113,901 results match your criteria hospitalized patients

An automated approach to determine antibody endpoint titers for COVID-19 by an enzyme-linked immunosorbent assay.

Immunohematology 2021 Mar;37(1):33-43

Center for Transfusion Medicine and Cellular Therapies, and Department of Pathology and Laboratory Medicine, Emory University School of Medicine , 201 Dowman Drive, Atlanta, GA 30322 , and Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School , 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115.

While a variety of therapeutic options continue to emerge for COVID-19 treatment, convalescent plasma (CP) has been used as a possible treatment option early in the pandemic. One of the most significant challenges with CP therapy, however, both when defining its efficacy and implementing its approach clinically, is accurately and efficiently characterizing an otherwise heterogenous therapeutic treatment. Given current limitations, our goal is to leverage a SARS antibody testing platform with a newly developed automated endpoint titer analysis program to rapidly define SARS-CoV-2 antibody levels in CP donors and hospitalized patients. Read More

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Venous Thromboembolism among Noncritically Ill Hospitalized Children: Key Considerations for the Pediatric Hospital Medicine Specialist.

Semin Thromb Hemost 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Venous thromboembolism (VTE) is a leading cause of morbidity and preventable harm among noncritically ill hospitalized children. Several clinical factors relevant to the noncritically ill hospitalized child significantly increase the risk of VTE including the presence of central venous catheters, systemic inflammation, and prolonged immobilization. Although risk mitigation strategies have been described, the diagnosis, treatment, and prevention of VTE require standardization of institutional practices combined with multidisciplinary collaboration among pediatric hospitalists, hematologists, and other care providers. Read More

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Combining urine antigen and blood polymerase chain reaction for the diagnosis of disseminated histoplasmosis in hospitalized patients with advanced HIV disease.

Med Mycol 2021 May 7. Epub 2021 May 7.

Laboratório de Biologia Molecular de Parasitas e Fungos, Instituto Adolfo Lutz, São Paulo 01246-000, Brazil.

Disseminated histoplasmosis (DH) is endemic in Latin America and the Caribbean where diagnostic tools are restricted. We carried-out a 1-year prospective cohort study at a referral hospital in São Paulo, Brazil. Participants had > or =18 years old, were hospitalized due to any indication and had CD4+ < 200 cells/µl. Read More

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Sleep in Aneurysmal Subarachnoid Hemorrhage Patients During Critical and Acute Care.

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):118-124

Background: Nurses caring for intensive care patients diagnosed with an aneurysmal subarachnoid hemorrhage (aSAH) conduct frequent neurological assessments and vital signs over an extended period during which patients are at risk of vasospasm. The frequency of assessments can negatively impact sleep, resulting in altered thought processes and mood, including delirium. There are 2 types of sleep during the night: non-rapid eye movement (non-REM) sleep and REM sleep (also called stage R). Read More

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Oxygenation Strategies in Critically Ill Patients With COVID-19.

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):75-82

Background: Severe acute respiratory syndrome coronavirus 2 is the virus that causes coronavirus disease 2019 (COVID-19). COVID-19 is a disease characterized by a range of clinical syndromes including variable degrees of respiratory symptoms from mild respiratory illness and severe interstitial pneumonia to acute respiratory distress syndrome, septic shock, coagulopathies, and multiorgan dysfunction. This virus carries the potential to manifest in a wide range of pulmonary findings and hypoxemias, from mild respiratory symptoms to more severe syndromes, such as acute respiratory distress syndrome. Read More

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Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study.

Ann Intensive Care 2021 May 7;11(1):70. Epub 2021 May 7.

Service de Réanimation et Urgences Pédiatriques, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron cedex, France.

Background: Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of cases. Leukodepletion may improve prognosis. A therapeutic strategy based on leukodepletion and extracorporeal life support (ECLS) according to different thresholds of leucocytes has been proposed by Rowlands and colleagues. Read More

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Derivation and validation of actionable quality indicators targeting reductions in complications for injury admissions.

Eur J Trauma Emerg Surg 2021 May 7. Epub 2021 May 7.

Axe Santé des Populations et Pratiques Optimales en Santé (Population Health and Optimal Health Practices Research Unit), Traumatologie-Urgence-Soins Intensifs (Trauma-Emergency-Critical Care Medicine), Centre de Recherche du CHU de Québec (Hôpital de l'Enfant-Jésus), Université Laval, Québec, QC, Canada.

Purpose: Approximately, one out of five patients hospitalized following injury will develop at least one hospital complication, more than three times that observed for general admissions. We currently lack actionable Quality Indicators (QI) targeting specific complications in this population. We aimed to derive and validate QI targeting hospital complications for injury admissions and develop algorithms to identify patient charts to review. Read More

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Clinical Characteristics of 195 Cases of COVID-19 with Gastrointestinal Symptoms COVID-19 with Gastrointestinal Symptoms.

Turk J Gastroenterol 2021 Feb;32(2):148-154

Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.

Background: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), have fever, dry cough, dyspnea, and fatigue. The disease has now become a global pandemic. The purpose of this study was to explore the relationship between COVID-19 and gastrointestinal (GI) symptoms. Read More

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February 2021

Thoracic Point-of-Care Ultrasound: A SARS-CoV-2 Data Repository for Future Artificial Intelligence and Machine Learning.

Surg Innov 2021 May 7:15533506211018671. Epub 2021 May 7.

Department of Surgery, 1267Anne Arundel Medical Center, Annapolis, MD, USA.

Current experience suggests that artificial intelligence (AI) and machine learning (ML) may be useful in the management of hospitalized patients, including those with COVID-19. In light of the challenges faced with diagnostic and prognostic indicators in SARS-CoV-2 infection, our center has developed an international clinical protocol to collect standardized thoracic point of care ultrasound data in these patients for later AI/ML modeling. We surmise that in the future AI/ML may assist in the management of SARS-CoV-2 patients potentially leading to improved outcomes, and to that end, a corpus of curated ultrasound images and linked patient clinical metadata is an invaluable research resource. Read More

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Epidemiology and outcome of influenza-associated infections among hospitalized patients with acute respiratory infections, Egypt national surveillance system, 2016-2019.

Influenza Other Respir Viruses 2021 May 7. Epub 2021 May 7.

Egypt Country Office, World Health Organization, Cairo, Egypt.

Introduction: Egypt has established different types of surveillance systems to monitor influenza activities, early detect outbreaks, and tailor efficient prevention and control strategies. This is the first study to describe epidemiology and outcome of influenza-associated infections among hospitalized patients using the National Electronic Disease Surveillance System (NEDSS) data, 2016-2019.

Methods: Data reported from 284 hospitals all over Egypt were extracted from the NEDSS. Read More

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Incomplete Recovery from COVID-19 associated Acute Kidney Injury (AKI) in Kidney Transplant Recipients: Prior Graft Injury Matters The Most.

Umberto Maggiore

Transpl Int 2021 May 7. Epub 2021 May 7.

Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.

Acute kidney injury (AKI) occurs frequently in the course of COVID-19 in the general population, its incidence ranging from 7% in hospitalized patients to above 20% in patients admitted to ICU. The definitive pathogenesis is still unclear. However, because in most cases the pattern of injury is acute tubular necrosis and endothelial injury, it is likely that most cases of AKI are the result of hemodynamic instability, cytokine-related injury, and dysfunction of the coagulation cascade. Read More

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Therapeutic strategies to fight COVID-19: Which is the status artis?

Br J Pharmacol 2021 May 7. Epub 2021 May 7.

Department of Experimental Medicine, Università degli studi della Campania 'Luigi Vanvitelli', Naples, Italy.

COVID-19 is a complex disease, and many difficulties are faced today especially in the proper choice of pharmacological treatments. The role of antiviral agents for COVID-19 is still being investigated and evidence for immunomodulatory and anti-inflammatory drugs is quite conflicting, whereas the use of corticosteroids is supported by robust evidence. The use of heparins in hospitalized critically ill patients is preferred over other anticoagulants. Read More

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Physician Palliative Education Associated With High Use of Hospice Care Service.

Am J Hosp Palliat Care 2021 May 7:10499091211014160. Epub 2021 May 7.

Superintendent Office & Division of Neurosurgery, Department of Surgery, 38010Taipei City Hospital, Taipei.

Background: Taiwan's National Health Insurance provides coverage for palliative and hospice care. The following 10 types of diseases have been added to the National Health Insurance reimbursement regulation: end-stage cancer, motor neuron disease, organic psychosis, brain degeneration, heart failure, chronic airway obstruction diseases, other lung diseases, chronic liver disease and cirrhosis, acute renal failure, and chronic renal failure.

Objective: This study aimed to determine the association between physicians' palliative education and use of hospice care in hospitalized patients at the end of life. Read More

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Relationship Between Fasting Glucose, HbA Levels, and the SYNTAX Score 2 in Patients With Non-ST-Elevation Myocardial Infarction.

Angiology 2021 May 7:33197211014678. Epub 2021 May 7.

Department of Cardiology, 52979Koc University Hospital, Istanbul, Turkey.

We evaluated if admission glycosylated hemoglobin (HbA) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary artery disease severity, according to the anatomical synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively evaluated in 359 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. Glucose intolerance was assessed by serum fasting glucose and HbA levels. Read More

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Does hospitalization of a patient in the intensive care unit cause anxiety and does restriction of visiting cause depression for the relatives of these patients during COVID-19 pandemic?

Int J Clin Pract 2021 May 6:e14328. Epub 2021 May 6.

Department of Critical Care Unit, Ankara City Hospital, Ankara, Turkey.

Objectives: During the pandemic, anxiety, stress, and depression may occur increasingly in the whole society. To evaluate the possible cause, incidence and levels of anxiety and depression in the relatives of the patients in the ICU in accordance with the patients' SARS-CoV-2 PCR result.

Materials And Method: The study was prospectively conducted on relatives of patients admitted to tertiary intensive care units during COVID-19 pandemic. Read More

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Discordant SARS-CoV-2 Detection in the Nasopharynx versus Trachea for Patients with Tracheostomies.

Laryngoscope 2021 May 6. Epub 2021 May 6.

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, Michigan, 48109.

Objective: Patients with tracheostomies have an anatomically altered connection between their upper and lower airways that could impact SARS-CoV-2 testing. Our goal was to evaluate for discordance in SARS-CoV-2 detection in hospitalized patients with COVID-19 and tracheostomies based on the site analyzed.

Methods: This single-institution study evaluated hospitalized patients with COVID-19 who had tracheostomies placed during their treatment. Read More

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Associations of Chronic Medication Adherence with Emergency Room Visits and Hospitalizations.

J Gen Intern Med 2021 May 6. Epub 2021 May 6.

Department of Quality Measurements and Research, Clalit Health Services, Tel Aviv, Israel.

Introduction: Good medication adherence is associated with decreased healthcare expenditure; however, adherence is usually assessed for single medication. We aim to explore the associations of adherence levels to 23 chronic medications with emergency room (ER) visits and hospitalizations. The primary endpoints are ER visits and hospitalizations in internal medicine and surgical wards. Read More

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Aerosol drug delivery to tracheotomized patients with COVID-19: Pragmatic suggestions for clinicians.

Can J Respir Ther 2021 30;57:49-52. Epub 2021 Apr 30.

Department of Respiratory Care, Texas State University, College of Health Professions, Round Rock, TX, USA.

Because of the wide and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the number of hospitalized patients with coronavirus disease 2019 (COVID-19) has rapidly increased medically complex and resource-intensive treatment requirements in health care settings. Although tracheostomy is frequently needed for critically ill patients requiring extended mechanical ventilation, it has been described as an aerosol-generating procedure that puts health care professionals at an increased risk of viral transmission. In addition, the delivery of aerosolized medications to this patient population has become controversial because of concerns on the transmission of SARS-CoV-2 via droplets. Read More

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Hospitalized Children With Familial Hypercholesterolemia and COVID-19: A Case for Preventive Anticoagulation.

Front Cardiovasc Med 2021 20;8:657719. Epub 2021 Apr 20.

Atherosclerosis Laboratory, Wihuri Research Institute, Helsinki, Finland.

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To the Operating Room! Positive Effects of a Healthcare Clown Intervention on Children Undergoing Surgery.

Front Public Health 2021 20;9:653884. Epub 2021 Apr 20.

Department of Clinical Psychology, Motol University Hospital, Prague, Czechia.

In the present study we examined the positive effects of a healthcare clown intervention on children undergoing surgeries, and the role parent-child relationships may play in their effectiveness. Children between 5 and 12 years, who were scheduled to undergo elective surgical procedures in a large university hospital, were randomly assigned to an intervention group (IG; = 35) that was visited by a healthcare clown, and a control group (CG; = 27) that received treatment as usual (i.e. Read More

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One delayed diagnosis of paragonimiasis case and literature review.

Respirol Case Rep 2021 May 28;9(5):e00750. Epub 2021 Apr 28.

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Human paragonimiasis has been appearing all over the world due to increased human migration, international travel, and worldwide food trading. However, delayed and missed diagnosis rates are also increasing due to atypical clinical manifestations and the lack of disease understanding by clinical workers. We describe the case of a 43-year-old man, who was hospitalized with cough and chest pain for two months. Read More

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Association of right ventricular dysfunction and pulmonary hypertension with adverse 30-day outcomes in COVID-19 patients.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007040. Epub 2021 Apr 19.

Department of Cardiology, Heart and Vascular Institute, Maimonides Medical Center, Brooklyn, NY, USA.

Background: Cardiac manifestations in COVID-19 are multifactorial and are associated with increased mortality. The clinical utility and prognostic value of echocardiography in COVID-19 inpatients is not clearly defined. We aim to identify echocardiographic parameters that are associated with 30-day clinical outcomes secondary to COVID-19 hospitalization. Read More

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A Combination of Atorvastatin and Aspirin Enhances the Pro-Regenerative Interactions of Marrow Stromal Cells and Stroke-Derived Monocytes .

Front Pharmacol 2021 20;12:589418. Epub 2021 Apr 20.

Department of Neurology, Institute for Stroke and Cerebrovascular Disease, McGovern Medical School at UTHealth, Houston, TX, United States.

Marrow stromal cells (MSCs) are being tested in clinical trials for stroke patients. MSCs appear to promote recovery through secretomes that promote modulation of immune cells, including myeloid phagocytes. Many stroke patients have comorbidities such as metabolic syndrome, hypertension, hypercholesterolemia, and diabetes for which they are prescribed medications that might affect the function of MSCs and monocytes (Mo) when they are administered in stroke patients. Read More

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Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson's Disease.

Front Neurosci 2021 20;15:633022. Epub 2021 Apr 20.

Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson's disease (PD).

Methods: A case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. Read More

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Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study.

Neuropsychiatr Dis Treat 2021 30;17:1267-1277. Epub 2021 Apr 30.

Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, People's Republic of China.

Objective: There have been studies exploring the association between handgrip and depression among community-dwelling adults; however, evidence for this association among hospitalized older adults is scarce. We aimed to use a larger-scale population from multiple centers to explore the association between low handgrip strength and depression.

Methods: This was a cross-sectional study that included hospitalized patients aged 65 years or older from different hospitals in China. Read More

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Clinical characteristics of vulnerable populations hospitalized and diagnosed with COVID-19 in Buenos Aires, Argentina.

Sci Rep 2021 May 6;11(1):9679. Epub 2021 May 6.

Neurosciences and Complex Systems Unit (EnyS), CONICET- Hosp. El Cruce "N. Kirchner" - Univ. National A. Jauretche, Fac. Med, Univ. Buenos Aires, Av Calchaqui 5401, CP B1888AAE, F. Varela, Province Buenos Aires, Argentina.

There is not in Argentina publications regarding the presentation of patients with COVID-19 requiring hospitalized and emergency care in vulnerable populations (lower incomes and less education tend at greater risk for poor health status and healthcare access), and it has few reports in developing countries. The objective is to determine whether in the care of vulnerable patients, to succeed against COVID-19, multiple public health tools and interventions will be needed to minimize morbidity and mortality. The study is a prospective cohort investigation of patients with lab-confirmed COVID-19, who required to any of the Health Centers response from April 8, 2020, to August 18, 2020. Read More

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Clinical impact of blood pressure variability in patients with COVID-19 and hypertension.

Blood Press Monit 2021 May 6. Epub 2021 May 6.

Division of Cardiology Division of Pulmonology and Allergy Division of Rheumatology and Infectious Disease, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.

Objective: This study aimed to investigate the relationship between blood pressure variability (BPV) and clinical outcomes in patients with coronavirus disease 2019 (COVID-19) and hypertension.

Methods: A total of 136 patients hospitalized with COVID-19 were enrolled in this study. Patients were grouped according to the presence of hypertension and BPV. Read More

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Safety Events in Children's Hospitals During the COVID-19 Pandemic.

Hosp Pediatr 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, Boston Children's Hospital and Harvard University, Boston, Massachusetts.

Background And Objectives: The coronavirus disease 2019 (COVID-19) pandemic has impacted hospitals, potentially affecting quality and safety. Our objective was to compare pediatric hospitalization safety events during the pandemic versus previous years.

Methods: In this retrospective cohort study of hospitalizations in the Pediatric Health Information System, we compared Pediatric Quality Indicator (PDI) rates from March 15 to May 31, 2017-2019 (pre-COVID-19), with those from March 15 to May 31, 2020 (during COVID-19). Read More

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Medication Use Among Patients With COVID-19 in a Large, National Dataset: Cerner Real-World Data™.

Clin Ther 2021 Apr 15. Epub 2021 Apr 15.

Department of Infectious Diseases, Nuvance Health, Danbury, Connecticut.

Purpose: The outbreak of coronavirus disease 2019 (COVID-19) required clinicians to use knowledge of therapeutic mechanisms of established drugs to piece together treatment regimens. The purpose of this study is to examine the trends in medication use among patients with COVID-19 across the United States using a national dataset.

Methods: We conducted a cross-sectional study of the COVID-19 cohort in the Cerner Real-World Data warehouse, which includes deidentified patient information for encounters associated with COVID-19 from December 1, 2019, through June 30, 2020. Read More

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Nurse practitioner hospitalists: An empowered role.

Nurs Outlook 2021 May 3. Epub 2021 May 3.

Washington State University College of Nursing Vancouver, Vancouver, WA.

Background: Nurse practitioners (NPs) are increasingly employed by hospital medicine groups and contribute to the care of the hospitalized adult patient. Prior research indicates NP hospitalists are empowered in their role.

Purpose: This national study describes the work experience of the NP hospitalist workforce. Read More

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