480,185 results match your criteria hospital mortality

IFNλ Therapy Prevents Severe Gastrointestinal Graft-versus-Host Disease.

Blood 2021 May 5. Epub 2021 May 5.

University of Washington, United States.

Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima-facie manifestation of graft-versus-host disease (GVHD) and is responsible for significant mortality after allogeneic bone marrow transplantation (BMT). Approaches to prevent GVHD to date focus on immune-suppression. Here we identify interferon-lambda (IFNl, IL-28/IL-29) as a key protector of GI GVHD immunopathology, notably within the intestinal stem cell (ISC) compartment. Read More

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Impact of myocardial infarction symptom presentation on emergency response and survival.

Eur Heart J Acute Cardiovasc Care 2021 May 5. Epub 2021 May 5.

Department of Cardiology, Nordsjællands Hospital, Dyrehavevej 29, Hillerød 2400, Denmark.

Aims: We examined associations between symptom presentation and chance of receiving an emergency dispatch and 30-day mortality among patients with acute myocardial infarction (MI).

Methods And Results: Copenhagen, Denmark has a 24-h non-emergency medical helpline and an emergency number 1-1-2 (equivalent to 9-1-1). Both services register symptoms/purpose of calls. Read More

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Antifibrotic Therapy: Is There a Role in Myositis-Interstitial Lung Disease?

Respiration 2021 May 5:1-10. Epub 2021 May 5.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Interstitial lung disease (ILD) is a cause of substantial morbidity and mortality amongst autoimmune diseases, including myositis. Despite first-line therapy with immunosuppression, many inflammatory ILDs advance to a fibrotic stage. In such patients, progressive fibrosis may be amenable to treatment with antifibrotic medications, which were initially studied and approved for the treatment of idiopathic pulmonary fibrosis. Read More

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Pulmonary Hypertension: The Hidden Danger for Newborns.

Steven H Abman

Neonatology 2021 May 5:1-7. Epub 2021 May 5.

Pediatric Pulmonary Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.

Despite growing awareness of the clinical importance of pulmonary hypertension (PH) in preterm infants, uncertainty persists regarding the different clinical settings in which abnormalities of pulmonary vascular growth, function, and structure contribute to high morbidity and mortality, and potential interventions to improve outcomes are uncertain. A major gap for improving outcomes of preterm infants with PH has been the limited characterization of the distinct settings of PH and related disease-specific mechanisms in preterm infants that represent diverse pulmonary vascular phenotypes of prematurity. In comparison with term newborns, preterm infants have a higher risk for developing hypoxemia due to suprasystemic levels of PH in preterm infants shortly after birth or persistent pulmonary hypertension of the newborn (PPHN). Read More

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Quick Sequential Organ Failure Assessment, Sequential Organ Failure Assessment, and Procalcitonin for Early Diagnosis and Prediction of Death in Elderly Patients with Suspicion of Sepsis in the Emergency Department, Based on Sepsis-3 Definition.

Gerontology 2021 May 5:1-10. Epub 2021 May 5.

School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Background: Sepsis is a disease with a high mortality rate without prompt treatment. However, this entity is difficult to diagnose in the elderly population in the emergency room; for this reason, it is necessary to have diagnostic tools for early detection.

Objective: The aim of the study was to determine the highest diagnostic yield of procalcitonin (PCT), Quick Sequential Organ Failure Assessment (qSOFA), and Sequential Organ Failure Assessment (SOFA) for sepsis (based on the sepsis-3 consensus), on admission at the emergency department, in those older than 65 years. Read More

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The Obesity Paradox in Elderly Patients Undergoing Emergency Surgery: A Nationwide Analysis.

J Surg Res 2021 May 2;265:195-203. Epub 2021 May 2.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Obesity has long been considered a risk factor for postoperative adverse events in surgery. We sought to study the impact of body mass index (BMI) on the clinical outcomes of the high-risk emergency general surgery (EGS) elderly patients.

Methods: All EGS ≥65 years old patients in the 2007-2016 ACS-NSQIP database, identified using the variables 'emergency' and 'surgspec,' were included. Read More

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Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27 signaling pathway.

Phytomedicine 2021 Apr 4;86:153563. Epub 2021 Apr 4.

Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality worldwide. Sorafenib (SORA), as a first-line therapeutic drug, has been used to treat HCC, but resistance poses a major limitation on the efficacy of SORA chemotherapy. Pristimerin (PRIS), a natural bioactive component isolated from various plant species in the Celastraceae and Hippocrateaceae families, has been reported to exhibit outstanding antitumor effects in several types of cells in vitro. Read More

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Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS).

J Hepatol 2021 Apr 24. Epub 2021 Apr 24.

Department of hepatogastroenterology, Hepatology and Liver Transplantation Unit, HCL Hopital de la Croix-Rousse, Lyon, France.

Background And Aims: Liver transplantation (LT) has been proposed to be an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to address the current clinical practice and outcomes of ACLF patients wait listed (WL) for LT in Europe.

Methods: Retrospective study including 308 consecutive ACLF patients, listed in 20 centres across 8 European countries, from January 2018 to June 2019. Read More

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Outcome of femoral-popliteal bypass procedures in different ethnic groups in England: A retrospective analysis of Hospital Episode Statistics.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.

Background: Previous studies, mainly from the United States, have reported worse outcomes from lower limb bypass procedures in ethnic minority populations. Limited nationwide data are available from ethnic minority populations from Europe. The aim of this study is to investigate outcomes from lower limb bypass procedures in ethnic minorities from England. Read More

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The association of Spondylitis and Aortic Aneurysm Disease.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Vascular Surgery, Larissa University Hospital, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larissa, Greece. Electronic address:

Objectives: The aim of this study is to assess any relation between spondylitis and aortic aneurysmal disease by reviewing the current literature.

Methods: A systematic search was undertaken using MEDLINE, EMBASE and CENTRAL databases till May 2019, for articles reporting on patients suffering from spondylitis and aortic aneurysm.

Results: The most involved aortic segment was infrarenal aorta (56. Read More

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Aortic neck IFU violations during EVAR for ruptured infrarenal aortic aneurysms are associated with increased in-hospital mortality.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Division of Vascular Surgery and Endovascular Therapy, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Objective: Vascular surgeons treating patients with ruptured abdominal aortic aneurysm (rAAA) must make rapid treatment decisions and sometimes lack immediate access to endovascular devices meeting the anatomic specifications of the patient at hand. We hypothesized that endovascular treatment of rAAA (rEVAR) outside manufacturer instructions-for-use (IFU) guidelines would have similar in-hospital mortality compared to patients treated on-IFU or with an infrarenal clamp during open repair (rOAR).

Methods: Vascular Quality Initiative (VQI) datasets for endovascular and open aortic repair were queried for patients presenting with ruptured infrarenal AAA between 2013-2018. Read More

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Anxiety and depression scores in patients subjected to arterial revascularization for critical limb ischemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Hospital Israelita Albert Einstein, Avenida Albert Einstein, 627, bloco A1, sala 422, Morumbi. ZIP: 05652-900. São Paulo, SP Brazil.

Objectives: This study aims to examine the changes in anxiety and depression scores in 138 patients with critical limb ischemia (rest pain or gangrene) who had no previous psychiatric history, at 30 days and 6 months after surgical revascularization.

Methods: Patients were submitted to a questionnaire-based evaluation using the Beck Anxiety and Depression Inventories before surgery (no more than three days before surgery) ("Pre-Op"), 30 days after surgical revascularization ("Early PO") and at least 6 months after surgical revascularization ("Late PO"). The cut-off scores for depression were (1) < 10, no depression or minimal depression; (2) 10‒18, mild to moderate depression; (3) 19‒29, moderate to severe depression; and (4) 30‒63, severe depression. Read More

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Comparison of Myeloablative Versus Reduced-Intensity Conditioning Regimens in Allogeneic Stem Cell Transplant Recipients with Acute Myelogenous Leukemia with MRD Negative Disease at the Time of Transplant: A Retrospective Cohort Study.

Transplant Cell Ther 2021 May 2. Epub 2021 May 2.

Blood and Marrow Transplant Center, AdventHealth Orlando Hospital, Orlando, FL 32804, USA. Electronic address:

Background/objective: The ideal conditioning intensity in allogeneic hematopoietic stem cell transplantation (HSCT) is evolving. Previous prospective studies comparing myeloablative versus reduced intensity conditioning regimens in adults with acute myelogenous leukemia (AML) have shown mixed results. In many of these studies, patients were not stratified based on measurable residual disease (MRD). Read More

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Mortality and Healthcare Utilization of Patients with Compensated Hypercapnia.

Ann Am Thorac Soc 2021 May 5. Epub 2021 May 5.

University of Michigan, 1259, Ann Arbor, Michigan, United States.

Rationale: Acute hypercapnic respiratory failure has been shown to be associated with worse outcomes for various disease states, but less is known about patients with compensated hypercapnic respiratory failure. Although these patients have a normal pH, it remains unknown whether chronically elevated partial pressures of carbon dioxide (PaCO2), irrespective of etiology, put patients at risk of adverse events.

Objectives: To understand the burden of and clinical factors associated with morbidity and mortality in patients with compensated hypercapnic respiratory failure. Read More

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Morbid obesity but not obesity is associated with increased mortality in patients undergoing endoscopic retrograde cholangiopancreatography: A national cohort study.

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The relationship between body weight and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) is unclear.

Objectives: This study aimed to investigate the impact of obesity and morbid obesity on mortality and ERCP-related complications in patients who underwent ERCP.

Methods: We conducted a US population-based retrospective cohort study using the Nationwide Readmissions Databases (2013-2014). Read More

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Serum phosphate is associated with mortality among patients admitted to ICU for acute pancreatitis.

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Service de Réanimation Médicale, CHRU Jean Minjoz, Besançon, France.

Background And Aims: Routine laboratory tests can be useful predictors in the early assessment of the severity and mortality of acute pancreatitis (AP). The aim of this study was to evaluate the accuracy of clinical and laboratory parameters for the prediction of mortality among patients admitted to the intensive care unit (ICU) for AP.

Methods: We conducted a retrospective analysis of prospectively collected data from Beth Israel Deaconess Hospital made publicly available to examine the relationship between routine clinical and laboratory parameters with respect to mortality for AP. Read More

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A nonrandomised pilot study to examine the feasibility and acceptability of reflexology in patients undergoing hospital-based haemodialysis (solitude study).

J Ren Care 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, Queen's University, Belfast, UK.

Background: Patients with end-stage kidney disease, receiving haemodialysis can experience complications-hypotension, headache, muscle cramp, chest pain, nausea and vomiting. Patients who experience all or some of these symptoms will often report reduced health-related quality of life (HRQOL) and poor sleep quality, which may lead to increased morbidity and mortality.

Objective: The objective of this pilot study is to evaluate the feasibility of a larger randomised controlled trial to determine the effect of foot reflexology on a cohort of patients undergoing hospital-based haemodialysis. Read More

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Qualitative research methods and its application in nephrology.

Nephrology (Carlton) 2021 May 5. Epub 2021 May 5.

Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

Chronic kidney disease is associated with an increased risk of mortality, comorbidities, and life-threatening complications. Invasive treatments including dialysis or transplantation, complex pharmacological therapies, dietary restrictions, and the ongoing need to attend follow-up appointments can place a substantial treatment burden on patients and carers and impair quality of life. This highlights the need for care that is responsive to the needs of patients and involves them in decision-making to achieve the most appropriate healthcare outcomes. Read More

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The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis.

J Intern Med 2021 May 5. Epub 2021 May 5.

Department of Cardiology, Skåne University Hospital, Malmö, Sweden.

Background: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention.

Objective: In this study, we evaluate endotrophin in human atherosclerotic plaques and circulating levels of PRO-C6 in patients with atherosclerosis, to determine the predictive potential of the biomarker. Read More

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Serum potassium levels and prognosis in HBV-associated decompensated cirrhosis.

J Clin Lab Anal 2021 May 5:e23775. Epub 2021 May 5.

Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.

Background: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV-related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV-DeCi patients.

Methods: Retrospective study included 155 subjects. Read More

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Letter to Editor regarding article, 'Association between dental factors and mortality'.

T Wu G Wang X Pan

Int Endod J 2021 Jun;54(6):1002

Department of Dental Implantology and Prosthodontics, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

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Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study.

Age Ageing 2021 May;50(3):631-640

Department of Internal Medicine, Haga Teaching Hospital, The Hague, the Netherlands.

Background: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting.

Objective: The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Read More

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What is the relationship between validated frailty scores and mortality for adults with COVID-19 in acute hospital care? A systematic review.

Age Ageing 2021 May;50(3):608-616

Department of Health Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.

Background And Aim: The aim of this systematic review was to quantify the association between frailty and COVID-19 in relation to mortality in hospitalised patients.

Methods: Medline, Embase, Web of Science and the grey literature were searched for papers from inception to 10 September 2020; the search was re-run in Medline up until the 9 December 2020. Screening, data extraction and quality grading were undertaken by two reviewers. Read More

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Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review.

Age Ageing 2021 May;50(3):744-757

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Background: anticoagulation is integral to stroke prevention for atrial fibrillation (AF), but there is evidence of under-treatment in older people in long-term care (LTC).

Objective: to synthesise evidence on the prevalence and outcomes (stroke, mortality or bleeding) of AF in LTC and the factors associated with the prescription of anticoagulation.

Methods: studies were identified from Medline, CINAHL, PsycINFO, Scopus and Web of Science from inception to 31 October 2019. Read More

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Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality.

PLoS One 2021 5;16(5):e0250653. Epub 2021 May 5.

Division of Cardiology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.

Background And Aims: Cardiovascular (CV) disease is the major cause of death in patients with end-stage kidney disease (ESKD). Left ventricular (LV) diastolic dysfunction reflects LV pressure overload and is common in patients with ESKD. Recently, there have been studies on the usefulness of central blood pressure (BP); however, the relationship between central BP and LV diastolic dysfunction is not clear in dialysis patients with preserved systolic function. Read More

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Components of clean delivery kits and newborn mortality in the Zambia Chlorhexidine Application Trial (ZamCAT): An observational study.

PLoS Med 2021 May 5;18(5):e1003610. Epub 2021 May 5.

Ariadne Labs, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: Neonatal infection, a leading cause of neonatal death in low- and middle-income countries, is often caused by pathogens acquired during childbirth. Clean delivery kits (CDKs) have shown efficacy in reducing infection-related perinatal and neonatal mortality. However, there remain gaps in our current knowledge, including the effect of individual components, the timeline of protection, and the benefit of CDKs in home and facility deliveries. Read More

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Age-adjusted Charlson comorbidity index score is the best predictor for severe clinical outcome in the hospitalized patients with COVID-19 infection.

Medicine (Baltimore) 2021 May;100(18):e25900

Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine.

Abstract: Aged population with comorbidities demonstrated high mortality rate and severe clinical outcome in the patients with coronavirus disease 2019 (COVID-19). However, whether age-adjusted Charlson comorbidity index score (CCIS) predict fatal outcomes remains uncertain.This retrospective, nationwide cohort study was performed to evaluate patient mortality and clinical outcome according to CCIS among the hospitalized patients with COVID-19 infection. Read More

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Quality of care and outcomes in internal medicine patients bedspaced to noninternal medicine units.

Medicine (Baltimore) 2021 May;100(18):e25737

Toronto General Hospital, Division of Internal Medicine, Sinai Health Systems and University Health Network, Toronto.

Abstract: Hospital overcrowding has led to a practice known as bedspacing (in which admitted patients are placed on a different specialty's inpatient ward), yet little is known about the impact of this practice on healthcare quality.We investigated whether hospital outcome measures differ between bedspaced general internal medicine (GIM) patients vs nonbedspaced patients.Our retrospective study included patients admitted to GIM wards at 2 academic hospitals (2012-2014), comparing bedspaced to nonbedspaced patients, and identifying adverse events from the hospital's Electronic Patient Record. Read More

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Seasonal variation in incidence and outcomes of out of hospital cardiac arrest: A retrospective national observational study in the United States.

Medicine (Baltimore) 2021 May;100(18):e25643

Department of Emergency Medicine.

Abstract: Out of hospital cardiac arrest (OHCA) remains a leading cause of mortality among adults in the United States. Environmental impact on incidence and outcomes of OHCA has not been fully investigated in recent years. Previous studies showed a possible increase in incidence and mortality in winter season and during seasons with temperature extremes. Read More

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Evaluation of the efficiency of corticosteroids in treating adult with sepsis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25610

Department of Infectious Diseases, Weifang People's Hospital, Weifang, Shandong Province, China.

Background: Sepsis is a worldwide health problem that is a leading cause of mortality due to infection. Sepsis is prevalent in infections that are complicated with organ failure. Generally, sepsis is intricate and impaired corticosteroid metabolism leads to complex outcomes. Read More

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