1,053 results match your criteria host plasminogen


[Relationship of single nucleotide polymorphisms and genetic susceptibility to sepsis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):630-632

Department of Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Science), Guangzhou 510080, Guangdong, China. Corresponding author: Hou Tieying, Email:

Sepsis is a clinical syndrome caused by the host reaction disorder induced by infection, which leads to serious organ function damage. Sepsis is a serious disease with high mortality, which is the main reason of death caused by infection. Single nucleotide polymorphisms (SNP) is one of the most common genetic variants in human, and is closely related to the genetic susceptibility, early diagnosis, disease development and prognosis of sepsis. Read More

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Euglobulin clot lysis time reveals a high frequency of fibrinolytic activation in trauma.

Thromb Res 2021 May 31;204:22-28. Epub 2021 May 31.

Division of Hematology, Department of Medicine and Blood Research Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Activation of the fibrinolytic system plays a central role in the host response to trauma. There is significant heterogeneity in the degree of fibrinolysis activation at baseline that is usually assessed by whole blood thromboelastography (TEG). Few studies have focused on plasma markers of fibrinolysis that could add novel insights into the frequency and mechanisms of fibrinolytic activation in trauma. Read More

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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) moonlights as an adhesin in Mycoplasma hyorhinis adhesion to epithelial cells as well as a plasminogen receptor mediating extracellular matrix degradation.

Vet Res 2021 Jun 3;52(1):80. Epub 2021 Jun 3.

Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Mycoplasma hyorhinis infects pigs causing polyserositis and polyarthritis, and has also been reported in a variety of human tumor tissues. The occurrence of disease is often linked with the systemic invasion of the pathogen. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH), one of the key enzymes of glycolysis, was reported as a surface multifunctional molecule in several bacteria. Read More

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Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients.

Front Immunol 2021 14;12:664209. Epub 2021 May 14.

Center for Experimental and Molecular Medicine, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Rationale: Systemic activation of procoagulant and inflammatory mechanisms has been implicated in the pathogenesis of COVID-19. Knowledge of activation of these host response pathways in the lung compartment of COVID-19 patients is limited.

Objectives: To evaluate local and systemic activation of coagulation and interconnected inflammatory responses in critically ill COVID-19 patients with persistent acute respiratory distress syndrome. Read More

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ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial Plasminogen Activator Inhibitor-1.

Am J Respir Cell Mol Biol 2021 May 18. Epub 2021 May 18.

Johns Hopkins University, 1466, Baltimore, Maryland, United States;

Endothelial dysfunction is implicated in the thrombotic events reported in COVID-19 patients, but underlying molecular mechanisms are unknown. Circulating levels of the coagulation cascade activator PAI-1 are substantially higher in COVID-19 patients with severe respiratory dysfunction than in patients with bacterial-sepsis and ARDS. Indeed, the elevation of PAI-1 is recognized as an early marker of endothelial dysfunction. Read More

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Clinical features and prognostic factors in Covid-19: A prospective cohort study.

EBioMedicine 2021 May 14;67:103378. Epub 2021 May 14.

From the Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Background: Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies.

Methods: We performed a prospective cohort study of patients with COVID-19 admitted to general ward or ICU who underwent serial blood sampling. Read More

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Endogenous and Borrowed Proteolytic Activity in the .

Microbiol Mol Biol Rev 2021 May 12;85(2). Epub 2021 May 12.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

SUMMARYThe spp. are tick-borne pathogenic spirochetes that include the agents of Lyme disease and relapsing fever. As part of their life cycle, the spirochetes traffic between the tick vector and the vertebrate host, which requires significant physiological changes and remodeling of their outer membranes and proteome. Read More

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Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties.

Elife 2021 04 20;10. Epub 2021 Apr 20.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of frog. Cath-MH has a single α-helical structure in membrane-mimetic environments and is antimicrobial against fungi and bacteria, especially Gram-negative bacteria. Read More

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Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy.

Oncol Lett 2021 May 29;21(5):423. Epub 2021 Mar 29.

Department of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand.

Cervical cancer remains a major health threat. Urokinase serves as a marker of metastatic tumors. The present study aimed to determine whether the expression levels of urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), before and during the course of radiotherapy, serve as prognostic markers for patients with cervical cancer. Read More

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Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury.

J Vis Exp 2021 03 21(169). Epub 2021 Mar 21.

Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan;

Lungs are continually faced with direct and indirect insults in the form of sterile (particles or reactive toxins) and infectious (bacterial, viral or fungal) inflammatory conditions. An overwhelming host response may result in compromised respiration and acute lung injury, which is characterized by lung neutrophil recruitment as a result of the patho-logical host immune, coagulative and tissue remodeling response. Sensitive microscopic methods to visualize and quantify murine lung cellular adaptations, in response to low-dose (0. Read More

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Fibrinolysis: A Primordial System Linked to the Immune Response.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

Molecular Neurotrauma and Haemostasis Laboratory, Australian Centre for Blood Diseases, Central Clinical School Melbourne, Monash University, Melbourne, VIC 3004, Australia.

The fibrinolytic system provides an essential means to remove fibrin deposits and blood clots. The actual protease responsible for this is plasmin, formed from its precursor, plasminogen. Fibrin is heralded as it most renowned substrate but for many years plasmin has been known to cleave many other substrates, and to also activate other proteolytic systems. Read More

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Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19-associated Coagulopathies.

Am J Respir Cell Mol Biol 2021 06;64(6):687-697

Division of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island; and.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of coronavirus disease (COVID-19) (the disease associated with SARS-CoV-2 infection), pulmonary and distal coagulopathies have caused morbidity and mortality in many patients. Currently, the molecular pathogenesis underlying COVID-19-associated coagulopathies are unknown. Read More

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Plasminogen: an enigmatic zymogen.

Blood 2021 May;137(21):2881-2889

Molecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Monash University, Melbourne VIC, Australia.

Plasminogen is an abundant plasma protein that exists in various zymogenic forms. Plasmin, the proteolytically active form of plasminogen, is known for its essential role in fibrinolysis. To date, therapeutic targeting of the fibrinolytic system has been for 2 purposes: to promote plasmin generation for thromboembolic conditions or to stop plasmin to reduce bleeding. Read More

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Surface Exposed GroEL Is a Multifunctional Protein.

Pathogens 2021 Feb 18;10(2). Epub 2021 Feb 18.

Department of Entomology, Rutgers University, New Brunswick, NJ 08901, USA.

The spirochete, , has a large number of membrane proteins involved in a complex life cycle, that includes a tick vector and a vertebrate host. Some of these proteins also serve different roles in infection and dissemination of the spirochete in the mammalian host. In this spirochete, a number of proteins have been associated with binding to plasminogen or components of the extracellular matrix, which is important for tissue colonization and dissemination. Read More

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February 2021

Interaction between Borrelia miyamotoi variable major proteins Vlp15/16 and Vlp18 with plasminogen and complement.

Sci Rep 2021 Mar 2;11(1):4964. Epub 2021 Mar 2.

Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.

Borrelia miyamotoi, a relapsing fever spirochete transmitted by Ixodid ticks causes B. miyamotoi disease (BMD). To evade the human host´s immune response, relapsing fever borreliae, including B. Read More

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Clone, expression and plasminogen binding property of three fructose-1,6-bisphosphate aldolases from Clonorchis sinensis.

Trop Biomed 2020 Dec;37(4):852-863

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Fructose-1,6-bisphosphate aldolase (FbA), a well characterized glycometabolism enzyme, has been found to participate in other important processes besides the classic catalysis. To understand the important functions of three fructose-1,6-bisphosphate aldolases from Clonorchis sinensis (CsFbAs, CsFbA-1/2/3) in host-parasite interplay, the open reading frames of CsFbAs were cloned into pET30a (+) vector and the resulting recombinant plasmids were transformed into Escherichia coli BL21 (DE3) for expression of the proteins. Purified recombinant CsFbAs proteins (rCsFbAs) were approximately 45. Read More

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December 2020

The fibrinolytic system enables the onset of infection in the mosquito vector and the mammalian host.

Sci Adv 2021 Feb 5;7(6). Epub 2021 Feb 5.

The W. Harry Feinstone Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

parasites must migrate across proteinaceous matrices to infect the mosquito and vertebrate hosts. Plasmin, a mammalian serine protease, degrades extracellular matrix proteins allowing cell migration through tissues. We report that gametes recruit human plasminogen to their surface where it is processed into plasmin by corecruited plasminogen activators. Read More

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February 2021

Molecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection.

Daru 2021 Jun 3;29(1):73-84. Epub 2021 Feb 3.

Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), 25200, Kuantan, Pahang, Malaysia.

Purpose: To predict potential inhibitors of alpha-enolase to reduce plasminogen binding of Streptococcus pneumoniae (S. pneumoniae) that may lead as an orally active drug. S. Read More

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The Central Role of Fibrinolytic Response in COVID-19-A Hematologist's Perspective.

Int J Mol Sci 2021 Jan 28;22(3). Epub 2021 Jan 28.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious and have severe pulmonary complications. Clinically, patients with COVID-19 run a rapidly progressive course of an acute respiratory tract infection with fever, sore throat, cough, headache and fatigue, complicated by severe pneumonia often leading to acute respiratory distress syndrome (ARDS). Read More

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January 2021

Mycobacterium tuberculosis glyceraldehyde-3-phosphate dehydrogenase plays a dual role-As an adhesin and as a receptor for plasmin(ogen).

Cell Microbiol 2021 May 16;23(5):e13311. Epub 2021 Feb 16.

National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India.

The spread of infection is directly determined by the ability of a pathogen to invade and infect host tissues. The process involves adherence due to host-pathogen interactions and traversal into deeper tissues. Mycobacterium tuberculosis (Mtb) primarily infects the lung but is unique in its ability to infect almost any other organ of the human host including immune privileged sites such as the central nervous system (CNS). Read More

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Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study.

Lancet Infect Dis 2021 06 20;21(6):876-886. Epub 2021 Jan 20.

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Germany. Electronic address:

Background: Lassa fever is endemic in several west African countries. Case-fatality rates ranging from 21% to 69% have been reported. The pathophysiology of the disease in humans and determinants of mortality remain poorly understood. Read More

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Yersinia pestis escapes entrapment in thrombi by targeting platelet function.

J Thromb Haemost 2020 12 20;18(12):3236-3248. Epub 2020 Sep 20.

Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Platelets are classically recognized for their role in hemostasis and thrombosis. Recent work has demonstrated that platelets can also execute a variety of immune functions. The dual prothrombotic and immunological roles of platelets suggest that they may pose a barrier to the replication or dissemination of extracellular bacteria. Read More

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December 2020

Novel Models of Colonization and Disease Reveal Modest Contributions of M-Like (SCM) Protein.

Microorganisms 2021 Jan 16;9(1). Epub 2021 Jan 16.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

is a common colonizing bacterium of the urogenital tract of cats and dogs that can also cause invasive disease in these animal populations and in humans. Although the virulence mechanisms of are not well-characterized, an M-like protein, SCM, has recently identified been as a potential virulence factor. SCM is a surface-associated protein that binds to host plasminogen and IgGs suggesting its possible importance in host-pathogen interactions. Read More

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January 2021

Fibrinolysis influences SARS-CoV-2 infection in ciliated cells.

bioRxiv 2021 Jan 8. Epub 2021 Jan 8.

Rapid spread of COVID-19 has caused an unprecedented pandemic worldwide, and an inserted furin site in SARS-CoV-2 spike protein (S) may account for increased transmissibility. Plasmin, and other host proteases, may cleave the furin site of SARS-CoV-2 S protein and γ subunits of epithelial sodium channels (γ ENaC), resulting in an increment in virus infectivity and channel activity. As for the importance of ENaC in the regulation of airway surface and alveolar fluid homeostasis, whether SARS-CoV-2 will share and strengthen the cleavage network with ENaC proteins at the single-cell level is urgently worthy of consideration. Read More

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January 2021

Strong interactions between Salp15 homologues from the tick I. ricinus and distinct types of the outer surface OspC protein from Borrelia.

Ticks Tick Borne Dis 2021 03 14;12(2):101630. Epub 2020 Dec 14.

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. Electronic address:

Ticks belonging to the genus Ixodes are parasites feeding on vertebrate blood and vectors for many pathogenic microbes, including Borrelia burgdorferi sensu lato spirochetes, the causative agent of Lyme borreliosis. The tick saliva contains a mixture of bioactive molecules showing a wide range of properties for efficient engorgement. One of the most extensively studied components of tick saliva is a 15-kDa salivary gland protein (Salp15) from Ixodes scapularis. Read More

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Zone of Interaction Between the Parasite and the Host: Protein Profile of the Body Cavity Fluid of Gasterosteus aculeatus L. Infected with the Cestode Schistocephalus solidus (Muller, 1776).

Acta Parasitol 2021 Jun 2;66(2):569-583. Epub 2021 Jan 2.

Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences, 185910, Petrozavodsk, Russia.

Purpose: During infection, the host and the parasite "communicate" with each other through various molecules, including proteins. The aim of this study was to describe the excretory-secretory proteins from the helminth Schistocephalus solidus and its intermediate host, the three-spined stickleback Gasterosteus aculeatus L., which are likely to be involved in interactions between them. Read More

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Proteomic and mechanistic study of Qingxuan Tongluo formula and curcumin in the treatment of Mycoplasma pneumoniae pneumonia.

Biomed Pharmacother 2021 Jan 2;133:110998. Epub 2020 Dec 2.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China. Electronic address:

Objective: Mycoplasma pneumoniae (MP) is the only pathogen in the Mycoplasma family that can cause respiratory symptoms, including acute upper respiratory tract infection and bronchitis, which are often attributed to Mycoplasma pneumoniae pneumonia (MPP). MPP is one of the diseases that commonly affects the pediatric respiratory system, but its pathogenesis is unclear. This study investigated the therapeutic effects and mechanisms of Qingxuan Tongluo formula and its main component, curcumin, on MPP. Read More

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January 2021

Salmonella Typhimurium enolase-like membrane protein is recognized by antibodies against human enolase and interacts with plasminogen.

Adv Clin Exp Med 2020 Dec;29(12):1433-1441

Department of Medical Biochemistry, Wroclaw Medical University, Poland.

Background: Enolase is generally known as the glycolytic pathway enzyme present in the cytoplasm of eukaryotic cells and in some microorganisms. In human cells, it is also a component of cell surface membranes, where it functions as a human plasminogen receptor.

Objectives: The study aimed to purify Salmonella enterica serovar Typhimurium cytosolic enolase and obtain the antibodies against this protein; to identify enolase on the surface of bacteria; and to find cross-reactivity and plasminogen binding properties. Read More

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December 2020

Als3-mediated attachment of enolase on the surface of Candida albicans cells regulates their interactions with host proteins.

Cell Microbiol 2021 Apr 14;23(4):e13297. Epub 2020 Dec 14.

Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow, Poland.

The multifunctional protein enolase has repeatedly been identified on the surface of numerous cell types, including a variety of pathogenic microorganisms. In Candida albicans-one of the most common fungal pathogens in humans-a surface-exposed enolase form has been previously demonstrated to play an important role in candidal pathogenicity. In our current study, the presence of enolase at the fungal cell surface under different growth conditions was examined, and a higher abundance of enolase at the surface of C. Read More

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Current Understanding of the Pathogenesis of Dengue Virus Infection.

Curr Microbiol 2021 Jan 24;78(1):17-32. Epub 2020 Nov 24.

Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. Read More

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January 2021