46,110 results match your criteria hpv infection


Influence of HIV infection on the distribution of high-risk HPV types among women with cervical precancerous lesions in Yaounde, Cameroon.

Int J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Objectives: To characterise the high-risk HPV types associated with cervical precancerous lesions in women living in Yaounde Cameroon, and to determine their distribution with HIV status.

Methods: Women with abnormal pap smears recorded from February 2015 to May 2019 at Saint Martin de Porres' Health Centre, Yaounde, Cameroon were recruited in the study after obtaining informed consent. Pap smears were collected and re-examined. Read More

View Article and Full-Text PDF

Current salivary biomarkers for detection of human papilloma virus-induced oropharyngeal squamous cell carcinoma.

Head Neck 2021 Jul 31. Epub 2021 Jul 31.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Human papilloma virus (HPV) infection is a key risk factor and etiology for oropharyngeal squamous cell carcinoma (OPSCC). HPV-induced OPSCC is rapidly increasing in incidence, with men experiencing increased mortality. When identified at an early stage, HPV-induced OPSCC can be successfully treated. Read More

View Article and Full-Text PDF

Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis.

Cancer Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, People's Republic of China.

Background: PLEK2 (pleckstrin) could bind to membrane-bound phosphatidylinositols and further promote cell spread. Recently, several studies have noted the importance of PLEK2 in tumor metastasis. However, the role of PLEK2 in head and neck squamous cell carcinoma (HNSCC) remains to be elucidated. Read More

View Article and Full-Text PDF

Assessing national cervical cancer screening guidelines: Results from an HIV testing clinic also screening for cervical cancer and HPV in Soweto, South Africa.

PLoS One 2021 30;16(7):e0255124. Epub 2021 Jul 30.

Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Objective: A screening centre in Soweto, South Africa (SA), investigated high-risk human papillomavirus (HR-HPV), HIV, cervical cancer risk amongst women.

Methods: This cross-sectional study (June 2018-March 2019) describes screening results (Roche Linear Array HPV test and Pap smear liquid based cytology) and history of screening (known HIV status, antiretroviral therapy [ART] use, previous Pap smears). Data were stratified by age group (18-29, 30+ years), HIV status, Pap smear results and tested for statistical significance. Read More

View Article and Full-Text PDF

Salivary High-Risk Human Papillomavirus DNA as a Biomarker for Human Papillomavirus-Driven Head and Neck Cancers.

J Mol Diagn 2021 Jul 26. Epub 2021 Jul 26.

Saliva & Liquid Biopsy Translational Laboratory, School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Queensland, Australia; Translational Research Institute, Queensland, Australia. Electronic address:

High-risk human papillomavirus (HR-HPV) infection is one of the major risk factors for head and neck cancers (HNC). Despite the rising incidence, biomarkers for detection, prognostication and disease monitoring of HPV-driven HNC (HPV-HNC) are lacking. To evaluate the capacity of salivary HR-HPV DNA as a biomarker for HPV-HNC, salivary HR-HPV status of 491 primary HNC patients and 10 recurrent HNC patients was investigated at diagnosis using qPCR and MassARRAY. Read More

View Article and Full-Text PDF

Validation of CINtec® PLUS Cytology Kit in the Diagnosis of Persistent HPV Infections - Cohort Study in the Portuguese Population.

J Cytol 2021 Apr-Jun;38(2):94-100. Epub 2021 May 10.

Department of Pathological, Cytological and Thanatological Anatomy, School of Health of the Polytechnic Institute of Porto, Porto, Portugal.

Context: The use of the CINtec® PLUS Cytology Kit as a complementary method of diagnosis is intended to contribute to a risk assessment of CIN II+ cervical lesions development, thus avoiding unnecessary colposcopy in negative cases. This method has proved to be effective in the follow-up of cervical lesions, although there is need for consistency in the approach of equivocal or negative cytological results, with persistent positive High-Risk Human Papillomavirus (HR-HPV) test.

Aims: The present study intends to retrospectively evaluate the capacity of the CINtec® to add information to the clinical practice within the screening and follow-up of cervical lesions. Read More

View Article and Full-Text PDF

The genetic diversity of "papillomavirome" in bovine teat papilloma lesions.

Anim Microbiome 2021 Jul 28;3(1):51. Epub 2021 Jul 28.

Laboratório de Microbiologia Molecular, Instituto de Ciências da Saúde, Universidade Feevale, Novo Hamburgo, RS, Brazil.

Background: Papillomaviruses are small nonenveloped, circular double-stranded DNA viruses that belong to the Papillomaviridae family. To date, 29 Bos taurus papillomavirus (BPV) types have been described. Studies involving mixed BPV infections have rarely been reported in contrast to human papillomavirus (HPV), which is commonly described in numerous studies showing coinfections. Read More

View Article and Full-Text PDF

Sexual behaviour, human papillomavirus and its vaccine: a qualitative study of adolescents and parents in Andalusia.

BMC Public Health 2021 Jul 28;21(1):1476. Epub 2021 Jul 28.

Department of Nursing, University of Granada, Granada, Spain.

Background: Human papillomavirus (HPV) is one of the most common sexually transmitted infections and can be prevented by vaccination. The purpose of this study is to gain a better understanding, by analysing interview responses of adolescents and parents, of how adolescent sexual behaviour is approached in families, how widespread knowledge about HPV is in Andalusia, the autonomous region with the lowest vaccination rate in Spain, as well as to learn more about the interviewees' position regarding vaccination.

Methods: A qualitative study by means of 15 focus groups of adolescents (N = 137, aged 14-17 years) and five focus groups of parents with children of those ages (N = 37) was conducted in the provinces of Granada, Seville and Jaén (Andalusia, Spain). Read More

View Article and Full-Text PDF

Effectiveness Of Human Papillomavirus (HPV) Vaccination Against Penile Hpv Infection In Men Who Have Sex With Men And Transgender Women.

J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: In the United States, HPV vaccination has been recommended since 2011 for males aged 11-12 years, with catch-up vaccination recommended through age 26 years for previously unvaccinated men who have sex with men (MSM).

Methods: During 2016-2018, a cross-sectional study enrolled MSM and transgender women aged 18-26 years in Seattle, Washington. Participants submitted self-collected penile swab specimens for HPV genotyping. Read More

View Article and Full-Text PDF

Tumor-infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma.

Clin Exp Dent Res 2021 Jul 28. Epub 2021 Jul 28.

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Aichi Medical University, Nagakute, Japan.

Objectives: Squamous cell carcinoma is the most common malignancy in the oral cavity. Moreover, human papillomavirus (HPV) infection has been recently implicated in the onset of oral squamous cell carcinoma (OSCC). Regulatory T cells (Tregs) are Forkhead box P3 (FoxP3) positive and are normally involved in the mechanism by which organisms escape attacks from their own immune system; however, in tumors, these cells are known to suppress antitumor immunity and block the attack against tumors. Read More

View Article and Full-Text PDF

Human Papillomavirus Infection and Cervical Dysplasia in a Subset of Arab American Women.

Womens Health Rep (New Rochelle) 2021 16;2(1):273-278. Epub 2021 Jul 16.

Department of Pathology, Wayne State University School of Medicine/Detroit Medical Center, Detroit, Michigan, USA.

With limited health data on Arab Americans (AAs), we sought to describe the health-seeking behaviors, prevalence of abnormal cervical cytology and high-risk human papillomavirus (HPV) serotypes, and the relationship with socioeconomic factors among a subset of AA women. Retrospective observational cohort study of women undergoing routine cancer screening at the Arab-American Center for Economic and Social Services clinic. Data collected included demographics, tobacco use, gross monthly income, prior Papanicolaou (Pap) smear history, and results of cervical cytology and high-risk HPV testing. Read More

View Article and Full-Text PDF

Health Disparities Associated with Females Reporting Human Papillomavirus Infection in the United States.

Womens Health Rep (New Rochelle) 2021 14;2(1):245-253. Epub 2021 Jul 14.

Roseman University of Health Sciences College of Dental Medicine, South Jordan, Utah, USA.

Few studies provide detailed findings about the health disparities of women being told by a physician whether they have ever had a human papillomavirus (HPV) infection. This study sought to characterize the prevalence and characteristics associated with women age 18 to 59 years in the United States who report being told they were infected with HPV. This study used data from the National Health and Nutritional Examination Survey. Read More

View Article and Full-Text PDF

A novel recombinant protein vaccine containing the different E7 proteins of the HPV16, 18, 6, 11 E7 linked to the HIV-1 Tat (47-57) improve cytotoxic immune responses.

Biotechnol Lett 2021 Jul 27. Epub 2021 Jul 27.

Department of Microbiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: Human papillomavirus infection (HPV) is the most common viral infection which is causes of cervical, penal, vulvar, anal and, oropharyngeal cancer. E7 protein of HPV is a suitable target for induction of T cell responses and controlling HPV-related cancer. The aim of the current study was to designed and evaluated a novel fusion protein containing the different E7 proteins of the HPV 16, 18, 6 and 11, linked to the cell-penetrating peptide HIV-1 Tat 49-57, in order to improve cytotoxic immune responses in in-vitro and in-vivo. Read More

View Article and Full-Text PDF

Human Papillomavirus-Associated Head and Neck Cancer.

J Am Board Fam Med 2021 Jul-Aug;34(4):832-837

From Division of Otolaryngology-Head and Neck Surgery, George Washington University, Washington, DC (JCN, SF, CM, PEZ).

Oropharyngeal squamous cell carcinoma (OPSCC) has historically been attributable to tobacco and alcohol exposure and saw a decline in incidence after societal norms shifted away from smoking. In recent decades, this disease has had a re-emergence due to human papillomavirus (HPV) infection, now surpassing cervical cancer as the number 1 cause of HPV-related cancer in the United States. HPV-positive OPSCC differs from HPV-negative disease in epidemiology, prognosis, treatment, and prevention. Read More

View Article and Full-Text PDF
November 2020

Population-based utility scores for HPV infection and oropharyngeal squamous cell carcinoma among Indigenous Australians.

BMC Public Health 2021 Jul 26;21(1):1455. Epub 2021 Jul 26.

Australian Research Centre for Population Oral Health, Adelaide Dental School, The University of Adelaide, Adelaide Health & Medical Sciences Building, Adelaide, 5005, Australia.

Background: Oropharyngeal squamous cell carcinoma (OPSCC) is associated with high mortality. Human papillomavirus (HPV) infection is a significant risk factor for OPSCC. Utilities are fundamental values representing the strength of individuals' preferences for specific health-related outcomes. Read More

View Article and Full-Text PDF

HPV infection and vaccination in Sub-Saharan Africa: 10 years of research in Tanzanian female adolescents.

Trop Med Int Health 2021 Jul 26. Epub 2021 Jul 26.

Mwanza Intervention Trials Unit, National Institute of Medical Research, Mwanza, Tanzania.

Cervical cancer is the leading cause of cancer-related morbidity and mortality in many Sub-Saharan African (SSA) countries, including Tanzania. Most cervical cancer cases worldwide are attributable to infection of the cervix with Human Papillomavirus (HPV), a vaccine-preventable sexually transmitted infection (STI). Over the past 10 years, we have conducted a programme of HPV research in pre-adolescents and adolescents in Mwanza, the second-largest city in Tanzania, which is situated in a malaria-endemic region. Read More

View Article and Full-Text PDF

Characterisation of anal intraepithelial neoplasia and anal cancer in HIV-positive men by immunohistochemical markers p16, Ki-67, HPV-E4, and DNA methylation markers.

Int J Cancer 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Cancer Center Amsterdam CCA, Amsterdam University Medical Centers (Amsterdam UMC), Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

Human papillomavirus (HPV)-induced anal intraepithelial neoplasia (AIN, graded 1-3) is highly prevalent in HIV-positive (HIV+) men-who-have-sex-with-men (MSM), but only a minority of lesions progresses to cancer. This study aimed to characterise comprehensively anal tissue samples from a cross-sectional series (n = 104) of HIV + MSM and longitudinal series (n = 40) of AIN2/3 progressing to cancer using different biomarkers. The cross-sectional series consisted of 8 normal, 26 AIN1, 45 AIN2, 15 AIN3 and 10 anal squamous cell carcinoma. Read More

View Article and Full-Text PDF

Anal Cancer with Mediastinal Lymph Node Metastasis.

Gastrointest Tumors 2021 Jun 8;8(3):134-137. Epub 2021 Mar 8.

Department of Hematology and Oncology, NYU Winthrop Hospital, Mineola, New York, USA.

Squamous cell carcinoma of the anal canal remains rare, with metastatic disease even less commonly reported. We present a case of a patient with both a prior history of squamous cell carcinoma of the anal canal as well as breast cancer, who was without evidence of disease for 1 year. She was subsequently found to have FDG-avid mediastinal lymphadenopathy, initially assumed to be related to her more recent breast cancer. Read More

View Article and Full-Text PDF

Immunotherapy Advances in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Its Relationship With Human Papillomavirus.

Front Immunol 2021 8;12:652054. Epub 2021 Jul 8.

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.

Head and neck cancer (HNC) is the sixth most common malignancy worldwide; head and neck squamous cell carcinoma (HNSCC) account for the most cases of HNC. Past smoking and alcohol consumption are common risk factors of HNSCC; however, an increasing number of cases associated with human papillomavirus (HPV) infection have been reported in recent years. The treatment of HNSCC is integrated and multimodal including traditional surgery, radiotherapy, chemotherapy, and targeted therapy. Read More

View Article and Full-Text PDF

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage.

Infect Dis Obstet Gynecol 2021 30;2021:9919446. Epub 2021 Jun 30.

Oncology Surgery Department, Hospital Regional de Alta Especialidad del Bajío, León, Guanajuato, Mexico.

Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Read More

View Article and Full-Text PDF

Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features.

Iran J Med Sci 2021 Jul;46(4):256-262

Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The role of human papillomavirus (HPV), as a common infection, has been evaluated in many cancers such as the cervix and squamous cell carcinoma of the head and neck. To the best of our knowledge, for the first time, the association of HPV with papillary thyroid carcinoma (PTC) and its pathologic features are investigated.

Methods: A retrospective cross-sectional study was conducted from May 2014 to January 2018 in several hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Read More

View Article and Full-Text PDF

[The cervical microbiota characteristics in patients with human papillomavirus infection].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):867-874

Department of Microbiology,School of Public Health, Southern Medical University, Guangzhou 510515, China Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

To investigate the characteristics of cervical microbiota in patients with HPV (Human Papillomavirus) infection, and to analyze the associations of cervical microbiota and HPV infection or cervicitis. 300 samples underwent HPV nucleic acid testing was collected in this case-control study from June 2019 to April 2020 in the Zhujiang Hospital of Southern Medical University, there were 150 cases allocated in HPV infection group (HPV+), and 150 cases of negative nucleic acid test were non-infectious Group (HPV-). Next-generation sequencing was used to sequence the V4 region of the bacterial 16S rRNA gene, and QIIME pipeline was used to analysis the microbiota composition of the two groups. Read More

View Article and Full-Text PDF

The impact of HPV vaccination on the prevention of oropharyngeal cancer: A scoping review.

Community Dent Health 2021 Jul 15. Epub 2021 Jul 15.

Centre for Dental Public Health and Primary Care, Queen Mary University London, United Kingdom.

Introduction: HPV-associated oropharyngeal cancer (OPC) has one of the most rapidly rising incidences of any cancer in high-income countries. HPV vaccination is being tested to prevent HPV-associated OPC.

Objective: To determine the effect of Human Papilloma Virus (HPV) vaccination on the prevention of OPC in adults worldwide. Read More

View Article and Full-Text PDF

Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India.

Indian J Ophthalmol 2021 Aug;69(8):2111-2115

Department of Molecular Genetics, Aravind Medical Research Foundation, Madurai; Department of Molecular Biology, Aravind Medical Research Foundation, Affiliated to Alagappa University, Karaikudi, India.

Purpose: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.

Methods: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.

Results: Of 106 RB patients, 55 were male and 51 were female. Read More

View Article and Full-Text PDF

Biologic and behavioral associations of estrogen receptor alpha positivity in head and neck squamous cell carcinoma.

Oral Oncol 2021 Jul 22;121:105461. Epub 2021 Jul 22.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address:

Objectives: Tumor HPV status is an established independent prognostic marker for oropharynx cancer (OPC). Recent studies have reported that tumor estrogen receptor alpha (ERα) positivity is also associated with prognosis independent of HPV. Little is known about the biologic and behavioral predictors of ERα positivity in head and neck squamous cell cancer (HNSCC). Read More

View Article and Full-Text PDF

Patterns of multiple human papillomavirus clearance during 5-aminolevulinic acid-based photodynamic therapy in patients with genital warts.

Photodiagnosis Photodyn Ther 2021 Jul 22:102454. Epub 2021 Jul 22.

Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Multiple human papillomavirus infections are commonly encountered in genital warts. Infection can be eliminated using 5-aminolevulinic acid-based photodynamic therapy. The aim of this study was to identify the preponderant genotypes and patterns of human papillomavirus co-infection clearance during photodynamic therapy in patients with genital warts. Read More

View Article and Full-Text PDF

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV.

Am J Pathol 2021 Jul 22. Epub 2021 Jul 22.

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA. Electronic address:

Viruses are the second leading cause of cancer worldwide, and human papillomavirus (HPV)-associated head and neck cancers are increasing in incidence in the United States. HPV preferentially infects the crypts of the tonsils rather than the surface epithelium. The present study sought to characterize the unique microenvironment within the crypts to better understand the host tropism of HPV to a lymphoid rich organ. Read More

View Article and Full-Text PDF

The Potential Impact of High-Risk Human Papillomavirus-Negative Cervical Intraepithelial Neoplasia 2+ on Primary Human Papillomavirus Screening.

Am J Clin Pathol 2021 Jul 24. Epub 2021 Jul 24.

Preventive Gynecology Unit, European Institute of Oncology IRCCS, Milan, Italy.

Objectives: To investigate the prevalence of high-risk human papillomavirus (HPV)-negative cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) and to analyze the distribution of other genotypes in this subset.

Methods: In total, 431 women who underwent excisional surgical treatment for CIN or ICC at the European Institute of Oncology, Milan, Italy, from January 2016 to December 2017 were retrospectively analyzed. The Linear Array HPV genotyping test (Roche Diagnostics) was performed on a postaliquot from high-risk-HPV-negative liquid-based cervical specimens, when available. Read More

View Article and Full-Text PDF

The characteristics and risk factors of human papillomavirus infection: an outpatient population-based study in Changsha, Hunan.

Sci Rep 2021 Jul 23;11(1):15128. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.

This cross-sectional study investigated the characteristics of cervical HPV infection in Changsha area and explored the influence of Candida vaginitis on this infection. From 11 August 2017 to 11 September 2018, 12,628 outpatient participants ranged from 19 to 84 years old were enrolled and analyzed. HPV DNA was amplified and tested by HPV GenoArray Test Kit. Read More

View Article and Full-Text PDF

Prevalence of High-Risk Human Papillomavirus Infections before and after Cervical Lesion Treatment, among Women Living with HIV.

J Clin Med 2021 Jul 15;10(14). Epub 2021 Jul 15.

Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

Even when receiving combination antiretroviral therapy, women living with HIV are at high risk of human papillomavirus (HPV) infection and/or cervical lesions, including cancer. Using data from the PapilloV prospective cohort, we evaluated the prevalence of high-risk HPV (HR-HPV) infections after cervical lesion treatment and investigated factors associated with their carriage. Women were followed up for three years with annual Pap smear and HPV genotyping. Read More

View Article and Full-Text PDF