17 results match your criteria hox genes'

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NPM1-mutated acute myeloid leukemia: from bench to bedside.

Blood 2020 10;136(15):1707-1721

Institute of Hematology, Centro Ricerche Emato-Oncologiche, Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy.

The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the aberrant cytoplasmic delocalization of NPM1 mutants. Because of its unique features, NPM1-mutated AML is recognized as a distinct entity in the 2017 World Health Organization (WHO) classification of hematopoietic neoplasms. Read More

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October 2020

Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers.

Cancers (Basel) 2020 Jun 14;12(6). Epub 2020 Jun 14.

The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.

Transcription factors encoded by () genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of gene expression plays key roles in the development of cancers. Their expression levels in cancers tend to differ based on tissue and tumor type. Read More

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Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye.

Neural Dev 2015 Jan 31;10. Epub 2015 Jan 31.

Institute of Molecular Biology, University of Oregon, 1370 Franklin Blvd, Eugene, OR, 97403, USA.

Background: Identifying the mechanisms by which cells remain irreversibly committed to their fates is a critical step toward understanding and being able to manipulate development and homeostasis. Polycomb group (PcG) proteins are chromatin modifiers that maintain transcriptional silencing, and loss of PcG genes causes widespread derepression of many developmentally important genes. However, because of their broad effects, the degree to which PcG proteins are used at specific fate choice points has not been tested. Read More

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January 2015

Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development.

Cell Mol Life Sci 2014 Jun 24;71(11):2149-64. Epub 2013 Sep 24.

Institut de Neurobiologie, Laboratoire Neurobiologie et Développement, CNRS-UPR3294, avenue de la Terrasse, 91198, Gif-sur-Yvette, France.

The combinatorial expression of Hox genes is an evolutionarily ancient program underlying body axis patterning in all Bilateria. In the head, the neural crest (NC)--a vertebrate innovation that contributes to evolutionarily novel skeletal and neural features--develops as a structure free of Hox-gene expression. The activation of Hoxa2 in the Hox-free facial NC (FNC) leads to severe craniofacial and brain defects. Read More

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"Self-regulation," a new facet of Hox genes' function.

Dev Dyn 2014 Jan 2;243(1):182-91. Epub 2013 Sep 2.

Instituto de Biomedicina y Biotecnologéa de Cantabria, . CSIC-SODERCAN-Universidad de Cantabria, Santander, Spain; Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.

Background: Precise temporal and spatial expression of the clustered Hox genes is essential for patterning the developing embryo. Temporal activation of Hox genes was shown to be cluster-autonomous. However, gene clustering appears dispensable for spatial colinear expression. Read More

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January 2014

Hoxa-5 acts in segmented somites to regulate cervical vertebral morphology.

Mech Dev 2013 Apr-May;130(4-5):226-40. Epub 2013 Feb 24.

Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA.

The vertebrate axial skeleton (vertebral column and ribs) is derived from embryonic structures called somites. Mechanisms of somite formation and patterning are largely conserved along the length of the body axis, but segments acquire different morphologies in part through the action of Hox transcription factors. Although Hox genes' roles in axial skeletal patterning have been extensively characterized, it is still not well understood how they interact with somite patterning pathways to regulate different vertebral morphologies. Read More

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Changes in Hox genes' structure and function during the evolution of the squamate body plan.

Nature 2010 Mar;464(7285):99-103

National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland.

Hox genes are central to the specification of structures along the anterior-posterior body axis, and modifications in their expression have paralleled the emergence of diversity in vertebrate body plans. Here we describe the genomic organization of Hox clusters in different reptiles and show that squamates have accumulated unusually large numbers of transposable elements at these loci, reflecting extensive genomic rearrangements of coding and non-coding regulatory regions. Comparative expression analyses between two species showing different axial skeletons, the corn snake and the whiptail lizard, revealed major alterations in Hox13 and Hox10 expression features during snake somitogenesis, in line with the expansion of both caudal and thoracic regions. Read More

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Stripy Ftz target genes are coordinately regulated by Ftz-F1.

Dev Biol 2009 Nov 11;335(2):442-53. Epub 2009 Aug 11.

Department of Entomology, University of Maryland, College Park, 20742, USA.

During development, cascades of regulatory genes act in a hierarchical fashion to subdivide the embryo into increasingly specified body regions. This has been best characterized in Drosophila, where genes encoding regulatory transcription factors form a network to direct the development of the basic segmented body plan. The pair-rule genes are pivotal in this process as they are responsible for the first subdivision of the embryo into repeated metameric units. Read More

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November 2009

More constraint on ParaHox than Hox gene families in early metazoan evolution.

Dev Biol 2009 Apr 27;328(2):173-87. Epub 2009 Jan 27.

Department of Zoology and Animal Biology, University of Geneva, 30 quai Ernest-Ansermet, CH-1211 Geneve 4, Switzerland.

Hox and ParaHox (H/P) genes belong to evolutionary-sister clusters that arose through duplication of a ProtoHOX cluster early in animal evolution. In contrast to bilaterians, cnidarians express, beside PG1, PG2 and Gsx orthologs, numerous Hox-related genes with unclear origin. We characterized from marine hydrozoans three novel Hox-related genes expressed at medusa and polyp stages, which include a Pdx/Xlox ParaHox ortholog induced 1 day later than Gsx during embryonic development. Read More

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Noncanonical role of Hox14 revealed by its expression patterns in lamprey and shark.

Proc Natl Acad Sci U S A 2008 May 30;105(18):6679-83. Epub 2008 Apr 30.

Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minami, Chuo-ku, Kobe 650-0047, Japan.

Hox genes are arranged in uninterrupted clusters in vertebrate genomes, and the nested patterns of their expression define spatial identities in multiple embryonic tissues. The ancestral Hox cluster of vertebrates has long been thought to consist of, maximally, 13 Hox genes. However, recently, Hox14 genes were discovered in three chordate lineages, the coelacanth, cartilaginous fishes, and amphioxus, but their expression patterns have not yet been analyzed. Read More

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Delimiting the conserved features of hunchback function for the trunk organization of insects.

Development 2008 Mar 23;135(5):881-8. Epub 2008 Jan 23.

Department of Genetics, University of Cologne, Zülpicherstrasse 47, Köln, Germany.

The gap gene hunchback in Drosophila acts during syncytial blastoderm stage via a short-range gradient and concentration-dependent activation or repression of target genes. Orthologues of hunchback can be easily found in other insects, but it has been unclear how well its functions are conserved. The segmentation process in most insect embryos occurs under cellular conditions, which should not allow the formation of diffusion-controlled transcription factor gradients. Read More

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The NK homeobox gene cluster predates the origin of Hox genes.

Curr Biol 2007 Apr 22;17(8):706-10. Epub 2007 Mar 22.

School of Integrative Biology, The University of Queensland, Brisbane Qld 4072, Australia.

Hox and other Antennapedia (ANTP)-like homeobox gene subclasses - ParaHox, EHGbox, and NK-like - contribute to key developmental events in bilaterians [1-4]. Evidence of physical clustering of ANTP genes in multiple animal genomes [4-9] suggests that all four subclasses arose via sequential cis-duplication events. Here, we show that Hox genes' origin occurred after the divergence of sponge and eumetazoan lineages and occurred concomitantly with a major evolutionary transition in animal body-plan complexity. Read More

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Computational identification of Ftz/Ftz-F1 downstream target genes.

Dev Biol 2006 Nov 12;299(1):78-90. Epub 2006 Jul 12.

Department of Biochemistry, Cellular and Developmental Biology, Mount Sinai Medical School, New York, NY 10029, USA.

Hox genes encode DNA binding transcription factors that regulate the body plans of metazoans by regulating the expression of downstream target 'realizator genes' that direct morphogenesis and growth. Although some Hox target genes have been identified, the code used by Hox proteins to select regulatory targets remains elusive. This failure is due, in part, to the overlapping and promiscuous DNA binding potential of different Hox proteins. Read More

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November 2006

Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression.

Nature 2006 Aug 7;442(7102):568-71. Epub 2006 Jun 7.

Howard Hughes Medical Institute and Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA.

The vertebral column exhibits segmentation and regionalization along the antero-posterior axis. During embryogenesis, the rhythmic production of the precursors of the vertebrae, the somites, imposes a segmented aspect to the spine, whereas the spine's regional differentiation is controlled by Hox genes. Here we show that in the paraxial mesoderm, Hoxb genes are first activated in a temporal collinear fashion in precursors located in the epiblast lateral to the primitive streak. Read More

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Unexpected variation of Hox genes' homeodomains in cephalopods.

Mol Phylogenet Evol 2006 Sep 26;40(3):872-9. Epub 2006 Apr 26.

Développement et Evolution, UMR 7622, CNRS et Université P et M Curie, Paris 6, Case 24, 9 quai St Bernard, 75252 Paris Cedex 05, France.

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September 2006

Hox and wings.

Jean Deutsch

Bioessays 2005 Jul;27(7):673-5

Equipe Developpement et Evolution, UMR 7622, CNRS et Universite P et M Curie, 9 quai St-Bernard, case 24, 75252 Paris Cedex 05, France.

In many bilaterian phyla, appendages are morphological traits that characterise the identity of the various body parts. In pterygote insects, wings are dorsal appendages on the thorax. The famous "bithorax" fly created by Ed Lewis is the emblematic example of the role of Hox genes. Read More

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Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells.

Oncogene 1999 Jan;18(4):1125-30

Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan.

The MLL (HRX/ALL-1 gene is frequently disrupted in infantile leukemias and therapy-related leukemias and fused to various translocation partner genes. We previously showed that chimeric MLL proteins localize in the nuclei in a fashion similar to that of MLL protein even if the partner gene encodes a cytoplasmic protein and indicated the importance of the N-terminal portion of MLL common to various MLL translocations. This time we established an inducible expression system for chimeric MLL-LTG9 and truncated N-terminal MLL proteins (MLL-Zf(-)) in 32Dcl3 cells. Read More

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January 1999
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