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Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid signaling.

Biomed Pharmacother 2021 Jul 31;142:111975. Epub 2021 Jul 31.

Bioresources Development Centre, National Biotechnology Development Agency, Ministry of Science and Technology, Ogbomoso, Oyo State, Nigeria. Electronic address:

This study aimed to explore the potential antioxidant, anti-inflammatory, and anti-apoptotic effects of omega 3 fatty acid (Ω-3) in a rat model of testicular torsion/detorsion (T/D). Under ketamine/xylazine anaesthesia, age-matched adult male Wistar rats of comparable weight underwent sham-operation or testicular torsion by fixing the left testis rotated at 720° for two and half hours. After detorsion, animals were treated with either olive oil as vehicle or Ω-3 subcutaneously for three days. Read More

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Safety and efficacy of a novel barrier film to prevent intrauterine adhesion formation after hysteroscopic myomectomy: The PREG1 clinical trial.

J Minim Invasive Gynecol 2021 Jul 31. Epub 2021 Jul 31.

Bicêtre hospital, Department of Obstetrics and Gynaecology, Le Kremlin Bicêtre, France.

Objective: To evaluate the safety and potential efficacy of a novel degradable polymer film (DPF), designed to act as a 7-day barrier to prevent intrauterine adhesions (IUAs), post hysteroscopic myomectomy.

Design: A prospective single arm, first-in-human clinical study.

Setting: Multicenter study involving 6 centers in France, Belgium and the Netherlands Patients: Women ≥40 years with no plans to conceive who qualified for hysteroscopic myomectomy (at least one 10 millimeter type 0, 1 or 2 myoma) and had a sounded length of the uterine cavity (fundus to exocervix) ranging between 6 - 9 cm, were considered eligible for the study. Read More

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Glycyrol is able to protect against the combination-induced toxicity in vitro/in vivo.

Toxicon 2021 Jul 31. Epub 2021 Jul 31.

College of Food Science and Nutritional Engineering, China Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 100083, China. Electronic address:

Fumonisin B1 (FB1) is a major food-borne mycotoxin commonly found in maize and maize-based products, while cadmium is one of the most common toxic heavy metals found in food, particularly in wheat and rice. Given the possibility of co-exposure to FB1 and cadmium for consumers, we elevated combined toxicity of FB1 and cadmium using both in vitro and in vivo models. Acute toxicity setting was employed in the present study. Read More

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Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1α/DNMT3a pathway via a TRAAK-dependent manner.

Clin Exp Pharmacol Physiol 2021 Aug 3. Epub 2021 Aug 3.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China.

Hypoxia-induced cardiac fibrosis is an important pathological process in cardiovascular disorders. This study aimed to determine whether low-intensity pulsed ultrasound (LIPUS), a novel and safe apparatus, could alleviate hypoxia-induced cardiac fibrosis, and to elucidate the underlying mechanisms. Hypoxia (1% O ) and transverse aortic constriction (TAC) were performed on neonatal rat cardiac fibroblasts and mice to induce cardiac fibrosis, respectively. Read More

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Impermeable Graphene Oxide Protects Silicon from Oxidation.

ACS Appl Mater Interfaces 2021 Aug 3. Epub 2021 Aug 3.

School of Molecular and Life Sciences, Curtin Institute of Functional Molecules and Interfaces, Curtin University, Bentley, Perth, Western Australia 6102, Australia.

The presence of a natural silicon oxide (SiO) layer over the surface of silicon (Si) has been a roadblock for hybrid semiconductor and organic electronics technology. The presence of an insulating oxide layer is a limiting operational factor, which blocks charge transfer and therefore electrical signals for a range of applications. Etching the SiO layer by fluoride solutions leaves a reactive Si-H surface that is only stable for few hours before it starts reoxidizing under ambient conditions. Read More

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Improving the safety and quality of end-of-life in an Australian private hospital setting: An audit of documented end-of-life care.

Australas J Ageing 2021 Aug 3. Epub 2021 Aug 3.

Hollywood Private Hospital, Nedlands, WA, Australia.

Objective: This study reviewed the audit outcomes of the documented end-of-life care in a private hospital against the Australian Commission on Safety and Quality in Health Care's five recommended processes of care (Essential Elements (EE) 1-5).

Methods: A retrospective database review of deaths over a three-year period was undertaken. This was followed by a sequential medical record audit (n = 100) to evaluate the end-of-life care documented in the three days preceding death. Read More

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Studying Microtemporal, Within-Person Processes of Diet, Physical Activity, and Related Factors Using the APPetite-Mobile-App: Feasibility, Usability, and Validation Study.

J Med Internet Res 2021 Jul 5;23(7):e25850. Epub 2021 Jul 5.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Background: Diet and physical activity (PA) have a major impact on physical and mental health. However, there is a lack of effective strategies for sustaining these health-protective behaviors. A shift to a microtemporal, within-person approach is needed to capture dynamic processes underlying eating behavior and PA, as they change rapidly across minutes or hours and differ among individuals. Read More

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Involvement of G-CSF, IL-6, and cortisol in transient neutrophilia after marathon races.

Eur J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Nutrition Management, Graduate School of Nursing and Nutrition, Tenshi College.

Objectives: The aim of this study was to clarify the mechanisms of the transient increase in neutrophils after running standard marathon races by measurement of cytokines involved in the production and survival of neutrophils, and cortisol.

Methods: Fourteen male runners who participated in the Hokkaido Marathon, which is the sole marathon race held in summer in Japan, and finished the standard marathon, were analyzed sequentially from the start until a maximum of 8 days after the finish.

Results: Neutrophilia was observed in all runners just after they reached the goal (mean neutrophils: 13,226/μl). Read More

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Can we clinically identify pre-symptomatic and asymptomatic COVID-19?

medRxiv 2021 Jul 26. Epub 2021 Jul 26.

Objectives: COVID-19 has had a severe impact on morbidity and mortality among nursing home (NH) residents. Earlier detection of SARS-CoV-2 may position us to better mitigate risk of spread. Both asymptomatic or pre-symptomatic transmission are common in outbreaks, and threshold temperatures, such as 38C, for screening for infection could miss timely detection in the majority. Read More

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Leaf Extract Reverses Alloxan/Nicotinamide-Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP-1, and Glucagon) and Enzymatic (-Amylase/-Glucosidase) Modulation.

Biomed Res Int 2021 23;2021:9920826. Epub 2021 Jul 23.

Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: is used in folk medicine across Afro-Asian regions of the world. Earlier, glucose lowering and pancreato-protective effects of leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide-induced diabetic rats; however, the underlying mechanism of antidiabetic effect and pancreato-protection remained unknown.

Objective: This study elucidated antidiabetic mechanisms and pancreato-protective effects of APLE in diabetic rats. Read More

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SUpporting wellbeing through PEeR-Befriending (SUPERB) feasibility trial: fidelity of peer-befriending for people with aphasia.

BMJ Open 2021 08 2;11(8):e047994. Epub 2021 Aug 2.

Centre for Language and Communication Science Research, City University of London, London, UK

Objective: To evaluate systematically the fidelity of a peer-befriending intervention for people with aphasia.

Design: SUpporting wellbeing through Peer-befriending (SUPERB) was a feasibility randomised controlled trial comparing usual care to usual care +peer-befriending. This paper reports on the fidelity of all intervention aspects (training and supervision of providers/befrienders; intervention visits) which was evaluated across all areas of the Behaviour Change Consortium framework. Read More

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Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?

Clin Biochem 2021 Jul 30. Epub 2021 Jul 30.

PPGCM, School of Medicine of Universidade Federal do Rio Grande do Sul (UFRGS). Neurology Division, Laboratório BRAIN and CETER - Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-903, Porto Alegre, RS, Brazil. Electronic address:

Background And Purpose: Triggering receptors expressed on myeloid cells 1 and 2 (TREM-1 and TREM-2) are cell surface receptors important for modulation of microglia immune response. In this study, we evaluate serum levels of TREM-1 and TREM-2 as potential biomarkers in acute ischemic stroke (AIS).

Material And Methods: Prospective cohort study of 50 patients with AIS admitted at our hospital. Read More

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Single- and Multiple-Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative, SPR206.

Antimicrob Agents Chemother 2021 Aug 2:AAC0073921. Epub 2021 Aug 2.

Spero Therapeutics Inc., Cambridge, MA.

Carbapenem-resistant and Enterobacterales are identified as urgent threats, and multidrug-resistant (MDR) and extended-spectrum beta-lactamases (ESBL)-producing pathogens are identified as a serious threat by the Centers for Disease Control and Prevention (CDC). SPR206 is a novel polymyxin derivative with potent and activity against , , and multiple clinically important species of Enterobacterales, including multidrug- and extensively drug-resistant strains. This was a first-in-human (FIH) double-blind, placebo-controlled, single- and multiple ascending dose study of the safety, tolerability, and pharmacokinetics (PK) of SPR206 in 94 healthy subjects. Read More

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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method.

Tissue Eng Regen Med 2021 Aug 2. Epub 2021 Aug 2.

Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.

Background: An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use of the leukocyte-platelet rich fibrin (L-PRF) in tissue engineering technology, different medical fields, including periodontology and implantology.

Methods: Eight biopsies were obtained from eight different donors and a modified culturing technique was developed to obtain HGFCs. The modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay was used to compare the cell viability when the modified culturing method was used in comparison to the standard method. Read More

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Defining Dravet syndrome: An essential pre-requisite for precision medicine trials.

Epilepsia 2021 Aug 2. Epub 2021 Aug 2.

Department of Medicine, Austin Health, Epilepsy Research Centre, University of Melbourne, Heidelberg, Vic., Australia.

Objective: The classical description of Dravet syndrome, the prototypic developmental and epileptic encephalopathy, is of a normal 6-month-old infant presenting with a prolonged, febrile, hemiclonic seizure and showing developmental slowing after age 1 year. SCN1A pathogenic variants are found in >80% of patients. Many patients have atypical features resulting in diagnostic delay and inappropriate therapy. Read More

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Black oil sunflower seed ingestion associated with renal azotemia, gastroesophageal ulceration, and a high mortality rate in four alpacas and two llamas.

J Am Vet Med Assoc 2021 Aug;259(4):406-414

Case Description: 4 alpacas and 2 llamas (11 months to 11 years old) from 2 properties were examined for lethargy (6/6), salivation and regurgitation (4/6), and recumbency (3/6). Signs developed approximately 48 to 72 hours after accidental access to black oil sunflower seeds.

Clinical Findings: 3 alpacas died suddenly prior to treatment and were necropsied. Read More

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[Associations Between Daytime Physical Activity and Sleep Patterns in Children With Epilepsy].

Hu Li Za Zhi 2021 Aug;68(4):53-63

PhD, RN, Professor, School of Nursing, College of Medicine, National Taiwan University, and Adjunct Supervisor, Department of Nursing, National Taiwan University Hospital, Taiwan, ROC.

Background: Epilepsy is one of the most common chronic neurological diseases in children. Sleep disorders tend to increase the risk of seizures, and research has found that moderate physical activity may improve the quantity and quality of sleep in adults. However, the link between physical activity level and sleep patterns in toddlers and preschool-age children with epilepsy remains unclear. Read More

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Deep Transfer Learning-Based Framework for COVID-19 Diagnosis Using Chest CT Scans and Clinical Information.

Shreyas Mishra

SN Comput Sci 2021 24;2(5):390. Epub 2021 Jul 24.

National Institute of Technology, Rourkela, India.

The Coronavirus Disease 2019 (COVID-19) which first emerged in Wuhan, China in late December, 2019, has now spread to all the countries in the world. Conventional testing methods such as the antigen test, serology tests, and polymerase chain reaction tests are widely used. However, the test results can take anything from a few hours to a few days to reach the patient. Read More

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Soluble CD163 Is a Predictor of Mortality in Patients With Decompensated Cirrhosis.

Front Med (Lausanne) 2021 15;8:698502. Epub 2021 Jul 15.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Soluble CD163 (sCD163) is a scavenger receptor membrane protein expressed almost exclusively on Kupffer cells and other macrophages. It was found to be associated with the severity of liver cirrhosis. The aim of the present study was to determine whether the novel biomarker sCD163 predicts outcomes in patients with decompensated cirrhosis. Read More

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Focal Neurologic Deficit After Epidural Catheter Removal Leads to Meningioma Diagnosis.

Cureus 2021 Jun 29;13(6):e16015. Epub 2021 Jun 29.

Anesthesiology, State University of New York Upstate Medical University, Syracuse, USA.

We present an unusual case of a 60-year-old female who developed subtle, new-onset left upper and lower extremity weakness on day five of perioperative thoracic epidural placement. The onset of a focal neurological deficit after epidural placement usually raises suspicion for the presence of an epidural hematoma, abscess, or traumatic cord lesion. However, in this patient, brain imaging revealed a large, previously undiagnosed intracranial mass. Read More

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Successful Treatment of Brevibacterium Bacteremia Solely With Antimicrobial Therapy.

Cureus 2021 Jun 28;13(6):e16004. Epub 2021 Jun 28.

Infectious Diseases, State University of New York Downstate Medical Center, New York, USA.

is a large genus that is not often involved in pathogenesis, however, since 1991 there have been several case reports of -associated illness, most often due to bacteremia in the setting of an immunocompromised patient with a central venous catheter (CVC). Here we detail the case of an elderly woman with many comorbidities and a peripherally inserted central catheter (PICC) line for over four years, who presented with septic shock and bacteremia. In nearly all previous cases of bacteremia it was thought to be due to a CVC which was removed as part of the treatment in conjunction with antibiotics. Read More

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Antimalarial Property and Acute Toxicity of the Leaves of L.

Evid Based Complement Alternat Med 2021 13;2021:2852442. Epub 2021 Jul 13.

Department of Pharmaceutical Chemistry, KNUST, Kumasi, Ghana.

The leaf of cacao L. is used in traditional medicine in Ghana for the treatment of malaria, yet, with no scientific evidence of its antimalarial property in animals. It was, therefore, studied to validate the antimalarial property in infected mice. Read More

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Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults.

Nat Sci Sleep 2021 24;13:1225-1241. Epub 2021 Jul 24.

Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.

Background: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle and social structure within the Arab-gulf region differ compared to those in the western world. This study was specifically conducted in Kuwait's population to investigate the link between sleep quality (SQ) and obesity in the absence of sleep apnea (SA) onset. Read More

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Adverse events following ChAdOx1 nCoV-19 Vaccine (COVISHIELD) amongst health care workers: A prospective observational study.

Med J Armed Forces India 2021 Jul 26;77:S283-S288. Epub 2021 Jul 26.

SSO Health, Head Quarters, Eastern Naval Command, Visakhapatnam, India.

Background: During ongoing COVID-19 pandemic, researchers worked enormously to develop effective vaccines against COVID-19 infection. Two Indian-made vaccines [Covishield (ChAdOx1 nCoV-19) and Covaxin] were granted Emergency Use Authorization. India launched its COVID-19 vaccination drive starting with healthcare workers (HCW). Read More

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Weekly Frequency of Meeting the Physical Activity Guidelines and Cardiometabolic Health in Children and Adolescents.

Med Sci Sports Exerc 2021 Jul 30. Epub 2021 Jul 30.

Ward Family Heart Center, Children's Mercy Hospital Kansas City, Kansas City, MO School of Medicine, University of Missouri Kansas City, Kansas City, MO Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, NO Division of Physical Activity and Weight Management, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS.

The current physical activity (PA) guidelines for children and adolescents in the U.S. recommend ≥60 minutes of moderate-to-vigorous intensity PA (MVPA), 7 days per week for cardiometabolic health (CmH) benefits. Read More

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Prospective Trial of Near-Infrared Spectroscopy for Continuous Noninvasive Monitoring of Free Fibular Flaps.

Ann Plast Surg 2021 Jul 29. Epub 2021 Jul 29.

From the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatolog, HaiDian District, Beijing, China Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, P.R. China.

Introduction: Some free flaps develop postoperative vessel thrombosis, which influences the flap survival rate. Early discovery and identification of vascular crisis are critical to the success rate of flap salvage. The primary aims of this study were to determine the features of postoperative blood supply changes in fibular flaps with normal and abnormal blood flow, using near-infrared spectroscopy (NIRS), to monitor oxygenation and blood flow, and to characterize the probable risk factors for vascular crisis. Read More

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Point prevalence survey of health-care associated infections and their risk factors in the tertiary-care referral hospitals of Southern Tunisia.

Infect Dis Health 2021 Jul 29. Epub 2021 Jul 29.

Community Health and Epidemiology Department, Hedi Chaker University Hospital, University of Sfax, Sfax, 3093, Tunisia.

Background: Health-care associated infections (HAI) are considered a public health problem and have substantial effect on mortality and morbidity. This study aimed to determine the prevalence of HAI in South Tunisian University Hospitals (UH) and to identify their risk factors.

Methods: We performed a point prevalence study, in the UH of Southern Tunisia in February 2019, including all hospitalized patients for at least 48 hours. Read More

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Early US experience with cardiac donation after circulatory death (DCD) using normothermic regional perfusion.

J Heart Lung Transplant 2021 Jul 10. Epub 2021 Jul 10.

Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Given the shortage of suitable donor hearts for cardiac transplantation and the growing interest in donation after circulatory death (DCD), our institution recently began procuring cardiac allografts from DCD donors.

Methods: Between October 2020 and March 2021, 15 patients with heart failure underwent cardiac transplantation using DCD allografts. Allografts were procured using a modified extracorporeal membrane oxygenation circuit for thoracic normothermic regional perfusion (TA-NRP) and were subsequently transported using cold static storage. Read More

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Neonatal mortality in the 2011 JAKIDS birth cohort.

Psychol Health Med 2021 Aug 2:1-9. Epub 2021 Aug 2.

Department of Child & Adolescent Health, University of the West Indies, Mona, Jamaica.

This study aimed to determine the mortality in a Jamaican birth cohort over a 3-month period. Data on the outcome of 87.5% of all births in Jamaica between July and September 2011 were used to determine trends in and determinants of neonatal mortality. Read More

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Study to Compare Capsule and Liquid Formulations of Enzalutamide After Single-Dose Administration Under Fasting Conditions in Prostate Cancer.

Oncologist 2021 Aug 1. Epub 2021 Aug 1.

Clinical Pharmacology Program, National Institutes of Health, Bethesda, Maryland, USA.

Lessons Learned: Limited evidence suggests an acceptable pharmacokinetic profile when enzalutamide is administered via a liquid formulation extracted from the commercially available liquid-filled soft-gelatin capsules. Tolerability may limit use in clinical practice.

Background: Enzalutamide is an established standard-of-care treatment for advanced prostate cancer with a commercially available formulation that may be inconvenient for some patients. Read More

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