Stroke 2017 06 9;48(6):1463-1469. Epub 2017 May 9.
From the Clinical Neurosciences, Neurology (I.P., S.M., T.P., M.K., P.L., T.E.) and Research Programs Unit, Molecular Neurology, Biomedicum Helsinki (I.P., J.S., P.L.), University of Helsinki, Finland; Department of Neurology, Helsinki University Hospital, Finland (I.P., S.M., T.P., M.K., P.L., T.E.); National Institute for Health and Welfare, Helsinki, Finland (A.J., M.J.); Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland (M.J.); School of Medicine, University of Tampere, Finland (N.O., P.J.K.); and FimLab Laboratories Ltd (N.O., P.J.K.) and Division of Vascular Surgery, Department of Surgery (N.O.), Tampere University Hospital, Finland.
Background And Purpose: Haptoglobin (Hp) is an acute phase plasma protein protecting tissues from oxidative damage. It exists in 2 variant alleles () giving rise to 3 protein isoforms with different biochemical properties and efficiency to limit oxidative stress. We previously found that variant is associated with stroke risk in the patients with carotid stenosis and the risk of ischemic cardiovascular events in a general population cohort. Read More