105 results match your criteria hpt lead


A Woman with a 27-Year History of Hyperparathyroidism and Hypercalcemia Who Was Diagnosed with Low-Grade Parathyroid Carcinoma.

Am J Case Rep 2021 Mar 11;22:e930301. Epub 2021 Mar 11.

Department of General, Endocrine and Vascular Surgery, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND Parathyroid carcinoma (PC), accounting for 0.005% of all cancers, is responsible for less than 1% of all cases of primary hyperparathyroidism, and equally affects males and females, usually in 4th or 5th decades of life. PC can occur sporadically and can be associated with congenital genetic syndromes such as hyperparathyroidism-jaw tumor syndrome (HPT-JT), isolated familial hyperparathyroidism, or multiple endocrine neoplasia 1 and 2 syndromes. Read More

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Two parathyroid adenomas in a Saudi female on hemodialysis diagnosed with tertiary hyperparathyroidism: a case report.

AME Case Rep 2021 25;5. Epub 2021 Jan 25.

Department of General Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.

A case of a 51-year-old female on hemodialysis 3 times per week for the past seven years was admitted to the endocrine surgery department on July of 2018 in Al-Hada Armed Forces hospital in Taif city, Saudi Arabia. Presented with complains of bone ache in her hip and lower limbs. Her labs showed that parathyroid hormone (PTH) has reached 4,267. Read More

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January 2021

Outcomes of a COVID-19 recovery program for patients hospitalized with SARS-CoV-2 infection in New York City: A prospective cohort study.

PM R 2021 Feb 18. Epub 2021 Feb 18.

Department of Rehabilitation Medicine, Weill Cornell Medicine, New York, New York, USA.

Background: In the spring of 2020, New York City was an epicenter of coronavirus disease 2019 (COVID-19). The post-hospitalization needs of COVID-19 patients were not understood and no outpatient rehabilitation programs had been described.

Objective: To evaluate whether a virtual rehabilitation program would lead to improvements in strength and cardiopulmonary endurance when compared with no intervention in patients discharged home with persistent COVID-19 symptoms. Read More

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February 2021

Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism.

Sci Rep 2021 Jan 12;11(1):653. Epub 2021 Jan 12.

Department of Otolaryngology - Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, No 6, Sec. West, Jiapu Rd., Puzi-City, Chiayi County, Taiwan.

Patients with end-stage renal disease (ESRD) may demonstrate secondary hyperparathyroidism (SHPT), characterized by parathyroid hormone oversecretion in response to electrolyte imbalance (e.g., hypocalcemia and hyperphosphatemia). Read More

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January 2021

Toxicity and accumulation of 6-OH-BDE-47 and newly synthesized 6,6'-diOH-BDE-47 in early life-stages of Zebrafish (Danio rerio).

Sci Total Environ 2021 Apr 17;763:143036. Epub 2020 Oct 17.

China State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Dihydroxylated polybrominated diphenyl ethers (diOH-PBDEs) appear to be natural products or metabolites of PBDEs in some marine organisms, yet its toxicity is still largely unknown. With a newly lab-synthesized diOH-PBDE, 6,6'-dihydroxy-2,2',4'4'-tetrabromodiphenyl ether (6,6'-diOH-BDE-47) in hand, the present study has provided the first data set to compare 6-hydroxy-2,2',4'4'- tetrabromodiphenyl ether (6-OH-BDE-47) and 6,6'-diOH-BDE-47 for their acute toxicity and accumulation, and thyroid hormone levels in treated zebrafish larvae. By real time-PCR technique, transcripts of hypothalamic-pituitary-thyroid axis associated genes were also investigated in developing larvae at 96 h post fertilization (96 hpf). Read More

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F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy.

Diagnostics (Basel) 2020 Oct 20;10(10). Epub 2020 Oct 20.

Section of Radiology and Radiation Oncology, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.

Tertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can be the end result of persistent secondary hyperparathyroidism and is most commonly observed in patients with long-standing chronic kidney disease (CKD) and often after renal transplantation. Untreated HPT can lead to progressive bone disease, fibrocystic osteitis, and soft-tissue calcifications, along with other severe complications. Read More

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October 2020

Are the thyroid and adrenal system alterations linked in depression?

Psychoneuroendocrinology 2020 12 29;122:104831. Epub 2020 Sep 29.

APF2R, Centre Hospitalier, Pôle 8/9, 68250 Rouffach, France.

Background: Disturbances in the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes have been frequently found in major depression. Given that glucocorticoids may inhibit thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion, it has been hypothesized that hypercortisolemia could lead to HPT axis abnormalities. So far, data on interactions between the HPA and HPT axes in depression remain inconclusive. Read More

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December 2020

Brown tumor complicating end-stage kidney disease.

Clin Nephrol Case Stud 2020 12;8:72-79. Epub 2020 Oct 12.

Department of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Baylor University Medical Center, Dallas, TX, USA.

Longstanding, severe hyperparathyroidism (HPT) can lead to the formation of "brown tumors". A brown tumor is a radiolucent bone lesion that is locally destructive; it is not a neoplasm, but rather a stromal mass consisting of fibrous tissue, poorly mineralized woven bone, and supporting vasculature. These tumors are a rare complication of advanced primary or secondary HPT. Read More

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October 2020

Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in .

IUCrJ 2020 Sep 25;7(Pt 5):934-948. Epub 2020 Aug 25.

Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City 701, Taiwan.

In , an important opportunistic pathogen that causes numerous acute and chronic infections, the hybrid two-component system (TCS) regulates the swarming ability and biofilm formation with a multistep phospho-relay, and consists of hybrid-sensor histidine kinase (HK), histidine-containing phospho-transfer protein (Hpt) and response regulator (RR). In this work, two crystal structures of HptB and the receiver domain of HK PA1611 (PA1611REC) of have been determined in order to elucidate their interactions for the transfer of the phospho-ryl group. The structure of HptB folds into an elongated four-helix bundle - helices α2, α3, α4 and α5, covered by the short N-terminal helix α1. Read More

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September 2020

The COVID-19 pandemic in Norway: The dominance of social implications in framing the policy response.

Health Policy Technol 2020 Dec 28;9(4):663-672. Epub 2020 Aug 28.

School of Humanities and Social Sciences, Aston University, Birmingham B4 7ET, United Kingdom.

Objectives: To describe the impact and policy response to the COVID-19 Pandemic on Norway and the implications this has for future policy development and Norwegian society.

Methods: Documentary analysis of publicly available statistics, government documents and media sources.

Results: Three different agendas motivated Norwegian policy: stemming the spread of the virus domestically, mitigating the impact on the economy and addressing the social costs of the policy response. Read More

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December 2020

Low-dose effects on thyroid disruption in zebrafish by long-term exposure to oxytetracycline.

Aquat Toxicol 2020 Oct 20;227:105608. Epub 2020 Aug 20.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Electronic address:

As a feed additive in agriculture, the antibiotic oxytetracycline (OTC) has become widely distributed in the natural environment, leading to the exposure of many organisms to low doses of OTC. Although OTC is clinically contraindicated in children because of its multiple side effects, the effect of exposure to low doses of environmental OTC on children is unknown, particularly during development. In this study, we investigated the effects of OTC on the thyroid endocrine system in zebrafish, through determinations of the whole-body contents of triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) by enzyme-linked immunosorbent assay, and analysis of the mRNA expression of regulatory genes involved in the hypothalamus-pituitary-thyroid (HPT) axis using quantitative real-time polymerase chain reaction. Read More

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October 2020

Remarkable Structural Diversity between Zr/Hf and Rare-Earth MOFs via Ligand Functionalization and the Discovery of Unique (4, 8)-c and (4, 12)-connected Frameworks.

J Am Chem Soc 2020 Sep 4;142(37):15986-15994. Epub 2020 Sep 4.

Department of Chemistry, University of Crete, Voutes, Heraklion 71003, Greece.

Ligand modification in MOFs provides great opportunities not only for the development of functional materials with new or enhanced properties but also for the discovery of novel structures. We report here that a sulfone-functionalized tetrahedral carboxylate-based ligand is capable of directing the formation of new and fascinating MOFs when combined with Zr/Hf and rare-earth metal cations (RE) with improved gas-sorption properties. In particular, the resulting M--SO (M: Zr, Hf) materials display a new type of the augmented -a net, which is different as compared to the -a framework formed by the nonfunctionalized tetrahedral ligand. Read More

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September 2020

Automated detection of severity of hypertension ECG signals using an optimal bi-orthogonal wavelet filter bank.

Comput Biol Med 2020 08 23;123:103924. Epub 2020 Jul 23.

Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore, Singapore; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Department of Biomedical Engineering, School of Science and Technology, SUSS, Singapore.

Hypertension (HPT) is a serious risk factor for cardiovascular disease and if not controlled in the early stage, can lead to serious complications. Long-standing HPT can induce heart muscle hypertrophy which will be reflected on electrocardiography (ECG). However, early stage of HPT may have no clinically discernible ECG perturbations, and is difficult to diagnose manually from the standard ECG. Read More

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Impact of in-feed sodium butyrate or sodium heptanoate protected with medium-chain fatty acids on gut health in weaned piglets challenged with F4.

Arch Anim Nutr 2020 Aug 28;74(4):271-295. Epub 2020 Feb 28.

Animal Nutrition and Welfare Service, Animal and Food Science Department, Facultat de Veterinària, Universitat Autònoma de Barcelona , Bellaterra, Spain.

Short and medium-chain fatty acids (SCFA and MCFA, respectively) are commonly used as feed additives in piglets to promote health and prevent post-weaning diarrhoea. Considering that the mechanism and site of action of these fatty acids can differ, a combined supplementation could result in a synergistic action. Considering this, it was aimed to assess the potential of two new in-feed additives based on butyrate or heptanoate, protected with sodium salts of MCFA from coconut distillates, against enterotoxigenic (ETEC) F4 using an experimental disease model. Read More

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Effects of chlorocholine chloride on pubertal development and reproductive functions in male rats.

Toxicol Lett 2020 Feb 2;319:1-10. Epub 2019 Nov 2.

Department of Toxicology, School of Public Health, Peking University Health Science Center, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China. Electronic address:

Chlorocholine chloride (CCC), a plant growth retardant, may act as an endocrine disruptor. Our previous study showed that pubertal CCC exposure in rats might decrease testosterone (T) synthesis. This study observed the changes in pubertal development and reproduction of male rats exposed to CCC and its underlying mechanisms. Read More

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February 2020

Uremic leontiasis ossea due to secondary hyperparathyroidism complicated by vitamin C deficiency in a non-adherent chronic hemodialysis patient: A case report.

Clin Nephrol Case Stud 2019 9;7:54-59. Epub 2019 Sep 9.

Department of Medicine.

Non-adherence to medical therapy in patients with end-stage kidney disease (ESKD) can lead to severe metabolic derangements rarely seen in the current medical era. Such complications may take the form of secondary hyperparathyroidism (HPT) leading to rare manifestations of bone mineral disease, and profound vitamin C deficiency from poor nutrition combined with removal of water-soluble vitamins during dialysis. Secondary HPT causes renal osteodystrophy which can lead to diffuse enlargement of the facial skeleton and morphological changes suggestive of leontiasis ossea. Read More

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September 2019

The role of intraoperative parathyroid hormone (IOPTH) determination for identification and surgical strategy of sporadic multiglandular disease in primary hyperparathyroidism (pHPT).

Best Pract Res Clin Endocrinol Metab 2019 10 8;33(5):101310. Epub 2019 Aug 8.

Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:

Intraoperative PTH monitoring (IOPTH) made minimally invasive parathyroidectomy in patients with primary HPT possible. However, with the increasing accuracy of preoperative localization studies there is a growing discussion if IOPTH is necessary in patients with localized single gland disease (concordant preoperative localization studies). Different interpretation criteria have been developed - each with their particular advantages and disadvantages, but the "perfect" criterion is still missing. Read More

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October 2019

Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism.

Front Endocrinol (Lausanne) 2019 23;10:489. Epub 2019 Jul 23.

Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.

Cryptorchidism, or undescended testis, is a well-known risk factor for testicular cancer and impaired semen quality in adulthood, conditions which have their origins in early fetal and postnatal life. In human pregnancy, the interplay of testicular and placental hormones as well as local regulatory factors and control by the hypothalamic-pituitary (HP) axis, lead to testicular descent by term. The normal masculine development may be disrupted by environmental factors or genetic defects and result in undescended testes. Read More

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Exceptional Strengthening of Biodegradable Mg-Zn-Ca Alloys through High Pressure Torsion and Subsequent Heat Treatment.

Materials (Basel) 2019 Aug 2;12(15). Epub 2019 Aug 2.

Physics of Nanostructured Materials, Faculty of Physics, University of Vienna, 1090 Vienna, Austria.

In this study, two biodegradable Mg-Zn-Ca alloys with alloy content of less than 1 wt % were strengthened via high pressure torsion (HPT). A subsequent heat treatment at temperatures of around 0.45 led to an additional, sometimes even larger increase in both hardness and tensile strength. Read More

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Circadian Control of Neuroendocrine Function: Implications for Health and Disease.

Curr Opin Physiol 2018 Oct 15;5:133-140. Epub 2018 Nov 15.

Department of Psychology, University of California, Berkeley, CA, 94720.

The circadian timing system orchestrates daily rhythms in physiology and behavior via the suprachiasmatic nucleus (SCN), the master brain clock. Because endocrine secretions have far-reaching influence on the brain and periphery, circadian regulation of hormones is essential for normal functioning and disruptions to circadian timing (e.g. Read More

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October 2018

Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(14):e15007

Spinal tumor center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Read More

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Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis.

Langenbecks Arch Surg 2019 Feb 7;404(1):71-79. Epub 2019 Feb 7.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Introduction: Tertiary hyperparathyroidism (tHPT), i.e., persistent HPT after kidney transplantation, affects 17-50% of transplant recipients. Read More

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February 2019

Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.

Ecotoxicol Environ Saf 2019 Apr 1;170:25-32. Epub 2018 Dec 1.

School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Organophosphate flame retardants (OPFRs) have been widely used as alternatives to polybrominated diphenyl ethers for fire prevention. OPFRs are suspected of causing potential thyroid disruption in humans. In fish, their thyroid hormone modulation is reported but the mechanisms of this modulation are less understood. Read More

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Functioning and quality of life in patients with neuropathy associated with anti-MAG antibodies.

J Neurol 2018 Dec 10;265(12):2927-2933. Epub 2018 Oct 10.

Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, Milan, Italy.

Although anti-myelin-associated glycoprotein (MAG) antibody neuropathy is reported as a slowly progressive disease, it can lead to significant disability and impairment of health-related quality of life (HR-QoL) and social participation. The aim of this cross-sectional study was to evaluate the functioning and HR-QoL determinants in 67 patients with anti-MAG neuropathy in terms of the International Classification of Functioning, Disability, and Health (ICF). Evaluations included: Medical Research Council (MRC) sum score, Sensory Modality Sum score (SMS), Berg balance scale (BBS), Fatigue Severity Scale (FSS), Visual Analogue Scale (VAS) for pain, 9-Hole Peg Test (9-HPT), 6-min Walk Distance (6MWD), Impact on Participation and Autonomy (IPA) and the physical component score (PCS) and mental component score (MCS) of the short-form-36 health status scale (SF-36) HR-QoL measure. Read More

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December 2018

Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice.

Authors:
F E Wondisford

Methods Mol Biol 2018 ;1801:155-161

Department of Medicine, Rutgers-Robert Wood Johnson Medical School, Henry Rutgers Term Chair and Chancellor Scholar Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.

As the genome of experimental animals has become easier to manipulate, a number of mouse models have been developed to understand in vivo thyroid hormone action. A major site of thyroid hormone action is the HPT axis. While several methods are available that provide a detailed understanding of the HPT axis in mice, many authors choose to include only cursory data about this axis, which can lead to erroneous conclusions about in vivo thyroid hormone action. Read More

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February 2019

Predicting Plasma Free Hemoglobin Levels in Patients Due to Medical Device-Related Hemolysis.

ASAIO J 2019 Mar/Apr;65(3):207-218

From the Center for Devices and Radiological Health, Silver Spring, Maryland.

Blood passage through medical devices can cause hemolysis and increased levels of plasma free hemoglobin (pfH) that may lead to adverse effects such as vasoconstriction and renal tubule injury. Although the hemolytic potential of devices is typically characterized in vitro using animal blood, the results can be impacted by various blood parameters, such as donor species. Moreover, it is unclear how to relate measured in vitro hemolysis levels to clinical performance because pfH accumulation in vivo depends on both hemolysis rate and availability of plasma haptoglobin (Hpt) that can bind and safely eliminate pfH. Read More

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Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma.

Anal Cell Pathol (Amst) 2018 7;2018:9718585. Epub 2018 Mar 7.

Policlinico Umerto I, II Division of Internal Medicine and Geriatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous dissemination; for this reason, we investigated, for the first time, the presence of circulating tumor cells (CTCs) in hemangiopericytoma patient by CellSearch® and SceenCell® devices. Peripheral blood samples were drawn and processed by CellSearch, an EpCAM-dependent device, and ScreenCell®, a device size based. Read More

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October 2018

Hypogonadism and male obesity: Focus on unresolved questions.

Authors:
Mathis Grossmann

Clin Endocrinol (Oxf) 2018 07 16;89(1):11-21. Epub 2018 May 16.

Department of Medicine Austin Health, University of Melbourne, Heidelberg, Vic, Australia.

Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. HPT axis suppression is likely mediated via pro-inflammatory cytokine and dysregulated leptin signalling and aggravated by associated comorbidities. Read More

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Current treatment of hypoparathyroidism: Theory versus reality waiting guidelines for children and adolescents.

Acta Biomed 2018 03 27;89(1):122-131. Epub 2018 Mar 27.

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The diagnosis of hypoparathyroidism(HPT)is readily made in the presence of hypocalcemia with markedly reduced or absent parathormone (PTH) levels. Currently available treatments for HPT include high dose vitamin D (ergocalciferol, D2 and cholecalciferol, D3) or, the active metabolite dihydroxy vitamin D (calcitriol), in addition to calcium supplements.This regimen, if not well monitored, can lead to hypercalciuria, as PTH deficiency impairs renal calcium reabsorption. Read More

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