112, USA.

Caribbean women experience a cervical cancer incidence rate that is three times higher than that among their North American counterparts. In this study, we performed a needs assessment of the knowledge and awareness of HPV, HPV vaccination, and cervical cancer and receipt of cervical cancer screening among an indigenous Caribbean community. We purposively recruited individuals aged ≥18 from a community health care clinic ( = 58) to complete a 57-item structured interview including items on demographics, cancer history, knowledge and awareness of HPV, HPV vaccines, cervical cancer, and cervical cancer screening. Read More

View Article and Full-Text PDF

Effect of Different Educational Interventions on Knowledge of HPV Vaccination and Cervical Cancer among Young Women: A Preliminary Report.

Int J Environ Res Public Health 2022 Apr 25;19(9). Epub 2022 Apr 25.

Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

The incidence and mortality rates of cervical cancer are rising among young women in Japan. In November 2021, the Japanese Ministry of Health, Labour, and Welfare reinstated the active recommendation for the human papillomavirus (HPV) vaccine, which was discontinued in June 2013 due to reports of adverse reactions, including chronic pain and motor dysfunction, following vaccination. However, vaccine hesitancy among the younger generation remains, and it is essential to identify the barriers in vaccination uptake. Read More

View Article and Full-Text PDF

Parental intention to vaccinate adolescents with HPV vaccine in selected communities in Ibadan, Southwest Nigeria: an application of Integrated Behavioral Model.

Hum Vaccin Immunother 2022 May 13:2069959. Epub 2022 May 13.

Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Parents have important roles to play for adolescents to get the human papillomavirus (HPV) vaccine, an effective measure in the prevention of cervical and other HPV-related cancers. It is important to understand the intention of parents to have their adolescents vaccinated for optimal uptake of the vaccine in Nigeria. This study investigated the intention of parents in five selected communities to get their adolescents vaccinated with HPV vaccine in Ibadan, Nigeria using the Integrated Behavioral Model (IBM). Read More

View Article and Full-Text PDF

Cervical cancer prevention in Africa: A policy analysis.

J Cancer Policy 2022 Jan 1;32:100321. Epub 2022 Jan 1.

Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E Young Dr S, Los Angeles, CA 90095, United States; UCLA Center for Health Policy Research, University of California, Los Angeles, 10960 Wilshire Blvd, Los Angeles, CA 90024, United States. Electronic address:

Background: Cervical cancer is a major public health challenge in Africa. We analyzed the presence and content of policies for the primary, secondary and tertiary prevention of cervical cancer in Africa, to identify areas of opportunity for policy strengthening in the region most affected by cervical cancer globally.

Methods: We searched for publicly-available policy documents among countries in Africa. Read More

View Article and Full-Text PDF
January 2022

Human Papillomavirus Vaccination Over Time in Heterosexual and Sexual Minority Adults in the United States.

Health Equity 2022 14;6(1):307-312. Epub 2022 Apr 14.

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.

Purpose: We proposed to identify the factors that determine the trends in human papillomavirus (HPV) vaccination initiation and completion among heterosexual and sexual minority adults.

Methods: Using National Health and Nutrition Examination Survey database from 2007 to 2016, we performed chi-squared tests and multivariate logistic regression analysis.

Results: Heterosexual females initiated vaccination at 23. Read More

View Article and Full-Text PDF

Knowledge, attitudes, and practices among Indonesian urban communities regarding HPV infection, cervical cancer, and HPV vaccination.

PLoS One 2022 12;17(5):e0266139. Epub 2022 May 12.

Faculty of Medicine Universitas Indonesia, Division of Gynecologic Oncology, Department of Obstetric and Gynaecology, Dr. Cipto Mangunkusumo Hospital, Greater Jakarta, DKI Jakarta, Indonesia.

Background: Few studies explored Indonesian understanding of cervical cancer (CC) and the human papillomavirus (HPV) vaccination. We aimed to investigate the association between knowledge, attitudes, and practices (KAP) and socio-demographical influences related to HPV, CC, and vaccination among Indonesian urban citizens.

Methods: We conducted an online survey during March 2020-August 2021 using the Snowball sampling technique. Read More

View Article and Full-Text PDF

Genetic variability in minor capsid protein (L2 gene) of human papillomavirus type 16 among Indian women.

Med Microbiol Immunol 2022 Jun 13;211(2-3):153-160. Epub 2022 May 13.

Savitribai Phule Pune University, Ganeshkhind Road, Pune, 411007, India.

Human papillomavirus type 16 (HPV-16) is the predominant genotype worldwide associated with invasive cervical cancer and hence remains as the focus for diagnostic development and vaccine research. L2, the minor capsid protein forms the packaging unit for the HPV genome along with the L1 protein and is primarily associated with transport of genomic DNA to the nucleus. Unlike L1, L2 is known to elicit cross-neutralizing antibodies and thus becomes a suitable candidate for pan-HPV prophylactic vaccine development. Read More

View Article and Full-Text PDF

Improved population coverage of the human papillomavirus vaccine after implementation of a school-based vaccination programme: the Singapore experience.

Singapore Med J 2022 May 13. Epub 2022 May 13.

Youth Preventive Services, Health Promotion Board, Singapore.

Introduction: Cervical cancer has a high disease burden in Singapore, and it is strongly associated with human papillomavirus (HPV) infections. Despite constant efforts to encourage vaccination, local HPV vaccine uptake remains low. Universal mass vaccination is a proven cost-effective method to reduce the cervical cancer disease burden. Read More

View Article and Full-Text PDF

[Human papillomavirus vaccination available for boys also; information for oral healthcare providers].

Ned Tijdschr Tandheelkd 2022 Apr;129:21

Recently, the Dutch National Immunization Programme has started to offer the human papillomavirus (HPV) vaccination to boys as well as girls from the age of 10. The vaccine protects against long-term HPV infection, which can lead to cervical, anogenital and oropharyngeal cancer. Besides malignant disorders, a HPV infection can also lead to certain disorders of the skin and oral cavity. Read More

View Article and Full-Text PDF

Prevalence and Distribution of Vaccine-Preventable Genital Human Papillomavirus(HPV) Genotypes in Ghanaian Women Presenting for Screening.

Cancer Control 2022 Jan-Dec;29:10732748221094721

Department of Pathology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.

Background: Cervical cancer is the most common gynaecologic cancer in Ghana where it is also the second most common cause of all female cancers. A number of vaccines are available to provide both individual and population-level protection against persistent infection with high-risk human papillomaviruses (HR-HPV) and reduce the burden of cervical cancer. Data on the epidemiology of vaccine-preventable papillomaviruses in Ghana is scant. Read More

View Article and Full-Text PDF