174 results match your criteria hpt child

Graves' disease in a five-month-old boy with an unusual treatment course.

J Pediatr Endocrinol Metab 2021 Mar 15;34(3):401-406. Epub 2020 Dec 15.

Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.

Objectives: Graves' disease (GD) is rare in children under age five years. Antithyroid drugs are typically first-line therapy but carry the risks of agranulocytosis and liver dysfunction.

Case Presentation: A male infant with multiple congenital anomalies, left ventricular hypertrophy, and neurologic dysfunction developed GD at five months of life. Read More

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Ten-year use of recombinant parathyroid hormone for the treatment of hypoparathyroidism in a boy with partial Jacobsen syndrome.

Pediatr Endocrinol Diabetes Metab 2021 ;27(1):57-61

Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pediatric hypoparathyroidism (HPT) is caused by inherited or acquired defects involving the synthesis or secretion of PTH, resistance to PTH action, or inappropriate regulation of PTH. Several syndromes such as DiGeorge syndrome, HDR (hypoparathyroidism, sensorineural deafness and renal dysplasia) syndrome, HRD (hypoparathyroidism, retardation, and dysmorphism) syndrome, Kenny-Caffey syndrome etc. may have associated HPT. Read More

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January 2021

Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease.

JAMA Netw Open 2020 10 1;3(10):e2019169. Epub 2020 Oct 1.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Importance: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis affecting multiple organs and commonly caused by somatic pathogenic variants in BRAF V600E and mitogen-activated protein kinase genes. Clinical features of ECD result from histiocytic involvement of various tissues; while endocrine involvement in ECD occurs frequently, the prevalence of central or primary hypothyroidism has not been thoroughly investigated.

Objective: To assess hypothalamus-pituitary-thyroid (HPT) dysfunction in patients with ECD. Read More

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October 2020

Immersive Virtual Environments and Wearable Haptic Devices in rehabilitation of children with neuromotor impairments: a single-blind randomized controlled crossover pilot study.

J Neuroeng Rehabil 2020 10 28;17(1):144. Epub 2020 Oct 28.

PERCRO Laboratory, Scuola Superiore Sant'Anna, Pisa, Italy.

Background: The past decade has seen the emergence of rehabilitation treatments using virtual reality. One of the advantages in using this technology is the potential to create positive motivation, by means of engaging environments and tasks shaped in the form of serious games. The aim of this study is to determine the efficacy of immersive Virtual Environments and weaRable hAptic devices (VERA) for rehabilitation of upper limb in children with Cerebral Palsy (CP) and Developmental Dyspraxia (DD). Read More

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October 2020

[Hypertrophy of palatine tonsils - possible treatment approaches].

Vestn Otorinolaringol 2020 ;85(3):57-63

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.

Objective: To evaluate the effectiveness of different approaches to the treatment of patients with hypertrophy of the palatine tonsils (HPT).

Material And Methods: 90 children with HPT of II-III degree and 20 healthy children (group 1) aged from 3 to 7 years were included in the study. Children with HPT were divided into three groups: group 2 - children who underwent tonsillotomy (=30), group 3 - children who underwent conservative treatment, including only topical use of Polyoxidonium (=30), group 4 - children who underwent complex treatment (tonsillotomy with subsequent local use of Polyoxidonium), (n=30). Read More

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Hormonal Treatments for Major Depressive Disorder: State of the Art.

Am J Psychiatry 2020 08 27;177(8):686-705. Epub 2020 May 27.

Child Study Center and Department of Radiology and Biomedical Imaging, Yale University, New Haven, Conn. (Dwyer); Department of Psychiatry, Case Western Reserve University, Cleveland, and Northcoast Behavioral Healthcare Hospital, Northfield, Ohio (Aftab); Yale School of Medicine, New Haven, Conn. (Radhakrishnan); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif., and VA Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez); Department of Psychiatry and Human Behavior, Butler Hospital, Brown University, Providence, R.I. (Carpenter); Department of Psychiatry, University of Texas at Austin (Nemeroff); Department of Psychiatry and Human Behavior, Emory University School of Medicine, Atlanta (McDonald); and Department of Psychiatry, University of Wisconsin-Madison (Kalin).

Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide. While numerous treatments for major depression exist, many patients do not respond adequately to traditional antidepressants. Read More

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Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study.

Medicine (Baltimore) 2020 May;99(20):e19948

Department of Radiology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

There are limited systematic studies on hematologic disease complicated by air leak syndrome (ALS). Physicians in radiology departments and hematology departments have a limited awareness of ALS.The aim of this study was to explore the similarities and differences in clinical data between the clinical group and imaging group in patients with hematologic disease complicated by ALS. Read More

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Cytokine and immunoglobulin spectra of tissue extracts from tonsils of children with hypertrophy and chronic tonsillitis.

Wiad Lek 2020 ;73(1):156-160

O. Kolomiychenko Otolaryngology Institute, Kyiv, Ukraine.

Objective: The aim: To compare the content of α and γ-interferons, interleukins 1β ,4, 10, IgA, IgG, as well as the level of the general forms of immune complexes in tissue extracts from tonsils of children with hypertrophy and chronic tonsillitis.

Patients And Methods Materials And Methods: We Studied Tonsils Of 25 Children Aged 5-12 Years With Hypertrophy Of Palatine Tonsils (hpt) And With Chronic Tonsillitis (ct). The Content Of α And γ – Interferons, Interleukins 1β, 4, 10, Iga, Igg In Tonsil Extract Was Determined By Immunofluorescence Assay. Read More

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Pregnant Patient on Hemodialysis Who Showed Remarkable Improvement of Severe Hyperparathyroidism by Strict Serum Phosphorus Control.

Intern Med 2020 Mar 18;59(5):689-694. Epub 2019 Nov 18.

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Japan.

We encountered a pregnant hemodialysis patient with severe hyperparathyroidism (HPT). Although her disease was considered to be refractory to medical treatment, the serum intact parathyroid hormone (PTH) level remarkably improved without manifestation of hypercalcemia through only strict serum phosphorus control, mainly via intensification of dialysis. The very strong correlation between the serum phosphorus level and serum intact PTH level suggested the possibility of secondary HPT. Read More

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Long-Term Outcomes of Parathyroidectomy in Hyperparathyroidism-Jaw Tumor Syndrome: Analysis of Five Families with CDC73 Mutations.

World J Surg 2020 02;44(2):508-516

Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.

Background: Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a rare disease caused by CDC73 germline mutations, with familial primary hyperparathyroidism (pHPT), ossifying jaw tumors, genito-urinary neoplasms. The present study was aimed at determining the long-term postoperative outcome of parathyroidectomy in HPT-JT.

Methods: A retrospective analysis of a single-center series of 20 patients from five unrelated HPT-JT families undergoing parathyroid surgery was performed. Read More

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February 2020

In early pubertal boys, testosterone and LH are associated with improved anti-oxidation during an aerobic exercise bout.

Endocrine 2019 11 4;66(2):370-380. Epub 2019 Aug 4.

Endocrine Unit, "Aretaieion" Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Purpose: To investigate the association of the hypothalamic-pituitary-testicular (HPT) axis with pro- and anti- oxidation, in relation to puberty and obesity in boys, before and after an aerobic exercise bout.

Methods: This is a cross-sectional human observational study of 92 healthy normal-weight, obese pre- and early- pubertal boys that underwent a blood sampling, before, and after an aerobic exercise bout at 70% VOmax, until exhaustion. LH, FSH, total testosterone (tT) and markers of pro- (TBARS and PCs) and anti- (GSH, GSSG, GPX, catalase, TAC) oxidation were measured. Read More

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November 2019

Semi-annual seasonal pattern of serum thyrotropin in adults.

Sci Rep 2019 07 25;9(1):10786. Epub 2019 Jul 25.

Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Circannual rhythmicity in thyroid-stimulating hormone (TSH) secretion is proposed, whereas evidences on seasonal peripheral thyroid hormones' fluctuation are contradictory. This study was designed to evaluate hypothalamic-pituitary-thyroid (HPT) seasonal secretion pattern using a big data approach. An observational, retrospective, big data trial was carried out, including all TSH measurements performed in a single laboratory between January 2010 and December 2017. Read More

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New Concepts About Familial Isolated Hyperparathyroidism.

Stephen J Marx

J Clin Endocrinol Metab 2019 Mar 8. Epub 2019 Mar 8.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD.

Context: Familial isolated hyperparathyroidism (FIHP) is defined as familial primary hyperparathyroidism (FH) without a characteristic extra-parathyroidal feature of a more complex hyperparathyroid syndrome. During 80 years, new concepts of FIHP have been developed within this definition. FIHP has been difficult to study due to small kindreds and mildly symptomatic cases. Read More

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Pain affect disrupted in children with posterior cerebellar tumor resection.

Ann Clin Transl Neurol 2019 02 2;6(2):344-354. Epub 2019 Jan 2.

Center for Pain and the Brain Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts 02215.

Objectives: Damage to the posterior cerebellum can cause affective deficits in patients. In adults, cerebellar infarcts result in thermal hyperalgesia and affect descending modulation of pain. This study evaluated the effect of resection of low-grade cerebellar tumors on pain processing in human children. Read More

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February 2019

The effect of Atlantic salmon consumption on the cognitive performance of preschool children - A randomized controlled trial.

Clin Nutr 2019 12 22;38(6):2558-2568. Epub 2018 Dec 22.

LMU - Ludwig-Maximilians-Universität München, Div. Metabolic & Nutritional Medicine, Dr. von Hauner Children's Hospital, Univ. of Munich Medical Center, Munich, Germany. Electronic address:

Background And Aims: Long chain polyunsaturated n-3 fatty acids (LC-PUFA) are of functional and structural importance for brain development. Observational studies have shown positive relations between fatty fish consumption and cognitive performance in children, but Results from intervention studies using supplementary n-3 LC-PUFA are conflicting. Salmon is a good source of n-3 LC-PUFA, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Read More

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December 2019

Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective.

J Bone Miner Res 2019 01 10;34(1):22-37. Epub 2018 Dec 10.

Calcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Canada.

We review advancing and overlapping stages for our understanding of the expressions of six hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903 to 1967), the introduction of robust measurement of serum calcium was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects, and inheritability was reported in each syndrome. The earliest reports of HPT syndromes were biased toward severe or striking manifestations. Read More

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January 2019

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms.

Biomed Res Int 2018 4;2018:1869613. Epub 2018 Oct 4.

MD, DSc, Professor, Head of the Department of ENT Diseases, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.

Background: Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhinomanometry (AARM) is an important method of examining nasal patency. Read More

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February 2019

Evidence of impaired pain modulation in adolescents with idiopathic scoliosis and chronic back pain.

Spine J 2019 04 19;19(4):677-686. Epub 2018 Oct 19.

Integrated Program in Neurosciences, McGill University, Montreal, Québec, Canada; McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Alan Edwards Centre for Research on Pain, Montreal, Québec, Canada; Department of Anesthesia, McGill University, Montreal, Québec, Canada. Electronic address:

Background Context: Although 40% of adolescent idiopathic scoliosis (AIS) patients present with chronic back pain, the pathophysiology and underlying pain mechanisms remain poorly understood. We hypothesized that development of chronic pain syndrome in AIS is associated with alterations in pain modulatory mechanisms.

Purpose: To identify the presence of sensitization in nociceptive pathways and to assess the efficacy of the diffuse noxious inhibitory control in patients with AIS presenting with chronic back pain. Read More

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Functioning and quality of life in patients with neuropathy associated with anti-MAG antibodies.

J Neurol 2018 Dec 10;265(12):2927-2933. Epub 2018 Oct 10.

Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, Milan, Italy.

Although anti-myelin-associated glycoprotein (MAG) antibody neuropathy is reported as a slowly progressive disease, it can lead to significant disability and impairment of health-related quality of life (HR-QoL) and social participation. The aim of this cross-sectional study was to evaluate the functioning and HR-QoL determinants in 67 patients with anti-MAG neuropathy in terms of the International Classification of Functioning, Disability, and Health (ICF). Evaluations included: Medical Research Council (MRC) sum score, Sensory Modality Sum score (SMS), Berg balance scale (BBS), Fatigue Severity Scale (FSS), Visual Analogue Scale (VAS) for pain, 9-Hole Peg Test (9-HPT), 6-min Walk Distance (6MWD), Impact on Participation and Autonomy (IPA) and the physical component score (PCS) and mental component score (MCS) of the short-form-36 health status scale (SF-36) HR-QoL measure. Read More

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December 2018

Prematurity and cardiovascular risk at early adulthood.

Child Care Health Dev 2019 01 21;45(1):71-78. Epub 2018 Sep 21.

Section of Developmental and Behavioral Pediatrics, JP Kennedy Research Center on Intellectual and Developmental Disabilities, University of Chicago Comer Children's Hospital, Chicago, Illinois.

Background: Theories of early stress exposure and allostatic load offer a lifespan perspective to adult health after prematurity based on these early stressors affecting endocrine and metabolic systems. In this study, we examine cardiovascular and metabolic risk by comparing two groups of preterm infants who experienced a full spectrum of neonatal illness and a term-born group at age 23.

Methods: Of the 215 infants recruited at birth, 84% participated at age 23. Read More

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January 2019

Effects of environmentally relevant concentrations of tris (2-butoxyethyl) phosphate on growth and transcription of genes involved in the GH/IGF and HPT axes in zebrafish (Danio rerio).

Chemosphere 2018 Dec 20;212:376-384. Epub 2018 Aug 20.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP), as one of the most widely used organophosphate flame retardants (OPFRs), is applied in nearly all manufactured items and materials. It has been reported that TBOEP could cause developmental impairments and disrupt the endocrine regulation of fish growth during acute toxic experiments. However, concentrations to which fish were exposed in these studies were greater than environmentally relevant concentrations ever reported. Read More

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December 2018

Mutations in IRS4 are associated with central hypothyroidism.

J Med Genet 2018 10 30;55(10):693-700. Epub 2018 Jul 30.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: Four genetic causes of isolated congenital central hypothyroidism (CeH) have been identified, but many cases remain unexplained. We hypothesised the existence of other genetic causes of CeH with a Mendelian inheritance pattern.

Methods: We performed exome sequencing in two families with unexplained isolated CeH and subsequently Sanger sequenced unrelated idiopathic CeH cases. Read More

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October 2018

Detection and clinical correlation of leukocortical lesions in pediatric-onset multiple sclerosis on multi-contrast MRI.

Mult Scler 2019 06 1;25(7):980-986. Epub 2018 Jun 1.

Departments of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Objective: To determine the frequency of cortical lesions (CLs) in patients with pediatric-onset multiple sclerosis (POMS) using multi-contrast magnetic resonance imaging (MRI), and the relationship between frontal CL load and upper limb dexterity assessed with the Nine-Hole Peg Test (9-HPT).

Methods: Participants completed the 9-HPT and were imaged on a 3T MRI scanner to collect T1-weighted three-dimensional (3D) magnetization prepared rapid gradient echo (MPRAGE), proton density-weighted, T2-weighted and fluid-attenuated inversion recovery (FLAIR) images. CLs were manually segmented using all MRI contrasts. Read More

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Current treatment of hypoparathyroidism: Theory versus reality waiting guidelines for children and adolescents.

Acta Biomed 2018 03 27;89(1):122-131. Epub 2018 Mar 27.


The diagnosis of hypoparathyroidism(HPT)is readily made in the presence of hypocalcemia with markedly reduced or absent parathormone (PTH) levels. Currently available treatments for HPT include high dose vitamin D (ergocalciferol, D2 and cholecalciferol, D3) or, the active metabolite dihydroxy vitamin D (calcitriol), in addition to calcium supplements.This regimen, if not well monitored, can lead to hypercalciuria, as PTH deficiency impairs renal calcium reabsorption. Read More

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Fatty fish intake and cognitive function: FINS-KIDS, a randomized controlled trial in preschool children.

BMC Med 2018 03 12;16(1):41. Epub 2018 Mar 12.

Institute of Marine Research (IMR), P.O Box 1870 Nordnes, NO-5817, Bergen, Norway.

Background: Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children. The purpose of the trial was to investigate whether an increased intake of fatty fish compared to meat improves cognitive function in children 4-6 years old. Read More

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An ICET- A survey on Hypoparathyroidism in Patients with Thalassaemia Major and Intermedia: A preliminary report.

Acta Biomed 2018 01 16;88(4):435-444. Epub 2018 Jan 16.

Quisisana Hospital, Ferrara.

Hypoparathyroidism (HPT) is a rare disease with leading symptoms of hypocalcemia, associated with high serum phosphorus levels and absent or inappropriately low levels of parathyroid hormone (PTH). In patients with thalassemias it is mainly attributed to transfusional iron overload, and suboptimal iron chelation therapy. The main objectives of this survey were to provide data on the prevalence, demographic and clinical features of HPT in thalassemia major (TM) and intermedia (TI) patients living in different countries, and to assess its impact in clinical medical practice. Read More

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January 2018

The Relationship between Physical Activity and Screen Time with the Risk of Hypertension in Children and Adolescents with Intellectual Disability.

Biomed Res Int 2017 2;2017:1940602. Epub 2017 Nov 2.

Institute of Nursing and Health Sciences, Medical Faculty, University of Rzeszów, Rzeszów, Poland.

Introduction: Children and adolescents with intellectual disability (ID) have significantly lower levels of physical activity compared to their peers without ID. Association between the level of physical activity and screen time with hypertension (HPT) in children and adolescents with ID has not been reported yet.

Aim: To assess the relationship between the level of physical activity and screen time with the prevalence of HPT in students with ID. Read More

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Familial Hyperparathyroidism - Disorders of Growth and Secretion in Hormone-Secretory Tissue.

Horm Metab Res 2017 11 14;49(11):805-815. Epub 2017 Nov 14.

Hospital das Clinicas, University of São Paulo School of Medicine Sao Paulo, Sao Paulo, Brazil.

Six syndromes of familial hyperparathyroidism are compared: 1) Familial hypocalciuric hypercalcemia (FHH) expresses primary hyperparathyroidism (PHPT) beginning at birth with lifelong hypercalcemia. There is nonsuppressed PTH secretion from outwardly normal parathyroid glands. It reflects germline heterozygous mutation in or . Read More

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November 2017

CDC73-Related Disorders: Clinical Manifestations and Case Detection in Primary Hyperparathyroidism.

J Clin Endocrinol Metab 2017 12;102(12):4534-4540

Department of Pathology, Leiden University Medical Center, the Netherlands.

Context: Heterozygous pathogenic germline variants in CDC73 predispose to the development of primary hyperparathyroidism (pHPT) and, less frequently, ossifying fibroma of the jaw and renal and uterine tumors. Clinical information on CDC73-related disorders has so far been limited to small case series.

Objective: To assess the clinical manifestations and penetrance in CDC73-related disorders and to improve case detection in pHPT. Read More

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December 2017