6,481 results match your criteria hox

Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.

Exp Biol Med (Maywood) 2021 Jul 22:15353702211030854. Epub 2021 Jul 22.

Department of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Deregulation of HOX transcription factor family has frequently been observed in multiple human cancers; however, their role in nasopharyngeal carcinoma remains largely unclear. In the present study, we found that HOX gene family is consistently upregulated in nasopharyngeal carcinoma and identified HOXA10 as one of the mostly upregulated HOX genes. Importantly, we show that HOXA10 overexpression is associated with transcriptional activation of multiple oncogenes essential for nasopharyngeal carcinoma carcinogenesis, including S-phase kinase-associated protein 2 (SKP2), calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), and matrix metalloproteinase 1 (MMP1). Read More

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Analyses of lamprey meis genes reveals that conserved inputs from hox, Meis and Pbx proteins control their expression in the hindbrain and neural tube.

Dev Biol 2021 Jul 23. Epub 2021 Jul 23.

Stowers Institute for Medical Research, Kansas City, MO, 64110, USA; Department of Anatomy and Cell Biology, Kansas University Medical Center, Kansas City, KS, 66160, USA. Electronic address:

Meis genes are known to play important roles in the hindbrain and neural crest cells of jawed vertebrates. To explore the roles of Meis genes in head development during evolution of vertebrates, we have identified four meis genes in the Sea Lamprey genome and characterized their patterns of expression and regulation, with a focus on the hindbrain and pharynx. Each of the lamprey meis genes displays temporally and spatially dynamic patterns of expression, some of which are coupled to rhombomeric domains in the developing hindbrain and select pharyngeal arches. Read More

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Long non-coding RNA HOTAIRM1-1 silencing in cartilage tissue induces osteoarthritis through microRNA-125b.

Exp Ther Med 2021 Sep 1;22(3):933. Epub 2021 Jul 1.

Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, P.R. China.

Aberrations in long noncoding RNA (lncRNA) expression have been recognized in numerous human diseases. In the present study, the of role the long noncoding RNA HOX antisense intergenic RNA myeloid 1 variant (HOTAIRM1-1) in regulating the pathological progression of osteoarthritis (OA) was investigated. The aberrant expression of HOTAIRM1-1 in OA was demonstrated, but the molecular mechanisms require further analysis. Read More

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September 2021

A chromosome-level reference genome of red swamp crayfish Procambarus clarkii provides insights into the gene families regarding growth or development in crustaceans.

Genomics 2021 Jul 22. Epub 2021 Jul 22.

Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing 210017, China; Jiangsu Key laboratory for Conservation and Utilization of freshwater Fisheries Germplasm Resources, Nanjing 210017, China. Electronic address:

Red swamp crayfish Procambarus clarkii is an ecologically and economically important crustacean species. Here, based on a de novo assembly strategy combining PacBio with Hi-C sequencing, we presented a high quality chromosome-level P. clarkii genome. Read More

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Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance.

Int J Mol Sci 2021 Jul 6;22(14). Epub 2021 Jul 6.

Laboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, Mexico.

Long non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they are currently considered to be master regulators of many pathological processes. Recent publications have shown that lncRNAs play important roles in the pathogenesis and progression of insulin resistance (IR) and glucose homeostasis by regulating inflammatory and lipogenic processes. lncRNAs regulate gene expression by binding to other non-coding RNAs, mRNAs, proteins, and DNA. Read More

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Developmental Inhibition of Long Intergenic Non-Coding RNA, , Impairs Dopamine Neuron Differentiation and Maturation.

Int J Mol Sci 2021 Jul 6;22(14). Epub 2021 Jul 6.

Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

The dopaminergic (DA) system is important for a range of brain functions and subcortical DA development precedes many cortical maturational processes. The dysfunction of DA systems has been associated with neuropsychiatric disorders such as schizophrenia, depression, and addiction. DA neuron cell fate is controlled by a complex web of transcriptional factors that dictate DA neuron specification, differentiation, and maturation. Read More

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NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML.

Cancers (Basel) 2021 Jul 10;13(14). Epub 2021 Jul 10.

Department of Women's and Children's Health, Haematology-Oncology Clinic and Lab, University of Padova, 35128 Padova, Italy.

Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, predominantly located in the nucleolus, that regulates a multiplicity of different biological processes. NPM1 localization in the cell is finely tuned by specific signal motifs, with two tryptophan residues (Trp) being essential for the nucleolar localization. In acute myeloid leukemia (AML), several NPM1 mutations have been reported, all resulting in cytoplasmic delocalization, but the putative biological and clinical significance of different variants are still debated. Read More

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There and Back Again: Hox Clusters Use Both DNA Strands.

J Dev Biol 2021 Jul 15;9(3). Epub 2021 Jul 15.

Department of Embryology, St. Petersburg State University, Universitetskaya nab. 7-9, 199034 Saint Petersburg, Russia.

Bilaterian animals operate the clusters of Hox genes through a rich repertoire of diverse mechanisms. In this review, we will summarize and analyze the accumulated data concerning long non-coding RNAs (lncRNAs) that are transcribed from sense (coding) DNA strands of Hox clusters. It was shown that antisense regulatory RNAs control the work of Hox genes in cis and trans, participate in the establishment and maintenance of the epigenetic code of Hox loci, and can even serve as a source of regulatory peptides that switch cellular energetic metabolism. Read More

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Occupational exposure influences control of disease in patients with chronic rhinosinusitis.

Rhinology 2021 Jul 20. Epub 2021 Jul 20.

Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.

Background: Chronic rhinosinusitis (CRS) is a frequent condition that is treated by endoscopic sinus surgery (ESS) when medical treatment fails. Irritating or sensitizing airborne agents can contribute to uncontrolled CRS. A prior study showed a linear correlation between occupational exposure and the number of ESS. Read More

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Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.

Lab Invest 2021 Jul 19. Epub 2021 Jul 19.

Department of Hematology, People's Hospital of Longhua District, Shenzhen, Guangdong Province, People's Republic of China.

Acute myeloid leukemia (AML) is a common subtype of leukemia, and a large proportion of patients with AML eventually develop drug resistance. Curcumin exerts cancer suppressive effects and increases sensitivity to chemotherapy in several diseases. This study aimed to investigate the mechanism by which curcumin affects the resistance of AML to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression. Read More

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Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage.

PLoS Genet 2021 Jul 19;17(7):e1009681. Epub 2021 Jul 19.

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Long noncoding RNAs (lncRNAs) have been shown to play important roles in gene regulatory networks acting in early development. There has been rapid turnover of lncRNA loci during vertebrate evolution, with few human lncRNAs conserved beyond mammals. The sequences of these rare deeply conserved lncRNAs are typically not similar to each other. Read More

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Evaluation of Gene Knockouts by CRISPR as Potential Targets for the Genetic Engineering of the Mosquito .

CRISPR J 2021 Jul 19. Epub 2021 Jul 19.

Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA; University of Monash, Clayton, Australia.

mosquitoes are a globally widespread vector of several human and animal pathogens. Their biology and behavior allow them to thrive in proximity to urban areas, rendering them a constant public health threat. Their mixed bird/mammal feeding behavior further offers a vehicle for zoonotic pathogens transmission to people and, separately, poses a threat to the conservation of insular birds. Read More

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Role and Mechanism of Exosome-Derived Long Noncoding RNA HOTAIR in Lung Cancer.

ACS Omega 2021 Jul 29;6(27):17217-17227. Epub 2021 Jun 29.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Xiamen City, Fujian Province 361001, China.

Background And Purpose: HOX transcript antisense RNA (HOTAIR) is a long noncoding RNA (lncRNA) that promotes tumor growth and metastasis. Exosomes can mediate intracellular communication in cancer by transferring active molecules. However, the role and mechanism of HOTAIR in nonsmall cell lung cancer (NSCLC) are still unclear. Read More

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HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2.

Jiangyan Yin Yi Guo

Cancer Med 2021 Jul 17. Epub 2021 Jul 17.

Department of General Surgery, Chongqing University Central Hospital (Chongqing Emergency Medical Center, Chongqing, China.

Purpose: The homeobox (HOX) family plays an important role in multi-biological processes, such as morphogenesis and tumors. However, the function of HOXD13 in colon cancer remains unclear.

Materials And Methods: The Cancer Genome Atlas database was used to analyze the expression of HOXD13 and its effect on the survival rate of colon cancer patients. Read More

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Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.

J Ethnopharmacol 2021 Jul 12;280:114413. Epub 2021 Jul 12.

Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, PR China. Electronic address:

Ethnopharmacological Relevance: Curcuma kwangsiensis S. G. Lee & C. Read More

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Variability and Time of Day Dependence of Ozone Photochemistry in Western Wildfire Plumes.

Environ Sci Technol 2021 Jul 13. Epub 2021 Jul 13.

NOAA Chemical Sciences Laboratory, Boulder, Colorado 80305, United States.

Understanding the efficiency and variability of photochemical ozone (O) production from western wildfire plumes is important to accurately estimate their influence on North American air quality. A set of photochemical measurements were made from the NOAA Twin Otter research aircraft as a part of the Fire Influence on Regional to Global Environments and Air Quality (FIREX-AQ) experiment. We use a zero-dimensional (0-D) box model to investigate the chemistry driving O production in modeled plumes. Read More

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Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.

Dev Dyn 2021 Jul 12. Epub 2021 Jul 12.

Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (CSIC-University of Cantabria-SODERCAN), Santander, Spain.

Background: The development of the amniote limb has been an important model system to study patterning mechanisms and morphogenesis. For proper growth and patterning, it requires the interaction between the distal sub-apical mesenchyme and the apical ectodermal ridge (AER) that involve the separate implementation of coordinated and tissue-specific genetic programs.

Results: Here, we produce and analyze the transcriptomes of both distal limb mesenchymal progenitors and the overlying ectodermal cells, following time-coursed dissections that cover from limb bud initiation to fully patterned limbs. Read More

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Homeotic change in segment identity derives the human vertebral formula from a chimpanzee-like one.

Am J Phys Anthropol 2021 Jul 6. Epub 2021 Jul 6.

Department of Human Evolutionary Biology, Harvard University, Cambridge, USA.

Objectives: One of the most contentious issues in paleoanthropology is the nature of the last common ancestor of humans and our closest living relatives, chimpanzees and bonobos (panins). The numerical composition of the vertebral column has featured prominently, with multiple models predicting distinct patterns of evolution and contexts from which bipedalism evolved. Here, we study total numbers of vertebrae from a large sample of hominoids to quantify variation in and patterns of regional and total numbers of vertebrae in hominoids. Read More

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Aberrant Expression of Long Non Coding RNA HOTAIR and De-Regulation of the Paralogous 13 HOX Genes Are Strongly Associated with Aggressive Behavior of Gastro-Entero-Pancreatic Neuroendocrine Tumors.

Int J Mol Sci 2021 Jun 30;22(13). Epub 2021 Jun 30.

Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", Via Mariano Semmola, 80131 Naples, Italy.

Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are rare diseases occurring in the gastrointestinal tract and pancreas. They are characterized by the loss of epithelial tubular gland elements, and by the increased expression of neuroendocrine markers. GEP-NENs are subdivided into two histo-pathological types, gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) and gastro-entero-pancreatic neuroendocrine carcinomas (GEP-NECs). Read More

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Genes: Roles in Development and Cancer.

Cancers (Basel) 2021 Jun 15;13(12). Epub 2021 Jun 15.

Genomics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Homeobox genes control body patterning and cell-fate decisions during development. The homeobox genes consist of many families, only some of which have been investigated regarding a possible role in tumorigenesis. Dysregulation of family genes have been widely implicated in cancer etiology. Read More

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A -Acting Mutation in the Promoter Is Associated with Cry1Ac Resistance in (L.).

Int J Mol Sci 2021 Jun 5;22(11). Epub 2021 Jun 5.

Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

The molecular mechanisms of insect resistance to Cry toxins generated from the bacterium (Bt) urgently need to be elucidated to enable the improvement and sustainability of Bt-based products. Although downregulation of the expression of midgut receptor genes is a pivotal mechanism of insect resistance to Bt Cry toxins, the underlying transcriptional regulation of these genes remains elusive. Herein, we unraveled the regulatory mechanism of the downregulation of the ABC transporter gene (also called ), a functional midgut receptor of the Bt Cry1Ac toxin in The promoters of Cry1Ac-susceptible and Cry1Ac-resistant strains were cloned and analyzed, and they showed clear differences in activity. Read More

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Blocking HOTAIR protects human chondrocytes against IL-1β-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis.

Int Immunopharmacol 2021 Jun 27;98:107903. Epub 2021 Jun 27.

Department of Joint Disease, Zhengzhou Orthopaedic Hospital, Zhengzhou, China. Electronic address:

Background: Long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) contributes to cartilage damages including osteoarthritis (OA). While, its role and mechanism in chondrocytes is incompletely clear.

Methods: HOTAIR, microRNA (miR)-222-3p and ADAM metalloproteinase-like domain 10 (ADAM10) expressions were detected by real-time quantitative PCR and western blotting. Read More

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Genome scanning reveals novel candidate genes for vertebral and teat number in the Beijing Black Pig.

Anim Genet 2021 Jun 30. Epub 2021 Jun 30.

Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture, Department of Animal Genetics and Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Porcine vertebral and teat numbers are variable and important economic traits in pig production. However, the quantitative trait loci (QTL) and candidate genes for both of these traits in the Beijing Black Pig are not yet known. In the present study, number of vertebrae and number of teats were obtained for 891 individuals of the Beijing Black Pig and genotyped using the Illumina Porcine 50 K BeadChip. Read More

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J Cell Biochem 2021 Jun 30. Epub 2021 Jun 30.

Retraction: "Down-regulation of the long noncoding RNA-HOX transcript antisense intergenic RNA inhibits the occurrence and progression of glioma," by Bin Yang, Zhen-Yu Wei, Bang-Qing Wang, Hua-Chao Yang, Jun-Yi Wang, Xing-Yao Bu, J Cell Biochem. 2018; 2278-2287: The above article, published online on 31 August 2017 in Wiley Online Library (https://onlinelibrary.wiley. Read More

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An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects.

Toxicology 2021 Jun 26;458:152843. Epub 2021 Jun 26.

Department for Innovative Testing Strategies, Center for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1, NL-3720BA, Bilthoven, the Netherlands. Electronic address:

Adverse outcome pathway (AOP) is a conceptual framework that links a molecular initiating event (MIE) via intermediate key events (KEs) with adverse effects (adverse outcomes, AO) relevant for risk assessment, through defined KE relationships (KERs). The aim of the present work is to describe a linear AOP, supported by experimental data, for skeletal craniofacial defects as the AO. This AO was selected in view of its relative high incidence in humans and the suspected relation to chemical exposure. Read More

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HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling.

DNA Repair (Amst) 2021 Jun 2:103141. Epub 2021 Jun 2.

Gene Regulation and Epigenetics Research Laboratory, Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, 76019, United States. Electronic address:

Long noncoding RNAs (lncRNAs) are pervasively transcribed from the mammalian genome as transcripts that are usually >200 nucleotides long. LncRNAs generally do not encode proteins but are involved in a variety of physiological processes, principally as epigenetic regulators. HOX transcript antisense intergenic RNA (HOTAIR) is a well-characterized lncRNA that has been implicated in several cancers and in various other diseases. Read More

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The lncRNA HOTAIR regulates autophagy and affects lipopolysaccharide-induced acute lung injury through the miR-17-5p/ATG2/ATG7/ATG16 axis.

J Cell Mol Med 2021 Jun 27. Epub 2021 Jun 27.

Department of Pulmonary and Critical Care Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Long non-coding ribonucleic acids (lncRNAs) play critical roles in acute lung injury (ALI). We aimed to explore the involvement of lncRNA HOX transcript antisense intergenic ribonucleic acid (HOTAIR) in regulating autophagy in lipopolysaccharide (LPS)-induced ALI. We obtained 1289 differentially expressed lncRNAs or messenger RNAs (mRNAs) via microarray analysis. Read More

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Phase separation drives aberrant chromatin looping and cancer development.

Nature 2021 Jul 23;595(7868):591-595. Epub 2021 Jun 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an aberrant chimera that invariably retains the nucleoporin IDR-tandemly dispersed repeats of phenylalanine and glycine residues. However, how unstructured IDRs contribute to oncogenesis remains unclear. Read More

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HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer.

J Cancer 2021 1;12(15):4626-4637. Epub 2021 Jun 1.

Department of Anatomy, Embryology Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea.

Tamoxifen is a commonly used drug to treat estrogen receptor-positive patients with breast cancer. Despite the outstanding efficacy of tamoxifen, approximately one-third of patients develop resistance toward it, thereby presenting a therapeutic challenge. genes may be involved in the acquisition of tamoxifen resistance. Read More

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Axial elongation of caudalized human organoids mimics aspects of neural tube development.

Development 2021 06 18;148(12). Epub 2021 Jun 18.

Gladstone Institutes, San Francisco, CA 94158, USA.

Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior body axis establishment and subsequent spinal cord development, but these processes cannot be interrogated directly in humans as they occur post-implantation. Here, we report an organoid model of neural tube extension derived from human pluripotent stem cell (hPSC) aggregates that have been caudalized with Wnt agonism, enabling them to recapitulate aspects of the morphological and temporal gene expression patterns of neural tube development. Elongating organoids consist largely of neuroepithelial compartments and contain TBXT+SOX2+ neuro-mesodermal progenitors in addition to PAX6+NES+ neural progenitors. Read More

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